Sara N Burke

Sara N Burke

Associate Professor, Associate Director Cognitive Aging And Memory Center

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 294-4979
Business Email: burkes@ufl.edu

About Sara N Burke

Dr. Burke is an Associate Professor of Neuroscience and Associate Director of the Cognitive Aging and Memory Center (CAM) at the University of Florida College of Medicine. She received her PhD in Neuroscience & Pharmacology in 2009 from the University of Arizona and went on to complete a Postdoctoral Fellowship (2009-2013) at her alma mater. The overarching goals of her NIH-funded research program are to 1) pinpoint alterations in how different brain regions communicate over the lifespan and how this contributes to loss of function in advanced age, and 2) to design therapeutic strategies for alleviating cognitive dysfunction in order to promote positive health outcomes in the elderly.

Research Profile

Dr. Burke’s research pertains to investigating mechanisms of cognition and determining how diet and metabolic function can increase resilience to memory loss in aging and disease. To answer these questions, her lab integrates data across multiple levels of analysis that includes neurophysiology, gene expression, anatomy and behavioral assays. Using these integrative approaches, current projects in her laboratory are focused on uncovering mechanisms of age-related impairments in hippocampal-dependent sensory discrimination across modalities in normal aging and a novel model of tau pathology (Ed and Ethel Moore Alzheimer’s Disease Research Program), identifying age-associated changes in medial temporal lobe-prefrontal functional connectivity that contribute to memory deficits (1R01AG049722; 1R21AG051004), and testing whether diet can globally improve neural network function in old animals (pilot grant sub-award of P30AG028740). Her rationale is that by elucidating how aging influences systems-level dynamics, her lab will be better positioned to develop interventions that broadly improve cognition and everyday living.

