Jeffrey R Martens

Jeffrey R Martens, Ph.D.

Chair And Professor

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (352) 294-5352
Business Email: martensj@ufl.edu

Research Profile

The Martens Lab is focused in two areas of Pharmacology and Therapeutics, including sensory Neuropharmacology and cardiovascular Pharmacology, with work in both the heart and olfactory systems.

In relation to the olfactory system, the lab’s work is devoted to understanding mechanisms of olfaction, pathogenesis of olfactory dysfunction, and the development of curative therapies for anosmia. Olfactory dysfunction in the general population is frequent, affecting at least 2.5 million people in the U.S. alone. In at least 20% of the cases, the etiology of the chemosensory disturbance cannot be identified. The Martens Lab was one of the first to demonstrate olfactory dysfunction as a clinical manifestation of an emerging class of human genetic disorders, termed ciliopathies, which involve defects in ciliary assembly, maintenance, and/or function. Most importantly, the lab has demonstrated that gene therapy can be used to successfully rescue anosmia resulting from the malformation/loss of cilia. Projects in the laboratory seek to identify direct mechanisms by which sensory input and deprivation regulate olfactory function and to learn how these are disrupted in disease states. Specifically, they work to elucidate the mechanisms underlying the transport of odorant signaling proteins into cilia of olfactory sensory neurons and their alterations in cilia-related disorders. In addition, work completed in the laboratory seeks to understand the importance of cilia for neurogenesis and cell differentiation, investigating their contribution to the regenerative properties of olfactory basal stem cells. Together, this work contributes to the understanding of the pathogenesis of human sensory perception diseases and paves the way for the development of treatments for olfactory loss in humans, where no curative therapies for ciliopathic disease exist.

In relation to the cardiovascular system, projects in the Martens Lab are focused on the identification of novel targets for the treatment of cardiac arrhythmias. In particular, the lab is interested in therapies for atrial fibrillation, which is the most common cardiac arrhythmia, affecting more than 2 million Americans. This electrical instability in the human heart can occur through a primary genetic defect in ion channel function or an acquired disorder attributable to ion channel dysregulation. They are interested in the regulation of voltage-gated potassium (Kv) channels that are vital for atrial repolarization in the human heart. Work in their laboratory is devoted to understanding the details of Kv channel regulation, trafficking, and pharmacological modulation and to learning how this is all integrated into the broader context of normal cardiomyocyte signaling and the pathogenesis of disease.

