Marcelo Febo

Marcelo Febo, Ph.D.

Associate Professor

Department: MD-PSYCHIATRY
Business Phone: (352) 294-4911
Business Email: febo@ufl.edu

About Marcelo Febo

Marcelo Febo completed his PhD at the University of Puerto Rico Medical School and postdoctoral studies at the University of Massachusetts Medical Center. His work focuses on measuring in vivo functional and structural changes in the rat brain following chronic drug exposure. Over the past decade he has pursued this goal through the use of high field functional magnetic resonance imaging in awake rats and mice. He has been funded early in his career by the National Institute on Drug Abuse to examine the relationship between cocaine sensitization and alterations in maternal brain activity. He is presently Program Director of Translational Research Imaging at the University of Florida Brain Institute and is also a faculty member of the Department of Psychiatry.

Accomplishments

UF College of Medicine Term Professor
2018-2019 · University of Florida, College of Medicine
Exemplary Teacher
2018 · University of Florida, College of Medicine
Elected Research Scientist Member
2016 · National Hispanic Science Network
Suzannah Bliss Tieman Award for Research
2009 · Northeast Undergraduate Research Organization for Neuroscience
Faculty Award
2009 · Northeast Undergraduate Research Organization for Neuroscience

Research Profile

Dr. Febo’s work focuses on using neuroimaging to study the neural correlates of addiction in rodent models. Functional magnetic resonance imaging (fMRI) allows us to inspect in vivo brain activation in response to a variety of cognitive, emotional and drug stimuli without disrupting the natural organization of the brain. The strength of the technique lies in its non-invasive nature that can permit longitudinal functional studies in the same animal over its adult life. The relatively good spatial and temporal resolution and the ever-growing database on the biological and biophysical basis of the blood oxygen level dependent (BOLD) signal make it a unique technique in preclinical and translational neuroscience research. Presently we are investigating several areas of interest that include: (i) the long term impact of chronic cocaine exposure on the brain dopaminergic system, (ii) the role of brain oxytocin and vasopressin systems on the processing of social stimuli, and (iii) the specific roles of the medial prefrontal cortex on motivation and emotion. Our work could contribute significantly to understanding conditions such as addiction, depression.

Open Researcher and Contributor ID (ORCID)

