Clayton Mathews

Clayton Mathews

Sebastian Family Professor

Department: MD-PATHOLOGY-GENERAL
Business Phone: (352) 273-9269
Business Email: cxm@ufl.edu

Publications

2020
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(11):14832-14849 [DOI] 10.1096/fj.202001495R. [PMID] 32918763.
2020
NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T-Cell Numbers.
Diabetes. 69(8):1749-1762 [DOI] 10.2337/db19-0979. [PMID] 32535552.
2020
Lipid mediators and biomarkers associated with type 1 diabetes development
JCI Insight. 5(16) [DOI] 10.1172/jci.insight.138034. [PMID] 32814707.
2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics. [DOI] 10.1089/dia.2020.0305. [PMID] 32833543.
2020
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
The Journal of nutritional biochemistry. 81 [DOI] 10.1016/j.jnutbio.2020.108381. [PMID] 32422424.
2020
Innate inflammation drives NK cell activation to impair Treg activity.
Journal of autoimmunity. 108 [DOI] 10.1016/j.jaut.2020.102417. [PMID] 32035746.
2019
Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.
Analytical chemistry. 91(9):5794-5801 [DOI] 10.1021/acs.analchem.9b00024. [PMID] 30843680.
2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Frontiers in immunology. 10 [DOI] 10.3389/fimmu.2019.00952. [PMID] 31118934.
2018
The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future.
Frontiers in endocrinology. 9 [DOI] 10.3389/fendo.2018.00051. [PMID] 29527189.
2018
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.
Nature genetics. 50(11):1574-1583 [DOI] 10.1038/s41588-018-0223-8. [PMID] 30275530.
2018
Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01053. [PMID] 29868014.
2018
Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-03367-w. [PMID] 29491378.
2018
Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of
Chemical science. 9(34):6944-6951 [DOI] 10.1039/c8sc02680g. [PMID] 30210768.
2018
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.
Diabetes. 67(4):697-703 [DOI] 10.2337/db17-0937. [PMID] 29343548.
2018
Correction to: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes.
Current diabetes reports. 18(10) [DOI] 10.1007/s11892-018-1068-3. [PMID] 30173405.
2018
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-22574-5. [PMID] 29540798.
2018
Abnormal islet sphingolipid metabolism in type 1 diabetes.
Diabetologia. 61(7):1650-1661 [DOI] 10.1007/s00125-018-4614-2. [PMID] 29671030.
2018
Mitochondrial Reactive Oxygen Species and Type 1 Diabetes.
Antioxidants & redox signaling. 29(14):1361-1372 [DOI] 10.1089/ars.2017.7346. [PMID] 29295631.
2017
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
Diabetes. 66(3):722-734 [DOI] 10.2337/db16-1025. [PMID] 27920090.
2017
Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.
Diabetes. 66(12):3061-3071 [DOI] 10.2337/db17-0106. [PMID] 28877912.
2017
T cells display mitochondria hyperpolarization in human type 1 diabetes.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-11056-9. [PMID] 28883439.
2017
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications. 8 [DOI] 10.1038/ncomms14477. [PMID] 28205519.
2017
Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes.
Diabetes. 66(3):710-721 [DOI] 10.2337/db16-0846. [PMID] 27920091.
2017
Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment.
Frontiers in endocrinology. 8 [DOI] 10.3389/fendo.2017.00232. [PMID] 28959234.
2017
Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications. 8 [DOI] 10.1038/ncomms16143. [PMID] 31305776.
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research. 77(3):672-683 [DOI] 10.1158/0008-5472.CAN-16-1765. [PMID] 27864347.
2017
Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.01313. [PMID] 29123516.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 23(2) [DOI] 10.1038/nm0217-264a. [PMID] 28170374.
2017
The Type 1 Diabetes-Resistance Locus Idd22 Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice.
Journal of immunology (Baltimore, Md. : 1950). 199(12):3991-4000 [DOI] 10.4049/jimmunol.1602037. [PMID] 29109122.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 23(8) [DOI] 10.1038/nm0817-1004a. [PMID] 28777787.