Publications

2020
Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities.
Chemical senses. 45(7):493-502 [DOI] 10.1093/chemse/bjaa038. [PMID] 32556127.
2020
Photoactivatable Odorants for Chemosensory Research.
ACS chemical biology. 15(9):2516-2528 [DOI] 10.1021/acschembio.0c00541. [PMID] 32865973.
2020
Maturation of the Olfactory Sensory Neuron and Its Cilia.
Chemical senses. [DOI] 10.1093/chemse/bjaa070. [PMID] 33075817.
2019
Initial Characterization of a Subpopulation of Inherent Oscillatory Mammalian Olfactory Receptor Neurons.
Chemical senses. 44(8):583-592 [DOI] 10.1093/chemse/bjz052. [PMID] 31420672.
2019
Intranasal Delivery of Adenoviral and AAV Vectors for Transduction of the Mammalian Peripheral Olfactory System.
Methods in molecular biology (Clifton, N.J.). 1950:283-297 [DOI] 10.1007/978-1-4939-9139-6_17. [PMID] 30783981.
2019
Mks6 mutations reveal tissue- and cell type-specific roles for the cilia transition zone.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(1):1440-1455 [DOI] 10.1096/fj.201801149R. [PMID] 30133325.
2019
Olfactory Loss and Dysfunction in Ciliopathies: Molecular Mechanisms and Potential Therapies.
Current medicinal chemistry. 26(17):3103-3119 [DOI] 10.2174/0929867325666180105102447. [PMID] 29303074.
2019
BBS4 is required for intraflagellar transport coordination and basal body number in mammalian olfactory cilia.
Journal of cell science. 132(5) [DOI] 10.1242/jcs.222331. [PMID] 30665891.
2018
Peripheral Gene Therapeutic Rescue of an Olfactory Ciliopathy Restores Sensory Input, Axonal Pathfinding, and Odor-Guided Behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(34):7462-7475 [DOI] 10.1523/JNEUROSCI.0084-18.2018. [PMID] 30061191.
2017
Anosmia-A Clinical Review.
Chemical senses. 42(7):513-523 [DOI] 10.1093/chemse/bjx025. [PMID] 28531300.
2017
Gene Therapeutic Reversal of Peripheral Olfactory Impairment in Bardet-Biedl Syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy. 25(4):904-916 [DOI] 10.1016/j.ymthe.2017.02.006. [PMID] 28237838.
2016
Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation.
Acta neuropathologica. 131(4):639-40 [DOI] 10.1007/s00401-016-1543-3. [PMID] 26839081.
2016
Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation.
Molecular cancer research : MCR. 14(1):26-34 [DOI] 10.1158/1541-7786.MCR-15-0343. [PMID] 26573141.
2015
Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress.
Oncogene. 34(35):4591-600 [DOI] 10.1038/onc.2014.384. [PMID] 25435365.
2015
Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(40):13761-72 [DOI] 10.1523/JNEUROSCI.1708-15.2015. [PMID] 26446227.
2015
SUMOylation regulates ciliary localization of olfactory signaling proteins.
Journal of cell science. 128(10):1934-45 [DOI] 10.1242/jcs.164673. [PMID] 25908845.
2014
Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia.
Nature communications. 5 [DOI] 10.1038/ncomms6813. [PMID] 25504142.
2014
Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes.
Circulation research. 114(6):982-92 [DOI] 10.1161/CIRCRESAHA.114.302711. [PMID] 24508725.
2013
Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases.
Molecular therapy : the journal of the American Society of Gene Therapy. 21(2):266-8 [DOI] 10.1038/mt.2013.4. [PMID] 23369965.
2013
Smelling the roses and seeing the light: gene therapy for ciliopathies.
Trends in biotechnology. 31(6):355-63 [DOI] 10.1016/j.tibtech.2013.03.005. [PMID] 23601268.
2012
Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America. 109(31):E2134-43 [DOI] 10.1073/pnas.1109370109. [PMID] 22509027.
2012
Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model.
Nature medicine. 18(9):1423-8 [PMID] 22941275.
View on: PubMed
2012
Redox, haem and CO in enzymatic catalysis and regulation.
Biochemical Society transactions. 40(3):501-7 [DOI] 10.1042/BST20120083. [PMID] 22616859.
2012
Redox-sensitive sulfenic acid modification regulates surface expression of the cardiovascular voltage-gated potassium channel Kv1.5.
Circulation research. 111(7):842-53 [DOI] 10.1161/CIRCRESAHA.111.263525. [PMID] 22843785.
2012
Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization.
Heart rhythm. 9(7):1133-1140.e6 [DOI] 10.1016/j.hrthm.2012.03.003. [PMID] 22406144.
2012
Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis.
The Journal of clinical investigation. 122(4):1233-45 [DOI] 10.1172/JCI60981. [PMID] 22446187.
2011
Induction of Ran GTP drives ciliogenesis.
Molecular biology of the cell. 22(23):4539-48 [DOI] 10.1091/mbc.E11-03-0267. [PMID] 21998203.
2011
Subunit-dependent axonal trafficking of distinct alpha heteromeric potassium channel complexes.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(37):13224-35 [DOI] 10.1523/JNEUROSCI.0976-11.2011. [PMID] 21917805.
2010
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.
Nature cell biology. 12(7):703-10 [DOI] 10.1038/ncb2073. [PMID] 20526328.
2010
Ion channel trafficking: a new therapeutic horizon for atrial fibrillation.
Heart rhythm. 7(9):1309-15 [DOI] 10.1016/j.hrthm.2010.02.017. [PMID] 20156596.
2010
Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes.
Journal of biomedicine & biotechnology. 2010 [DOI] 10.1155/2010/624719. [PMID] 20467587.
2010
PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane.
Nature neuroscience. 13(1):36-44 [DOI] 10.1038/nn.2462. [PMID] 20010819.
2010
The AP-1 clathrin adaptor facilitates cilium formation and functions with RAB-8 in C. elegans ciliary membrane transport.
Journal of cell science. 123(Pt 22):3966-77 [DOI] 10.1242/jcs.073908. [PMID] 20980383.
2010
The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development.
Human molecular genetics. 19(22):4330-44 [DOI] 10.1093/hmg/ddq355. [PMID] 20729296.
2009
Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.
Circulation research. 104(12):1390-8 [DOI] 10.1161/CIRCRESAHA.108.192773. [PMID] 19443837.
2009
Antifibrillatory agents and potassium channels in the atria: pore block versus channel trafficking.
Molecular interventions. 9(2):79-86 [DOI] 10.1124/mi.9.2.7. [PMID] 19401540.
2009
Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome.
Human molecular genetics. 18(11):1909-23 [DOI] 10.1093/hmg/ddp112. [PMID] 19279158.