0000-0001-8981-4163

Publications

2020
Contextual experience modifies functional connectome indices of topological strength and efficiency.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-76935-0. [PMID] 33199790.
2020
Volumetric magnetic resonance and diffusion tensor imaging of C58/J mice: neural correlates of repetitive behavior.
Brain imaging and behavior. 14(6):2084-2096 [DOI] 10.1007/s11682-019-00158-9. [PMID] 31342238.
2020
Traffic-related particulate matter affects behavior, inflammation, and neural integrity in a developmental rodent model.
Environmental research. 183 [DOI] 10.1016/j.envres.2020.109242. [PMID] 32097814.
2020
The role of BTBD9 in the cerebral cortex and the pathogenesis of restless legs syndrome.
Experimental neurology. 323 [DOI] 10.1016/j.expneurol.2019.113111. [PMID] 31715135.
2020
The Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome.
Neuroscience. 440:85-96 [DOI] 10.1016/j.neuroscience.2020.05.021. [PMID] 32446853.
2020
Robustness of sex-differences in functional connectivity over time in middle-aged marmosets.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-73811-9. [PMID] 33024242.
2020
Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22(2):213-223 [DOI] 10.1093/ntr/ntz052. [PMID] 30958557.
2020
Differential Effect of Repeated Lipopolysaccharide Treatment and Aging on Hippocampal Function and Biomarkers of Hippocampal Senescence.
Molecular neurobiology. 57(10):4045-4059 [DOI] 10.1007/s12035-020-02008-y. [PMID] 32651758.
2020
Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-66706-2. [PMID] 32572041.
2020
Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.00034. [PMID] 32153384.
2020
Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism.
American journal of physiology. Gastrointestinal and liver physiology. 318(4):G673-G681 [DOI] 10.1152/ajpgi.00301.2019. [PMID] 32003605.
2020
Exposure to smoke from high- but not low-nicotine cigarettes leads to signs of dependence in male rats and potentiates the effects of nicotine in female rats.
Pharmacology, biochemistry, and behavior. 196 [DOI] 10.1016/j.pbb.2020.172998. [PMID] 32681850.
2020
Diffusion magnetic resonance imaging-derived free water detects neurodegenerative pattern induced by interferon-γ.
Brain structure & function. 225(1):427-439 [DOI] 10.1007/s00429-019-02017-1. [PMID] 31894407.
2020
Mechanism of Manganese Dysregulation of Dopamine Neuronal Activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(30):5871-5891 [DOI] 10.1523/JNEUROSCI.2830-19.2020. [PMID] 32576620.
2019
Volumetric magnetic resonance and diffusion tensor imaging at 17.6 Tesla of inbred C58/J mice: neural correlates of repetitive behavior.
Brain Imaging and Behavior. 9(8)
2019
The Role of BTBD9 in Striatum and Restless Legs Syndrome.
eNeuro. 6(5) [DOI] 10.1523/ENEURO.0277-19.2019. [PMID] 31444227.
2019
The psychoactive cathinone derivative pyrovalerone alters locomotor activity and decreases dopamine receptor expression in zebrafish (Danio rerio).
Brain and behavior. 9(11) [DOI] 10.1002/brb3.1420. [PMID] 31625691.
2019
The effects of acute and repeated methylenedioxypyrovalerone (MDPV) administration on striatal transcriptome networks in male long evans rats.
Neuroscience letters. 712 [DOI] 10.1016/j.neulet.2019.134499. [PMID] 31536752.
2019
Sustained Captopril-Induced Reduction in Blood Pressure Is Associated With Alterations in Gut-Brain Axis in the Spontaneously Hypertensive Rat.
Journal of the American Heart Association. 8(4) [DOI] 10.1161/JAHA.118.010721. [PMID] 30755073.
2019
Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats.
Neuropharmacology. 160 [DOI] 10.1016/j.neuropharm.2019.107756. [PMID] 31487496.
2019
Relationship between nicotine intake and reward function in rats with intermittent short versus long access to nicotine
Nicotine & Tobacco Research.
2019
Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(17):3249-3263 [DOI] 10.1523/JNEUROSCI.2944-18.2019. [PMID] 30804095.
2019
Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats.
Cannabis and cannabinoid research. 4(4):240-254 [DOI] 10.1089/can.2019.0049. [PMID] 32042924.
2019
Neither biological nor symptomatology reductionism: A call for integration in psychopathology research.
The Behavioral and brain sciences. 42 [DOI] 10.1017/S0140525X18001279. [PMID] 30940260.
2019
Multiscale Imaging Reveals Aberrant Functional Connectome Organization and Elevated Dorsal Striatal Arc Expression in Advanced Age.
eNeuro. 6(6) [DOI] 10.1523/ENEURO.0047-19.2019. [PMID] 31826916.
2019
Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats.
Acta physiologica (Oxford, England). 226(2) [DOI] 10.1111/apha.13256. [PMID] 30656835.
2019
Free-water imaging of the hippocampus is a sensitive marker of Alzheimer’s disease.
NeuroImage. Clinical. 24 [DOI] 10.1016/j.nicl.2019.101985. [PMID] 31470214.
2019
Enhancing effects of acute exposure to cannabis smoke on working memory performance.
Neurobiology of learning and memory. 157:151-162 [DOI] 10.1016/j.nlm.2018.12.001. [PMID] 30521850.
2019
Effects in rtas of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood.
