Kesavalu N Lakshmyya

Kesavalu N Lakshmyya, B.V.Sc., M.Sc., S.C.C.

Professor

Department: DN-PERIODONTICS
Business Phone: (352) 273-6500
Business Email: kesavalu@ufl.edu

About Kesavalu N Lakshmyya

University of Florida Term Professor, Adjunct Professor of Oral Biology, College of Dentistry, Member, Center for Translational Research in Neurodegenerative Diseases, College of Medicine. Phone: 352-273-6500 Laboratory: 352-273-6515 Fax: 352-273-6192

Email: kesavalu@dental.ufl.edu Room D10-23 PO Box 100434

Accomplishments

Professor
2019-Current · Department of Periodontology, College of Dentistry, University of Florida
University of Florida Term Professor
2017-2020 · University of Florida
Associate Professor
2006-2019 · Department of Periodontology, College of Dentistry, University of Florida
Associate Research Professor
2000-2006 · Department of Oral Health Science, University of Kentucky
Assistant Research Professor
1999-2000 · Department of Periodontics, College of Dentistry, University of Texas Health Science Center

Research Profile

MAIN RESEARCH FOCUS: Role of microRNA in periodontal disease. Association between periodontal disease and cardiovascular disease (Clinical study). Association between periodontal pathogens and atherosclerosis (Basic study). Association between periodontal pathogens and Rheumatoid arthritis (Basic study). Association between periodontal pathogens and Alzheimer’s disease (Basic study). Pathogenesis of Osteonecrosis of Jaw (ONJ).

CURRENT RESEARCH: Role of microRNA in periodontal disease. Association between Periodontal disease and Alzheimer’s disease. Periodontal pathogens invasion, proliferation, and dissemination to systemic tissues/cells. Periodontal pathogens (polybacterial) infection and atherosclerosis. Association between Periodontal disease and rheumatoid arthritis. Association between Periodontal disease and stroke. Periodontal disease and Osteonecrosis of Jaw.

