Jose F Abisambra

Jose F Abisambra

Associate Professor, Program Co-Director MS In Neuroscience Graduate Program

Department: MD-NEUROSCIENCE-GENERAL
Business Email: j.abisambra@ufl.edu

About Jose F Abisambra

Dr. Abisambra is an Associate Professor of Neuroscience and Assistant Dean of Diversity & Health Equity at the University of Florida College of Medicine. He received his PhD in Medical Sciences/Molecular Medicine in 2010 from the University of South Florida and went on to complete a Postdoctoral Fellowship (2010-2012) at his alma mater. The overarching goal of his research program is to investigate the molecular mechanisms linking tau and ER dysfunction with neurodegeneration. This focus creates an opportunity to investigate the integration of essential cellular functions for development, aging, and disease by targeting one organelle. Ultimately, this work can aid in the identification of therapeutic targets for more than 30 million people currently suffering from tauopathies worldwide.

Research Profile

Dr. Abisambra’s research pertains to investigating fundamental biological processes critical to neuronal function that converge with endoplasmic reticulum (ER) proteins. His lab’s currently supported projects focus on the impact of the Unfolded Protein Response on neurodegenerative processes in Alzheimer’s and related proteinopathies. His work explores protein synthesis (Meier et al., 2016), trafficking (mitochondria, Golgi apparatus, plasma membrane, etc.) (Jinwal et al., 2010), folding (Abisambra et al., 2012; Abisambra et al., 2013a), and clearance (proteasome and autophagy) (Abisambra et al., 2013b) as fundamental processes during brain development, aging, and stress. He further investigates the impact of the ER on calcium homeostasis and lipid/carbohydrate metabolism (Abisambra et al., 2010) in the context of whole neuronal function. Alterations to these processes are linked to the pathogenesis of 25 known neurodegenerative disorders that share a common pathological hallmark: intracellular aggregation of tau. These tauopathies include Alzheimer’s disease (AD), chronic traumatic encephalopathy/traumatic brain injury (CTE/TBI; reviewed in (Abisambra and Scheff, 2014), and fronto-temporal degeneration with tau inclusions (FTD-tau).

Open Researcher and Contributor ID (ORCID)