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2019
Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood.
Psychopharmacology. 236(9):2773-2784 [DOI] 10.1007/s00213-019-05255-7. [PMID] 31044291.
2019
Characterization of Brain Metabolism by Nuclear Magnetic Resonance.
Chemphyschem : a European journal of chemical physics and physical chemistry. 20(2):216-230 [DOI] 10.1002/cphc.201800917. [PMID] 30536696.
2019
Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis.
NeuroImage. 202 [DOI] 10.1016/j.neuroimage.2019.116138. [PMID] 31472250.
2018
Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems
Frontiers in bioscience (Scholar ed. Online). 309-325 [DOI] 10.2741/s518. [PMID] 29293435.
2018
The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis.
Current pharmaceutical design. 23(39):6050-6061 [DOI] 10.2174/1381612823666170823101713. [PMID] 28831923.
2018
Systemic Inflammation Mediates Age-Related Cognitive Deficits.
Frontiers in aging neuroscience. 10 [DOI] 10.3389/fnagi.2018.00236. [PMID] 30127734.
2018
Simultaneous quantification of cannabinoids tetrahydrocannabinol, cannabidiol and CB1 receptor antagonist in rat plasma: An application to characterize pharmacokinetics after passive cannabis smoke inhalation and co-administration of rimonabant.
Journal of pharmaceutical and biomedical analysis. 160:119-125 [DOI] 10.1016/j.jpba.2018.07.004. [PMID] 30077950.
2018
Multifunctional Nanotherapeutics for the Treatment of neuroAIDS in Drug Abusers.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-31285-w. [PMID] 30154522.
2018
Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems.
Frontiers in bioscience (Scholar edition). 10:309-325 [PMID] 29293435.
View on: PubMed
2018
MEMRI reveals altered activity in brain regions associated with anxiety, locomotion, and cardiovascular reactivity on the elevated plus maze in the WKY vs SHR rats.
Brain imaging and behavior. 12(5):1318-1331 [DOI] 10.1007/s11682-017-9798-4. [PMID] 29181695.
2018
Self-administration of the synthetic cathinone MDPV enhances reward function via a nicotinic receptor dependent mechanism.
Neuropharmacology. 137:286-296 [DOI] 10.1016/j.neuropharm.2018.05.008. [PMID] 29778945.
2018
Menthol enhances nicotine-induced locomotor sensitization and in vivo functional connectivity in adolescence.
Journal of psychopharmacology (Oxford, England). 32(3):332-343 [DOI] 10.1177/0269881117719265. [PMID] 28747086.
2018
Genetic addiction risk score (GARS) ™, a predictor of vulnerability to opioid dependence.
Frontiers in bioscience (Elite edition). 10:175-196 [PMID] 28930612.
View on: PubMed
2018
Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone.
Neuropharmacology. 137:178-193 [DOI] 10.1016/j.neuropharm.2018.04.031. [PMID] 29729891.
2018
Functional Connectivity of Chronic Cocaine Use Reveals Progressive Neuroadaptations in Neocortical, Striatal, and Limbic Networks.
eNeuro. 5(4) [DOI] 10.1523/ENEURO.0081-18.2018. [PMID] 30073194.
2018
Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits.
Journal of affective disorders. 229:213-223 [DOI] 10.1016/j.jad.2017.12.089. [PMID] 29324369.
2018
Diffusion MRI-derived free water measures neurodegenerative patterns induced by interferon-ɣ.
Brain Structure & Function. 34(1):182-191
2018
Cocaine differentially affects synaptic activity in memory and midbrain areas of female and male rats: an in vivo MEMRI study.
Brain imaging and behavior. 12(1):201-216 [DOI] 10.1007/s11682-017-9691-1. [PMID] 28236167.
2018
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.
EC psychology and psychiatry. 7(8):564-579 [PMID] 30417173.
View on: PubMed
2018
MEMRI reveals altered activity in brain regions associated with anxiety, locomotion, and cardiovascular reactivity on the elevated plus maze in the WKY vs SHR rats
Brain Imaging and Behavior. [DOI] 10.1007/s11682-017-9798-4. [PMID] 29181695.
2017
In Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line.
Frontiers in neurology. 8 [DOI] 10.3389/fneur.2017.00663. [PMID] 29375461.
2017
Lyme and Dopaminergic Function: Hypothesizing Reduced Reward Deficiency Symptomatology by Regulating Dopamine Transmission
Journal of systems and integrative neuroscience. [DOI] 10.15761/JSIN.1000163. [PMID] 28736624.
2017
Lyme and Dopaminergic Function: Hypothesizing Reduced Reward Deficiency Symptomatology by Regulating Dopamine Transmission.
Journal of systems and integrative neuroscience. 3(3) [DOI] 10.15761/JSIN.1000163. [PMID] 28736624.
2017
Metal Transporter Zip14 (Slc39A14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity
The Journal of Neuroscience. 37(25):5996-6006 [DOI] 10.1523/JNEUROSCI.0285-17.2017.
2017
Neurogenetics of acute and chronic opiate/opioid abstinence: treating symptoms and the cause.
Frontiers in bioscience (Landmark edition). 22:1247-1288 [PMID] 28199203.
View on: PubMed
2017
Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats.
PloS one. 12(7) [DOI] 10.1371/journal.pone.0180738. [PMID] 28671997.
2017
Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog.
Stroke. 48(7):1948-1956 [DOI] 10.1161/STROKEAHA.117.016474. [PMID] 28588054.