Publications

2018
Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection.
Pathogens and Disease. 76(8) [DOI] 10.1093/femspd/fty076. [PMID] 30351354.
2018
Role of oral and gut microbiome in nitric oxide-mediated colon motility.
Nitric oxide : biology and chemistry. 73:81-88 [DOI] 10.1016/j.niox.2017.06.003. [PMID] 28602746.
2013
Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer’s Disease Brain Tissue
Journal of Alzheimer's disease : JAD. 36(4):665-677 [DOI] 10.3233/JAD-121918. [PMID] 23666172.
2013
Polymicrobial Infection With Major Periodontal Pathogens Induced Periodontal Disease and Aortic Atherosclerosis in Hyperlipidemic Apoe(Null) Mice
PLoS One. 8(2) [DOI] 10.1371/journal.pone.0057178. [PMID] 23451182.
2013
Regulation of Tlr2-Mediated Tolerance and Cross-Tolerance Through Irak4 Modulation By Mir-132 and Mir-212
Journal of Immunology. 190(3):1250-1263 [DOI] 10.4049/jimmunol.1103060. [PMID] 23264652.
2012
Enhanced Alveolar Bone Loss in a Model of Non-Invasive Periodontitis in Rice Rats
Oral Diseases. 18(5):459-468 [DOI] 10.1111/j.1601-0825.2011.01893.x. [PMID] 22233442.
2012
Increased atherogenesis during Streptococcus mutans infection in ApoE-null mice.
Journal of dental research. 91(3):255-60 [DOI] 10.1177/0022034511435101. [PMID] 22262633.
2012
Oncologic Doses of Zoledronic Acid Induce Osteonecrosis of the Jaw-Like Lesions in Rice Rats (Oryzomys Palustris) With Periodontitis
Journal of Bone and Mineral Research. 27(10):2130-2143 [DOI] 10.1002/jbmr.1669. [PMID] 22623376.
2011
Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease.
Infection and immunity. 79(4):1597-605 [DOI] 10.1128/IAI.01062-10. [PMID] 21263019.
2011
Polymicrobial Periodontal Pathogen Transcriptomes in Calvarial Bone and Soft Tissue
Molecular oral microbiology. 26(5):303-320 [DOI] 10.1111/j.2041-1014.2011.00619.x. [PMID] 21896157.
2011
Refinement of the Rice Rat (Oryzomys Palustris) Model of Periodontitis and Zoledronic Acid-Induced Osteonecrosis of the Jaw
Journal of the American Association for Laboratory Animal Science. 50:726-727
2010
Gingival RAGE expression in calorie-restricted versus ad libitum-fed rats.
Journal of periodontology. 81(10):1481-7 [DOI] 10.1902/jop.2010.100019. [PMID] 20572766.
2010
Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats.
Infection and immunity. 78(11):4560-9 [DOI] 10.1128/IAI.00703-10. [PMID] 20805334.
2010
Systemic Inflammatory Responses in Progressing Periodontitis During Pregnancy in a Baboon Model
Clinical and Experimental Immunology. 162(3):550-559 [DOI] 10.1111/j.1365-2249.2010.04202.x. [PMID] 21070210.
2010
Tannerella Forsythia Infection-Induced Calvarial Bone and Soft Tissue Transcriptional Profiles
Molecular oral microbiology. 25:317-330
2010
The Rice Rat (Oryzomys Palustris) Model for Periodontal Disease: Characterization of the Lesions and Technical Features of the Model
Journal of the American Association for Laboratory Animal Science. 49
2010
Virulence of Major Periodontal Pathogens and Lack of Humoral Immune Protection in a Rat Model of Periodontal Disease
Oral Diseases. 16(7):686-695 [DOI] 10.1111/j.1601-0825.2010.01678.x. [PMID] 20846155.
2010
Porphyromonas Gingivalis Infection-Induced Tissue and Bone Transcriptional Profiles
Molecular oral microbiology. 25(1):61-74 [DOI] 10.1111/j.2041-1014.2009.00555.x. [PMID] 20331794.
2008
Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration
. 87:687-691
2007
Omega-3 fatty acid regulates inflammatory cytokine/mediator messenger RNA expression in Porphyromonas gingivalis-induced experimental periodontal disease.
Oral microbiology and immunology. 22(4):232-9 [PMID] 17600534.
View on: PubMed
2007
Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease.
Infection and immunity. 75(4):1704-12 [PMID] 17210663.
View on: PubMed
2000
Resorption of a calcium hydroxide/iodoform paste (Vitapex) in root canal therapy for primary teeth: a case report.
Pediatric dentistry. 22(6):517-20 [PMID] 11132515.
View on: PubMed

Grants

Dec 2019 ACTIVE
Dominant microRNAs as biomarkers in innate immunity and periodontitis
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Feb 2018 – Aug 2020
Periodontal Bacteria augment Progression of Abeta and Tau Pathology
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Aug 2017 – Jul 2020
Periodontal bacteria and Alzheimers disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2014 ACTIVE
Role of Periodontitis in Osteonecrosis of the Jaw Pathophysiology in Rice Rats
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Mar 2011 – May 2017
Periodontal Pathogens and Cardiovascular Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR

Education

M.Sc., Medical Microbiology
1979 · All India Institute of Medical Sciences, New Delhi, India.
S.C.C., Advanced Statistics
1975 · Institute of Agricultural Research Statistics, New Delhi, India.
B.V.Sc., Veterinary Medicine and Surgery
1971 · Madras University, Chennai, India.

Teaching Profile

Courses Taught
2011-2020
GMS6198 Bacterial Pathogenesis Journal Club
2011-2014
DEN6971 Research for Master’s Thesis
2014
GMS6029 Brain Journal Club
2012-2013
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2012-2013
IDH4905 Individual Work
2013
DEN6681 Craniofacial Pathobiology
2011-2012
DEN6656 Introduction to Advanced Periodontology
2011-2012
PHA5902 Research Pharmacodyna
2011-2012
GMS6161 Introduction to Oral Biology II
2011
GMS6160 Introduction to Oral Biology I
2010
DEN8290 Special Topics

Contact Details

Phones:
Business:
(352) 273-6500
Emails:
Business:
kesavalu@ufl.edu