Karen McFarland,
Assistant Scientist
Department:
MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone:
(352) 273-9554
Business Email:
karen.mcfarland@neurology.ufl.edu
Teaching Profile
Courses Taught
2019
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-9952-8678
Publications
2024
Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
[DOI] 10.1002/alz.13693.
[PMID] 38441274.
2024
Plasma Alzheimer’s biomarkers and brain amyloid in Hispanic and non-Hispanic older adults.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
20(1):437-446
[DOI] 10.1002/alz.13456.
[PMID] 37671801.
2023
A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies.
Molecular therapy. Methods & clinical development.
31
[DOI] 10.1016/j.omtm.2023.101146.
[PMID] 38027063.
2023
Clinical utility of plasma Aβ42/40 ratio by LC-MS/MS in Alzheimer’s disease assessment.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2023.12.12.23299878.
[PMID] 38168329.
2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications.
11(1)
[DOI] 10.1186/s40478-023-01581-2.
[PMID] 37337279.
2023
Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive.
Frontiers in neurology.
14
[DOI] 10.3389/fneur.2023.1179205.
[PMID] 37602238.
2022
Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation.
Neuropathology and applied neurobiology.
48(2)
[DOI] 10.1111/nan.12779.
[PMID] 34825397.
2022
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.
Alzheimer's research & therapy.
14(1)
[DOI] 10.1186/s13195-022-01044-1.
[PMID] 35897046.
2022
Impact of APOE genotype on prion-type propagation of tauopathy.
Acta neuropathologica communications.
10(1)
[DOI] 10.1186/s40478-022-01359-y.
[PMID] 35440098.
2022
MhcII Regulates Transmission of α-Synuclein-Seeded Pathology in Mice.
International journal of molecular sciences.
23(15)
[DOI] 10.3390/ijms23158175.
[PMID] 35897751.
2022
Microglia in Alzheimer’s Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
19(1):186-208
[DOI] 10.1007/s13311-021-01179-3.
[PMID] 35286658.
2021
Il-10 signaling reduces survival in mouse models of synucleinopathy.
NPJ Parkinson's disease.
7(1)
[DOI] 10.1038/s41531-021-00169-8.
[PMID] 33741985.
2021
Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer’s disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
17(6):984-1004
[DOI] 10.1002/alz.12254.
[PMID] 33480174.
2021
Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo
Life Science Alliance.
4(7)
[DOI] 10.26508/lsa.202101108.
[PMID] 34127518.
2021
Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.
Molecular neurodegeneration.
16(1)
[DOI] 10.1186/s13024-021-00453-4.
[PMID] 33957936.
2021
Utility of Plasma Neurofilament Light in the 1Florida Alzheimer’s Disease Research Center (ADRC).
Journal of Alzheimer's disease : JAD.
79(1):59-70
[DOI] 10.3233/JAD-200901.
[PMID] 33216030.
2020
Correction: Pulse-Field capillary electrophoresis of repeat-primed PCR amplicons for analysis of large repeats in Spinocerebellar Ataxia Type 10.
PloS one.
15(4)
[DOI] 10.1371/journal.pone.0231746.
[PMID] 32298361.
2020
Founder Effects of Spinocerebellar Ataxias in the American Continents and the Caribbean.
Cerebellum (London, England).
19(3):446-458
[DOI] 10.1007/s12311-020-01109-7.
[PMID] 32086717.
2020
Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease.
Acta neuropathologica communications.
8(1)
[DOI] 10.1186/s40478-020-0891-3.
[PMID] 32164763.
2020
Pulse-Field capillary electrophoresis of repeat-primed PCR amplicons for analysis of large repeats in Spinocerebellar Ataxia Type 10.
PloS one.
15(3)
[DOI] 10.1371/journal.pone.0228789.
[PMID] 32160188.
2019
Olfactory Function in SCA10.
Cerebellum (London, England).
18(1):85-90
[DOI] 10.1007/s12311-018-0954-1.
[PMID] 29922950.
2019
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression.
Acta neuropathologica communications.
7(1)
[DOI] 10.1186/s40478-019-0787-2.
[PMID] 31477175.
2018
Intron retention induced by microsatellite expansions as a disease biomarker.
Proceedings of the National Academy of Sciences of the United States of America.
115(16):4234-4239
[DOI] 10.1073/pnas.1716617115.
[PMID] 29610297.
2017
Correction to: SPG7 and Impaired Emotional Communication.
Cerebellum (London, England).
16(5-6)
[DOI] 10.1007/s12311-017-0901-6.
[PMID] 29181771.
2017
Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions
PLOS ONE.
12(4)
[DOI] 10.1371/journal.pone.0175958.
[PMID] 28423040.
2017
Parkinson Disease and Autoimmune Disorders-What Can We Learn From Genome-wide Pleiotropy?
JAMA neurology.
74(7):769-770
[DOI] 10.1001/jamaneurol.2017.0843.
[PMID] 28586798.
2017
Parkinson’s disease associated with pure ATXN10 repeat expansion.
NPJ Parkinson's disease.
3
[DOI] 10.1038/s41531-017-0029-x.
[PMID] 28890930.
2017
SPG7 and Impaired Emotional Communication.
Cerebellum (London, England).
16(2):595-598
[DOI] 10.1007/s12311-016-0818-5.
[PMID] 27557734.
2016
A case report of SPG11 mutations in a Chinese ARHSP-TCC family.
BMC neurology.
