Jada Lewis

Jada Lewis

Professor, Co-Deputy Director McKnight Brain Institute

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-9666
Business Email: jada.lewis@ufl.edu

Publications

2020
Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes
Molecular Therapy. [DOI] 10.1016/j.ymthe.2020.10.007. [PMID] 33128896.
2020
Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy
Molecular Neurobiology. 57(4):1986-2001 [DOI] 10.1007/s12035-019-01859-4.
2018
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
Acta Neuropathologica. 136(6):919-938 [DOI] 10.1007/s00401-018-1895-y. [PMID] 30140941.
2018
Characterization of Gene Regulation and Protein Interaction Networks for Matrin 3 Encoding Mutations Linked to Amyotrophic Lateral Sclerosis and Myopathy
Scientific Reports. 8(1) [DOI] 10.1038/s41598-018-21371-4. [PMID] 29511296.
2018
Designing antibodies against LRRK2-targeted tau epitopes.
PloS one. 13(9) [DOI] 10.1371/journal.pone.0204367. [PMID] 30261006.
2018
Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology.
Molecular neurodegeneration. 13(1) [DOI] 10.1186/s13024-018-0253-9. [PMID] 29776378.
2018
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.
PLoS biology. 16(12) [DOI] 10.1371/journal.pbio.2006265. [PMID] 30571694.
2018
Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis.
Molecular and cellular neurosciences. 92:17-26 [DOI] 10.1016/j.mcn.2018.05.009. [PMID] 29859891.
2018
Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3
Acta Neuropathologica Communications. 6(1) [DOI] 10.1186/s40478-018-0631-0. [PMID] 30563574.
2016
Generation of a New Transgenic Mouse Model for Assessment of Tau Gene Silencing Therapies
Alzheimers Research & Therapy. 8 [DOI] 10.1186/s13195-016-0202-1. [PMID] 27593210.
2015
IFN-γ promotes τ phosphorylation without affecting mature tangles
The FASEB's Journal. 29(10):4384-98 [DOI] 10.1096/fj.15-275834. [PMID] 26156074.
2015
Studies of Alternative Isoforms Provide Insight Into Tdp-43 Autoregulation and Pathogenesis
RNa. 21(8):1419-1432 [DOI] 10.1261/rna.047647.114. [PMID] 26089325.
2015
Subcellular Localization of Matrin 3 Containing Mutations Associated With Als and Distal Myopathy
PLoS One. 10(11) [DOI] 10.1371/journal.pone.0142144. [PMID] 26528920.
2014
Understanding the Role of Progranulin in Alzheimer’s Disease
. 20(10):1099-1100
2014
Therapeutic and Diagnostic Challenges for Frontotemporal Dementia
Frontiers in Aging Neuroscience. 6 [DOI] 10.3389/fnagi.2014.00204. [PMID] 25191265.
2014
Tau Promotes Neurodegeneration Through Global Chromatin Relaxation
Nature Neuroscience. 17(3):357-U48 [DOI] 10.1038/nn.3639. [PMID] 24464041.
2014
Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study.
Neurobiology of aging. 35(6):1364-74 [DOI] 10.1016/j.neurobiolaging.2013.12.009. [PMID] 24411290.
2014
Effects of the C57Bl/6 Strain Background On Tauopathy Progression in the Rtg4510 Mouse Model
Molecular neurodegeneration. 9 [DOI] 10.1186/1750-1326-9-8. [PMID] 24428919.
2014
Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling
PLoS One. 9(1) [DOI] 10.1371/journal.pone.0086513. [PMID] 24466128.
2014
Novel Marker for the Onset of Frontotemporal Dementia: Early Increase in Activity-Dependent Neuroprotective Protein (Adnp) in the Face of Tau Mutation
PLoS One. 9(1) [DOI] 10.1371/journal.pone.0087383. [PMID] 24489906.
2013
Ran Proteins and Rna Foci From Antisense Transcripts in C9Orf72 Als and Frontotemporal Dementia
Proceedings of the National Academy of Sciences. 110(51):E4968-E4977 [DOI] 10.1073/pnas.1315438110. [PMID] 24248382.
2013
Lrrtm3 Interacts With App and Bace1 and Has Variants Associating With Late-Onset Alzheimer’s Disease (Load)
PLoS One. 8(6) [DOI] 10.1371/journal.pone.0064164. [PMID] 23750206.
2013
In Vivo Functional Brain Mapping in a Conditional Mouse Model of Human Tauopathy (Tau(P301L)) Reveals Reduced Neural Activity in Memory Formation Structures
Molecular neurodegeneration. 8 [DOI] 10.1186/1750-1326-8-9. [PMID] 23379588.
2013
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited alpha-synuclein accumulation and age-dependent sensorimotor deficits
Human Molecular Genetics. 22(10):2067-2082 [DOI] 10.1093/hmg/ddt057. [PMID] 23393156.
2013
Characteristics of Tbs-Extractable Hyperphosphorylated Tau Species: Aggregation Intermediates in Rtg4510 Mouse Brain
