Eduardo Candelario-Jalil

Eduardo Candelario-Jalil

Associate Professor, Graduate Co-Coordinator Neuroscience Graduate Program

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-7116
Business Email: ecandelario@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-3631-1989

Publications

2020
Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies.
Experimental neurology. 335 [DOI] 10.1016/j.expneurol.2020.113518. [PMID] 33144066.
2020
Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: A translational perspective.
Experimental neurology. 335 [DOI] 10.1016/j.expneurol.2020.113494. [PMID] 33035516.
2020
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell metabolism. 32(6):1041-1051.e6 [DOI] 10.1016/j.cmet.2020.11.005. [PMID] 33207244.
2020
Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
Frontiers in neurology. 11 [DOI] 10.3389/fneur.2020.00887. [PMID] 32973660.
2019
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke.
Neurochemistry international. 127:94-102 [DOI] 10.1016/j.neuint.2019.03.004. [PMID] 30872008.
2019
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke.
American journal of physiology. Cell physiology. 316(2):C135-C153 [DOI] 10.1152/ajpcell.00136.2018. [PMID] 30379577.
2019
A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer’s disease.
Neuropharmacology. 160 [DOI] 10.1016/j.neuropharm.2019.107785. [PMID] 31541651.
2019
Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration.
International journal of molecular sciences. 20(9) [DOI] 10.3390/ijms20092293. [PMID] 31075861.
2018
Age-Dependent Decrease in Adropin is Associated with Reduced Levels of Endothelial Nitric Oxide Synthase and Increased Oxidative Stress in the Rat Brain.
Aging and disease. 9(2):322-330 [DOI] 10.14336/AD.2017.0523. [PMID] 29896421.
2018
Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
Frontiers in neuroscience. 12 [DOI] 10.3389/fnins.2018.00089. [PMID] 29527151.
2018
Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia.
Biochemical and biophysical research communications. 497(1):410-415 [DOI] 10.1016/j.bbrc.2018.02.096. [PMID] 29448097.
2017
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Alters Cell Cycle Progression in Human Neuroblastoma Cell Lines.
Neurotoxicity research. 32(4):649-660 [DOI] 10.1007/s12640-017-9782-1. [PMID] 28721631.
2017
Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats.
PloS one. 12(7) [DOI] 10.1371/journal.pone.0180738. [PMID] 28671997.
2017
Selective Inhibition of Janus Kinase 3 Has No Impact on Infarct Size or Neurobehavioral Outcomes in Permanent Ischemic Stroke in Mice.
Frontiers in neurology. 8 [DOI] 10.3389/fneur.2017.00363. [PMID] 28790974.
2017
Spatiotemporal Changes in P-glycoprotein Levels in Brain and Peripheral Tissues Following Ischemic Stroke in Rats.
Journal of experimental neuroscience. 11 [DOI] 10.1177/1179069517701741. [PMID] 28469478.
2017
Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog.
Stroke. 48(7):1948-1956 [DOI] 10.1161/STROKEAHA.117.016474. [PMID] 28588054.
2017
Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery.
Brain and behavior. 7(5) [DOI] 10.1002/brb3.688. [PMID] 28523230.
2017
Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid.
Journal of neuroinflammation. 14(1) [DOI] 10.1186/s12974-017-0793-x. [PMID] 28143498.
2016
Adropin reduces paracellular permeability of rat brain endothelial cells exposed to ischemia-like conditions.
Peptides. 81:29-37 [DOI] 10.1016/j.peptides.2016.03.009. [PMID] 27020249.
2016
Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1-42 induced neurotoxicity and memory impairment.
Scientific reports. 6 [DOI] 10.1038/srep25226. [PMID] 27142962.
2015
Neuroinflammation and Neurodegeneration: Pinpointing Pathological and Pharmacological Targets.
BioMed research international. 2015 [DOI] 10.1155/2015/487241. [PMID] 26295039.
2015
Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
Scientific reports. 5 [DOI] 10.1038/srep17956. [PMID] 26648273.
2014
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke.
Journal of neurochemistry. 129(1):130-42 [DOI] 10.1111/jnc.12607. [PMID] 24225006.
2013
Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke.
Molecular brain. 6 [DOI] 10.1186/1756-6606-6-14. [PMID] 23522154.
2013
Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(45):17814-26 [DOI] 10.1523/JNEUROSCI.2346-12.2013. [PMID] 24198371.
2013
Activation of the Lipoxin A4 Receptor Reduces Infarct Size and Neuroinflammation in a Rat Model of Ischemic Stroke
Journal of Neurochemistry. 125:133-134
2012
Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia.
Journal of neuroinflammation. 9 [DOI] 10.1186/1742-2094-9-2. [PMID] 22214188.
2011
Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment.
Stroke. 42(5):1345-50 [DOI] 10.1161/STROKEAHA.110.600825. [PMID] 21454822.
2011
Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice.
Journal of neuroinflammation. 8 [DOI] 10.1186/1742-2094-8-108. [PMID] 21871134.
2010
Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 30(2):370-80 [DOI] 10.1038/jcbfm.2009.223. [PMID] 19844242.
2010
Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.
Journal of neuroinflammation. 7 [DOI] 10.1186/1742-2094-7-2. [PMID] 20064241.
2010
Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia.
Journal of neurochemistry. 112(1):134-49 [DOI] 10.1111/j.1471-4159.2009.06433.x. [PMID] 19840223.
2009
Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke.
PloS one. 4(8) [DOI] 10.1371/journal.pone.0006597. [PMID] 19668371.
2009
A role for cyclooxygenase-1 in beta-amyloid-induced neuroinflammation.
Aging. 1(4):350-3 [PMID] 20157521.
View on: PubMed
2009
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia.
Neuroscience. 158(3):983-94 [DOI] 10.1016/j.neuroscience.2008.06.025. [PMID] 18621108.
2009
Increased apparent diffusion coefficients on MRI linked with matrix metalloproteinases and edema in white matter after bilateral carotid artery occlusion in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 29(2):308-16 [DOI] 10.1038/jcbfm.2008.121. [PMID] 18941468.
2009
Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics.
Current opinion in investigational drugs (London, England : 2000). 10(7):644-54 [PMID] 19579170.
View on: PubMed
2009
Opposite effects of anandamide and N-arachidonoyl dopamine in the regulation of prostaglandin E and 8-iso-PGF formation in primary glial cells.