2017
Sigma-1 receptor regulation of dopamine neurotransmission: beyond the surface membrane.
Nature Communications. 8(1)
2017
Improvement of long-term memory access with a pro-dopamine regulator in an elderly male: Are we targeting dopamine tone?
Journal of systems and integrative neuroscience. 3(3) [DOI] 10.15761/JSIN.1000165. [PMID] 29423319.
2017
Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery.
Brain and behavior. 7(5) [DOI] 10.1002/brb3.688. [PMID] 28523230.
2017
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.
Nature communications. 8(1) [DOI] 10.1038/s41467-017-02087-x. [PMID] 29263318.
2017
Zinc transporter ZIP14 (SLC39A14) is a gatekeeper against manganese-related neurotoxicity as occurs in Parkinson’s disease and dystonia.
The Journal of Neuroscience. 37(25):5996-6006
2017
Pro-Dopamine Regulator – (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome (RDS).
Journal of reward deficiency syndrome and addiction science. 3(1):3-13 [PMID] 28804788.
View on: PubMed
2017
Improvement of long-term memory access with a pro-dopamine regulator in an elderly male: Are we targeting dopamine tone?
Journal of systems and integrative neuroscience. [DOI] 10.15761/JSIN.1000165. [PMID] 29423319.
2017
Hybrid magneto-plasmonic liposomes for multimodal image-guided and brain-targeted HIV treatment.
Nanoscale. 10(1):184-194 [DOI] 10.1039/c7nr07255d. [PMID] 29210401.
2017
Hypothesizing Music Intervention Enhances Brain Functional Connectivity Involving Dopaminergic Recruitment: Common Neuro-correlates to Abusable Drugs.
Molecular neurobiology. 54(5):3753-3758 [DOI] 10.1007/s12035-016-9934-y. [PMID] 27246565.
2017
A Single Angiotensin II Hypertensive Stimulus Is Associated with Prolonged Neuronal and Immune System Activation in Wistar-Kyoto Rats.
Frontiers in physiology. 8 [DOI] 10.3389/fphys.2017.00592. [PMID] 28912720.
2017
Cannabidiol for the Treatment of Drug-Resistant Epilepsy in Children: Current State of Research
Journal of Pediatric Neurology. 15(4):143-150 [DOI] 10.1055/s-0037-1598109.
2017
Cocaine differentially affects synaptic activity in memory and midbrain areas of female and male rats: an in vivo MEMRI study.
Brain Imaging and Behavior.
2017
Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape.
Current neuropharmacology. 15(1):184-194 [PMID] 27174576.
View on: PubMed
2017
Hypothesizing That Neuropharmacological and Neuroimaging Studies of Glutaminergic-Dopaminergic Optimization Complex (KB220Z) Are Associated With “Dopamine Homeostasis” in Reward Deficiency Syndrome (RDS).
Substance use & misuse. 52(4):535-547 [DOI] 10.1080/10826084.2016.1244551. [PMID] 28033474.
2017
Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome.
Frontiers in bioscience (Landmark edition). 22:669-691 [PMID] 27814639.
View on: PubMed
2017
Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome.
Frontiers in bioscience (Landmark edition). 22:669-691
2017
Electropuncture promotes CNS-dependent release of mesenchymal stem cells.
Cell Stem Cell. 35(5):1303-1315
2017
Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z
PLoS One. [DOI] 10.1371/journal.pone.0174774. [PMID] 28445527.
2017
Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z.
PloS one. 12(4) [DOI] 10.1371/journal.pone.0174774. [PMID] 28445527.
2017
Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia.
Neurobiology of disease. 106:124-132 [DOI] 10.1016/j.nbd.2017.06.015. [PMID] 28673740.
2017
High magnetic field fMRI compliant carbon nanofiber neural probes.
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2017
Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells.
Stem cells (Dayton, Ohio). 35(5):1303-1315 [DOI] 10.1002/stem.2613. [PMID] 28299842.
2016
Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats.
PloS one. 11(4) [DOI] 10.1371/journal.pone.0153327. [PMID] 27065006.
2016
Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1
Neuroscience letters. [DOI] 10.1016/j.neulet.2016.01.014. [PMID] 26777426.
2016
Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1.
Neuroscience letters. 615:21-7 [DOI] 10.1016/j.neulet.2016.01.014. [PMID] 26777426.
2016
Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior.
Oncotarget. 7(15):19111-23 [DOI] 10.18632/oncotarget.8088. [PMID] 26992232.
2016
Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial.
Austin addiction sciences. 1(2) [PMID] 27840857.
View on: PubMed
2016
In vivo imaging reveals impaired connectivity across cortical and subcortical networks in a mouse model of DYT1 dystonia.
Neurobiology of disease. 95:35-45 [DOI] 10.1016/j.nbd.2016.07.005. [PMID] 27404940.
2016
KB220Z™ a Pro-Dopamine Regulator Associated with the Protracted, Alleviation of Terrifying Lucid Dreams. Can We Infer Neuroplasticity-induced Changes in the Reward Circuit?
Journal of reward deficiency syndrome and addiction science. 2(1):3-13 [DOI] 10.17756/jrdsas.2016-022. [PMID] 28210713.
2016
Low-Resolution Electromagnetic Tomography (LORETA) of changed Brain Function Provoked by Pro-Dopamine Regulator (KB220z) in one Adult ADHD case.