2016
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 22(12):1482-1487 [DOI] 10.1038/nm.4203. [PMID] 27798614.
2016
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes. 65(12):3765-3775 [PMID] 27669730.
View on: PubMed
2016
Genetic risk analysis of a patient with fulminant autoimmune type 1 diabetes mellitus secondary to combination ipilimumab and nivolumab immunotherapy.
Journal for immunotherapy of cancer. 4 [DOI] 10.1186/s40425-016-0196-z. [PMID] 28031819.
2016
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.
Diabetologia. 59(11):2448-2458 [DOI] 10.1007/s00125-016-4067-4. [PMID] 27506584.
2016
Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes.
Clinical and experimental immunology. 183(3):350-7 [DOI] 10.1111/cei.12731. [PMID] 26462724.
2016
Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study.
Scientific reports. 6 [DOI] 10.1038/srep31479. [PMID] 27558530.
2015
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.
Journal of immunology (Baltimore, Md. : 1950). 194(3):1169-77 [DOI] 10.4049/jimmunol.1302676. [PMID] 25548220.
2015
Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver.
BMC biochemistry. 16 [DOI] 10.1186/s12858-015-0051-8. [PMID] 26358560.
2015
Repurposed biological scaffolds: kidney to pancreas.
Organogenesis. 11(2):47-57 [DOI] 10.1080/15476278.2015.1067354. [PMID] 26252820.
2015
Reply To Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and Beta-Cells
Journal of Biological Chemistry. 290(16):10571-10 [DOI] 10.1074/jbc.L115.648600. [PMID] 25910833.
2015
Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.
Arthritis & rheumatology (Hoboken, N.J.). 67(1):225-37 [DOI] 10.1002/art.38882. [PMID] 25252121.
2015
Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes.
Diabetes. 64(12):4171-83 [DOI] 10.2337/db15-0546. [PMID] 26269022.
2015
How the location of superoxide generation influences the β-cell response to nitric oxide.
The Journal of biological chemistry. 290(12):7952-60 [DOI] 10.1074/jbc.M114.627869. [PMID] 25648890.
2015
Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.
American journal of physiology. Regulatory, integrative and comparative physiology. 309(5):R525-34 [DOI] 10.1152/ajpregu.00544.2014. [PMID] 26084699.
2015
Association of the mt-ND2 5178A/C polymorphism with Parkinson’s disease.
Neuroscience letters. 587:98-101 [DOI] 10.1016/j.neulet.2014.12.005. [PMID] 25511548.
2015
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.
The Journal of clinical investigation. 125(1):448-55 [DOI] 10.1172/JCI78492. [PMID] 25500887.
2015
Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.
Diabetes. 64(11):3885-90 [DOI] 10.2337/db15-0449. [PMID] 26216853.
2015
Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells.
Journal of proteomics & bioinformatics. 8(6):126-132 [PMID] 26401069.
View on: PubMed
2015
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes. 64(11):3873-84 [DOI] 10.2337/db15-0164. [PMID] 26185279.
2014
In search of a surrogate: engineering human beta cell lines for therapy.
Trends in endocrinology and metabolism: TEM. 25(8):378-80 [DOI] 10.1016/j.tem.2014.05.006. [PMID] 24958526.
2014
Metabolic abnormalities in the pathogenesis of type 1 diabetes.
Current diabetes reports. 14(9) [DOI] 10.1007/s11892-014-0519-8. [PMID] 25023213.
2014
Use of chemical probes to detect mitochondrial ROS by flow cytometry and spectrofluorometry.
Methods in enzymology. 542:223-41 [DOI] 10.1016/B978-0-12-416618-9.00012-1. [PMID] 24862269.
2013
Do β-cells generate peroxynitrite in response to cytokine treatment?
The Journal of biological chemistry. 288(51):36567-78 [DOI] 10.1074/jbc.M113.522243. [PMID] 24194521.
2012
Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes.
The review of diabetic studies : RDS. 9(4):169-87 [DOI] 10.1900/RDS.2012.9.169. [PMID] 23804259.
2012
Inherited β-cell dysfunction in lean individuals with type 2 diabetes.
Diabetes. 61(7):1659-60 [DOI] 10.2337/db12-0373. [PMID] 22723272.
2012
The use of leptin as treatment for type 1 diabetes mellitus: counterpoint.
Pediatric diabetes. 13(1):74-6 [DOI] 10.1111/j.1399-5448.2011.00796.x. [PMID] 21884562.
2012
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Journal of immunology (Baltimore, Md. : 1950). 188(8):4113-21 [DOI] 10.4049/jimmunol.1103113. [PMID] 22422888.
2012
Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines.
European journal of clinical investigation. 42(11):1244-51 [DOI] 10.1111/j.1365-2362.2012.02711.x. [PMID] 22924552.
2012
Oxidative stress and beta cell dysfunction.
Methods in molecular biology (Clifton, N.J.). 900:347-62 [DOI] 10.1007/978-1-60761-720-4_17. [PMID] 22933078.
2011
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.
Infection and immunity. 79(7):2746-54 [DOI] 10.1128/IAI.01291-10. [PMID] 21518789.
2011
The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes.
Diabetologia. 54(9):2232-6 [DOI] 10.1007/s00125-011-2244-z. [PMID] 21773685.
2011
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Journal of immunology (Baltimore, Md. : 1950). 186(1):195-202 [DOI] 10.4049/jimmunol.1002104. [PMID] 21106855.
2011
Role of genetics in resistance to type 1 diabetes.
Diabetes/metabolism research and reviews. 27(8):849-53 [DOI] 10.1002/dmrr.1260. [PMID] 22069272.
2011
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.
Diabetes. 60(8):2086-91 [DOI] 10.2337/db11-0373. [PMID] 21659497.
2011
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.
Diabetes. 60(8):2144-51 [DOI] 10.2337/db10-1222. [PMID] 21715554.
2011
mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic β-cell.
Diabetes. 60(1):355-9 [DOI] 10.2337/db10-1241. [PMID] 20980458.
2011
Methods to assess beta cell death mediated by cytotoxic T lymphocytes.
Journal of visualized experiments : JoVE. (52) [DOI] 10.3791/2724. [PMID] 21712795.
2011
Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts.
Molecular genetics and metabolism. 104(3):255-60 [DOI] 10.1016/j.ymgme.2011.07.023. [PMID] 21846590.
2011
Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.
Biochimica et biophysica acta. 1812(11):1532-41 [DOI] 10.1016/j.bbadis.2011.07.016. [PMID] 21839170.
2011
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.
Journal of immunology (Baltimore, Md. : 1950). 187(2):911-8 [DOI] 10.4049/jimmunol.1100588. [PMID] 21690321.
2011
Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.
PloS one. 6(6) [DOI] 10.1371/journal.pone.0020617. [PMID] 21738580.
2010
Attacking the source: anti-PDX-1 responses in type 1 diabetes.
Laboratory investigation; a journal of technical methods and pathology. 90(1):6-8 [DOI] 10.1038/labinvest.2009.121. [PMID] 20038945.
2010
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.
Journal of immunology (Baltimore, Md. : 1950). 185(9):5247-58 [DOI] 10.4049/jimmunol.1001472. [PMID] 20881184.
2010
Use of nonobese diabetic mice to understand human type 1 diabetes.
Endocrinology and metabolism clinics of North America. 39(3):541-61 [DOI] 10.1016/j.ecl.2010.05.001. [PMID] 20723819.
2009
Chapter 24 Quantification, localization, and tissue specificities of mouse mitochondrial reactive oxygen species production.
Methods in enzymology. 456:439-57 [DOI] 10.1016/S0076-6879(08)04424-8. [PMID] 19348903.
2009
Evaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter.
Cloning and stem cells. 11(2):245-57 [DOI] 10.1089/clo.2008.0074. [PMID] 19508115.
2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes. 58(10):2277-84 [DOI] 10.2337/db09-0557. [PMID] 19628781.
2009
MerTK regulates thymic selection of autoreactive T cells.
Proceedings of the National Academy of Sciences of the United States of America. 106(12):4810-5 [DOI] 10.1073/pnas.0900683106. [PMID] 19251650.
2009
Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice.
Circulation research. 105(3):287-94 [DOI] 10.1161/CIRCRESAHA.109.193995. [PMID] 19423844.
2008
Role of increased ROS dissipation in prevention of T1D.
Annals of the New York Academy of Sciences. 1150:157-66 [DOI] 10.1196/annals.1447.045. [PMID] 19120287.