Journal of neurochemistry. 109(2):452-64 [DOI] 10.1111/j.1471-4159.2009.05966.x. [PMID] 19200337.
2009
Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells.
Journal of neuroinflammation. 6 [DOI] 10.1186/1742-2094-6-26. [PMID] 19751497.
2008
Cyclooxygenase inhibition in ischemic brain injury.
Current pharmaceutical design. 14(14):1401-18 [PMID] 18537663.
View on: PubMed
2008
Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 28(2):431-8 [PMID] 17700631.
View on: PubMed
2008
Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats.
Clinical science (London, England : 1979). 115(2):69-77 [DOI] 10.1042/CS20070415. [PMID] 18307414.
2008
Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells.
Archives of biochemistry and biophysics. 477(2):253-8 [DOI] 10.1016/j.abb.2008.06.017. [PMID] 18621015.
2008
Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences.
Pharmacological research. 57(4):266-73 [DOI] 10.1016/j.phrs.2008.03.003. [PMID] 18439837.
2008
Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2.
Glia. 56(8):844-55 [DOI] 10.1002/glia.20658. [PMID] 18383341.
2008
Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells.
Rheumatology international. 28(10):1017-22 [DOI] 10.1007/s00296-008-0564-1. [PMID] 18368410.
2008
Detrimental effects of tropisetron on permanent ischemic stroke in the rat.
BMC neuroscience. 9 [DOI] 10.1186/1471-2202-9-19. [PMID] 18254974.
2007
Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat.
The Journal of pharmacology and experimental therapeutics. 323(2):488-98 [PMID] 17704356.
View on: PubMed
2007
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats.
Journal of neurochemistry. 100(4):1108-20 [PMID] 17176264.
View on: PubMed
2007
Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia.
Journal of neuroinflammation. 4 [PMID] 17927823.
View on: PubMed
2006
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production.
Journal of neuroimmunology. 174(1-2):39-51 [PMID] 16529823.
View on: PubMed
2006
Effects of coffees before and after special treatment procedure on cell membrane potentials in stomach cells.
Methods and findings in experimental and clinical pharmacology. 28(6):369-72 [PMID] 16894406.
View on: PubMed
2006
Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB.
Journal of neurochemistry. 96(3):680-93 [PMID] 16405508.
View on: PubMed
2006
Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine.
Pharmacological research. 53(4):391-6 [PMID] 16574428.
View on: PubMed
2005
The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway.
Biochemical pharmacology. 70(3):369-80 [PMID] 15922994.
View on: PubMed
2005
Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia.
Glia. 51(3):199-208 [PMID] 15800925.
View on: PubMed
2005
Therapeutic efficacy of ozone in patients with diabetic foot.
European journal of pharmacology. 523(1-3):151-61 [PMID] 16198334.
View on: PubMed
2005
Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum.
Journal of molecular neuroscience : MN. 27(3):303-10 [PMID] 16280600.
View on: PubMed
2005
Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat.
Journal of neuroinflammation. 2(1) [PMID] 15656909.
View on: PubMed
2005
Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells.
Journal of neurochemistry. 93(3):549-59 [PMID] 15836614.
View on: PubMed
2004
Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide-stimulated primary human monocytes.
Scandinavian journal of rheumatology. Supplement. 119:28-32 [PMID] 15515409.
View on: PubMed
2004
Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion.
Liver international : official journal of the International Association for the Study of the Liver. 24(1):55-62 [PMID] 15102001.
View on: PubMed
2004
Expression of 5-HT3A receptors in cells of the immune system.
Scandinavian journal of rheumatology. Supplement. 119:9-11 [PMID] 15515405.
View on: PubMed
2004
Tropisetron inhibits serotonin-induced PGE2 release from macrophage-like synovial cells in serum-free tissue culture.
Scandinavian journal of rheumatology. Supplement. 119 [PMID] 15515410.
View on: PubMed
2004
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat.
Brain research. 1007(1-2):98-108 [PMID] 15064140.
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2003
Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates.
BMC pharmacology. 3 [PMID] 12807536.
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2003
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats.
Brain research. 990(1-2):1-7 [PMID] 14568323.
View on: PubMed
2003
Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia.
Journal of neurochemistry. 86(3):545-55 [PMID] 12859668.
View on: PubMed
2003
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils.
Neuroscience research. 47(2):245-53 [PMID] 14512150.
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2002
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia.
European journal of pharmacology. 453(2-3):189-95 [PMID] 12398903.
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2002
Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury.
Pharmacological research. 45(4):333-9 [PMID] 12030798.
View on: PubMed
2002
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils.
Brain research. 927(2):212-5 [PMID] 11821016.
View on: PubMed
2001
“Mangifera indica L. extract (QF808) reduces ischaemia-induced neuronal loss and oxidative damage in the gerbil brain”.
Free radical research. 35(5):465-73 [PMID] 11767405.
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2001
Oxidative preconditioning affords protection against carbon tetrachloride-induced glycogen depletion and oxidative stress in rats.
Journal of applied toxicology : JAT. 21(4):297-301 [PMID] 11481663.
View on: PubMed
2001
Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats.
Pharmacological research. 44(5):391-6 [PMID] 11712870.
View on: PubMed
2001
Selective vulnerability to kainate-induced oxidative damage in different rat brain regions.
Journal of applied toxicology : JAT. 21(5):403-7 [PMID] 11746182.
View on: PubMed
2001
Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils.
Neuroscience research. 41(3):233-41 [PMID] 11672836.
View on: PubMed
2000
Nimesulide limits kainate-induced oxidative damage in the rat hippocampus.
European journal of pharmacology. 390(3):295-8 [PMID] 10708736.
View on: PubMed