0000-0001-6341-679X

Publications

2020
Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention.
Progress in neurobiology. [DOI] 10.1016/j.pneurobio.2020.101892. [PMID] 32795489.
2020
The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review.
Experimental neurology. 326 [DOI] 10.1016/j.expneurol.2020.113180. [PMID] 31930992.
2020
Tau-mediated dysregulation of RNA: Evidence for a common molecular mechanism of toxicity in frontotemporal dementia and other tauopathies.
Neurobiology of disease. 141 [DOI] 10.1016/j.nbd.2020.104939. [PMID] 32413399.
2019
Proteomic Techniques to Examine Neuronal Translational Dynamics.
International journal of molecular sciences. 20(14) [DOI] 10.3390/ijms20143524. [PMID] 31323794.
2019
Tau drives translational selectivity by interacting with ribosomal proteins.
Acta neuropathologica. 137(4):571-583 [DOI] 10.1007/s00401-019-01970-9. [PMID] 30759285.
2019
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models.
Nature medicine. 25(1):165-175 [DOI] 10.1038/s41591-018-0275-4. [PMID] 30617325.
2018
Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models.
Journal of Alzheimer's disease : JAD. 62(1):347-359 [DOI] 10.3233/JAD-170617. [PMID] 29439332.
2018
Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer’s disease.
Neurobiology of aging. 72:188.e3-188.e12 [DOI] 10.1016/j.neurobiolaging.2018.08.001. [PMID] 30201328.
2018
Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration.
Frontiers in aging neuroscience. 10 [DOI] 10.3389/fnagi.2018.00403. [PMID] 30618710.
2018
Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-22993-4. [PMID] 29545551.
2018
RNA binding proteins co-localize with small tau inclusions in tauopathy.
Acta neuropathologica communications. 6(1) [DOI] 10.1186/s40478-018-0574-5. [PMID] 30068389.
2017
A new opportunity for MEMRI.
Aging. 9(8):1855-1856 [DOI] 10.18632/aging.101283. [PMID] 28854148.
2017
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies.
Aging and disease. 8(3):257-266 [DOI] 10.14336/AD.2017.0112. [PMID] 28580182.
2017
Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach.
Neurobiology of aging. 56:78-86 [DOI] 10.1016/j.neurobiolaging.2017.04.007. [PMID] 28500878.
2016
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.
Cell reports. 15(7):1455-1466 [DOI] 10.1016/j.celrep.2016.04.045. [PMID] 27160897.
2016
MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.
PloS one. 11(2) [DOI] 10.1371/journal.pone.0149451. [PMID] 26871438.
2016
Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(3):1001-7 [DOI] 10.1523/JNEUROSCI.3029-15.2016. [PMID] 26791227.
2016
PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration.
Current Alzheimer research. 13(2):150-63 [PMID] 26679859.
View on: PubMed
2015
Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer’s Disease Brain.
Journal of Alzheimer's disease : JAD. 48(3):687-702 [DOI] 10.3233/JAD-150298. [PMID] 26402096.
2014
Brain injury in the context of tauopathies.
Journal of Alzheimer's disease : JAD. 40(3):495-518 [DOI] 10.3233/JAD-131019. [PMID] 24496078.
2014
Primary age-related tauopathy (PART): a common pathology associated with human aging.
Acta neuropathologica. 128(6):755-66 [DOI] 10.1007/s00401-014-1349-0. [PMID] 25348064.
2013
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.
Biological psychiatry. 74(5):367-74 [DOI] 10.1016/j.biopsych.2013.02.027. [PMID] 23607970.
2013
Imbalance of Hsp70 family variants fosters tau accumulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(4):1450-9 [DOI] 10.1096/fj.12-220889. [PMID] 23271055.
2013
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(22):9498-507 [DOI] 10.1523/JNEUROSCI.5397-12.2013. [PMID] 23719816.
2012
Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.
The Journal of biological chemistry. 287(29):24814-20 [DOI] 10.1074/jbc.M112.367268. [PMID] 22674575.
2012
DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.
Journal of molecular biology. 421(4-5):653-61 [DOI] 10.1016/j.jmb.2012.02.003. [PMID] 22343013.
2012
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
The Journal of biological chemistry. 287(48):40661-9 [DOI] 10.1074/jbc.M112.384800. [PMID] 23035116.
2011
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.
The Journal of biological chemistry. 286(19):16976-83 [DOI] 10.1074/jbc.M110.182493. [PMID] 21367866.
2011
The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau.
Journal of natural products. 74(1):38-44 [DOI] 10.1021/np100572z. [PMID] 21141876.
2011
ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(40):14413-23 [DOI] 10.1523/JNEUROSCI.3135-11.2011. [PMID] 21976526.
2011
Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.
Current neuropharmacology. 9(4):623-31 [DOI] 10.2174/157015911798376226. [PMID] 22654720.
2010
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
The Journal of biological chemistry. 285(4):2498-505 [DOI] 10.1074/jbc.M109.057208. [PMID] 19889640.
2010
Hsc70 rapidly engages tau after microtubule destabilization.
The Journal of biological chemistry. 285(22):16798-805 [DOI] 10.1074/jbc.M110.113753. [PMID] 20308058.
2010
Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases.
Molecular and cellular pharmacology. 2(2):43-46 [PMID] 20523917.
View on: PubMed
2010
LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer’s disease.
PloS one. 5(1) [DOI] 10.1371/journal.pone.0008556. [PMID] 20049331.
2010
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.
Molecular neurodegeneration. 5 [DOI] 10.1186/1750-1326-5-45. [PMID] 21040568.
2010
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(46):15374-82 [DOI] 10.1523/JNEUROSCI.3155-10.2010. [PMID] 21084594.
2010
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(2):591-9 [DOI] 10.1523/JNEUROSCI.4815-09.2010. [PMID] 20071522.

Grants

Sep 2019 ACTIVE
Developing new conditional models to study tauopathy, amyloidosis, and their interaction
Role:
Funding: NATL INST OF HLTH NINDS
Sep 2019 ACTIVE
Tau-mediated regulation of ribosomes in health and disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2019 ACTIVE
Exosomes from Adipose-derived Stem Cells Modulate Age-dependent Progression of Tauopathies
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIA
Sep 2018 – Sep 2019
The impact of PERK on Post-traumatic Tauopathy in Alzheimers Disease
Role: Principal Investigator
Funding: UNIV OF KENTUCKY via US ARMY MED RES ACQUISITION
Sep 2018 ACTIVE
PERK as a Central Mediator of Neurotoxicity in Tauopathies
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2018 ACTIVE
Elucidating the pathological consequences of tau-ribosome interactions
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2018 – Jun 2019
Myocardial Tauopathy: A New Pathogenesis and Treatment for Heart Disease
Role: Principal Investigator
Funding: MEDICAL UNIV OF SOUTH CAROLINA via AMER HEART ASSOCIATION
Aug 2015 – Jul 2020
Molecular clock and skeletal muscle weakness
Role: Project Manager
Funding: NATL INST OF HLTH NIAMS

Teaching Profile

Courses Taught
2019-2020
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
2019-2020
GMS7794 Neuroscience Seminar
2019
GMS6705 Functional Human Neuroanatomy

Contact Details

Emails: