Yuqing Li

Yuqing Li, PhD

Professor Of Neurology

Department: MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone: (352) 273-6546
Business Email: yuqingli@ufl.edu

About Yuqing Li

Dr. Li’s research is mainly focused on the pathophysiology and experimental therapeutics of dystonia and restless legs syndrome. He is also broadly interested in animal models of movement disorders, basal ganglia and cerebellum, and molecular and cellular mechanisms of synaptic plasticity during development and learning. His lab’s expertise is to perform conditional mutagenesis and AAV infection in mice where selected genes are altered in specific neurons or circuits in the brain during a defined period throughout the animal’s life cycle. His lab also uses C. elegans to dissect gene-gene interaction and gene function. This powerful approach allows Dr. Li and his co-workers to apply functional genomics, in vitro electrophysiology, in vivo animal imaging, neurochemistry, optogenetic or chemogenetic approaches to understand the pathogenesis of neurological disorders and to develop an effective treatment.

Research Profile

Dr. Li’s research is mainly focused on pathophysiology and experimental therapeutics of dystonia and restless legs syndrome. He is also broadly interested in animal models of movement disorders and in molecular and cellular mechanisms of synaptic plasticity during development and learning. His lab’s expertise is to perform conditional mutagenesis in mouse where selected genes are altered in specific neurons or circuits in the brain and in defined period during animal’s development. This powerful approach allows Dr. Li and his co-workers to apply functional genomics and other multidisciplinary approaches to understand the pathogenesis of neurological disorders and to develop effective treatment.

Publications

2020
BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome
Brain Structure & Function. 225(6):1-18 [DOI] 10.1007/s00429-020-02090-x. [PMID] 32468214.
2020
Deficiency of Meis1, a transcriptional regulator, in mice and worms: neurochemical and behavioral characterizations with implications in the restless legs syndrome
Journal of Neurochemistry. 155(5):522-537 [DOI] 10.1111/jnc.15177. [PMID] 32910473.
2020
Mu opioid receptor knockout mouse: Phenotypes with implications on restless legs syndrome
Journal of Neuroscience Research. 98(8):1532-1548 [DOI] 10.1002/jnr.24637. [PMID] 32424971.
2020
Probing the relationship between BTBD9 and MEIS1 in C. elegans and mouse
Experimental Results. 1(e8) [DOI] https://doi.org/10.1017/exp.2020.12.
2020
The abnormal firing of Purkinje cells in the knockin mouse model of DYT1 dystonia
Brain research bulletin. 165:14-22 [DOI] 10.1016/j.brainresbull.2020.09.011.
2020
The role of BTBD9 in the cerebellum, sleep-like behaviors and the restless legs syndrome
Neuroscience. 440:85-96 [DOI] 10.1016/j.neuroscience.2020.05.021. [PMID] 32446853.
2020
The role of BTBD9 in the cerebral cortex and the pathogenesis of restless legs syndrome
Experimental Neurology. 323 [DOI] 10.1016/j.expneurol.2019.113111. [PMID] 31715135.
2020
Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice
Neurobiology of Disease. 134 [DOI] 10.1016/j.nbd.2019.104638. [PMID] 31618684.
2019
Hyperactivity, dopaminergic abnormalities, iron deficiency and anemia in an in vivo opioid receptors knockout mouse: Implications for the restless legs syndrome
Behavioural brain research. 374 [DOI] 10.1016/j.bbr.2019.112123. [PMID] 31376441.
2019
Improved survival and overt “dystonic” symptoms in a torsinA hypofunction mouse model
Behavioural brain research. 381 [DOI] 10.1016/j.bbr.2019.112451. [PMID] 31891745.
2019
Neuropeptide S Ameliorates Cognitive Impairment of APP/PS1 Transgenic Mice by Promoting Synaptic Plasticity and Reducing Aβ Deposition
Frontiers in Behavioral Neuroscience. 13 [DOI] 10.3389/fnbeh.2019.00138. [PMID] 31293402.
2019
The role of BTBD9 in striatum and restless legs syndrome
eNeuro. 6(5) [DOI] 10.1523/ENEURO.0277-19.2019. [PMID] 31444227.
2018
Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome
Frontiers in Behavioral Neuroscience. 12 [DOI] 10.3389/fnbeh.2018.00199. [PMID] 30233336.
2017
Animal models of RLS phenotypes
Sleep Medicine. 31:23-28 [DOI] 10.1016/j.sleep.2016.08.002. [PMID] 27839945.
2016
Electromyographic Evidence in Support of a Knock-in Mouse Model of Dyt1 Dystonia
Movement Disorders. 31(11):1633-1639 [DOI] 10.1002/mds.26677.
2016
In vivo imaging reveals impaired connectivity across cortical and subcortical networks in a mouse model of DYT1 dystonia.
Neurobiology of disease. 95:35-45 [DOI] 10.1016/j.nbd.2016.07.005. [PMID] 27404940.
2016
Nf1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum
Current biology : CB. 26(22):2992-3003 [DOI] 10.1016/j.cub.2016.09.010. [PMID] 27773571.
2015
Behavioral and Electrophysiological Characterization of Dyt1 Heterozygous Knockout Mice
PLoS One. 10(3) [DOI] 10.1371/journal.pone.0120916. [PMID] 25874703.
2015
Decreased dopamine receptor 1 activity and impaired motor-skill transfer in Dyt1 ΔGAG heterozygous knock-in mice.
Behavioural brain research. 279:202-10 [DOI] 10.1016/j.bbr.2014.11.037. [PMID] 25451552.
2014
Neuronal Targets for Reducing Mutant Huntingtin Expression To Ameliorate Disease in a Mouse Model of Huntington’s Disease
Nature medicine. 20(5):540-545 [DOI] 10.1038/nm.3514. [PMID] 24784230.
2013
Engineering Animal Models of Dystonia
Movement Disorders. 28(7):990-1000 [DOI] 10.1002/mds.25583. [PMID] 23893455.
2013
Pre-Synaptic Release Deficits in a Dyt1 Dystonia Mouse Model
PLoS One. 8(8) [DOI] 10.1371/journal.pone.0072491. [PMID] 23967309.
2012
Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models.
Behavioural brain research. 227(1):12-20 [DOI] 10.1016/j.bbr.2011.10.024. [PMID] 22040906.
2012
Abnormal Nuclear Envelopes in the Striatum and Motor Deficits in Dyt11 Myoclonus-Dystonia Mouse Models
Human Molecular Genetics. 21(4):916-925 [DOI] 10.1093/hmg/ddr528. [PMID] 22080833.
2012
Alteration of striatal dopaminergic neurotransmission in a mouse model of DYT11 myoclonus-dystonia.
PloS one. 7(3) [DOI] 10.1371/journal.pone.0033669. [PMID] 22438980.
2012
An Anticholinergic Reverses Motor Control and Corticostriatal Ltd Deficits in Dyt1 Delta Gag Knock-in Mice
Behavioural brain research. 226(2):465-472 [DOI] 10.1016/j.bbr.2011.10.002. [PMID] 21995941.
2012
Enhanced Hippocampal Long-Term Potentiation and Fear Memory in Btbd9 Mutant Mice
PLoS One. 7(4) [DOI] 10.1371/journal.pone.0035518. [PMID] 22536397.
2012
Improved Motor Performance in Dyt1 Delta Gag Heterozygous Knock-in Mice By Cerebellar Purkinje-Cell Specific Dyt1 Conditional Knocking-Out
Behavioural brain research. 230(2):389-398 [DOI] 10.1016/j.bbr.2012.02.029. [PMID] 22391119.
2012
Motor restlessness, sleep disturbances, thermal sensory alterations and elevated serum iron levels in Btbd9 mutant mice.
Human molecular genetics. 21(18):3984-92 [DOI] 10.1093/hmg/dds221. [PMID] 22678064.
2011
Motor Deficits and Decreased Striatal Dopamine Receptor 2 Binding Activity in the Striatum-Specific Dyt1 Conditional Knockout Mice
PLoS One. 6(9) [DOI] 10.1371/journal.pone.0024539. [PMID] 21931745.

