Thomas B Ladd

Thomas B Ladd

Scientific Research Manager

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-9690
Business Email: tomladd@ufl.edu

Publications

2020
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Alzheimer's research & therapy. 12(1) [DOI] 10.1186/s13195-020-00622-5. [PMID] 32430033.
2019
APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model.
Cell reports. 27(5):1345-1355.e6 [DOI] 10.1016/j.celrep.2019.03.087. [PMID] 31042463.
2019
Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-48884-w. [PMID] 31467300.
2019
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
The Journal of biological chemistry. 294(29):11276-11285 [DOI] 10.1074/jbc.RA119.008041. [PMID] 31167792.
2019
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
The Journal of experimental medicine. 216(11):2479-2491 [DOI] 10.1084/jem.20190430. [PMID] 31467037.
2018
Designing antibodies against LRRK2-targeted tau epitopes.
PloS one. 13(9) [DOI] 10.1371/journal.pone.0204367. [PMID] 30261006.
2018
High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
EMBO molecular medicine. 10(11) [DOI] 10.15252/emmm.201809027. [PMID] 30341064.
2018
Short Aβ peptides attenuate Aβ42 toxicity in vivo.
The Journal of experimental medicine. 215(1):283-301 [DOI] 10.1084/jem.20170600. [PMID] 29208777.
2018
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease.
The Journal of experimental medicine. 215(9):2247-2264 [DOI] 10.1084/jem.20180484. [PMID] 30158114.
2015
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.
Molecular neurodegeneration. 10 [DOI] 10.1186/s13024-015-0021-z. [PMID] 26169917.
2015
Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.
Molecular neurodegeneration. 10 [DOI] 10.1186/s13024-015-0029-4. [PMID] 26223783.
2014
Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.
Biochemistry. 53(12):1947-57 [DOI] 10.1021/bi401521t. [PMID] 24620716.
2014
Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.
PloS one. 9(10) [DOI] 10.1371/journal.pone.0111553. [PMID] 25350374.
2014
γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.
The Journal of biological chemistry. 289(6):3276-87 [DOI] 10.1074/jbc.M113.512921. [PMID] 24352661.
2013
Steroids as γ-secretase modulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(9):3775-85 [DOI] 10.1096/fj.12-225649. [PMID] 23716494.
2012
Overlapping profiles of Aβ peptides in the Alzheimer’s disease and pathological aging brains.
Alzheimer's research & therapy. 4(3) [DOI] 10.1186/alzrt121. [PMID] 22621179.
2012
Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).
The Journal of biological chemistry. 287(48):40629-40 [DOI] 10.1074/jbc.M112.418442. [PMID] 23043097.
2012
Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases.
Journal of medicinal chemistry. 55(23):10749-65 [DOI] 10.1021/jm301630s. [PMID] 23181502.
2011
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
The Journal of biological chemistry. 286(46):39804-12 [DOI] 10.1074/jbc.M111.274696. [PMID] 21868378.
2008
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
The Journal of biological chemistry. 283(25):17049-54 [DOI] 10.1074/jbc.M802912200. [PMID] 18426795.
2008
Substrate-targeting gamma-secretase modulators.
Nature. 453(7197):925-9 [DOI] 10.1038/nature07055. [PMID] 18548070.
2006
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
Journal of neurochemistry. 96(2):355-65 [PMID] 16300630.
View on: PubMed
2006
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(10):1671-9 [PMID] 16873890.
View on: PubMed
2006
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.
Molecular neurodegeneration. 1 [PMID] 17105660.
View on: PubMed
2006
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.
Molecular neurodegeneration. 1 [PMID] 16930450.
View on: PubMed
2005
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.
Nature medicine. 11(5):545-50 [PMID] 15834426.
View on: PubMed
2004
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.
The Journal of biological chemistry. 279(41):43148-56 [PMID] 15252014.
View on: PubMed
2004
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.
The Journal of biological chemistry. 279(15):15153-60 [PMID] 14704149.
View on: PubMed

Patents

Published April 2010
Reducing Abeta42 Levels and Abeta Aggregation (MAYO CLINIC)
#2011/0021471 A1

Contact Details

Phones:
Business:
(352) 273-9690
Emails:
Business:
tomladd@ufl.edu