Journal of Alzheimer's disease : JAD. 33(1):249-263 [DOI] 10.3233/JAD-2012-121093. [PMID] 22941973.
2013
Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared To Normal Controls
Neuron. 79(6):1094-1108 [DOI] 10.1016/j.neuron.2013.07.037. [PMID] 24050400.
2013
Anti-tau antibodies: hitting the target.
Neuron. 80(2):254-6 [DOI] 10.1016/j.neuron.2013.10.009. [PMID] 24139027.
2012
Achievements and Challenges in Creating Animal Models of Frontotemporal Dementias
Dementia and Geriatric Cognitive Disorders. 33:5-6
2012
Neuronal Sensitivity To Tdp-43 Overexpression Is Dependent On Timing of Induction
Acta Neuropathologica. 123(6):807-823 [DOI] 10.1007/s00401-012-0979-3. [PMID] 22539017.
2012
Progranulin Regulates Neuronal Outgrowth Independent of Sortilin
Molecular neurodegeneration. 7 [DOI] 10.1186/1750-1326-7-33. [PMID] 22781549.
2012
Strikingly different clinicopathologic phenotypes determined by progranulin mutation dosage
American journal of human genetics. 90(6):1102-1107 [DOI] 10.1016/j.ajhg.2012.04.021.. [PMID] 22608501.
2011
Expression of Mutant Tdp-43 Induces Neuronal Dysfunction in Transgenic Mice
Molecular neurodegeneration. 6 [DOI] 10.1186/1750-1326-6-73. [PMID] 22029574.
2011
Homeostatic Responses By Surviving Cortical Pyramidal Cells in Neurodegenerative Tauopathy
Acta Neuropathologica. 122(5):551-564 [DOI] 10.1007/s00401-011-0877-0. [PMID] 21968531.
2011
Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study
Brain Structure & Function. 216(1):31-42 [DOI] 10.1007/s00429-010-0295-4.. [PMID] 21152933.
2010
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice
The Journal of Neuroscience. 30(32):10851-10859 [DOI] 10.1523/JNEUROSCI.1630-10.2010. [PMID] 20702714.
2010
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggests a role for progranulin in successful aging
The American Journal Of Pathology. 177(1):311-324 [DOI] 10.2353/ajpath.2010.090915. [PMID] 20522652.
2010
Sorting Out Frontotemporal Dementia?
Neuron. 68(4):601-603 [DOI] 10.1016/j.neuron.2010.11.014. [PMID] 21092851.
2010
Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs
Experimental Neurology. 223(2):385-393 [DOI] 10.1016/j.expneurol.2009.07.029. [PMID] 19665462.
2010
Targeting Abeta and tau in Alzheimer’s disease, an early interim report
Experimental Neurology. 223(2):252-266 [DOI] 10.1016/j.expneurol.2009.07.035. [PMID] 19716367.
2009
Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy
The American Journal Of Pathology. 174(1):228-238 [DOI] 10.2353/ajpath.2009.080764. [PMID] 19074615.
2009
Aging is not associated with proteasome impairment in UPS reporter mice
PLoS One. 4(6) [DOI] 10.1371/journal.pone.0005888. [PMID] 19517018.
2008
A novel calcium-binding protein is associated with tau proteins in tauopathy
Journal of Neurochemistry. 106(1):96-106 [DOI] 10.1111/j.1471-4159.2008.05339.x. [PMID] 18346207.
2008
Apparent behavioral benefits of Tau overexpression in P301L Tau transgenic miceIn vivo silencing of alpha-synuclein using naked siRNA
. 15(4):605-614
2008
Biologic models of neurodegenerative disorders
Handbook of Clinical Neurology. 89:173-188
2008
In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons
The Journal of Neuroscience. 28(4):862-867 [DOI] 10.1523/JNEUROSCI.3072-08.2008. [PMID] 18216194.
2008
In vivo silencing of alpha-synuclein using naked siRNA
Molecular Neurodegeneration. 3 [DOI] 10.1186/1750-1326-3-19. [PMID] 18976489.
2007
Accumulation Of Pathological Tau Species And Memory Loss In A Conditional Model Of Tauopathy.
The Journal of Neuroscience. 27(14):3650-62 [DOI] 10.1523/JNEUROSCI.0587-07.2007. [PMID] 17409229.
2007
Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice
The American Journal Of Pathology. 171(6):2012-2020 [DOI] 10.2353/ajpath.2007.070403. [PMID] 18055549.
2006
Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice
Neuroscience letters. 409(2):95-99 [DOI] 10.1016/j.neulet.2006.09.021. [PMID] 17010516.
2006
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice
Proceedings of the National Academy of Sciences. 103(25):9673-9678 [DOI] 10.1073/pnas.0602913103. [PMID] 16769887.
2005
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)
The Journal of Neuroscience. 25(46):10637-10647 [DOI] 10.1523/JNEUROSCI.3279-05.2005. [PMID] 16291936.
2005
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
