Habibeh Khoshbouei

Habibeh Khoshbouei

Professor

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-8115
Business Email: habibeh@ufl.edu

Publications

2020
A novel approach to study markers of dopamine signaling in peripheral immune cells.
Journal of immunological methods. 476 [DOI] 10.1016/j.jim.2019.112686. [PMID] 31634479.
2020
Microglia senescence occurs in both substantia nigra and ventral tegmental area.
Glia. 68(11):2228-2245 [DOI] 10.1002/glia.23834. [PMID] 32275335.
2020
Microglia and Other Myeloid Cells in Central Nervous System Health and Disease.
The Journal of pharmacology and experimental therapeutics. 375(1):154-160 [DOI] 10.1124/jpet.120.265058. [PMID] 32238454.
2020
Mechanism of Manganese Dysregulation of Dopamine Neuronal Activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(30):5871-5891 [DOI] 10.1523/JNEUROSCI.2830-19.2020. [PMID] 32576620.
2020
Allosterically Potentiated α7 Nicotinic Acetylcholine Receptors: Reduced Calcium Permeability and Current-Independent Control of Intracellular Calcium.
Molecular pharmacology. 98(6):695-709 [DOI] 10.1124/molpharm.120.000012. [PMID] 33020143.
2020
Dystrophic microglia in late-onset Alzheimer’s disease.
Glia. 68(4):845-854 [DOI] 10.1002/glia.23782. [PMID] 31922322.
2020
Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson’s disease.
Experimental neurology. 325 [DOI] 10.1016/j.expneurol.2019.113159. [PMID] 31843492.
2020
Heterogeneity of dopamine release sites in health and degeneration.
Neurobiology of disease. 134 [DOI] 10.1016/j.nbd.2019.104633. [PMID] 31698055.
2019
Clustered Kv2.1 decreases dopamine transporter activity and internalization.
The Journal of biological chemistry. 294(17):6957-6971 [DOI] 10.1074/jbc.RA119.007441. [PMID] 30824538.
2019
Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway.
Brain, behavior, and immunity. 82:239-252 [DOI] 10.1016/j.bbi.2019.08.191. [PMID] 31470080.
2019
Elevated bone marrow sympathetic drive precedes systemic inflammation in angiotensin II hypertension.
American journal of physiology. Heart and circulatory physiology. 317(2):H279-H289 [DOI] 10.1152/ajpheart.00510.2018. [PMID] 31150271.
2019
Methamphetamine regulation of activity and topology of ventral midbrain networks.
PloS one. 14(9) [DOI] 10.1371/journal.pone.0222957. [PMID] 31536584.
2018
The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction.
Pharmacology & therapeutics. 186:152-167 [DOI] 10.1016/j.pharmthera.2018.01.009. [PMID] 29360540.
2018
The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson’s Disease.
Brain, behavior, and immunity. 70:21-35 [DOI] 10.1016/j.bbi.2018.03.020. [PMID] 29551693.
2018
Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine.
Neurotoxicology. 67:121-128 [DOI] 10.1016/j.neuro.2018.05.003. [PMID] 29782882.
2018
Microglial activation occurs late during preclinical Alzheimer’s disease.
Glia. 66(12):2550-2562 [DOI] 10.1002/glia.23510. [PMID] 30417428.
2018
Methamphetamine neurotoxicity, microglia, and neuroinflammation.
Journal of neuroinflammation. 15(1) [DOI] 10.1186/s12974-018-1385-0. [PMID] 30541633.
2018
HIV-1 Tat regulation of dopamine transmission and microglial reactivity is brain region specific.
Glia. 66(9):1915-1928 [DOI] 10.1002/glia.23447. [PMID] 29733459.
2018
Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone.
Neuropharmacology. 137:178-193 [DOI] 10.1016/j.neuropharm.2018.04.031. [PMID] 29729891.
2018
Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(2):484-497 [DOI] 10.1523/JNEUROSCI.2604-17.2017. [PMID] 29175958.
2018
Hippocampal glial cells modulate morphine-induced behavioral responses.
Physiology & behavior. 191:37-46 [DOI] 10.1016/j.physbeh.2018.04.003. [PMID] 29626506.
2018
Glial cells modulate hippocampal synaptic plasticity in morphine dependent rats.
Brain research bulletin. 140:97-106 [DOI] 10.1016/j.brainresbull.2018.04.006. [PMID] 29678774.
2017
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.
Nature communications. 8(1) [DOI] 10.1038/s41467-017-02087-x. [PMID] 29263318.
2017
A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.
PloS one. 12(5) [DOI] 10.1371/journal.pone.0173565. [PMID] 28467418.
2017
Alpha-synuclein modulates dopamine neurotransmission.
Journal of chemical neuroanatomy. 83-84:41-49 [DOI] 10.1016/j.jchemneu.2016.06.001. [PMID] 27334403.
2017
HIV, Tat and dopamine transmission.
Neurobiology of disease. 105:51-73 [DOI] 10.1016/j.nbd.2017.04.015. [PMID] 28457951.
2017
Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.
