Jennifer L Bizon

Jennifer L Bizon

Professor & Interim Chair, Co-Director Cognitive Aging And Memory Center

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 294-5149
Business Email: bizonj@ufl.edu

About Jennifer L Bizon

Dr. Jennifer Bizon is a Professor and Interim Chair of the Department of Neuroscience. She received her Bachelor of Science from the University of North Carolina at Chapel Hill (1993) and her Ph.D. in Neurobiology and Behavior from University of California, Irvine (1998). She received postdoctoral training at Johns Hopkins University (1998-2003) and then established her own laboratory at Texas A&M University prior to joining the University of Florida College of Medicine in 2010. Her research program is broadly focused on understanding brain aging and its implications for cognitive function. Dr. Bizon currently serves on the Executive Committee for the Evelyn F. and William L. McKnight Brain Institute. She participates in the training of medical students, graduate students, undergraduates, and postdoctoral fellows. She is co-Director of a T32 for pre-doctoral training in Alzheimer’s disease and related dementias.

Accomplishments

Fellow, Hedwig van Amerigen Executive Leadership in Academic Medicine
2020-Current · Drexel University
Florida Research Foundation Professorship
2018-2021 · University of Florida, College of Medicine
Term Professorship
2017-2020 · University of Florida, College of Medicine
Exemplary Teaching Award
2011-Current · University of Florida, College of Medicine
Montague-Center for Teaching Excellence Scholar
2008 · College of Liberal Arts, Texas A&M University

Research Profile

Dr. Bizon’s research program is broadly focused on understanding brain aging and its implications for cognitive function. Specifically, her laboratory employs an integrative approach that combines cognitive assessments with molecular, pharmacological and optogenetic methodologies. Recent work has uncovered disruptions in both glutamatergic and GABAergic signaling in the aged brain that contribute to impairments in cognitive flexibility, working memory and decision making (for example, Banuelos et al., 2014; McQuail et al., 2016, Beas et al., 2017). Her lab has also used optogenetic approaches to demonstrate age-associated differences in the neural circuits of decision making (Hernandez et al., 2019).