Publications

2020
A Cross-species Model of Dual-Task Walking in Young and Older Humans and Rats.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.00276. [PMID] 32982717.
2020
Sex Differences in Age-Related Impairments Vary Across Cognitive an Physical Assessments in Rats
Behavioral neuroscience (Online). 134(2):69-81 [DOI] 10.1037/bne0000352.
2020
Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen.
Aging. 12(9):7963-7984 [DOI] 10.18632/aging.103116. [PMID] 32369441.
2020
Age-Related Alterations in Prelimbic Cortical Neuron Arc Expression Vary by Behavioral State and Cortical Layer.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.588297. [PMID] 33192482.
2020
Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(46):8913-8923 [DOI] 10.1523/JNEUROSCI.1163-20.2020. [PMID] 33051354.
2020
Auditory Processing Deficits Are Selectively Associated with Medial Temporal Lobe Mnemonic Function and White Matter Integrity in Aging Macaques.
Cerebral cortex (New York, N.Y. : 1991). 30(5):2789-2803 [DOI] 10.1093/cercor/bhz275. [PMID] 31833551.
2019
Visual Object Discrimination Impairment as an Early Predictor of Mild Cognitive Impairment and Alzheimer’s Disease.
Journal of the International Neuropsychological Society : JINS. 25(7):688-698 [DOI] 10.1017/S1355617719000316. [PMID] 31111810.
2019
Theta-gamma cascades and running speed.
Journal of neurophysiology. 121(2):444-458 [DOI] 10.1152/jn.00636.2018. [PMID] 30517044.
2019
The perirhinal cortex supports spatial intertemporal choice stability.
Neurobiology of learning and memory. 162:36-46 [DOI] 10.1016/j.nlm.2019.05.002. [PMID] 31125611.
2019
Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats.
Epilepsia. 60(5):e52-e57 [DOI] 10.1111/epi.14723. [PMID] 30963545.
2019
What are the later life contributions to reserve, resilience, and compensation?
Neurobiology of aging. 83:140-144 [DOI] 10.1016/j.neurobiolaging.2019.03.023. [PMID] 31732017.
2019
Methodological Considerations on the Use of Different Spectral Decomposition Algorithms to Study Hippocampal Rhythms.
eNeuro. 6(4) [DOI] 10.1523/ENEURO.0142-19.2019. [PMID] 31324673.
2019
Animal models of cognitive aging and circuit-specific vulnerability.
Handbook of clinical neurology. 167:19-36 [DOI] 10.1016/B978-0-12-804766-8.00002-9. [PMID] 31753133.
2019
Age and Ketogenic Diet Have Dissociable Effects on Synapse-Related Gene Expression Between Hippocampal Subregions.
Frontiers in aging neuroscience. 11 [DOI] 10.3389/fnagi.2019.00239. [PMID] 31607897.
2019
Multiscale Imaging Reveals Aberrant Functional Connectome Organization and Elevated Dorsal Striatal Arc Expression in Advanced Age.
eNeuro. 6(6) [DOI] 10.1523/ENEURO.0047-19.2019. [PMID] 31826916.
2018
Tract-Specific White Matter Correlates of Age-Related Reward Devaluation Deficits in Macaque Monkeys.
Journal of neuroimaging in psychiatry & neurology. 3(2):13-26 [DOI] 10.17756/jnpn.2018-023. [PMID] 30198011.
2018
The Antiepileptic Ketogenic Diet Alters Hippocampal Transporter Levels and Reduces Adiposity in Aged Rats.
The journals of gerontology. Series A, Biological sciences and medical sciences. 73(4):450-458 [DOI] 10.1093/gerona/glx193. [PMID] 29040389.
2018
Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging.
Trends in neurosciences. 41(6):349-359 [DOI] 10.1016/j.tins.2018.03.001. [PMID] 29555181.
2018
Perforant Path Fiber Loss Results in Mnemonic Discrimination Task Deficits in Young Rats.
Frontiers in systems neuroscience. 12 [DOI] 10.3389/fnsys.2018.00061. [PMID] 30618655.
2018
Impaired discrimination with intact crossmodal association in aged rats: A dissociation of perirhinal cortical-dependent behaviors.
Behavioral neuroscience. 132(3):138-151 [DOI] 10.1037/bne0000246. [PMID] 29809042.
2018
Experience-Dependent Effects of Muscimol-Induced Hippocampal Excitation on Mnemonic Discrimination.
Frontiers in systems neuroscience. 12 [DOI] 10.3389/fnsys.2018.00072. [PMID] 30687032.
2018
Age-Related Declines in Prefrontal Cortical Expression of Metabotropic Glutamate Receptors that Support Working Memory.
eNeuro. 5(3) [DOI] 10.1523/ENEURO.0164-18.2018. [PMID] 29971246.
2018
Age-related changes in ‘hub’ neurons.
Aging. 10(10):2551-2552 [DOI] 10.18632/aging.101606. [PMID] 30348907.
2018
A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus.
Frontiers in aging neuroscience. 10 [DOI] 10.3389/fnagi.2018.00391. [PMID] 30559660.
2018
Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.
Neurobiology of aging. 70:217-232 [DOI] 10.1016/j.neurobiolaging.2018.06.028. [PMID] 30031931.
2018
A separable two-dimensional random field model of binary response data from multi-day behavioral experiments.
Journal of neuroscience methods. 307:175-187 [DOI] 10.1016/j.jneumeth.2018.04.006. [PMID] 29679704.
2017
Attentional updating and monitoring and affective shifting are impacted independently by aging in macaque monkeys.
Behavioural brain research. 322(Pt B):329-338 [DOI] 10.1016/j.bbr.2016.06.056. [PMID] 27368416.
2017
Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination.
Frontiers in systems neuroscience. 11 [DOI] 10.3389/fnsys.2017.00049. [PMID] 28713251.
2017
Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(37):8965-8974 [DOI] 10.1523/JNEUROSCI.0531-17.2017. [PMID] 28821661.
