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Center for Translational Research in Neurodegenerative Disease College of Medicine
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Yehia Daaka

Yehia Daaka, PhD

Professor

Department: MD-ANATOMY
Business Phone: (352) 273-8112
Business Email: ydaaka@ufl.edu

On This Page

Teaching Profile

Courses Taught

Research Profile

Research in the Daaka lab focuses on understanding the biological roles of G protein-coupled and androgen receptors that instruct embryonic development and continue to function in adulthood. He has been involved in crucial discoveries that unraveled contribution of these receptors to human pathophysiologic processes; for example, in the initiation and progression of cancer. Research from the Daaka lab on the function of these receptor systems has contributed to their recognition as targets for cancer therapy, and over the last decade several anti-cancer drugs have been developed against these molecules. Current projects examine contribution of the G protein-coupled receptors and their heterotrimeric G proteins and Arrestin effectors to the progression of prostate cancer from androgen-dependent to castration-resistant state, and in the metastasis of kidney cancer. We are also studying post-translational modification of androgen receptor by S-nitrosylation and its role in progression of the disease. Another area of investigation in the Daaka lab is centered on studying mechanisms involved in vesicle trafficking in recurrent urinary tract infections, with emphasis on the G proteins dynamin that support fission of vesicles from the plasma membrane into the cytosol.

Open Researcher and Contributor ID (ORCID)

0000-0002-9129-6593

Publications

Academic Articles

Grants

  1. The American Society for Cell Biology Early Career Meeting Grant Application Requirements

    Role:
    Principal Investigator
    Funding:
    AMERICAN SOCIETY FOR CELL BIOLOGY

  2. A Novel Drug Target for Aggressive Prostate Cancer

    Role:
    Principal Investigator
    Funding:
    US DEPT OF VETERANS AFFAIRS

  3. Florida Academic Cancer Center Alliance Seed Grants

    Role:
    Project Manager
    Funding:
    UF HEALTH SHANDS HOSPITAL

  4. UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program

    Role:
    Project Manager
    Funding:
    UF HEALTH SHANDS HOSPITAL

  5. UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program

    Role:
    Project Manager
    Funding:
    UF HEALTH SHANDS HOSPITAL

  6. Florida Minority Cancer Research and Training Center: Feasibility Studies

    Role:
    Co-Investigator
    Funding:
    NATL INST OF HLTH NCI

  7. The Florida Prostate Cancer Research Training Opportunities for Outstanding Leaders (ReTOOL) Program: Creating Opportunities for Minority HBCU Students

    Role:
    Project Manager
    Funding:
    US ARMY MED RES ACQUISITION

  8. Vesicle Trafficking and Bacteria Invasion

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH NIAID

  9. Haskell Hess Professorship/F004510

    Role:
    Principal Investigator
    Funding:
    UF FOUNDATION

Contact Details

Phones:
Business:
(352) 273-8112
Emails:
Business:
ydaaka@ufl.edu
Addresses:
Business Mailing:
PO Box 103633
2033 MOWRY RD # 255
 GAINESVILLE FL 32610