Publications

2020
Distinct relationships between risky decision making and cocaine self-administration under short- and long-access conditions.
Progress in neuro-psychopharmacology & biological psychiatry. 98 [DOI] 10.1016/j.pnpbp.2019.109791. [PMID] 31676462.
2020
Testicular hormones mediate robust sex differences in impulsive choice in rats.
eLife. 9 [DOI] 10.7554/eLife.58604. [PMID] 32985975.
2020
Regulation of risky decision making by gonadal hormones in males and females.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. [DOI] 10.1038/s41386-020-00827-0. [PMID] 32919406.
2019
Deconstructing value-based decision making via temporally selective manipulation of neural activity: Insights from rodent models.
Cognitive, affective & behavioral neuroscience. 19(3):459-476 [DOI] 10.3758/s13415-018-00649-0. [PMID] 30341621.
2019
Enhancing effects of acute exposure to cannabis smoke on working memory performance.
Neurobiology of learning and memory. 157:151-162 [DOI] 10.1016/j.nlm.2018.12.001. [PMID] 30521850.
2019
Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats.
eLife. 8 [DOI] 10.7554/eLife.46174. [PMID] 31017572.
2019
The perirhinal cortex supports spatial intertemporal choice stability.
Neurobiology of learning and memory. 162:36-46 [DOI] 10.1016/j.nlm.2019.05.002. [PMID] 31125611.
2019
Age and Ketogenic Diet Have Dissociable Effects on Synapse-Related Gene Expression Between Hippocampal Subregions.
Frontiers in aging neuroscience. 11 [DOI] 10.3389/fnagi.2019.00239. [PMID] 31607897.
2018
A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus.
Frontiers in aging neuroscience. 10 [DOI] 10.3389/fnagi.2018.00391. [PMID] 30559660.
2018
Age-Related Declines in Prefrontal Cortical Expression of Metabotropic Glutamate Receptors that Support Working Memory.
eNeuro. 5(3) [DOI] 10.1523/ENEURO.0164-18.2018. [PMID] 29971246.
2018
Contributions of medial prefrontal cortex to decision making involving risk of punishment.
Neuropharmacology. 139:205-216 [DOI] 10.1016/j.neuropharm.2018.07.018. [PMID] 30009836.
2018
Experience-Dependent Effects of Muscimol-Induced Hippocampal Excitation on Mnemonic Discrimination.
Frontiers in systems neuroscience. 12 [DOI] 10.3389/fnsys.2018.00072. [PMID] 30687032.
2018
Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging.
Trends in neurosciences. 41(6):349-359 [DOI] 10.1016/j.tins.2018.03.001. [PMID] 29555181.
2018
Stress-induced corticosterone secretion covaries with working memory in aging.
Neurobiology of aging. 71:156-160 [DOI] 10.1016/j.neurobiolaging.2018.07.015. [PMID] 30144648.
2017
Prefrontal cortical GABAergic signaling and impaired behavioral flexibility in aged F344 rats.
Neuroscience. 345:274-286 [DOI] 10.1016/j.neuroscience.2016.02.014. [PMID] 26873002.
2017
Optogenetic Inhibition Reveals Distinct Roles for Basolateral Amygdala Activity at Discrete Time Points During Risky Decision Making
The Journal of Neuroscience. 37(48):11537-11548 [DOI] 10.1523/JNEUROSCI.2344-17.2017.
2017
Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection.
Neurobiology of learning and memory. 137:36-47 [DOI] 10.1016/j.nlm.2016.10.012. [PMID] 27815215.
2017
Rodent age-related impairments in discriminating perceptually similar objects parallel those observed in humans.
Hippocampus. 27(7):759-776 [DOI] 10.1002/hipo.22729. [PMID] 28342259.
2017
Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task.
Behavioural brain research. 321:130-136 [DOI] 10.1016/j.bbr.2017.01.001. [PMID] 28057530.
2017
Decline of prefrontal cortical-mediated executive functions but attenuated delay discounting in aged Fischer 344 × brown Norway hybrid rats.
Neurobiology of aging. 60:141-152 [DOI] 10.1016/j.neurobiolaging.2017.08.025. [PMID] 28946018.
2017
Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.
Neurobiology of aging. 53:122-137 [DOI] 10.1016/j.neurobiolaging.2017.01.023. [PMID] 28259065.
2017
Adolescent Cannabinoid Use and Cognition; Unexpected Results from a Rat Model of Cannabinoid Self-Administration.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 42(5):983-984 [DOI] 10.1038/npp.2016.212. [PMID] 27654216.
2016
Sex differences in a rat model of risky decision making.
Behavioral neuroscience. 130(1):50-61 [DOI] 10.1037/bne0000111. [PMID] 26653713.
2016
NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(50):12537-12548 [PMID] 27807032.
View on: PubMed
2016
Age-related changes in tonic activation of presynaptic versus extrasynaptic γ-amniobutyric acid type B receptors in rat medial prefrontal cortex.
Neurobiology of aging. 45:88-97 [DOI] 10.1016/j.neurobiolaging.2016.05.015. [PMID] 27459929.
2016
Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis.
Hippocampus. 26(4):455-71 [DOI] 10.1002/hipo.22535. [PMID] 26418152.
2016
Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats.
Psychopharmacology. 233(14):2787-97 [DOI] 10.1007/s00213-016-4321-y. [PMID] 27256354.
