John Koren

John Koren,

RES AST PROF

Department: Department of Neuroscience
Business Phone: (646) 260-2131
Business Email: jkoren@ufl.edu

Teaching Profile

Courses Taught
2022-2023
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-6017-1763

Publications

2021
Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy.
International journal of molecular sciences. 22(3) [DOI] 10.3390/ijms22031186. [PMID] 33530349.
2021
Effects of altered tau expression on dentate granule cell excitability in mice.
Experimental neurology. 343 [DOI] 10.1016/j.expneurol.2021.113766. [PMID] 34029610.
2021
The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition.
Journal of medicinal chemistry. 64(3):1545-1557 [DOI] 10.1021/acs.jmedchem.0c01700. [PMID] 33428418.
2020
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
Nature Communications. 11(1) [DOI] 10.1038/s41467-019-14082-5. [PMID] 31949159.
2020
The Right Tool for the Job: An Overview of Hsp90 Inhibitors.
Advances in experimental medicine and biology. 1243:135-146 [DOI] 10.1007/978-3-030-40204-4_9. [PMID] 32297216.
2019
Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins.
International journal of biological macromolecules. 127:136-145 [DOI] 10.1016/j.ijbiomac.2019.01.035. [PMID] 30639592.
2018
Hsp90 and FKBP51: complex regulators of psychiatric diseases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1738) [DOI] 10.1098/rstb.2016.0532. [PMID] 29203717.
2018
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-06486-6. [PMID] 30341316.
2018
Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.
ACS chemical biology. 13(8):2288-2299 [DOI] 10.1021/acschembio.8b00454. [PMID] 29893552.
2017
Hsp90 activator Aha1 drives production of pathological tau aggregates.
Proceedings of the National Academy of Sciences of the United States of America. 114(36):9707-9712 [DOI] 10.1073/pnas.1707039114. [PMID] 28827321.
2017
Human cyclophilin 40 unravels neurotoxic amyloids.
PLoS biology. 15(6) [DOI] 10.1371/journal.pbio.2001336. [PMID] 28654636.
2017
Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.
Frontiers in neuroscience. 11 [DOI] 10.3389/fnins.2017.00724. [PMID] 29311797.
2017
Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma
Scientific Reports. 7(1) [DOI] 10.1038/s41598-017-18344-4. [PMID] 29263415.
2016
RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures.
Nano letters. 16(10):6099-6108 [DOI] 10.1021/acs.nanolett.6b02274. [PMID] 27669096.
2016
Stressing Out Hsp90 in Neurotoxic Proteinopathies.
Current topics in medicinal chemistry. 16(25):2829-38 [PMID] 27072699.
2015
A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species.
Cell reports. 13(10):2159-73 [DOI] 10.1016/j.celrep.2015.10.073. [PMID] 26628369.
2014
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.
ACS chemical biology. 9(8):1698-705 [DOI] 10.1021/cb500256u. [PMID] 24934503.
2014
Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions.
Expert opinion on investigational drugs. 23(5):611-28 [DOI] 10.1517/13543784.2014.902442. [PMID] 24669860.
2014
HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.
Cancer research. 74(23):7125-36 [DOI] 10.1158/0008-5472.CAN-14-1017. [PMID] 25297628.
2014
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.
Current Alzheimer research. 11(1):59-68 [PMID] 24251390.
2013
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Journal of Alzheimer's disease & Parkinsonism. 2013(Suppl 10) [PMID] 25258700.
2013
Reconstructing the Hsp90/Tau Machine.
Current enzyme inhibition. 9(1):41-45 [PMID] 23798910.
2013
The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance.
CNS & neurological disorders drug targets. 12(8):1157-62 [PMID] 24040820.
2012
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
The Journal of biological chemistry. 287(48):40661-9 [DOI] 10.1074/jbc.M112.384800. [PMID] 23035116.
2012
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance.
PloS one. 7(4) [DOI] 10.1371/journal.pone.0035566. [PMID] 22563386.
2011
Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies.
Molecular neurobiology. 44(1):65-70 [DOI] 10.1007/s12035-011-8182-4. [PMID] 21523562.
2011
Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.
Current neuropharmacology. 9(4):623-31 [DOI] 10.2174/157015911798376226. [PMID] 22654720.
2011
Neuronal life span versus health span: principles of natural selection at work in the degenerating brain.
Journal of molecular neuroscience : MN. 45(3):467-72 [DOI] 10.1007/s12031-011-9540-4. [PMID] 21559875.
2011
The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau.
Journal of natural products. 74(1):38-44 [DOI] 10.1021/np100572z. [PMID] 21141876.
2011
The earliest tau dysfunction in Alzheimer’s disease? Tau phosphorylated at s422 as a toxic seed.
The American journal of pathology. 179(5):2148-51 [DOI] 10.1016/j.ajpath.2011.08.020. [PMID] 21964186.
2011
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.
The Journal of biological chemistry. 286(19):16976-83 [DOI] 10.1074/jbc.M110.182493. [PMID] 21367866.
2010
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
The Journal of biological chemistry. 285(4):2498-505 [DOI] 10.1074/jbc.M109.057208. [PMID] 19889640.
2010
Hsc70 rapidly engages tau after microtubule destabilization.
The Journal of biological chemistry. 285(22):16798-805 [DOI] 10.1074/jbc.M110.113753. [PMID] 20308058.
2010
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.
Molecular neurodegeneration. 5 [DOI] 10.1186/1750-1326-5-45. [PMID] 21040568.
2010
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(46):15374-82 [DOI] 10.1523/JNEUROSCI.3155-10.2010. [PMID] 21084594.
2010
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(2):591-9 [DOI] 10.1523/JNEUROSCI.4815-09.2010. [PMID] 20071522.
2009
Chaperone signalling complexes in Alzheimer’s disease.
Journal of cellular and molecular medicine. 13(4):619-30 [PMID] 19449461.
2009
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(39):12079-88 [DOI] 10.1523/JNEUROSCI.3345-09.2009. [PMID] 19793966.

Contact Details

Phones:
Business:
(646) 260-2131
Emails:
Business:
jkoren@ufl.edu
Addresses:
Business Mailing:
PO Box 100244
GAINESVILLE FL 32610