2009
Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state.
The Journal of biological chemistry. 284(31):20556-61 [DOI] 10.1074/jbc.M109.015651. [PMID] 19473966.
2009
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the cyclic-nucleotide-gated channel in olfactory sensory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(34):10541-51 [DOI] 10.1523/JNEUROSCI.1590-09.2009. [PMID] 19710307.
2009
Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: a parallel comparison of acute and chronic signaling to adenylyl cyclase.
The Journal of biological chemistry. 284(33):22108-22 [DOI] 10.1074/jbc.M109.030411. [PMID] 19520863.
2009
Olfactory cilia: linking sensory cilia function and human disease.
Chemical senses. 34(5):451-64 [DOI] 10.1093/chemse/bjp020. [PMID] 19406873.
2008
Caveolin regulates kv1.5 trafficking to cholesterol-rich membrane microdomains.
Molecular pharmacology. 73(3):678-85 [PMID] 18045854.
View on: PubMed
2008
Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid.
Journal of molecular and cellular cardiology. 44(2):323-35 [PMID] 18155022.
View on: PubMed
2008
Olfactory cilia: our direct neuronal connection to the external world.
Current topics in developmental biology. 85:333-70 [DOI] 10.1016/S0070-2153(08)00812-0. [PMID] 19147011.
2007
Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons.
Proceedings of the National Academy of Sciences of the United States of America. 104(40):15917-22 [PMID] 17898177.
View on: PubMed
2007
Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop.
Circulation. 116(10):e320-35 [PMID] 17768297.
View on: PubMed
2007
S-acylation regulates Kv1.5 channel surface expression.
American journal of physiology. Cell physiology. 293(1):C152-61 [PMID] 17344312.
View on: PubMed
2007
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.
Proceedings of the National Academy of Sciences of the United States of America. 104(6):1805-10 [PMID] 17261810.
View on: PubMed
2007
Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytes.
The Journal of biological chemistry. 282(40):29612-20 [PMID] 17673464.
View on: PubMed
2006
Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17.
Current biology : CB. 16(12):1211-6 [PMID] 16782012.
View on: PubMed
2006
Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels.
Proceedings of the National Academy of Sciences of the United States of America. 103(42):15635-40 [PMID] 17032767.
View on: PubMed
2005
Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current.
American journal of physiology. Cell physiology. 289(1):C49-57 [PMID] 15703204.
View on: PubMed
2004
Targeting of ion channels to membrane microdomains: localization of KV channels to lipid rafts.
Trends in pharmacological sciences. 25(1):16-21 [PMID] 14723974.
View on: PubMed
2004
Functional role of lipid raft microdomains in cyclic nucleotide-gated channel activation.
Molecular pharmacology. 65(3):503-11 [PMID] 14978228.
View on: PubMed
2004
Localization of ion channels to lipid Raft domains within the cardiovascular system.
Trends in cardiovascular medicine. 14(2):37-42 [PMID] 15030787.
View on: PubMed
2003
Kv channel subunits that contribute to voltage-gated K+ current in renal vascular smooth muscle.
Pflugers Archiv : European journal of physiology. 445(6):697-704 [PMID] 12632190.
View on: PubMed
2001
Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels.
American journal of physiology. Lung cellular and molecular physiology. 281(1):L1-12 [PMID] 11404238.
View on: PubMed
2001
Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae.
The Journal of biological chemistry. 276(11):8409-14 [PMID] 11115511.
View on: PubMed
2000
Differential targeting of Shaker-like potassium channels to lipid rafts.
The Journal of biological chemistry. 275(11):7443-6 [PMID] 10713042.
View on: PubMed
1999
Modulation of Kv channel alpha/beta subunit interactions.
Trends in cardiovascular medicine. 9(8):253-8 [PMID] 11094335.
View on: PubMed
1999
Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature.
Circulation research. 85(6):489-97 [PMID] 10488051.
View on: PubMed
1998
Angiotensin IV receptor-mediated activation of lung endothelial NOS is associated with vasorelaxation.
The American journal of physiology. 275(6):L1061-8 [DOI] 10.1152/ajplung.1998.275.6.L1061. [PMID] 9843842.
1998
Ion channels in vascular smooth muscle: alterations in essential hypertension.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 218(3):192-203 [PMID] 9648936.
View on: PubMed
1998
Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy.
Proceedings of the National Academy of Sciences of the United States of America. 95(5):2664-9 [PMID] 9482944.
View on: PubMed
1996
Alterations in rat interlobar artery membrane potential and K+ channels in genetic and nongenetic hypertension.
Circulation research. 79(2):295-301 [PMID] 8756007.
View on: PubMed
1996
Angiotensin II regulation of intracellular calcium in astroglia cultured from rat hypothalamus and brainstem.
Journal of neurochemistry. 67(3):996-1004 [PMID] 8752105.
View on: PubMed
1996
Angiotensin II type 2 receptor-mediated regulation of rat neuronal K+ channels.
Circulation research. 79(2):302-9 [PMID] 8756008.
View on: PubMed
1996
Effects of intravenous anesthetics on atrial wavelength and atrioventricular nodal conduction in guinea pig heart. Potential antidysrhythmic properties and clinical implications.
Anesthesiology. 85(2):393-402 [PMID] 8712456.
View on: PubMed
1996
Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart.
Circulation. 94(10):2551-9 [PMID] 8921800.
View on: PubMed
1996
Voltage-dependent chloride channels: invertebrates to man.
The Journal of experimental zoology. 275(4):277-82 [PMID] 8759924.
View on: PubMed
1995
Frequency-dependent effects of propofol on atrioventricular nodal conduction in guinea pig isolated heart. Mechanism and potential antidysrhythmic properties.
Anesthesiology. 83(2):382-94; discussion 24A [PMID] 7631961.
View on: PubMed
1994
The cardiac effects of a novel A1-adenosine receptor agonist in guinea pig isolated heart.
The Journal of pharmacology and experimental therapeutics. 271(3):1371-82 [PMID] 7996449.
View on: PubMed

