Research Snapshot: Drs. Cara Croft and Todd Golde

New preclinical research led by UF neuroscientists shows that tau proteins, considered a hallmark of Alzheimer’s disease pathology, build up in brain cells of mice and continue to be cleared. The novel finding published in the journal Acta Neuropathologica indicates that reversing pathological tau formations could be possible.

Understanding the cellular processes behind the turnover could help guide the development of future therapeutic strategies aimed at such a reverse, the researchers reported.

In the new study, investigators engineered non-infectious viruses and introduced them to thin sections of brain tissue from mice to track old and new tau protein in different colors and follow it over several weeks. The researchers used microscopy to capture images of the living brain tissue every few days to track the new and old tau protein clumps and discovered that the old tau protein clumps were gradually being cleared away.

“We hope that future research will lead to further understanding of how the cells are able to clear these tau clumps and whether this helps to make the cell healthy,” said first author Cara Croft, Ph.D., a postdoctoral associate in the lab of Todd Golde, M.D., Ph.D., the study’s senior author and director of UF’s McKnight Brain Institute.

“If this clearance process is beneficial, then it is likely that we can start to test whether drugs or other methods are able to speed up this process and may form a new avenue for treatment of Alzheimer’s disease or other diseases that involve changes in tau,” Croft said.

Read the paper in Acta Neuropathologica.