Journal of neurochemistry. 140(4):662-678 [DOI] 10.1111/jnc.13743. [PMID] 27424880.
2016
Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane.
Nature communications. 7 [DOI] 10.1038/ncomms10423. [PMID] 26804245.
2016
Methamphetamine-induced enhancement of hippocampal long-term potentiation is modulated by NMDA and GABA receptors in the shell-accumbens.
Synapse (New York, N.Y.). 70(8):325-35 [DOI] 10.1002/syn.21905. [PMID] 27029021.
2016
The effects of GABAA and NMDA receptors in the shell-accumbens on spatial memory of METH-treated rats.
Pharmacology, biochemistry, and behavior. 142:23-35 [DOI] 10.1016/j.pbb.2015.12.008. [PMID] 26708956.
2016
Methamphetamine Regulation of Firing Activity of Dopamine Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(40):10376-10391 [PMID] 27707972.
View on: PubMed
2015
Dopamine Transporter Activity Is Modulated by α-Synuclein.
The Journal of biological chemistry. 290(49):29542-54 [DOI] 10.1074/jbc.M115.691592. [PMID] 26442590.
2015
Dopamine Transporter Activity Is Modulated by α-synuclein.
The Journal of biological chemistry. [DOI] 10.1074/jbc.M115.639880. [PMID] 26048988.
2014
Chronic Methamphetamine Increases Alpha-Synuclein Protein Levels in the Striatum and Hippocampus but not in the Cortex of Juvenile Mice.
Journal of addiction & prevention. 2(2) [PMID] 25621291.
View on: PubMed
2014
Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing.
The Journal of biological chemistry. 289(32):22246-57 [DOI] 10.1074/jbc.M114.563056. [PMID] 24962577.
2013
Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.
Synapse (New York, N.Y.). 67(5):245-57 [DOI] 10.1002/syn.21635. [PMID] 23280858.
2013
The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.
Neurotoxicology. 35:121-8 [DOI] 10.1016/j.neuro.2013.01.002. [PMID] 23313730.
2012
PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene.
Toxicological sciences : an official journal of the Society of Toxicology. 125(1):233-47 [DOI] 10.1093/toxsci/kfr261. [PMID] 21987461.
2012
Single cell measurement of dopamine release with simultaneous voltage-clamp and amperometry.
Journal of visualized experiments : JoVE. (69) [DOI] 10.3791/3798. [PMID] 23207721.
2011
α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.
The Journal of biological chemistry. 286(51):43933-43 [DOI] 10.1074/jbc.M111.241232. [PMID] 21990355.
2010
Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus.
PloS one. 5(6) [DOI] 10.1371/journal.pone.0011382. [PMID] 20614033.
2009
Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.
The Journal of biological chemistry. 284(5):2978-89 [DOI] 10.1074/jbc.M805298200. [PMID] 19047053.
2008
Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function.
Neurotoxicology. 29(5):846-54 [DOI] 10.1016/j.neuro.2008.07.008. [PMID] 18761371.
2008
PI3K signaling supports amphetamine-induced dopamine efflux.
Biochemical and biophysical research communications. 372(4):656-61 [DOI] 10.1016/j.bbrc.2008.05.091. [PMID] 18510945.
2006
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.
Neuron. 51(4):417-29 [PMID] 16908408.
View on: PubMed
2005
Amphetamine induces dopamine efflux through a dopamine transporter channel.
Proceedings of the National Academy of Sciences of the United States of America. 102(9):3495-500 [PMID] 15728379.
View on: PubMed
2004
Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter.
Molecular pharmacology. 66(1):137-43 [PMID] 15213305.
View on: PubMed
2004
N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux.
PLoS biology. 2(3) [PMID] 15024426.
View on: PubMed
2003
Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism.
The Journal of biological chemistry. 278(14):12070-7 [PMID] 12556446.
View on: PubMed
2003
Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress.
Life sciences. 73(6):715-26 [PMID] 12801593.
View on: PubMed
2002
Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala.
Pharmacology, biochemistry, and behavior. 71(3):407-17 [PMID] 11830175.
View on: PubMed
2002
Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 27(1):25-34 [PMID] 12062904.
View on: PubMed
2002
Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress.
Neuroscience. 112(1):13-21 [PMID] 12044468.
View on: PubMed
2002
Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress.
Neuropharmacology. 43(7):1139-47 [PMID] 12504920.
View on: PubMed
1998
Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.
Journal of neurochemistry. 71(6):2239-51 [PMID] 9832121.
View on: PubMed