Grants

Sep 2019 ACTIVE
Active Roles of Glial Cells in Olfaction and Age-Related Olfactory Decline
Role:
Funding: NATL INST OF HLTH NIA
Feb 2019 ACTIVE
ASPET SURF renewal
Role: Principal Investigator
Funding: AMER SOC PHARMACOLOGY & EXPERIM THERAPEU
Jun 2016 – May 2018
OR-DRPD-ROF2016: Visualizing viral entry into neurons and the brain: Changing the paradigm
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Feb 2016 – Jan 2019
AMERICAN SOCIETY OF PHARMACOLOGY AND EXPERIMENTAL THERAPIES(ASPET) SUMMER UNDERGRADUATE RESEARCH FELLOWSHIP (SURF)
Role: Principal Investigator
Funding: AMER SOC PHARMACOLOGY & EXPERIM THERAPEU
Jul 2015 ACTIVE
Oppelt Memorial Support Fund
Role: Principal Investigator
Funding: UF FOU
Jul 2015 ACTIVE
Research Pharmacology I
Role: Principal Investigator
Funding: UF FOU
Jul 2015 ACTIVE
Research Pharmacology III
Role: Principal Investigator
Funding: UF FOU
Jul 2015 ACTIVE
Research Pharmacology IV
Role: Principal Investigator
Funding: UF FOU
Jul 2015 ACTIVE
Research Pharmacology IX
Role: Principal Investigator
Funding: UF FOU
Jul 2015 ACTIVE
Research Pharmacology V
Role: Principal Investigator
Funding: UF FOU
Jul 2015 ACTIVE
Research Pharmacology VII
Role: Principal Investigator
Funding: UF FOU
Jul 2015 ACTIVE
Research Pharmacology VIII – Marters
Role: Principal Investigator
Funding: UF FOU
Jul 2015 ACTIVE
Research Pharmacology VI
Role: Principal Investigator
Funding: UF FOU
Jul 2014 ACTIVE
Martens-Maren Chair Fund
Role: Principal Investigator
Funding: **UF FOU UNRESTRICTED DONATION
Apr 2014 – Mar 2020
Olfactory Signaling, Cilia, and Sensory Disorders
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCD
May 2012 ACTIVE
Research I
Role: Principal Investigator
Funding: UF FOU
Jul 2009 ACTIVE
Maren Professorship
Role: Principal Investigator
Funding: UF FOU
May 2003 ACTIVE
New Proposal entered at request of Contracts & Grants to change Fund # from 171 to 209.
Role: Principal Investigator
Funding: UF FOU
May 2003 ACTIVE
Professor Pharmacology/Exp Therapeutics
Role: Principal Investigator
Funding: UF FOU

Teaching Profile

Courses Taught
2019-2021
GMS6530 Medical Pharmacology and Therapeutics II: Cardiovascular, Renal and Respiratory Systems
2019-2020
GMS6551 Fundamentals of Medical Pharmacology and Therapeutics
2018-2020
GMS6560 Molecules to Man: Past, Present and Future Therapeutic Strategies for Disease
2016-2020
GMS6847 Translational Research and Therapeutics: Bench, Bedside, Community, & Policy
2020
PAS5026 Pharmacotherapeu 2
2015-2020
DEN6262 Prin of Pharmacology
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016
GMS7794 Neuroscience Seminar
2016
MDU4002 Introduction to Medical Science Seminar 2

Contact Details

Phones:
Business:
(352) 294-5352
Emails:
Business:
martensj@ufl.edu