Open journal of clinical & medical case reports. 2(11) [PMID] 27610420.
View on: PubMed
2016
Neurobiology of KB220Z-Glutaminergic-Dopaminergic Optimization Complex [GDOC] as a Liquid Nano: Clinical Activation of Brain in a Highly Functional Clinician Improving Focus, Motivation and Overall Sensory Input Following Chronic Intake.
Clinical medical reviews and case reports. 3(5) [DOI] 10.23937/2378-3656/1410104. [PMID] 29214221.
2016
Neuronutrient Amino-Acid Therapy Protects Against Reward Deficiency Syndrome: Dopaminergic Key to Homeostasis and Neuroplasticity.
Current pharmaceutical design. 22(38):5837-5854 [PMID] 27510492.
View on: PubMed
2016
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(9):1378-1389 [DOI] 10.1016/j.euroneuro.2016.07.007. [PMID] 27461514.
2016
Pilot clinical observations between food and drug seeking derived from fifty cases attending an eating disorder clinic.
Journal of behavioral addictions. 5(3):533-41 [DOI] 10.1556/2006.5.2016.055. [PMID] 27502054.
2016
Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline.
Frontiers in aging neuroscience. 8 [DOI] 10.3389/fnagi.2016.00158. [PMID] 27468264.
2016
The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(9):2352-65 [DOI] 10.1038/npp.2016.40. [PMID] 26997298.
2016
Hypothesizing that, A Pro-Dopamine Regulator (KB220Z) Should Optimize, but Not Hyper-Activate the Activity of Trace Amine-Associated Receptor 1 (TAAR-1) and Induce Anti-Craving of Psychostimulants in the Long-Term.
Journal of reward deficiency syndrome and addiction science. 2(1):14-21 [DOI] 10.17756/jrdsas.2016-023. [PMID] 28317038.
2015
Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction
. [DOI] 10.17756/jrds.2015-009. [PMID] 26052557.
2015
Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction.
Journal of reward deficiency syndrome. 1(1):65-68 [PMID] 26052557.
View on: PubMed
2015
Neurogenetic and epigenetic correlates of adolescent predisposition to and risk for addictive behaviors as a function of prefrontal cortex dysregulation.
Journal of child and adolescent psychopharmacology. 25(4):286-92 [DOI] 10.1089/cap.2014.0146. [PMID] 25919973.
2015
Neurogenetics and gene therapy for reward deficiency syndrome: are we going to the Promised Land?
Expert opinion on biological therapy. 15(7):973-85 [DOI] 10.1517/14712598.2015.1045871. [PMID] 25974314.
2015
Neuroquantum Theories of Psychiatric Genetics: Can Physical Forces Induce Epigenetic Influence On Future Genomes?
Neuroquantology. 13(1):90-103
2015
Using the Neuroadaptagen KB200z™ to Ameliorate Terrifying, Lucid Nightmares in RDS Patients: the Role of Enhanced, Brain-Reward, Functional Connectivity and Dopaminergic Homeostasis.
Journal of reward deficiency syndrome. 1(1):24-35 [PMID] 26065033.
View on: PubMed
2015
rsfMRI effects of KB220Z™ on neural pathways in reward circuitry of abstinent genotyped heroin addicts.
Postgraduate medicine. 127(2):232-41 [PMID] 25526228.
View on: PubMed
2015
Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model.
Scientific reports. 5 [DOI] 10.1038/srep11178. [PMID] 26058556.
2015
Using the Neuroadaptagen KB200z™ to Ameliorate Terrifying, Lucid Nightmares in RDS Patients: the Role of Enhanced, Brain-Reward, Functional Connectivity and Dopaminergic Homeostasis
. [DOI] 10.17756/jrds.2015-006. [PMID] 26065033.
2015
Increased free water in the substantia nigra of Parkinson’s disease: a single-site and multi-site study.
Neurobiology of aging. 36(2):1097-104 [DOI] 10.1016/j.neurobiolaging.2014.10.029. [PMID] 25467638.
2015
Putative dopamine agonist (KB220Z) attenuates lucid nightmares in PTSD patients: role of enhanced brain reward functional connectivity and homeostasis redeeming joy.
Journal of behavioral addictions. 4(2):106-15 [DOI] 10.1556/2006.4.2015.008. [PMID] 26132915.
2015
Hypothesizing Balancing Endorphinergic and Glutaminergic Systems to Treat and Prevent Relapse to Reward Deficiency Behaviors: Coupling D-Phenylalanine and N-Acetyl-L-Cysteine (NAC) as a Novel Therapeutic Modality.
Clinical medical reviews and case reports. 2(8) [PMID] 26900600.
View on: PubMed
2015
Designer Drugs: A Synthetic Catastrophe.
Journal of reward deficiency syndrome. 1(2):82-86 [PMID] 27617301.
View on: PubMed
2015
Dopamine in the Brain: Hypothesizing Surfeit or Deficit Links to Reward and Addiction.
Journal of reward deficiency syndrome. 1(3):95-104 [PMID] 27398406.
View on: PubMed
2015
Coupling Neurogenetics (GARS™) and a Nutrigenomic Based Dopaminergic Agonist to Treat Reward Deficiency Syndrome (RDS): Targeting Polymorphic Reward Genes for Carbohydrate Addiction Algorithms.
Journal of reward deficiency syndrome. 1(2):75-80 [PMID] 27617300.
View on: PubMed
2015
Corrigendum: Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model.
Scientific reports. 5 [DOI] 10.1038/srep15922. [PMID] 26679741.
2015
Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?
Molecular neurobiology. 52(3):1862-1869 [DOI] 10.1007/s12035-015-9110-9. [PMID] 25750061.
2015
Central neural activation following contact sensitivity peripheral immune challenge: evidence of brain-immune regulation through C fibres.
