Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
The Journal of biological chemistry. 286(46):39804-12 [DOI] 10.1074/jbc.M111.274696. [PMID] 21868378.
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
Journal of neurochemistry. 96(2):355-65 [PMID] 16300630.
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(10):1671-9 [PMID] 16873890.
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.
Molecular neurodegeneration. 1 [PMID] 17105660.
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.
Molecular neurodegeneration. 1 [PMID] 16930450.
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.
Nature medicine. 11(5):545-50 [PMID] 15834426.
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.
The Journal of biological chemistry. 279(41):43148-56 [PMID] 15252014.
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.
The Journal of biological chemistry. 279(15):15153-60 [PMID] 14704149.
Published April 2010
Reducing Abeta42 Levels and Abeta Aggregation (MAYO CLINIC)#2011/0021471 A1