2008
mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III.
The Journal of biological chemistry. 283(16):10690-7 [DOI] 10.1074/jbc.M708801200. [PMID] 18281288.
2008
Commonalities of genetic resistance to spontaneous autoimmune and free radical–mediated diabetes.
Free radical biology & medicine. 45(9):1263-70 [DOI] 10.1016/j.freeradbiomed.2008.07.020. [PMID] 18718526.
2008
MerTK is required for apoptotic cell-induced T cell tolerance.
The Journal of experimental medicine. 205(1):219-32 [DOI] 10.1084/jem.20062293. [PMID] 18195070.
2007
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.
Blood. 109(2):653-60 [PMID] 17008547.
View on: PubMed
2007
Autoreactive T-cell responses: new technology in pursuit of an old nemesis.
Pediatric diabetes. 8(5):249-51 [PMID] 17850466.
View on: PubMed
2007
Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species production.
The Journal of biological chemistry. 282(8):5171-9 [PMID] 17189252.
View on: PubMed
2006
HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950). 176(5):3257-65 [PMID] 16493087.
View on: PubMed
2006
Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility.
Diabetes. 55(12):3455-62 [PMID] 17130492.
View on: PubMed
2005
DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice.
Gene therapy. 12(23):1679-85 [PMID] 16107864.
View on: PubMed
2005
Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex.
Diabetes. 54(5):1603-6 [PMID] 15855353.
View on: PubMed
2005
Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction.
Journal of immunology (Baltimore, Md. : 1950). 175(2):1248-56 [PMID] 16002729.
View on: PubMed
2005
mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes.
Diabetologia. 48(2):261-7 [PMID] 15692809.
View on: PubMed
2005
Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.
The Journal of biological chemistry. 280(16):15727-34 [PMID] 15705591.
View on: PubMed
2005
Utility of murine models for the study of spontaneous autoimmune type 1 diabetes.
Pediatric diabetes. 6(3):165-77 [PMID] 16109074.
View on: PubMed
2004
Generation, maintenance, and adoptive transfer of diabetogenic T-cell lines/clones from the nonobese diabetic mouse.
Methods in molecular medicine. 102:213-25 [PMID] 15286388.
View on: PubMed
2004
ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential.
Diabetes. 53 Suppl 1:S125-9 [PMID] 14749277.
View on: PubMed
2003
Reduced thymic expression of islet antigen contributes to loss of self-tolerance.
Annals of the New York Academy of Sciences. 1005:412-7 [PMID] 14679103.
View on: PubMed
2003
Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.
Immunogenetics. 55(7):491-6 [PMID] 14513297.
View on: PubMed
2002
Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice.
Free radical biology & medicine. 32(8):744-51 [PMID] 11937300.
View on: PubMed
2002
New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.
Transplantation. 73(8):1333-6 [PMID] 11981430.
View on: PubMed
2002
Rodent models for the study of type 2 diabetes in children (juvenile diabesity).
Pediatric diabetes. 3(3):163-73 [PMID] 15016157.
View on: PubMed
2001
Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants.
Proceedings of the National Academy of Sciences of the United States of America. 98(1):235-40 [PMID] 11136257.
View on: PubMed
2000
Reevaluation of the major histocompatibility complex genes of the NOD-progenitor CTS/Shi strain.
Diabetes. 49(1):131-4 [PMID] 10615961.
View on: PubMed
1999
Constitutive differences in antioxidant defense status distinguish alloxan-resistant and alloxan-susceptible mice.
Free radical biology & medicine. 27(3-4):449-55 [PMID] 10468221.
View on: PubMed
1999
MHC characterization of ALR and ALS mice: respective similarities to the NOD and NON strains.
Immunogenetics. 49(7-8):722-6 [PMID] 10369935.
View on: PubMed
1999
Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.
Diabetes. 48(11):2189-96 [PMID] 10535453.
View on: PubMed
1999
Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.
Diabetes. 48(3):543-51 [PMID] 10078554.
View on: PubMed

