Christopher G Janus

Christopher G Janus

Research Assistant Professor

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-9662
Business Email: cjanus@ufl.edu

Publications

2020
Phenotypic evaluation of a childhood-onset parkinsonism-dystonia mouse model with inherent postural abnormalities.
Brain research bulletin. 166:54-63 [DOI] 10.1016/j.brainresbull.2020.10.018. [PMID] 33147520.
2019
Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy.
Human molecular genetics. 28(19):3255-3269 [DOI] 10.1093/hmg/ddz151. [PMID] 31261380.
2019
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
The Journal of experimental medicine. 216(11):2479-2491 [DOI] 10.1084/jem.20190430. [PMID] 31467037.
2018
Locomotor differences in mice expressing wild-type human α-synuclein.
Neurobiology of aging. 65:140-148 [DOI] 10.1016/j.neurobiolaging.2018.01.020. [PMID] 29477894.
2018
Short Aβ peptides attenuate Aβ42 toxicity in vivo.
The Journal of experimental medicine. 215(1):283-301 [DOI] 10.1084/jem.20170600. [PMID] 29208777.
2018
SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice.
Proceedings of the National Academy of Sciences of the United States of America. 115(8):E1769-E1778 [DOI] 10.1073/pnas.1720739115. [PMID] 29437953.
2018
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease.
The Journal of experimental medicine. 215(9):2247-2264 [DOI] 10.1084/jem.20180484. [PMID] 30158114.
2017
The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.
Molecular neurodegeneration. 12(1) [DOI] 10.1186/s13024-017-0215-7. [PMID] 28978354.
2016
A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.
PloS one. 11(2) [DOI] 10.1371/journal.pone.0149410. [PMID] 26894278.
2016
Better Utilization of Mouse Models of Neurodegenerative Diseases in Preclinical Studies: From the Bench to the Clinic.
Methods in molecular biology (Clifton, N.J.). 1438:311-47 [DOI] 10.1007/978-1-4939-3661-8_18. [PMID] 27150098.
2015
Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains.
Neurobiology of aging. 36(9):2519-32 [DOI] 10.1016/j.neurobiolaging.2015.05.010. [PMID] 26089165.
2015
IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.
Neuron. 85(3):519-33 [DOI] 10.1016/j.neuron.2014.11.020. [PMID] 25619653.
2015
Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy.
PloS one. 10(11) [DOI] 10.1371/journal.pone.0142144. [PMID] 26528920.
2015
Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.
Journal of neurochemistry. 133(3):452-64 [DOI] 10.1111/jnc.13022. [PMID] 25557022.
2015
Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.
Molecular therapy : the journal of the American Society of Gene Therapy. 23(1):53-62 [DOI] 10.1038/mt.2014.180. [PMID] 25228069.
2014
Differences in Memory Development Among C57Bl/6Ncr1, 12952/Svpascrl, and Fvb/Ncrl Mice After Delay and Trace Fear Conditioning
Comparative Medicine. 64(1):4-12
2014
Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.
Journal of Huntington's disease. 3(1):73-86 [DOI] 10.3233/JHD-130087. [PMID] 25062766.
2014
The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice.
Behavioural brain research. 259:253-60 [DOI] 10.1016/j.bbr.2013.11.010. [PMID] 24239696.
2013
Normal cognition in transgenic BRI2-Aβ mice.
Molecular neurodegeneration. 8 [DOI] 10.1186/1750-1326-8-15. [PMID] 23663320.
2012
Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.
Alzheimer's research & therapy. 4(3) [DOI] 10.1186/alzrt124. [PMID] 22697412.
2012
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(21):7137-45 [DOI] 10.1523/JNEUROSCI.0188-12.2012. [PMID] 22623658.
2012
Lrrk2 Knockout Mice Have An Intact Dopaminergic System But Display Alterations in Exploratory and Motor Co-Ordination Behaviors
Molecular neurodegeneration. 7 [DOI] 10.1186/1750-1326-7-25. [PMID] 22647713.
2011
Increased Aggression in Males in Transgenic Tg2576 Mouse Model of Alzheimer’s Disease
Behavioural brain research. 216(1):77-83 [DOI] 10.1016/j.bbr.2010.07.016. [PMID] 20655336.
2011
Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.
Nature neuroscience. 14(6):694-6 [DOI] 10.1038/nn.2829. [PMID] 21572432.
2010
Ifn-Gamma Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid Beta Precursor Protein Transgenic Mice
Journal of Immunology. 184(9):5333-5343 [DOI] 10.4049/jimmunol.0903382. [PMID] 20368278.
2007
Plaques, tangles, and memory loss in mouse models of neurodegeneration.
Behavior genetics. 37(1):79-100 [PMID] 17072762.
View on: PubMed

Grants

Sep 2020 ACTIVE
A Systems Approach to Targeting Innate Immunity in AD
Role:
Funding: MAYO CLINIC via NATL INST OF HLTH NIA
Aug 2019 ACTIVE
Immunotherapy targeting the HPA axis in Alzheimers disease
Role:
Funding: NATL INST OF HLTH NIA
Sep 2018 – Aug 2020
A Systems Approach to Targeting Innate Immunity in AD
Role:
Funding: NATL INST OF HLTH NIA
Aug 2017 ACTIVE
Pathological spread and outcomes of alpha-synuclein mutants
Role:
Funding: NATL INST OF HLTH NINDS
Feb 2017 – Mar 2018
Corticotropin-releasing hormone (CRH) Immunotherapy for Alzheimers disease
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Dec 2016 – Nov 2019
Is there a form of benign brain amyloidosis in aging?
Role:
Funding: NATL INST OF HLTH NIA

Teaching Profile

Courses Taught
2019
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
2013
CLP7980 Research for Doctoral Dissertation

Contact Details

Phones:
Business:
(352) 273-9662
Emails:
Business:
cjanus@ufl.edu