16
[DOI] 10.1186/s12883-016-0604-5.
[PMID] 27256065.
2015
ADAR2-dependent GluA2 editing regulates cocaine seeking.
Molecular psychiatry.
20(11):1460-6
[DOI] 10.1038/mp.2014.134.
[PMID] 25349168.
2015
SMRT Sequencing of Long Tandem Nucleotide Repeats in SCA10 Reveals Unique Insight of Repeat Expansion Structure.
PloS one.
10(8)
[DOI] 10.1371/journal.pone.0135906.
[PMID] 26295943.
2015
Spinocerebellar ataxia type 10 in Chinese Han.
Neurology. Genetics.
1(3)
[DOI] 10.1212/NXG.0000000000000026.
[PMID] 27066563.
2014
Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.
Cerebellum (London, England).
13(2):269-302
[DOI] 10.1007/s12311-013-0539-y.
[PMID] 24307138.
2014
MeCP2: a novel Huntingtin interactor.
Human molecular genetics.
23(4):1036-44
[DOI] 10.1093/hmg/ddt499.
[PMID] 24105466.
2014
Repeat interruptions in spinocerebellar ataxia type 10 expansions are strongly associated with epileptic seizures.
Neurogenetics.
15(1):59-64
[DOI] 10.1007/s10048-013-0385-6.
[PMID] 24318420.
2014
Spinocerebellar ataxia type 10 in Peru: the missing link in the Amerindian origin of the disease.
Journal of neurology.
261(9):1691-4
[DOI] 10.1007/s00415-014-7394-8.
[PMID] 24935856.
2013
Expansion of the Spinocerebellar ataxia type 10 (SCA10) repeat in a patient with Sioux Native American ancestry.
PloS one.
8(11)
[DOI] 10.1371/journal.pone.0081342.
[PMID] 24278426.
2013
Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington’s disease.
Journal of Huntington's disease.
2(3):263-77
[DOI] 10.3233/JHD-130066.
[PMID] 25062675.
2013
Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability.
European journal of human genetics : EJHG.
21(11):1272-6
[DOI] 10.1038/ejhg.2013.32.
[PMID] 23443018.
2013
Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10.
Journal of neurology, neurosurgery, and psychiatry.
84(12):1409-11
[DOI] 10.1136/jnnp-2013-305080.
[PMID] 23813740.
2012
Characterization of Sequence Interruptions in Attct Repeat Expansions in Sca10
.
78
2012
Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington’s disease.
PloS one.
7(7)
[DOI] 10.1371/journal.pone.0041423.
[PMID] 22848491.
2012
Olfactory impairment in familial ataxias.
Journal of neurology, neurosurgery, and psychiatry.
83(10):970-4
[DOI] 10.1136/jnnp-2012-302770.
[PMID] 22791905.
2012
To Investigate Olfactory Impairment in Cerebellar Ataxia
.
78
2012
Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: a toxic RNA gain-of-function model.
Journal of neuroscience research.
90(3):706-14
[DOI] 10.1002/jnr.22786.
[PMID] 22065565.
2012
Transgenic models of spinocerebellar ataxia type 10: modeling a repeat expansion disorder.
Genes.
3(3):481-491
[DOI] 10.3390/genes3030481.
[PMID] 24533179.
2011
Molecular biology of Huntington’s disease.
Handbook of clinical neurology.
100:25-81
[DOI] 10.1016/B978-0-444-52014-2.00003-3.
[PMID] 21496570.
2008
Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
28(42):10720-33
[DOI] 10.1523/JNEUROSCI.2126-08.2008.
[PMID] 18923047.
2006
Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
26(30):7885-97
[PMID] 16870734.
2005
Genetic locus half baked is necessary for morphogenesis of the ectoderm.
Developmental dynamics : an official publication of the American Association of Anatomists.
233(2):390-406
[PMID] 15768401.
2005
Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly.
Development (Cambridge, England).
132(5):1105-16
[PMID] 15689372.
Grants
Apr 2021
– Feb 2023
Epitranscriptomic changes in models of Alzheimers disease
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Sep 2020
– Aug 2022
A Systems Approach to Targeting Innate Immunity in AD
Role: Co-Investigator
Funding: MAYO CLINIC
via NATL INST OF HLTH NIA
Feb 2020
– Feb 2021
Tau plasma levels and Plasma amyloid tests in AD
Role: Principal Investigator
Funding: QUEST DIAGNOSTICS INC
Aug 2019
– Jul 2022
Immunotherapy targeting the HPA axis in Alzheimers disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2018
– Aug 2020
A Systems Approach to Targeting Innate Immunity in AD
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Aug 2017
– May 2023
PRECEDE: PREsurgical Cognitive Evaluation via Digital clockfacEdrawing
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2016
ACTIVE
Health Disparities in Osteoarthritis: Biological Aging, Stress, and Pain – Modulation by Resilience Factors
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Apr 2016
– Mar 2017
Mechanisms of neurodegeneration in ataxia.
Role: Principal Investigator
Funding: UF FOUNDATION
Education
PhD
1997-2004
·
University of Rochester, Department of Biology, Rochester, NY
BS
1993-1993
·
King's College, Wilkes-Barre, PA
Contact Details
Phones:
- Business:
- (352) 273-9554
Emails:
- Business:
- karen.mcfarland@neurology.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100236
GAINESVILLE FL 32610 - Business Street:
-
BMS, J486
CTRND
1275 Center Drive
Gainesville FL 32610