Grants

Sep 2020 ACTIVE
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
Role: Principal Investigator
Funding: UNIV OF ALABAMA BIRMINGHAM via NATL INST OF HLTH NIDDK
Sep 2020 ACTIVE
Engineered tolerogenic exosomes for treating type 1 diabetes autoimmunity
Role:
Funding: NATL INST OF HLTH NIDDK
Feb 2020 ACTIVE
Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes
Role: Principal Investigator
Funding: BATTELLE MEMORIAL INST via NATL INST OF HLTH NIDDK
Sep 2019 ACTIVE
Evaluation of safety, tolerability and immunological responses to Lactobacillus johnsonii N6.2 supplementation in adults with Diabetes type 1
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Aug 2019 ACTIVE
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
Role:
Funding: NATL INST OF HLTH NIDDK
Jan 2019 ACTIVE
The Role of IFN? supplementation in T cell effector function in Patients with Chronic Granulomatous Disease
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via HORIZON THERAPEUTICS
Apr 2018 ACTIVE
Network for Pancreatic Organ Donors – nPOD
Role:
Funding: JDRF
Apr 2017 ACTIVE
Metabolic Origins of Nonalcoholic Steatohepatitis
Role: Principal Investigator
Funding: UNIV OF MARYLAND via NATL INST OF HLTH NIDDK
Apr 2017 ACTIVE
Advanced Liver 3-D Tissue Models for Drug Development Applications to Support Toxicology, Drug Metabolism, Target ID & Pharmacology
Role: Project Manager
Funding: ADV REGENERATIVE MANUFACTURING INST via US ARMY RESEARCH LABORATORY
Oct 2016 – Jun 2019
Serum protein biomarkers for predicting type 1 diabetes development
Role: Principal Investigator
Funding: PACIFIC NW NATL LAB via NATL INST OF HLTH NIDDK
Aug 2016 – Jul 2019
Insulin Specific T and B cells in Type 1 Diabetes
Role: Principal Investigator
Funding: UNIVERSITY OF COLORADO DENVER via NATL INST OF HLTH NIDDK
May 2015 – May 2019
Type 1 IFN in Type 1 Diabetes: Influencing Beta-Cell and CD8+ T cell interactions
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2015 – May 2017
Therapeutic Targeting of immune metabolism
Role: Project Manager
Funding: UF DIV OF SPONSORED RESEARCH
Jan 2015 – Aug 2018
Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
Role: Principal Investigator
Funding: PACIFIC NW NATL LAB via NATL INST OF HLTH NIDDK
Jan 2015 – Dec 2017
Mechanisms of Type 1 Diabetes Remission Induced by Combination Therapy
Role: Principal Investigator
Funding: AMER DIABETES ASSOCIATION
Sep 2014 – Jun 2019
Genetic Regulation of Human Beta Cell Destruction
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2014 – Aug 2018
Defining Islet Heterogeneity Using Single Islet Transcriptomics
Role:
Funding: UNIV OF TENNESSEE via NATL INST OF HLTH NIDDK
Jun 2012 – May 2017
mt-Nd2 and Resistance to Autoimmune Diseases
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Apr 2011 ACTIVE
Sebastian Family Chair in Diabetes Research
Role: Principal Investigator
Funding: UF FOU

Teaching Profile

Courses Taught
2020
GMS6143 Cells of the Innate Immune System
2008-2020
GMS5905 Special Topics in Biomedical Sciences
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
MCB7979 Advanced Research
2018
BME7980 Research for Doctoral Dissertation
2015-2017
GMS6895 CTS Journal Club
2014
GMS6140 Principles of Immunology
2012
GMS6382 Special Topics in Immunology
2010
IDH4917 Undergrad Research
2010
GMS6921 Immunology/Microbiology Journal Colloquy

Contact Details

Phones:
Business:
(352) 273-9269
Emails:
Business:
cxm@ufl.edu