Proceedings of the National Academy of Sciences. 102(19):6990-6995 [DOI] 10.1073/pnas.0500466102. [PMID] 15867159.
2005
Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau
Journal of neurocytology. 34(6):397-410 [DOI] 10.1007/s11068-006-8726-0. [PMID] 16902761.
2005
Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice
The Journal of Neuroscience. 25(5):1226-1233 [DOI] 10.1523/JNEUROSCI.3263-04.2005. [PMID] 15689560.
2005
Tau suppression in a neurodegenerative mouse model improves memory function
Science. 309(5733):476-481 [DOI] 10.1126/science.1113694. [PMID] 16020737.
2004
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau
The American Journal Of Pathology. 164(1):347-353 [DOI] 10.1016/S0002-9440(10)63124-0. [PMID] 14695347.
2004
Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins
Journal of Neurochemistry. 90(4):829-838 [DOI] 10.1111/j.1471-4159.2004.02558.x. [PMID] 15287888.
2004
The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer’s transgenic mice
Neuroreport. 15(1):73-77 [PMID] 15106834.
View on: PubMed
2004
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
Human Molecular Genetics. 13(7):703-714 [DOI] 10.1093/hmg/ddh083. [PMID] 14962978.
2004
Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice
Neurobiology of Disease. 15(3):553-562 [DOI] 10.1016/j.nbd.2003.12.011. [PMID] 15056463.
2004
Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer’s disease: linkage of poorer cognitive performance to tau pathology in forebrain
Brain Research. 1012(1-2):29-41 [DOI] 10.1016/j.brainres.2004.02.081. [PMID] 15158158.
2003
Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice
The American Journal Of Pathology. 163(3):1057-1067 [DOI] 10.1016/S0002-9440(10)63465-7. [PMID] 12937146.
2003
Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutations
The American Journal Of Pathology. 162(1):213-218 [DOI] 10.1016/S0002-9440(10)63812-6. [PMID] 12507904.
2003
Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau
Journal of neurocytology. 32(9):1091-1105 [DOI] 10.1023/B:NEUR.0000021904.61387.95. [PMID] 15044841.
2002
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility
Journal of Neurochemistry. 83(6):1498-1508 [DOI] 10.1046/j.1471-4159.2002.01241.x. [PMID] 12472903.
2001
Analysis of tauopathies with transgenic mice
Trends in Molecular Medicine. 7(10):467-470 [DOI] 10.1016/S1471-4914(01)02123-2. [PMID] 11597522.
2001
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
Science. 293(5534):1487-1491 [DOI] 10.1126/science.1058189. [PMID] 11520987.
2001
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles
Science. 293(5530):711-714 [DOI] 10.1126/science.1062382. [PMID] 11408621.
2000
The molecular genetics of the tauopathies
Experimental Gerontology. 35(4):461-471 [DOI] 10.1016/S0531-5565(00)00114-5. [PMID] 10959034.
2000
Neurofibrillary tangles, amyotrophy, and progressive motor impairment in Tau mutant (P301L) transgenic mice
Nature Genetics. 25:402-405
2000
Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions
Brain Research. 853(1):5-14 [DOI] 10.1016/S0006-8993(99)02124-1. [PMID] 10627302.
2000
Animal Models of tau dysfunction
Neuroscience. 3(5):63-72
1999
5′ Splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10
Journal of Biological Chemistry. 274(21):15134-15143 [DOI] 10.1074/jbc.274.21.15134. [PMID] 10329720.
1999
Accelerated filament formation from tau protein with specific FTDP-17 missense mutations
FEBS Letters. 447(2-3):195-199 [DOI] 10.1016/S0014-5793(99)00294-X. [PMID] 10214944.
1998
A common human beta globin splicing mutation modeled in mice
Blood. 91(6):2152-2156 [PMID] 9490703.
View on: PubMed
1998
Rapid genotyping of mice with hemoglobinopathies and globin transgenes
Biochemical Genetics. 36(1-2):65-77 [DOI] 10.1023/A:1018752219810. [PMID] 9562907.
1996
Gene Modification via plug and socket gene targeting
The Journal of clinical investigation. 97(1):3-5 [DOI] 10.1172/JCI118403. [PMID] 8550847.
1995
A mouse model for beta 0-thalassemia
Proceedings of the National Academy of Sciences. 92(25):11608-11612 [DOI] 10.1073/pnas.92.25.11608. [PMID] 8524813.
1994
Deletion and replacement of the mouse adult beta-globin genes by a “€œplug and socket”€ repeated targeting strategy
Molecular And Cellular Biology. 14(10):6936-6943 [DOI] 10.1128/MCB.14.10.6936. [PMID] 7935410.