Immunology. 146(2):206-16 [DOI] 10.1111/imm.12479. [PMID] 25967648.
2015
Can Genetic Testing Provide Information to Develop Customized Nutrigenomic Solutions for Reward Deficiency Syndrome?
Clinical medical reviews and case reports. 2(1) [PMID] 26225358.
View on: PubMed
2015
Brain Reward Pathway Dysfunction in Maternal Depression and Addiction: A Present and Future Transgenerational Risk.
Journal of reward deficiency syndrome. 1(3):105-116 [PMID] 27617302.
View on: PubMed
2015
Assessing contributions of nucleus accumbens shell subregions to reward-seeking behavior.
Drug and Alcohol Dependence. 153:369-373
2015
Addiction Treatment in America: After Money or Aftercare?
Journal of reward deficiency syndrome. 1(3):87-94 [PMID] 26835513.
View on: PubMed
2015
A new day for an old emotion: studying fear learning using awake mouse functional magnetic resonance imaging (Commentary on Harris et al.).
The European journal of neuroscience. 42(5):2123-4 [DOI] 10.1111/ejn.13014. [PMID] 26173793.
2015
Enhancing Brain Pregnenolone May Protect Cannabis Intoxication but Should Not Be Considered as an Anti-addiction Therapeutic: Hypothesizing Dopaminergic Blockade and Promoting Anti-Reward.
Journal of reward deficiency syndrome. 1(1):20-23 [PMID] 26306328.
View on: PubMed
2014
Functional neural-bone marrow pathways: implications in hypertension and cardiovascular disease.
Hypertension (Dallas, Tex. : 1979). 63(6):e129-39 [DOI] 10.1161/HYPERTENSIONAHA.114.02440. [PMID] 24688127.
2014
Repetitive Mild Traumatic Brain Injury Mice Exhibit Structural and Histopathological Alterations and Long-Term Behavioral Changes
Journal of Neurotrauma. 31(12)
2014
Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric.
Journal of behavioral addictions. 3(3):149-56 [DOI] 10.1556/JBA.3.2014.019. [PMID] 25317338.
2014
Cocaine-associated odor cue re-exposure increases blood oxygenation level dependent signal in memory and reward regions of the maternal rat brain.
Drug and alcohol dependence. 134:167-177 [DOI] 10.1016/j.drugalcdep.2013.09.032. [PMID] 24183499.
2014
Oxytocin and vasopressin modulation of the neural correlates of motivation and emotion: results from functional MRI studies in awake rats.
Brain research. 1580:8-21 [DOI] 10.1016/j.brainres.2014.01.019. [PMID] 24486356.
2014
Altered inflammatory response is associated with an impaired autonomic input to the bone marrow in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979). 63(3):542-50 [DOI] 10.1161/HYPERTENSIONAHA.113.02722. [PMID] 24366083.
2014
Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study.
Neurobiology of aging. 35(6):1364-74 [DOI] 10.1016/j.neurobiolaging.2013.12.009. [PMID] 24411290.
2014
Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in rats.
The international journal of neuropsychopharmacology. 18(2) [DOI] 10.1093/ijnp/pyu011. [PMID] 25552431.
2014
Behavioral Alterations and Dependence Following Acute and Chronic Exposure To Cannabis Smoke
Neuropsychopharmacology. 39(1):S599-S600
2013
Behavioral effects of acclimatization to restraint protocol used for awake animal imaging.
Journal of neuroscience methods. 217(1-2):63-6 [DOI] 10.1016/j.jneumeth.2013.03.023. [PMID] 23562621.
2013
Hypothesizing that designer drugs containing cathinones (“bath salts”) have profound neuro-inflammatory effects and dangerous neurotoxic response following human consumption.
Medical hypotheses. 81(3):450-5 [DOI] 10.1016/j.mehy.2013.06.007. [PMID] 23845561.
2013
In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures.
Molecular neurodegeneration. 8 [DOI] 10.1186/1750-1326-8-9. [PMID] 23379588.
2013
Neural processing of a cocaine-associated odor cue revealed by functional MRI in awake rats.
Neuroscience letters. 534:160-5 [DOI] 10.1016/j.neulet.2012.11.054. [PMID] 23262077.
2013
Predator odor-evoked BOLD activation in the awake rat: modulation by oxytocin and V₁a vasopressin receptor antagonists.
Brain research. 1494:70-83 [DOI] 10.1016/j.brainres.2012.11.045. [PMID] 23219972.
2012
Gestational valproate alters BOLD activation in response to complex social and primary sensory stimuli.
PloS one. 7(5) [DOI] 10.1371/journal.pone.0037313. [PMID] 22615973.
2012
Effects of cocaine on maternal behavior and neurochemistry.
Current Neuropharmacology. 10(1):53-63
2012
Firing patterns of maternal rat prelimbic neurons during spontaneous contact with pups.
Brain research bulletin. 88(5):534-42 [DOI] 10.1016/j.brainresbull.2012.05.012. [PMID] 22643133.
2012
Effects of cocaine on maternal behavior and neurochemistry.
Current neuropharmacology. 10(1):53-63 [DOI] 10.2174/157015912799362760. [PMID] 22942878.
2012
Cocaine sensitization increases kyphosis and modulates neural activity in adult nulliparous rats.
Brain sciences. 2(4) [DOI] 10.3390/brainsci2040667. [PMID] 24371520.
2011
A bold view at the lactating brain: fMRI studies of suckling in awake dams
Journal of Neuroendocrinology. 23(11):1009-1019
2011
A bold view of the lactating brain: functional magnetic resonance imaging studies of suckling in awake dams.
Journal of neuroendocrinology. 23(11):1009-19 [DOI] 10.1111/j.1365-2826.2011.02184.x. [PMID] 21722215.