2015
Affective and cognitive mechanisms of risky decision making.
Neurobiology of learning and memory. 117:60-70 [DOI] 10.1016/j.nlm.2014.03.002. [PMID] 24642448.
2015
Characterizing olfactory binary mixture interactions in Fischer 344 rats using behavioral reaction times.
Chemical senses. 40(5):325-34 [DOI] 10.1093/chemse/bjv014. [PMID] 25877697.
2015
Dissociable roles for the basolateral amygdala and orbitofrontal cortex in decision-making under risk of punishment.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(4):1368-79 [DOI] 10.1523/JNEUROSCI.3586-14.2015. [PMID] 25632115.
2015
Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment.
Frontiers in aging neuroscience. 7 [DOI] 10.3389/fnagi.2015.00043. [PMID] 25883567.
2015
Molecular aspects of age-related cognitive decline: the role of GABA signaling.
Trends in molecular medicine. 21(7):450-60 [DOI] 10.1016/j.molmed.2015.05.002. [PMID] 26070271.
2015
Interaction of Basal Forebrain Cholinergic Neurons With the Glucocorticoid System in Stress Regulation and Cognitive Impairment
Frontiers in Aging Neuroscience. 7 [DOI] 10.3389/tnagi.2015.00043.
2014
Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39(4):955-62 [DOI] 10.1038/npp.2013.295. [PMID] 24145852.
2014
Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats.
Experimental physiology. 99(2):442-53 [DOI] 10.1113/expphysiol.2013.075242. [PMID] 24142453.
2014
Characterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparation.
Journal of neurophysiology. 111(2):273-86 [DOI] 10.1152/jn.00129.2013. [PMID] 24133226.
2014
Characterizing olfactory perceptual similarity using carbon chain discrimination in Fischer 344 rats.
Chemical senses. 39(4):323-31 [DOI] 10.1093/chemse/bju001. [PMID] 24488965.
2014
Lesions of the Orbitofrontal Cortex Reduce Risk-Taking in Rats
Neuropsychopharmacology. 39(1)
2014
Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairment.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(10):3457-66 [DOI] 10.1523/JNEUROSCI.5192-13.2014. [PMID] 24599447.
2014
Subtypes of Prefrontal Cortical Nmda Receptors in Working Memory and Normal Aging
Neuropsychopharmacology. 39(1)
2013
Adolescent Risk Taking, Dopamine, and Cocaine: a Vicious Cycle
Biological Psychiatry. 73:40S-41S
2013
Age-related changes in rostral basal forebrain cholinergic and GABAergic projection neurons: relationship with spatial impairment.
Neurobiology of aging. 34(3):845-62 [DOI] 10.1016/j.neurobiolaging.2012.06.013. [PMID] 22817834.
2013
Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity.
The European journal of neuroscience. 37(11):1779-88 [DOI] 10.1111/ejn.12191. [PMID] 23510331.
2013
Α4β2 and α7 nicotinic acetylcholine receptor binding predicts choice preference in two cost benefit decision-making tasks.
Neuroscience. 230:121-31 [DOI] 10.1016/j.neuroscience.2012.10.067. [PMID] 23159316.
2013
Distinct manifestations of executive dysfunction in aged rats.
Neurobiology of aging. 34(9):2164-74 [DOI] 10.1016/j.neurobiolaging.2013.03.019. [PMID] 23601673.
2012
GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats.
Neurobiology of aging. 33(6):1124.e1-12 [DOI] 10.1016/j.neurobiolaging.2011.11.011. [PMID] 22169202.
2012
Decreased interactions in protein kinase A-glucocorticoid receptor signaling in the hippocampus after selective removal of the basal forebrain cholinergic input.
Hippocampus. 22(3):455-65 [DOI] 10.1002/hipo.20912. [PMID] 21254302.
2012
Characterizing cognitive aging of working memory and executive function in animal models.
Frontiers in aging neuroscience. 4 [DOI] 10.3389/fnagi.2012.00019. [PMID] 22988438.
2012
Characterizing cognitive aging of spatial and contextual memory in animal models.
Frontiers in aging neuroscience. 4 [DOI] 10.3389/fnagi.2012.00012. [PMID] 22988436.
2012
Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost-benefit decision making tasks in rats.
Psychopharmacology. 224(4):489-99 [DOI] 10.1007/s00213-012-2777-y. [PMID] 22760484.
2012
Challenges and opportunities for characterizing cognitive aging across species.
Frontiers in aging neuroscience. 4 [DOI] 10.3389/fnagi.2012.00006. [PMID] 22988434.
2012
Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation.
Neuroscience. 200:74-90 [DOI] 10.1016/j.neuroscience.2011.10.028. [PMID] 22056599.
2012
Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure.
Behavioural pharmacology. 23(1):54-65 [DOI] 10.1097/FBP.0b013e32834eb07d. [PMID] 22129556.
2012
Characterizing cognitive aging in humans with links to animal models.
Frontiers in aging neuroscience. 4 [DOI] 10.3389/fnagi.2012.00021. [PMID] 22988439.
2011
Accelerating drug discovery for Alzheimer’s disease: best practices for preclinical animal studies.
Alzheimer's research & therapy. 3(5) [DOI] 10.1186/alzrt90. [PMID] 21943025.
2011
Dopaminergic modulation of risky decision-making.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(48):17460-70 [DOI] 10.1523/JNEUROSCI.3772-11.2011. [PMID] 22131407.