Grants

Sep 2019 ACTIVE
Developing new conditional models to study tauopathy, amyloidosis, and their interaction
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2019 ACTIVE
Immunotherapy targeting the HPA axis in Alzheimers disease
Role:
Funding: NATL INST OF HLTH NIA
Aug 2019 ACTIVE
Elucidating factors that modulate tauopathy and cellular degeneration to guide therapeutic development
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Mar 2019 ACTIVE
The Two Faces of Hypoxia in Alzheimer's Disease
Role:
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Sep 2018 ACTIVE
Clinical and Translational Pre-doctoral training in Alzheimers Disease and Related Dementias
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2018 ACTIVE
APOE as a modifier of prion-like spread in dementia
Role:
Funding: NATL INST OF HLTH NIA
Sep 2017 – May 2018
APOE as a modifier of prion-like spread in dementia
Role:
Funding: NATL INST OF HLTH NIA
Sep 2017 – Jun 2020
Uncovering targets that block pathological interactions between Abeta and tau
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Mar 2017 ACTIVE
Towards understanding the role of immune regulation of Apolipoprotein E function in Alzheimers disease proteostasis
Role:
Funding: NATL INST OF HLTH NIA
Feb 2017 – Sep 2019
Large-scale identification of genes that suppress concurrent Abeta42 and tau pathology in vivo
Role:
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Dec 2016 – Nov 2019
Is there a form of benign brain amyloidosis in aging?
Role:
Funding: NATL INST OF HLTH NIA
Aug 2016 – Sep 2019
New mouse models to dissect out the function of the ALS-associated protein Matrin 3
Role: Principal Investigator
Funding: AMYOTROPHIC LATERAL SCLEROSIS ASSOC
Aug 2015 ACTIVE
University of Florida – Mt. Sinai Medical Center AD Research Center
Role:
Funding: NATL INST OF HLTH NIA
Jul 2015 – Jun 2018
Towards a knockdown therapy for tauopathy
Role: Principal Investigator
Funding: BRIGHTFOCUS FOU
Apr 2015 ACTIVE
Clinical and Translational Science Institute (CTSI)
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jul 2014 – Jun 2017
Optogenetic modeling of primary and secondary CNS…….
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Apr 2014 – Mar 2016
Einstein Aging Study ? Neuropathology Core
Role: Principal Investigator
Funding: MAYO CLINIC via NATL INST OF HLTH
Jul 2013 – Jun 2018
Biological and Pathological Interactions between Tau and LRRK2
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2010 ACTIVE
Animal Models in neurodegenerative Disease
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO

Teaching Profile

Courses Taught
2019-2020
GMS5905 Special Topics in Biomedical Sciences
2019
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
2019
GMS6705 Functional Human Neuroanatomy
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2013,2015-2017
GMS6750 Molecular Pathobiology of Neural Disease
2011-2015
GMS6792 Neuroscience Graduate Research Seminar
2014
GMS7794 Neuroscience Seminar

Contact Details

Phones:
Business:
(352) 273-9666
Emails:
Business:
jada.lewis@ufl.edu