Susan Fromholt

Susan Fromholt

Biological Scientist II

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 392-3383
Business Email: sfromhol@ufl.edu

Publications

2020
Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis.
Acta neuropathologica communications. 8(1) [DOI] 10.1186/s40478-020-00911-y. [PMID] 32252825.
2018
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
Acta neuropathologica. 136(6):919-938 [DOI] 10.1007/s00401-018-1895-y. [PMID] 30140941.
2018
Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology.
Molecular neurodegeneration. 13(1) [DOI] 10.1186/s13024-018-0253-9. [PMID] 29776378.
2018
Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3.
Acta neuropathologica communications. 6(1) [DOI] 10.1186/s40478-018-0631-0. [PMID] 30563574.
2017
Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.
Journal of neurochemistry. 140(1):140-150 [DOI] 10.1111/jnc.13864. [PMID] 27727458.
2017
Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications. 5(1) [DOI] 10.1186/s40478-017-0502-0. [PMID] 29237481.
2016
Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.
Acta neuropathologica. 132(6):827-840 [PMID] 27704280.
View on: PubMed
2016
Generation of a new transgenic mouse model for assessment of tau gene silencing therapies.
Alzheimer's research & therapy. 8 [DOI] 10.1186/s13195-016-0202-1. [PMID] 27593210.
2016
Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways.
Acta neuropathologica. 131(1):103-14 [DOI] 10.1007/s00401-015-1514-0. [PMID] 26650262.
2016
Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications. 4(1) [DOI] 10.1186/s40478-016-0393-5. [PMID] 27863507.
2015
Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.
Human molecular genetics. 24(4):1019-35 [DOI] 10.1093/hmg/ddu517. [PMID] 25305079.
2015
Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.
Acta neuropathologica communications. 3 [DOI] 10.1186/s40478-015-0252-9. [PMID] 26566997.
2015
Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.
Journal of neurochemistry. 133(3):452-64 [DOI] 10.1111/jnc.13022. [PMID] 25557022.
2015
Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.
Molecular therapy : the journal of the American Society of Gene Therapy. 23(1):53-62 [DOI] 10.1038/mt.2014.180. [PMID] 25228069.
2014
Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease.
Journal of neurochemistry. 128(2):305-14 [DOI] 10.1111/jnc.12451. [PMID] 24032979.
2014
Experimental transmissibility of mutant SOD1 motor neuron disease.
Acta neuropathologica. 128(6):791-803 [DOI] 10.1007/s00401-014-1342-7. [PMID] 25262000.
2014
Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.
Journal of Huntington's disease. 3(1):73-86 [DOI] 10.3233/JHD-130087. [PMID] 25062766.
2013
Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3765-79 [DOI] 10.1523/JNEUROSCI.4251-12.2013. [PMID] 23447589.
2012
Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice.
Alzheimer's research & therapy. 4(2) [DOI] 10.1186/alzrt110. [PMID] 22537779.
2011
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Human molecular genetics. 20(14):2770-82 [DOI] 10.1093/hmg/ddr176. [PMID] 21515588.
2005
Membrane redistribution of gangliosides and glycosylphosphatidylinositol-anchored proteins in brain tissue sections under conditions of lipid raft isolation.
Biochimica et biophysica acta. 1686(3):200-8 [PMID] 15629689.
View on: PubMed
2005
Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.
Experimental neurology. 195(1):208-17 [PMID] 15953602.
View on: PubMed
2005
The role of Trp-82 in the folding of intestinal fatty acid binding protein.
Proteins. 61(1):176-83 [PMID] 16080148.
View on: PubMed
2003
Systematic synthesis and MAG-binding activity of novel sulfated GM1b analogues as mimics of Chol-1 (alpha-series) gangliosides: highly active ligands for neural siglecs.
Carbohydrate research. 338(16):1621-39 [PMID] 12873419.
View on: PubMed
2002
Anti-ganglioside antibodies bind with enhanced affinity to gangliosides containing very long chain fatty acids.
Neurochemical research. 27(7-8):847-55 [PMID] 12374222.
View on: PubMed
2002
Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration.
Proceedings of the National Academy of Sciences of the United States of America. 99(12):8412-7 [PMID] 12060784.
View on: PubMed
2002
Immunoglobulin G-class mouse monoclonal antibodies to major brain gangliosides.
Analytical biochemistry. 302(2):276-84 [PMID] 11878808.
View on: PubMed
2000
High-affinity anti-ganglioside IgG antibodies raised in complex ganglioside knockout mice: reexamination of GD1a immunolocalization.
Journal of neurochemistry. 75(1):404-12 [PMID] 10854286.
View on: PubMed

Contact Details

Phones:
Business:
(352) 392-3383
Emails:
Business:
sfromhol@ufl.edu