2011
Increased interactions between PKA and NF-κB signaling in the hippocampus following loss of cholinergic input.
Neuroscience. 192:485-93 [DOI] 10.1016/j.neuroscience.2011.05.074. [PMID] 21723926.
2011
Novel age-dependent learning deficits in a mouse model of Alzheimer’s disease: implications for translational research.
Neurobiology of aging. 32(7):1273-85 [DOI] 10.1016/j.neurobiolaging.2009.08.003. [PMID] 19720431.
2011
Risk, reward, and decision-making in a rodent model of cognitive aging.
Frontiers in neuroscience. 5 [DOI] 10.3389/fnins.2011.00144. [PMID] 22319463.
2010
Good things come to those who wait: attenuated discounting of delayed rewards in aged Fischer 344 rats.
Neurobiology of aging. 31(5):853-62 [DOI] 10.1016/j.neurobiolaging.2008.06.004. [PMID] 18657883.
2009
Spatial reference and working memory across the lifespan of male Fischer 344 rats.
Neurobiology of aging. 30(4):646-55 [PMID] 17889407.
View on: PubMed
2009
Enhanced calcium buffering in F344 rat cholinergic basal forebrain neurons is associated with age-related cognitive impairment.
Journal of neurophysiology. 102(4):2194-207 [DOI] 10.1152/jn.00301.2009. [PMID] 19675291.
2009
Long-lasting sensitization of reward-directed behavior by amphetamine.
Behavioural brain research. 201(1):74-9 [DOI] 10.1016/j.bbr.2009.01.034. [PMID] 19428619.
2009
Balancing risk and reward: a rat model of risky decision making.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 34(10):2208-17 [DOI] 10.1038/npp.2009.48. [PMID] 19440192.
2009
Blockade of GABA(B) receptors completely reverses age-related learning impairment.
Neuroscience. 164(3):941-7 [DOI] 10.1016/j.neuroscience.2009.08.055. [PMID] 19723562.
2008
Chronic, low-dose prenatal exposure to methylmercury impairs motor and mnemonic function in adult C57/B6 mice.
Behavioural brain research. 191(1):55-61 [DOI] 10.1016/j.bbr.2008.03.008. [PMID] 18436314.
2008
Learning strategy selection in the water maze and hippocampal CREB phosphorylation differ in two inbred strains of mice.
Learning & memory (Cold Spring Harbor, N.Y.). 15(4):183-8 [DOI] 10.1101/lm.783108. [PMID] 18353993.
2008
Long-term effects of prior cocaine exposure on Morris water maze performance.
Neurobiology of learning and memory. 89(2):185-91 [PMID] 17904876.
View on: PubMed
2007
Deficits across multiple cognitive domains in a subset of aged Fischer 344 rats.
Neurobiology of aging. 28(6):928-36 [PMID] 16806587.
View on: PubMed
2007
Intact spatial learning in adult Tg2576 mice.
Neurobiology of aging. 28(3):440-6 [PMID] 16504344.
View on: PubMed
2005
More is less: neurogenesis and age-related cognitive decline in Long-Evans rats.
Science of aging knowledge environment : SAGE KE. 2005(7) [PMID] 15716513.
View on: PubMed
2004
Neurogenesis in a rat model of age-related cognitive decline.
Aging cell. 3(4):227-34 [PMID] 15268756.
View on: PubMed
2004
Transcriptional mechanisms of hippocampal aging.
Experimental gerontology. 39(11-12):1613-22 [PMID] 15582277.
View on: PubMed
2003
Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline.
The European journal of neuroscience. 18(1):215-9 [PMID] 12859354.
View on: PubMed
2003
Emergence of a cue strategy preference on the water maze task in aged C57B6 x SJL F1 hybrid mice.
Learning & memory (Cold Spring Harbor, N.Y.). 10(6):520-4 [PMID] 14657263.
View on: PubMed
2003
Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment.
Experimental gerontology. 38(1-2):71-7 [PMID] 12543263.
View on: PubMed
2003
Effects of hippocampal cholinergic deafferentation on learning strategy selection in a visible platform version of the water maze.
Hippocampus. 13(6):676-84 [PMID] 12962313.
View on: PubMed
2002
Decreased glucocorticoid receptor mRNA and dysfunction of HPA axis in rats after removal of the cholinergic innervation to hippocampus.
The European journal of neuroscience. 16(7):1399-404 [PMID] 12406000.
View on: PubMed
2001
Hypothalamic-pituitary-adrenal axis function and corticosterone receptor expression in behaviourally characterized young and aged Long-Evans rats.
The European journal of neuroscience. 14(10):1739-51 [PMID] 11860468.
View on: PubMed
1999
Subpopulations of striatal interneurons can be distinguished on the basis of neurotrophic factor expression.
The Journal of comparative neurology. 408(2):283-98 [PMID] 10333275.
View on: PubMed
1996
Acidic fibroblast growth factor mRNA is expressed by basal forebrain and striatal cholinergic neurons.
The Journal of comparative neurology. 366(3):379-89 [PMID] 8907353.
View on: PubMed
1996
In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning.
Neuroscience. 74(3):741-56 [PMID] 8884770.
View on: PubMed
1995
NGF mRNA is expressed by GABAergic but not cholinergic neurons in rat basal forebrain.
The Journal of comparative neurology. 360(3):454-62 [PMID] 8543651.
View on: PubMed