2017
Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.
Neurobiology of aging. 53:122-137 [DOI] 10.1016/j.neurobiolaging.2017.01.023. [PMID] 28259065.
2017
Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection.
Neurobiology of learning and memory. 137:36-47 [DOI] 10.1016/j.nlm.2016.10.012. [PMID] 27815215.
2017
Rodent age-related impairments in discriminating perceptually similar objects parallel those observed in humans.
Hippocampus. 27(7):759-776 [DOI] 10.1002/hipo.22729. [PMID] 28342259.
2017
Decline of prefrontal cortical-mediated executive functions but attenuated delay discounting in aged Fischer 344 × brown Norway hybrid rats.
Neurobiology of aging. 60:141-152 [DOI] 10.1016/j.neurobiolaging.2017.08.025. [PMID] 28946018.
2016
Discrimination performance in aging is vulnerable to interference and dissociable from spatial memory.
Learning & memory (Cold Spring Harbor, N.Y.). 23(7):339-48 [DOI] 10.1101/lm.042069.116. [PMID] 27317194.
2016
Movement Enhances the Nonlinearity of Hippocampal Theta.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(15):4218-30 [DOI] 10.1523/JNEUROSCI.3564-15.2016. [PMID] 27076421.
2015
Age-related impairments in object-place associations are not due to hippocampal dysfunction.
Behavioral neuroscience. 129(5):599-610 [DOI] 10.1037/bne0000093. [PMID] 26413723.
2015
The neural representation of 3-dimensional objects in rodent memory circuits.
Behavioural brain research. 285:60-6 [DOI] 10.1016/j.bbr.2014.09.001. [PMID] 25205370.
2014
Back to the future: preserved hippocampal network activity during reverse ambulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(45):15022-31 [DOI] 10.1523/JNEUROSCI.1129-14.2014. [PMID] 25378167.
2014
Multiple frequency audio signal communication as a mechanism for neurophysiology and video data synchronization.
Journal of neuroscience methods. 238:35-42 [DOI] 10.1016/j.jneumeth.2014.09.018. [PMID] 25256648.
2013
Activation patterns in superficial layers of neocortex change between experiences independent of behavior, environment, or the hippocampus.
Cerebral cortex (New York, N.Y. : 1991). 23(9):2225-34 [DOI] 10.1093/cercor/bhs209. [PMID] 22806267.
2013
Transcription of the immediate-early gene Arc in CA1 of the hippocampus reveals activity differences along the proximodistal axis that are attenuated by advanced age.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(8):3424-33 [DOI] 10.1523/JNEUROSCI.4727-12.2013. [PMID] 23426670.
2012
Representation of three-dimensional objects by the rat perirhinal cortex.
Hippocampus. 22(10):2032-44 [DOI] 10.1002/hipo.22060. [PMID] 22987680.
2012
Layer V perirhinal cortical ensemble activity during object exploration: a comparison between young and aged rats.
Hippocampus. 22(10):2080-93 [DOI] 10.1002/hipo.22066. [PMID] 22987683.
2012
Characterizing cognitive aging of recognition memory and related processes in animal models and in humans.
Frontiers in aging neuroscience. 4 [DOI] 10.3389/fnagi.2012.00015. [PMID] 22988437.
2012
Greater running speeds result in altered hippocampal phase sequence dynamics.
Hippocampus. 22(4):737-47 [DOI] 10.1002/hipo.20936. [PMID] 21538659.
2011
Age-associated deficits in pattern separation functions of the perirhinal cortex: a cross-species consensus.
Behavioral neuroscience. 125(6):836-47 [DOI] 10.1037/a0026238. [PMID] 22122147.
2011
The influence of objects on place field expression and size in distal hippocampal CA1.
Hippocampus. 21(7):783-801 [DOI] 10.1002/hipo.20929. [PMID] 21365714.
2010
Pattern separation deficits may contribute to age-associated recognition impairments.
Behavioral neuroscience. 124(5):559-73 [DOI] 10.1037/a0020893. [PMID] 20939657.
2010
Senescent synapses and hippocampal circuit dynamics.
Trends in neurosciences. 33(3):153-61 [DOI] 10.1016/j.tins.2009.12.003. [PMID] 20071039.
2008
Glutamate receptor-mediated restoration of experience-dependent place field expansion plasticity in aged rats.
Behavioral neuroscience. 122(3):535-48 [DOI] 10.1037/0735-7044.122.3.535. [PMID] 18513124.
2008
Sequence reactivation in the hippocampus is impaired in aged rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(31):7883-90 [DOI] 10.1523/JNEUROSCI.1265-08.2008. [PMID] 18667620.
2006
Neural plasticity in the ageing brain.
Nature reviews. Neuroscience. 7(1):30-40 [PMID] 16371948.
View on: PubMed
2006
Organization of hippocampal cell assemblies based on theta phase precession.
Hippocampus. 16(9):785-94 [PMID] 16921501.
View on: PubMed
2006
Phase precession in hippocampal interneurons showing strong functional coupling to individual pyramidal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(52):13485-92 [PMID] 17192431.
View on: PubMed
2005
Differential encoding of behavior and spatial context in deep and superficial layers of the neocortex.
Neuron. 45(5):667-74 [PMID] 15748843.
View on: PubMed
2004
3D-catFISH: a system for automated quantitative three-dimensional compartmental analysis of temporal gene transcription activity imaged by fluorescence in situ hybridization.
Journal of neuroscience methods. 139(1):13-24 [PMID] 15351517.
View on: PubMed
2004
Visual sensitivity across the menstrual cycle.
Visual neuroscience. 21(4):513-31 [PMID] 15579218.
View on: PubMed

