Christian Lessard

Christian Lessard

RES AST PROF

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-9690
Business Email: chles60@ufl.edu

Publications

2020
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Alzheimer's research & therapy. 12(1) [DOI] 10.1186/s13195-020-00622-5. [PMID] 32430033.
2019
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
The Journal of biological chemistry. 294(29):11276-11285 [DOI] 10.1074/jbc.RA119.008041. [PMID] 31167792.
2019
Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Alzheimer's research & therapy. 11(1) [DOI] 10.1186/s13195-019-0469-0. [PMID] 30711010.
2018
High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
EMBO molecular medicine. 10(11) [DOI] 10.15252/emmm.201809027. [PMID] 30341064.
2017
γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.
EMBO molecular medicine. 9(7):950-966 [DOI] 10.15252/emmm.201607265. [PMID] 28539479.
2015
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
PloS one. 10(12) [DOI] 10.1371/journal.pone.0144758. [PMID] 26678856.
2011
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
The Journal of biological chemistry. 286(46):39794-803 [DOI] 10.1074/jbc.M111.277228. [PMID] 21868380.
2010
And four equals one: presenilin takes the gamma-secretase role by itself.
Proceedings of the National Academy of Sciences of the United States of America. 107(50):21236-7 [DOI] 10.1073/pnas.1016284108. [PMID] 21135249.
2005
The overexpression of presenilin2 and Alzheimer’s-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.
Cellular signalling. 17(4):437-45 [PMID] 15601622.
View on: PubMed

Contact Details

Phones:
Business:
(352) 273-9690
Emails:
Business:
chles60@ufl.edu