Susan Fromholt,
Biological Scientist III
Department:
Department of Neuroscience
Business Phone:
(352) 294-5159
Business Email:
sfromhol@ufl.edu
Publications
Academic Articles
2024
Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.
Molecular neurodegeneration.
19(1)
[DOI] 10.1186/s13024-024-00710-2.
[PMID] 38365847.
2023
Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice.
Viruses.
15(9)
[DOI] 10.3390/v15091819.
[PMID] 37766226.
2022
Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer’s Disease.
Biomolecules.
12(7)
[DOI] 10.3390/biom12070886.
[PMID] 35883442.
2022
Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts.
Free neuropathology.
3(9)
[DOI] 10.17879/freeneuropathology-2022-3766.
[PMID] 35494163.
2022
TAPPing into the potential of inducible tau/APP transgenic mice.
Neuropathology and applied neurobiology.
48(3)
[DOI] 10.1111/nan.12791.
[PMID] 35067965.
2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.
Molecular neurodegeneration.
16(1)
[DOI] 10.1186/s13024-021-00486-9.
[PMID] 34503546.
2020
Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis.
Acta neuropathologica communications.
8(1)
[DOI] 10.1186/s40478-020-00911-y.
[PMID] 32252825.
2018
Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3.
Acta neuropathologica communications.
6(1)
[DOI] 10.1186/s40478-018-0631-0.
[PMID] 30563574.
2018
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
Acta neuropathologica.
136(6):919-938
[DOI] 10.1007/s00401-018-1895-y.
[PMID] 30140941.
2018
Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology.
Molecular neurodegeneration.
13(1)
[DOI] 10.1186/s13024-018-0253-9.
[PMID] 29776378.
2017
Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.
Journal of neurochemistry.
140(1):140-150
[DOI] 10.1111/jnc.13864.
[PMID] 27727458.
2017
Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications.
5(1)
[DOI] 10.1186/s40478-017-0502-0.
[PMID] 29237481.
2016
Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.
Acta neuropathologica.
132(6):827-840
[PMID] 27704280.
2016
Generation of a new transgenic mouse model for assessment of tau gene silencing therapies.
Alzheimer's research & therapy.
8(1)
[DOI] 10.1186/s13195-016-0202-1.
[PMID] 27593210.
2016
Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways.
Acta neuropathologica.
131(1):103-14
[DOI] 10.1007/s00401-015-1514-0.
[PMID] 26650262.
2016
Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications.
4(1)
[DOI] 10.1186/s40478-016-0393-5.
[PMID] 27863507.
2015
Direct and Indirect Mechanisms for Wild-Type Sod1 To Enhance the Toxicity of Mutant Sod1 in Bigenic Transgenic Mice
Human Molecular Genetics.
24(4):1019-1035
[DOI] 10.1093/hmg/ddu517.
[PMID] 25305079.
2015
Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.
Acta neuropathologica communications.
3
[DOI] 10.1186/s40478-015-0252-9.
[PMID] 26566997.
2015
Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.
Journal of neurochemistry.
133(3):452-64
[DOI] 10.1111/jnc.13022.
[PMID] 25557022.
2015
Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.
Molecular therapy : the journal of the American Society of Gene Therapy.
23(1):53-62
[DOI] 10.1038/mt.2014.180.
[PMID] 25228069.
2014
Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease.
Journal of neurochemistry.
128(2):305-14
[DOI] 10.1111/jnc.12451.
[PMID] 24032979.
2014
Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.
Journal of Huntington's disease.
3(1):73-86
[DOI] 10.3233/JHD-130087.
[PMID] 25062766.
2014
Experimental transmissibility of mutant SOD1 motor neuron disease.
Acta neuropathologica.
128(6):791-803
[DOI] 10.1007/s00401-014-1342-7.
[PMID] 25262000.
2013
Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
33(9):3765-79
[DOI] 10.1523/JNEUROSCI.4251-12.2013.
[PMID] 23447589.
2012
Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice.
Alzheimer's research & therapy.
4(2)
[DOI] 10.1186/alzrt110.
[PMID] 22537779.
2011
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Human molecular genetics.
20(14):2770-82
[DOI] 10.1093/hmg/ddr176.
[PMID] 21515588.
2005
Membrane redistribution of gangliosides and glycosylphosphatidylinositol-anchored proteins in brain tissue sections under conditions of lipid raft isolation.
Biochimica et biophysica acta.
1686(3):200-8
[PMID] 15629689.
2005
Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.
Experimental neurology.
195(1):208-17
[PMID] 15953602.
2005
The role of Trp-82 in the folding of intestinal fatty acid binding protein.
Proteins.
61(1):176-83
[PMID] 16080148.
2003
Systematic synthesis and MAG-binding activity of novel sulfated GM1b analogues as mimics of Chol-1 (alpha-series) gangliosides: highly active ligands for neural siglecs.
Carbohydrate research.
338(16):1621-39
[PMID] 12873419.
2002
Anti-ganglioside antibodies bind with enhanced affinity to gangliosides containing very long chain fatty acids.
Neurochemical research.
27(7-8):847-55
[PMID] 12374222.
2002
Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration.
Proceedings of the National Academy of Sciences of the United States of America.
99(12):8412-7
[PMID] 12060784.
2002
Immunoglobulin G-class mouse monoclonal antibodies to major brain gangliosides.
Analytical biochemistry.
302(2):276-84
[PMID] 11878808.
2000
High-affinity anti-ganglioside IgG antibodies raised in complex ganglioside knockout mice: reexamination of GD1a immunolocalization.
Journal of neurochemistry.
75(1):404-12
[PMID] 10854286.
Contact Details
Phones:
- Business:
- (352) 294-5159
Emails:
- Business:
- sfromhol@ufl.edu
Addresses:
- Business Mailing:
-
Box 100159
1275 Center Drive BMS J492
Gainesville FL 32610 - Business Street:
-
1275 Center Drive, BMS J492
Gainesville FL 32610