Grants

Sep 2020 ACTIVE
Characterization of Meis1 mutant mice and implications in restless legs syndrome and other sleep disorders
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2020 ACTIVE
Characterization of the involvement of the cerebellum in animal models of C9orf72 ALS/FTD
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2018 ACTIVE
Non-Invasive Markers of Neurodegeneration in Movement Disorders
Role:
Funding: NATL INST OF HLTH NINDS
Jan 2016 – Dec 2018
Opioid System and Restless Syndrome: A Knockout Mouse Approach to Elucidate Its Role
Role: Principal Investigator
Funding: MUNDIPHARMA RESEARCH LTD
Aug 2015 – Jul 2016
characterization of meisl heterozygous knockout mice
Role: Principal Investigator
Funding: RESTLESS LEGS SYNDROME FOUNDATION
Jan 2014 – Mar 2020
Restless Legs Syndrome: Pathophysiology using Btbd9 Conditional Knockout Mice
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2011 – Dec 2016
Pathophysiology of DYT1 Dystonia: Targeted Mouse Models
Role: Principal Investigator
Funding: UF FOU
May 2011 – Dec 2016
RLS replacement for 94393
Role: Principal Investigator
Funding: UF FOU
May 2011 – Dec 2016
P50 companion project to 00105729
Role: Principal Investigator
Funding: UF FOU
May 2011 – Dec 2016
DYT12 Companion to 00094395
Role: Principal Investigator
Funding: UF FOU
May 2011 – Dec 2016
epsilon-sarcoglycan UFF to 94399 R03
Role: Principal Investigator
Funding: UF FOU

Teaching Profile

Courses Taught
2011-2020
GMS6029 Brain Journal Club
2018
CHM7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation

Contact Details

Phones:
Business:
(352) 273-6546
Emails:
Business:
yuqingli@ufl.edu