2011
Biological role of interleukin-1beta in defensive-aggressive behaviour.
Journal of biological regulators and homeostatic agents. 25(3):323-9 [PMID] 22023756.
View on: PubMed
2011
BOLD signal response to cocaine varies with sexual receptivity in female rats.
Neuroreport. 22(1):19-22 [DOI] 10.1097/WNR.0b013e3283416f81. [PMID] 21048520.
2011
Functional magnetic resonance imaging in awake animals.
Reviews in the neurosciences. 22(6):665-74 [DOI] 10.1515/RNS.2011.050. [PMID] 22098446.
2011
Increased BOLD activation to predator stressor in subiculum and midbrain of amphetamine-sensitized maternal rats.
Brain research. 1382:118-27 [DOI] 10.1016/j.brainres.2010.11.092. [PMID] 21134359.
2011
Prefrontal cell firing in male rats during approach towards sexually receptive female: interactions with cocaine.
Synapse (New York, N.Y.). 65(4):271-7 [DOI] 10.1002/syn.20843. [PMID] 20687107.
2011
Technical and conceptual considerations for performing and interpreting functional MRI studies in awake rats.
Frontiers in psychiatry. 2 [DOI] 10.3389/fpsyt.2011.00043. [PMID] 21808625.
2010
Inactivation or inhibition of neuronal activity in the medial prefrontal cortex largely reduces pup retrieval and grouping in maternal rats.
Brain research. 1325:77-88 [DOI] 10.1016/j.brainres.2010.02.027. [PMID] 20156425.
2010
Estradiol: a key biological substrate mediating the response to cocaine in female rats.
Hormones and behavior. 58(1):33-43 [DOI] 10.1016/j.yhbeh.2009.12.003. [PMID] 20026119.
2010
Central vasopressin V1a receptors modulate neural processing in mothers facing intruder threat to pups.
Neuropharmacology. 58(1):107-16 [DOI] 10.1016/j.neuropharm.2009.06.023. [PMID] 19573540.
2010
Effect of cocaine sensitization prior to pregnancy on maternal care and aggression in the rat.
Psychopharmacology. 209(1):127-35 [DOI] 10.1007/s00213-010-1777-z. [PMID] 20101390.
2009
Blood oxygen level-dependent signal responses in corticolimbic ’emotions’ circuitry of lactating rats facing intruder threat to pups.
The European journal of neuroscience. 30(5):934-45 [DOI] 10.1111/j.1460-9568.2009.06875.x. [PMID] 19709175.
2009
Cocaine-induced metabolic activation in cortico-limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate.
Neuroscience letters. 465(3):267-71 [DOI] 10.1016/j.neulet.2009.07.065. [PMID] 19638299.
2009
Oxytocin modulates unconditioned fear response in lactating dams: an fMRI study.
Brain research. 1302:183-93 [DOI] 10.1016/j.brainres.2009.09.043. [PMID] 19766607.
2008
Imaging the neural circuitry and chemical control of aggressive motivation
Bmc Neuroscience.
2008
Imaging the neural circuitry and chemical control of aggressive motivation.
BMC neuroscience. 9 [DOI] 10.1186/1471-2202-9-111. [PMID] 19014547.
2008
Nursing stimulation is more than tactile sensation: It is a multisensory experience.
Hormones and behavior. 54(2):330-9 [DOI] 10.1016/j.yhbeh.2008.02.024. [PMID] 18440003.
2007
Development of cocaine sensitization before pregnancy affects subsequent maternal retrieval of pups and prefrontal cortical activity during nursing.
Neuroscience. 148:400-412
2006
Hemodynamic and metabolic changes induced by cocaine in anesthetized rat observed with multimodal functional MRI.
Psychopharmacology. 185(4):479-86 [PMID] 16550388.
View on: PubMed
2006
Functional magnetic resonance imaging in conscious animals: a new tool in behavioural neuroscience research
Journal of Neuroendocrinology. 18(5):307-318
2005
Estrogen influences cocaine-induced blood oxygen level-dependent signal changes in female rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(5):1132-6 [PMID] 15689549.
View on: PubMed
2005
Functional magnetic resonance imaging shows oxytocin activates brain regions associated with mother-pup bonding during suckling.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(50):11637-44 [PMID] 16354922.
View on: PubMed
2005
Pup suckling is more rewarding than cocaine: evidence from functional magnetic resonance imaging and three-dimensional computational analysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(1):149-56 [PMID] 15634776.
View on: PubMed
2005
The neural consequences of repeated cocaine exposure revealed by functional MRI in awake rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 30(5):936-43 [PMID] 15637636.
View on: PubMed
2004
Cocaine alters GABA(B)-mediated G-protein activation in the ventral tegmental area of female rats: modulation by estrogen.
Synapse (New York, N.Y.). 54(1):30-6 [PMID] 15300882.
View on: PubMed
2004
Imaging cocaine-induced changes in the mesocorticolimbic dopaminergic system of conscious rats.
Journal of neuroscience methods. 139(2):167-76 [PMID] 15488229.
View on: PubMed
2003
Estrogen-dependent alterations in D2/D3-induced G protein activation in cocaine-sensitized female rats.
Journal of neurochemistry. 86(2):405-12 [PMID] 12871581.
View on: PubMed
2002
Estrogen and opioids interact to modulate the locomotor response to cocaine in the female rat.
Brain research. 943(1):151-61 [PMID] 12088849.
View on: PubMed