Grants

Jul 2019 ACTIVE
Multi-pronged Approach to Recalibrating the Inflammatory Cascade in Ischemic Stroke with BET blockade
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2019 ACTIVE
Degrading BET Proteins is Neuroprotective in Ischemic Stroke
Role: Mentor
Funding: NATL INST OF HLTH NINDS
Jan 2019 – Mar 2019
BET protein degradation is neuroprotective in ischemic stroke.?
Role: Mentor
Funding: AMER HEART ASSOCIATION
Sep 2018 ACTIVE
Neurovascular Protection by Adropin in Ischemic Stroke
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2018 – Sep 2019
Effects of VCE-004.8, a cannabidiol quinone derivative, on experimental ischemic stroke
Role: Principal Investigator
Funding: EMERALD HEALTH PHARMA
Sep 2017 – Aug 2019
Neurovascular Protection by Adropin in Ischemic Stroke
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2016 – Jun 2018
Prostacyclin Receptor Activation and Neurovascular Protection in Ischemic Stroke
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Mar 2014 – Feb 2016
Selexipag Neuroprotection in Ischemic Stroke
Role: Principal Investigator
Funding: UF FOU
Jul 2011 – Dec 2017
Cyclooxygenase-2 Regulation of Blood-Brain Barrier Opening in Ischemic Stroke
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH

Teaching Profile

Courses Taught
2014,2016-2018,2018-2020
GMS6029 Brain Journal Club
2014-2020
GMS6023 Principles of Neuroscience III: Molecular Neuropharmacology and its Clinical Application
2016,2018-2019
GMS7794 Neuroscience Seminar
2019
GMS6705 Functional Human Neuroanatomy
2018
GMS7980 Research for Doctoral Dissertation
2013-2016
GMS6024 Princ Neuroscience 4
2013
GMS7795 Special Topics in Neuroscience

Contact Details

Phones:
Business:
(352) 273-7116
Emails: