Dr. Malú Tansey
Dr. Malú Tansey
Director, Center for Translation Research in Neurodegenerative Disease
Professor. Department of Neuroscience
Investigator, Evelyn F, and William L McKnight Brain Institute
Investigator, Norman Fixel Institute for Neurological Diseases
Ph.D., University of Texas Southwestern, 1992
B.S./M.S, Stanford University
Office Phone: 352-494-4096
Research Focus and Aims
The general interests of my laboratory include investigating the role and regulation of neuroinflammatory and immune system responses in modulating the gene-environment interactions that determine risk for development and progression of neurodegenerative and neuropsychiatric disease.
We employ molecular, cellular, biochemical, pharmacological, immunohistological, fixed and live-cell high-content imaging, and behavioral assays to address important mechanistic questions with the long-term goal of developing novel therapeutics for the prevention and/or treatment of chronic neurodegenerative and neuropsychiatric diseases characterized by chronic neuroinflammation.
- The gut microbiome and neuroinflammation in amyotrophic lateral sclerosis? Emerging clinical evidence.Houser M, Tansey MG, Glass JD, Hertzberg VS. Fournier CN, Neurobiol Dis. 2018 Oct 12. pii: S0969-9961(18)30687-9. doi: 10.1016/j.nbd.2018.10.007. [Epub ahead of print] Review. No abstract available. PMID: 30321601
- α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis.Butkovich LM, Houser MC, Tansey MG. Front Neurosci. 2018 Sep 11;12:626. doi: 10.3389/fnins.2018.00626. eCollection Review. PMID:30258347
- Challenges in Passive ImmunizationStrategies to Treat Parkinson Disease. Manfredsson FP, Tansey MG, Golde TE. JAMA Neurol. 2018 Oct 1;75(10):1180-1181. doi: 10.1001/jamaneurol.2018.0346. No abstract available. PMID: 29913004
- What does plasma CRP tell us about peripheral and central inflammation in depression?Felger JC, Haroon E, Patel TA, Goldsmith DR, Wommack EC, Woolwine BJ, Le NA, Feinberg R, Tansey MG, Miller AH. Mol Psychiatry. 2018 Jun 12. doi: 10.1038/s41380-018-0096-3. [Epub ahead of print] PMID:29895893