Grants

Sep 2020 ACTIVE
Opioid and cannabinoid interactions in pain and reward
Role: Project Manager
Funding: NATL INST OF HLTH NIDA
Sep 2020 ACTIVE
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role:
Funding: NATL INST OF HLTH NINDS
Jul 2020 ACTIVE
OR-DRPD-ROF2020: Adolescent Traumatic Brain Injury and the Implications of Repetitive Head Impacts (RHI) on the Developing Brain
Role:
Funding: UF RESEARCH
Jul 2020 ACTIVE
OR-DRPD-ROF2020:Role of the Hyperdirect Basal Ganglia Pathway in Mediating Repetitive, Inflexible Behavior
Role:
Funding: UF RESEARCH
Feb 2020 ACTIVE
Imaging Networks of Affective Behaviors and Dopamine in Alzheimers Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Feb 2020 ACTIVE
Interrogating stress-relieving neural circuits to alleviate cardiovascular disease
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Jul 2019 ACTIVE
Multi-pronged Approach to Recalibrating the Inflammatory Cascade in Ischemic Stroke with BET blockade
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Jun 2019 ACTIVE
DRPD-ROF2019: A Microfluidics Optrode: A Next Generation Approach to Brain Network Modulation in Parkinsons Disease
Role: Principal Investigator
Funding: UF RESEARCH
May 2019 – Jul 2020
VA-Gainesville IPA for Marjory Pompilus
Role: Mentor
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2018 ACTIVE
Non-Invasive Markers of Neurodegeneration in Movement Disorders
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Sep 2018 ACTIVE
Neurovascular Protection by Adropin in Ischemic Stroke
Role:
Funding: NATL INST OF HLTH NINDS
Sep 2018 – Oct 2020
Systems Control of Normal Aging and Alzheimer's Disease
Role: Principal Investigator
Funding: THE JACKSON LABORATORY via NATL INST OF HLTH NIA
May 2018 ACTIVE
The role of the gut-microbiome-brain axis in cardiovascular disease following prenatal exposure to nicotine
Role:
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Apr 2018 ACTIVE
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role:
Funding: NATL INST OF HLTH NINDS
Jan 2018 ACTIVE
National High Magnetic Field Laboratory Renewal 2018-2022
Role:
Funding: FL STATE UNIV via NATL SCIENCE FOU
Dec 2017 – Jul 2018
VA-Gainesville IPA for Luis M. Colon-Perez, Ph.D.
Role: Mentor
Funding: *NF/SGVHS Malcom Randall VA Medical Cent
Sep 2017 – Aug 2019
Neurovascular Protection by Adropin in Ischemic Stroke
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Sep 2017 ACTIVE
Preclinical Imaging of Adolescent Cannabidiol on Brain Structure and Functional Connectivity
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Jul 2016 ACTIVE
Tobacco: relationship between reduced nicotine content and reinforcement in rats
Role:
Funding: NATL INST OF HLTH NIDA
Jul 2016 – Jun 2018
Prostacyclin Receptor Activation and Neurovascular Protection in Ischemic Stroke
Role:
Funding: AMER HEART ASSOCIATION
Apr 2016 – Mar 2017
AGE-ASSOCIATED FUNCTIONAL CONNECTIVITY DECLINES IN THE
Role: Project Manager
Funding: UF ALZHEIMER'S DISEASE RESEARCH CENTER
Aug 2015 ACTIVE
University of Florida – Mt. Sinai Medical Center AD Research Center
Role:
Funding: NATL INST OF HLTH NIA
Jun 2015 – Sep 2017
Effects of Cannabidol Use on the Developing Brain in Medically Refractory Childhood Epilepsy
Role: Project Manager
Funding: FL DEPT OF HLTH REFRACTORY INTRACTABLE E
Apr 2015 – Mar 2018
Imaging In Vivo Neural of Synthetic Cathinones
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Feb 2015 ACTIVE
Mapping Towards a Cure Identification of Neurophysiologic Signatures of Trigeminal Neuralgia Pain
Role: Project Manager
Funding: UF FOU via THE FACIAL PAIN RESEARCH FOU
Mar 2014 – Dec 2017
Direct Functional Imaging of Electrical Brain Stimulation
Role: Project Manager
Funding: ARIZONA STATE UNIVERSITY via NATL INST OF HLTH NINDS
Jul 2013 ACTIVE
The Bachmann-Strauss Dystonia & Parkinson's Disease COE
Role: Project Manager
Funding: UF FOU
Jul 2013 – Jul 2016
The Bachmann-Strauss Dystonia & Parkinson's Disease COE
Role: Project Manager
Funding: BACHMANN-STRAUSS DYSTONIA & PARKINSON FO via DUKE UNIV
Jan 2013 – Dec 2018
National High Magnetic Field Laboratory
Role:
Funding: FL STATE UNIV via NATL SCIENCE FOU
Jul 2011 – Jun 2016
Faculty Start-up Funds
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO

Education

Fellowship, Functional Magnetic Resonance Imaging
2005 · University of Massachusetts Medical Center, Worcester, MA
PhD, Physiology
2003 · University of Puerto Rico Medical Sciences Campus, San Juan, PR
BSc, Biology
1997 · University of Puerto Rico, Humacao, PR

Teaching Profile

Courses Taught
2019-2020
GMS6082 Introduction to Functional Magnetic Resonance Imaging
2020
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
2019
GMS6705 Functional Human Neuroanatomy
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2013-2016
GMS6024 Princ Neuroscience 4
2015
VEM5110 Animal Systems 1
2014
GMS7794 Neuroscience Seminar
2013
GMS7795 Special Topics in Neuroscience

Contact Details

Phones:
Business:
(352) 294-4911
Emails:
Business:
febo@ufl.edu