Adamantios Mamais, MSc, PhD
Hough Family Fellow, Research Assistant Professor Of Neurology
Department:
MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone:
(352) 273-5550
Business Email:
adamantios.mamais@neurology.ufl.edu
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-5546-7084
Publications
2024
The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons
Stem Cell Reports.
19(2):163-173
[DOI] 10.1016/j.stemcr.2024.01.001.
[PMID] 38307024.
2023
Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2.
Cells.
13(1)
[DOI] 10.3390/cells13010053.
[PMID] 38201257.
2023
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.09.14.557532.
[PMID] 37745519.
2023
Disease mechanisms as subtypes: Lysosomal dysfunction in the endolysosomal Parkinson’s disease subtype.
Handbook of clinical neurology.
193:33-51
[DOI] 10.1016/B978-0-323-85555-6.00009-6.
[PMID] 36803821.
2023
Perspective on the current state of the LRRK2 field
npj Parkinson's Disease.
9(1)
[DOI] 10.1038/s41531-023-00544-7.
[PMID] 37393318.
2023
The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary but distinct disease-relevant phenotypes in human neurons.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.04.30.538317.
[PMID] 37163109.
2022
Convergence of signalling pathways in innate immune responses and genetic forms of Parkinson’s disease.
Neurobiology of disease.
169
[DOI] 10.1016/j.nbd.2022.105721.
[PMID] 35405260.
2022
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
PLoS biology.
20(5)
[DOI] 10.1371/journal.pbio.3001621.
[PMID] 35507910.
2021
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
PLOS Biology.
19(12)
[DOI] 10.1371/journal.pbio.3001480.
[PMID] 34914695.
2021
Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
Molecular neurodegeneration.
16(1)
[DOI] 10.1186/s13024-021-00441-8.
[PMID] 33741046.
2020
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.
Science translational medicine.
12(565)
[DOI] 10.1126/scitranslmed.aay0399.
[PMID] 33055242.
2020
LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Science advances.
6(46)
[DOI] 10.1126/sciadv.abb2454.
[PMID] 33177079.
2020
Sequential screening nominates the Parkinson’s disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
Neurobiology of Disease.
141
[DOI] 10.1016/j.nbd.2020.104948.
[PMID] 32434048.
2020
The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Cell reports.
31(5)
[DOI] 10.1016/j.celrep.2020.107614.
[PMID] 32375042.
2019
Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2.
Neurochemical research.
44(6):1446-1459
[DOI] 10.1007/s11064-018-2650-4.
[PMID] 30291536.
2019
Genetic analysis of neurodegenerative diseases in a pathology cohort.
Neurobiology of aging.
76:214.e1-214.e9
[DOI] 10.1016/j.neurobiolaging.2018.11.007.
[PMID] 30528841.
2019
LRRK2 links genetic and sporadic Parkinson’s disease.
Biochemical Society transactions.
47(2):651-661
[DOI] 10.1042/BST20180462.
[PMID] 30837320.
2019
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils
Neurobiology of Disease.
129:67-78
[DOI] 10.1016/j.nbd.2019.05.012.
[PMID] 31102768.
2018
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson’s disease brains with Lewy body pathology.
Brain research.
1701:75-84
[DOI] 10.1016/j.brainres.2018.07.023.
[PMID] 30055128.
2018
Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.
NPJ Parkinson's disease.
4
[DOI] 10.1038/s41531-018-0049-1.
[PMID] 29707617.
2018
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition.
Bioscience reports.
38(2)
[DOI] 10.1042/BSR20171669.
[PMID] 29563162.
2018
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Human molecular genetics.
27(18):3257-3271
[DOI] 10.1093/hmg/ddy232.
[PMID] 29917075.
2017
Hexokinases link DJ-1 to the PINK1/parkin pathway.
Molecular neurodegeneration.
12(1)
[DOI] 10.1186/s13024-017-0212-x.
[PMID] 28962651.
2016
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Scientific reports.
6
[DOI] 10.1038/srep35106.
[PMID] 27731364.
2014
A Parkinson’s disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Human molecular genetics.
23(18):4887-905
[DOI] 10.1093/hmg/ddu202.
[PMID] 24794857.
2014
Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.
The Journal of biological chemistry.
289(31):21386-400
[DOI] 10.1074/jbc.M113.528463.
[PMID] 24942733.
2014
Dysregulation of glucose metabolism is an early event in sporadic Parkinson’s disease.
Neurobiology of aging.
35(5):1111-5
[DOI] 10.1016/j.neurobiolaging.2013.11.001.
[PMID] 24300239.
2014
GTP binding controls complex formation by the human ROCO protein MASL1.
The FEBS journal.
281(1):261-74
[DOI] 10.1111/febs.12593.
[PMID] 24286120.
2014
LRRK2: dropping (kinase) inhibitions and seeking an (immune) response.
Journal of neurochemistry.
129(6):895-7
[DOI] 10.1111/jnc.12691.
[PMID] 24661004.
2014
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Nature communications.
5
[DOI] 10.1038/ncomms6827.
[PMID] 25500533.
2013
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson’s disease brains with Lewy Body pathology compared to idiopathic cases.
Neurobiology of disease.
58:183-90
[DOI] 10.1016/j.nbd.2013.05.017.
[PMID] 23747310.
2013
Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.
PloS one.
8(8)
[DOI] 10.1371/journal.pone.0070724.
[PMID] 23967090.
2013
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Biochimica et biophysica acta.
1833(12):2900-2910
[DOI] 10.1016/j.bbamcr.2013.07.020.
[PMID] 23916833.
2013
Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Biochemical and biophysical research communications.
441(4):862-6
[DOI] 10.1016/j.bbrc.2013.10.159.
[PMID] 24211199.
2012
Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
PloS one.
7(10)
[DOI] 10.1371/journal.pone.0047784.
[PMID] 23082216.
2011
Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies.
Acta neuropathologica.
122(4):415-28
[DOI] 10.1007/s00401-011-0857-4.
[PMID] 21773886.
2011
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
PloS one.
6(7)
[DOI] 10.1371/journal.pone.0022489.
[PMID] 21799870.
2009
Relationship of p21-activated kinase (PAK) and filopodia to persistence and oncogenic transformation.
Journal of cellular physiology.
220(3):576-85
[DOI] 10.1002/jcp.21788.
[PMID] 19384897.
2007
Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination.
Nucleic acids research.
35(18):6311-21
[PMID] 17881376.
2003
Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences.
The EMBO journal.
22(19):5197-207
[PMID] 14517257.
Grants
Jul 2023
ACTIVE
Iron homeostasis and inflammatory responses in human LRRK2 astrocytes
Role: Principal Investigator
Funding: FOX FOU, MICHAEL J
Dec 2022
ACTIVE
Dysregulation of iron homeostasis by mutant LRRK2 in human neurons
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2020
ACTIVE
PATHOLOGIC LRRK2 SIGNALING IN FAMILIAL AND IDIOPATHIC PARKINSON'S DISEASE
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Education
PhD in Neuroscience
2005-2010
·
UCL Institute of Neurology, U.K.
MSc in Molecular Medicine
2001-2002
·
University College London, U.K.
BSc in Molecular Biology
1998-2001
·
University College London, U.K.
Contact Details
Phones:
- Business:
- (352) 273-5550
Emails:
- Business:
- adamantios.mamais@neurology.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100159
GAINESVILLE FL 32610 - Business Street:
-
1275 CENTER DR
GAINESVILLE FL 32610