Grants

Jun 2020 ACTIVE
iPSCs-derived cortical neurons with Xq27-q28 deletion display altered morphology, transcriptomics, maturation and increased neuronal activity
Role: Principal Investigator
Funding: XTRAORDINARY JOY FOUNDATION
Sep 2018 ACTIVE
Alpha-synuclein Regulates Dopamine Transporter Functions
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Feb 2018 – Feb 2020
Role of Microglia in Primary Age Related Tauopathy and in Sporadic (late-onset) Alzheimer's Disease
Role:
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Dec 2017 – Nov 2019
Functional interplay between D2 autoreceptor and dopamine transporter
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2017 – Jun 2018
Functional interaction between microglia and dopamine neurons
Role: Principal Investigator
Funding: INT BRAIN RES ORG
Mar 2017 – Feb 2019
Interactions between microglia and dopaminergic neurons regulates dopamine neurotransmission
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Aug 2016 – Aug 2019
OR-DRPD-ROF2016: A Neurodevelopmental Theory of Social and Environmental Isolation in Autism
Role:
Funding: UF RESEARCH
Jul 2016 ACTIVE
The Human Thalamocortical Network in tourette syndrome
Role:
Funding: NATL INST OF HLTH NINDS
Jul 2015 ACTIVE
Methamphetamine regulates the dopamine transporter via an intracellular mechanism
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Apr 2015 – Apr 2016
Shared Nikon A1R multiphoton laser scanning confocal sys
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Nov 2011 – Apr 2016
Alpha-synuclein regulates dopamine transporter functions
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Oct 2011 – Jun 2017
Start up funds
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO

Teaching Profile

Courses Taught
2012-2016,2018-2020
GMS6029 Brain Journal Club
2014-2020
GMS6023 Principles of Neuroscience III: Molecular Neuropharmacology and its Clinical Application
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2017-2018
EGN4912 Engineering Directed Independent Research
2014-2018
GMS7794 Neuroscience Seminar
2013
GMS7795 Special Topics in Neuroscience

Contact Details

Phones:
Business:
(352) 273-8115
Emails:
Business:
habibeh@ufl.edu