Grants

Sep 2020 ACTIVE
Role of MCHR1 signaling in olfactory function
Role:
Funding: NATL INST OF HLTH NIDCD
Apr 2020 ACTIVE
Cyclic ketogenic therapy as treatment for Alzheimers disease-related metabolic decline, tau pathology and cognitive impairments
Role:
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Aug 2019 ACTIVE
Immunotherapy targeting the HPA axis in Alzheimers disease
Role:
Funding: NATL INST OF HLTH NIA
Feb 2019 ACTIVE
Metabolic Interventions for Enhancing Cognitive Resilience in Aging and Alzheimers Disease.
Role:
Funding: NATL INST OF HLTH NIA
Sep 2018 ACTIVE
Clinical and Translational Pre-doctoral training in Alzheimers Disease and Related Dementias
Role:
Funding: NATL INST OF HLTH NINDS
Sep 2018 ACTIVE
Decision making and basolateral amygdala dysfunction in aging
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Apr 2018 ACTIVE
Hippocampal and dopaminergic?mechanisms of novelty detection underlying cognitive resilience in aging
Role:
Funding: NATL INST OF HLTH NIA
Mar 2018 ACTIVE
Interactions of Perirhinal Tau Pathology and Aging in Cognitive Dysfunction
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Sep 2017 – Aug 2018
Metabolic Mechanisms for Treating Cognitive Aging
Role:
Funding: NATL INST OF HLTH NIA
May 2017 – Jul 2019
Neural circuits and mechanisms underlying maladaptive risk-taking following cocaine self-administration
Role:
Funding: NATL INST OF HLTH NIDA
Jan 2017 – Mar 2019
The Impact of Perirhinal Cortical Tau Pathology on Pre-clinical Alzheimers Disease Cognitive Decline
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Jan 2017 ACTIVE
Cognitive Augmentation through Neuroplasticity (CAN)
Role: Project Manager
Funding: US DEPT OF DEFENSE DARPA
Jan 2017 – Jun 2020
Laboratory Studies of Neurons from Blood Cells
Role: Principal Investigator
Funding: UF FOU via XTRAORDINARY JOY FOUNDATION
Sep 2016 ACTIVE
Testing and forecasting hippocampal theta wave propagation in learning and memory
Role:
Funding: NATL INST OF HLTH NIMH
Aug 2015 – Aug 2018
Molecular and physiological determinants of age-related working memory decline
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Apr 2015 ACTIVE
Risk taking and cocaine use: interactions, mechanisms, and therapeutic targets
Role: Project Manager
Funding: NATL INST OF HLTH NIDA
May 2014 – Mar 2020
Neural Mechanisms of Cognitive Decline in Aging
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2010 – Jun 2016
New Faculty Start-Up Package-Bizon
Role: Principal Investigator
Funding: UF FOU
Apr 2008 ACTIVE
Evelyn F. McKnight Brain Research Program in Age-Related Memory Loss.
Role: Project Manager
Funding: MCKNIGHT FOU

Education

Postdoctoral Fellow
1998-2003 · Johns Hopkins University
Ph.D., Department of Neurobiology and Behavior
1998 · University of California, Irvine
B.S., Highest Honors in Psychology
1993 · University of North Carolina at Chapel Hill

Teaching Profile

Courses Taught
2019-2020
BMS6020 Clinical Neuroscience
2017-2019
GMS6705 Functional Human Neuroanatomy
2019
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2015-2017
GMS6895 CTS Journal Club
2013-2015
GMS6024 Princ Neuroscience 4
2014
PHA7979 Advanced Research
2014
GMS7794 Neuroscience Seminar
2011,2013
GMS6029 Brain Journal Club

Contact Details

Phones:
Business:
(352) 294-5149
Emails:
Business:
bizonj@ufl.edu