Grants

Apr 2020 ACTIVE
Cyclic ketogenic therapy as treatment for Alzheimers disease-related metabolic decline, tau pathology and cognitive impairments
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Feb 2019 ACTIVE
Metabolic Interventions for Enhancing Cognitive Resilience in Aging and Alzheimers Disease.
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Sep 2018 ACTIVE
Decision making and basolateral amygdala dysfunction in aging
Role:
Funding: NATL INST OF HLTH NIA
Apr 2018 ACTIVE
Hippocampal and dopaminergic?mechanisms of novelty detection underlying cognitive resilience in aging
Role:
Funding: NATL INST OF HLTH NIA
Sep 2017 – Aug 2018
Metabolic Mechanisms for Treating Cognitive Aging
Role: Mentor
Funding: NATL INST OF HLTH NIA
Apr 2017 ACTIVE
Age-associated changes?in hippocampal circuits and cognitive function
Role:
Funding: NATL INST OF HLTH NIA
Jan 2017 – Mar 2019
The Impact of Perirhinal Cortical Tau Pathology on Pre-clinical Alzheimers Disease Cognitive Decline
Role:
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Jan 2017 ACTIVE
Cognitive Augmentation through Neuroplasticity (CAN)
Role:
Funding: US DEPT OF DEFENSE DARPA
Sep 2016 ACTIVE
Testing and forecasting hippocampal theta wave propagation in learning and memory
Role:
Funding: NATL INST OF HLTH NIMH
Aug 2016 – May 2019
Single-Cell Imaging of Functional Connectivity as a Window into Cognitive Aging
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Apr 2016 – Mar 2017
AGE-ASSOCIATED FUNCTIONAL CONNECTIVITY DECLINES IN THE
Role: Principal Investigator
Funding: UF ALZHEIMER'S DISEASE RESEARCH CENTER
Apr 2016 – Mar 2017
Claude D Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jan 2016 ACTIVE
The contribution of declines in functional connectivity to cognitive aging
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Aug 2015 – May 2017
Neurogenesis and Memory Network Dynamics during Normal
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Apr 2015 – Mar 2016
Claude D. Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jun 2014 – May 2016
Neurogenesis and memory dynamics during normal aging
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Apr 2008 ACTIVE
Evelyn F. McKnight Brain Research Program in Age-Related Memory Loss.
Role: Project Manager
Funding: MCKNIGHT FOU

Teaching Profile

Courses Taught
2019-2020
BMS6020 Clinical Neuroscience
2020
GMS7795 Special Topics in Neuroscience
2017-2020
GMS6705 Functional Human Neuroanatomy
2015,2020
GMS7794 Neuroscience Seminar
2018
GMS7980 Research for Doctoral Dissertation
2014-2018
GMS6022 Prin Neuroscience 2
2014,2017
GMS6029 Brain Journal Club
2014-2016
GMS6024 Princ Neuroscience 4
2016
BME6907 BME Project

Contact Details

Phones:
Business:
(352) 294-4979
Emails:
Business:
burkes@ufl.edu