Dr. Benoit Giasson
Investigator, CTRND and McKnight Brain Institute
Post-Doc, Pathology and Laboratory Medicine (John Trojanowski), University of Pennsylvania, 2001-2003
Post-Doc, Pathology and Laboratory Medicine (Virginia Lee), University of Pennsylvania, 1998-2001
Ph.D., Biochemistry, McGill University, Canada- 1997
B.Sc., Biochemistry, McGill University, Canada- 1991
Contact D. Giasson
Office Phone: 352-273-9363
Lab Phone: 352-273-9367
Research Focus and Aims
My research is focused on understanding the cellular mechanisms and molecular interactions involved as underlying causes of neurodegenerative diseases. I have published numerous studies on the mechanisms and consequences of aberrant proteinaceous inclusions associated with neurodegenerative diseases. A primary research interest is to expand the understanding of the regulation of protein levels, function, interactions and folding that affect protein aggregation in the nervous system. This goal includes studying the natural biological activities involved in the regulation of proper protein folding and processing, as well as cellular activities that act as “countermeasures” to prevent, reverse or eliminate proteinaceous inclusions. In addition, my research includes characterizing the effects of environments factors on genetic products that have been involved in neurodegenerative diseases since such studies have provided strong evidence indicating that environmental factors have an important role in influencing disease presentation and progression. In my laboratory we pursue these goals using a diverse spectrum of complementary techniques including histological and biochemical studies of human postmortem tissues and transgenic mice, molecular biology, cell culture applications, protein interactions and aggregation assays, biochemical assays of protein modifications and several imaging procedures. The overall goals of these studies is to provide novel and significant insights into both the normal function of neuronal proteins involved in neurodegenerative diseases as well as the development of therapeutic strategies to prevent aberrant protein aggregation and neuronal demise. As a mentor I have over 8 years of experience in mentoring and training graduate students and postdoctoral fellows.
Join the team!
We welcome applications from undergraduate/graduate students and post-doctoral fellows who would like to join the lab team