Karen McFarland

Karen McFarland

Research Assistant Professor

Department: MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone: (352) 273-9554

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9952-8678

Publications

2020
Correction: Pulse-Field capillary electrophoresis of repeat-primed PCR amplicons for analysis of large repeats in Spinocerebellar Ataxia Type 10.
PloS one. 15(4) [DOI] 10.1371/journal.pone.0231746. [PMID] 32298361.
2020
Utility of Plasma Neurofilament Light in the 1Florida Alzheimer’s Disease Research Center (ADRC).
Journal of Alzheimer's disease : JAD. [DOI] 10.3233/JAD-200901. [PMID] 33216030.
2020
Pulse-Field capillary electrophoresis of repeat-primed PCR amplicons for analysis of large repeats in Spinocerebellar Ataxia Type 10.
PloS one. 15(3) [DOI] 10.1371/journal.pone.0228789. [PMID] 32160188.
2020
Founder Effects of Spinocerebellar Ataxias in the American Continents and the Caribbean.
Cerebellum (London, England). 19(3):446-458 [DOI] 10.1007/s12311-020-01109-7. [PMID] 32086717.
2020
Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease.
Acta neuropathologica communications. 8(1) [DOI] 10.1186/s40478-020-0891-3. [PMID] 32164763.
2019
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
The Journal of experimental medicine. 216(11):2479-2491 [DOI] 10.1084/jem.20190430. [PMID] 31467037.
2019
Olfactory Function in SCA10.
Cerebellum (London, England). 18(1):85-90 [DOI] 10.1007/s12311-018-0954-1. [PMID] 29922950.
2019
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression.
Acta neuropathologica communications. 7(1) [DOI] 10.1186/s40478-019-0787-2. [PMID] 31477175.
2018
Intron retention induced by microsatellite expansions as a disease biomarker.
Proceedings of the National Academy of Sciences of the United States of America. 115(16):4234-4239 [DOI] 10.1073/pnas.1716617115. [PMID] 29610297.
2017
Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions.
PloS one. 12(4) [DOI] 10.1371/journal.pone.0175958. [PMID] 28423040.
2017
Parkinson Disease and Autoimmune Disorders-What Can We Learn From Genome-wide Pleiotropy?
JAMA neurology. 74(7):769-770 [DOI] 10.1001/jamaneurol.2017.0843. [PMID] 28586798.
2017
Parkinson’s Disease Associated With Pure Atxn10 Repeat Expansion
NPJ Parkinson's disease. 3 [DOI] 10.1038/s41531-017-0029-x. [PMID] 28890930.
2017
SPG7 and Impaired Emotional Communication.
Cerebellum (London, England). 16(2):595-598 [DOI] 10.1007/s12311-016-0818-5. [PMID] 27557734.
2017
Correction to: SPG7 and Impaired Emotional Communication.
Cerebellum (London, England). 16(5-6) [DOI] 10.1007/s12311-017-0901-6. [PMID] 29181771.
2016
A case report of SPG11 mutations in a Chinese ARHSP-TCC family.
BMC neurology. 16 [DOI] 10.1186/s12883-016-0604-5. [PMID] 27256065.
2015
ADAR2-dependent GluA2 editing regulates cocaine seeking.
Molecular psychiatry. 20(11):1460-6 [DOI] 10.1038/mp.2014.134. [PMID] 25349168.
2015
SMRT Sequencing of Long Tandem Nucleotide Repeats in SCA10 Reveals Unique Insight of Repeat Expansion Structure.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0135906. [PMID] 26295943.
2015
Spinocerebellar ataxia type 10 in Chinese Han.
Neurology. Genetics. 1(3) [DOI] 10.1212/NXG.0000000000000026. [PMID] 27066563.
2014
MeCP2: a novel Huntingtin interactor.
Human molecular genetics. 23(4):1036-44 [DOI] 10.1093/hmg/ddt499. [PMID] 24105466.
2014
Repeat interruptions in spinocerebellar ataxia type 10 expansions are strongly associated with epileptic seizures.
Neurogenetics. 15(1):59-64 [DOI] 10.1007/s10048-013-0385-6. [PMID] 24318420.
2014
Spinocerebellar ataxia type 10 in Peru: the missing link in the Amerindian origin of the disease.
Journal of neurology. 261(9):1691-4 [DOI] 10.1007/s00415-014-7394-8. [PMID] 24935856.
2014
Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.
Cerebellum (London, England). 13(2):269-302 [DOI] 10.1007/s12311-013-0539-y. [PMID] 24307138.
2013
Expansion of the Spinocerebellar ataxia type 10 (SCA10) repeat in a patient with Sioux Native American ancestry.
PloS one. 8(11) [DOI] 10.1371/journal.pone.0081342. [PMID] 24278426.
2013
Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington’s disease.
Journal of Huntington's disease. 2(3):263-77 [DOI] 10.3233/JHD-130066. [PMID] 25062675.
2013
Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability.
European journal of human genetics : EJHG. 21(11):1272-6 [DOI] 10.1038/ejhg.2013.32. [PMID] 23443018.
2013
Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10.
Journal of neurology, neurosurgery, and psychiatry. 84(12):1409-11 [DOI] 10.1136/jnnp-2013-305080. [PMID] 23813740.
2012
Transgenic models of spinocerebellar ataxia type 10: modeling a repeat expansion disorder.
Genes. 3(3):481-91 [DOI] 10.3390/genes3030481. [PMID] 24533179.
2012
Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: a toxic RNA gain-of-function model.
Journal of neuroscience research. 90(3):706-14 [DOI] 10.1002/jnr.22786. [PMID] 22065565.
2012
To Investigate Olfactory Impairment in Cerebellar Ataxia
. 78
2012
Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington’s disease.
PloS one. 7(7) [DOI] 10.1371/journal.pone.0041423. [PMID] 22848491.
2012
Characterization of Sequence Interruptions in Attct Repeat Expansions in Sca10
. 78
2012
Olfactory impairment in familial ataxias.
Journal of neurology, neurosurgery, and psychiatry. 83(10):970-4 [DOI] 10.1136/jnnp-2012-302770. [PMID] 22791905.
2011
Molecular biology of Huntington’s disease.
Handbook of clinical neurology. 100:25-81 [DOI] 10.1016/B978-0-444-52014-2.00003-3. [PMID] 21496570.
2008
Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(42):10720-33 [DOI] 10.1523/JNEUROSCI.2126-08.2008. [PMID] 18923047.
2005
Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly.
Development (Cambridge, England). 132(5):1105-16 [PMID] 15689372.
View on: PubMed

Grants

Sep 2020 ACTIVE
A Systems Approach to Targeting Innate Immunity in AD
Role:
Funding: MAYO CLINIC via NATL INST OF HLTH NIA
Jun 2020 ACTIVE
1Florida Alzheimers Disease Research Center
Role:
Funding: NATL INST OF HLTH NIA
Feb 2020 ACTIVE
Tau plasma levels and Plasma amyloid tests in AD
Role: Principal Investigator
Funding: QUEST DIAGNOSTICS INC
Aug 2019 ACTIVE
Immunotherapy targeting the HPA axis in Alzheimers disease
Role:
Funding: NATL INST OF HLTH NIA
Aug 2019 ACTIVE
Elucidating factors that modulate tauopathy and cellular degeneration to guide therapeutic development
Role:
Funding: NATL INST OF HLTH NIA
Sep 2018 – Aug 2020
A Systems Approach to Targeting Innate Immunity in AD
Role:
Funding: NATL INST OF HLTH NIA
Aug 2017 ACTIVE
PRECEDE: PREsurgical Cognitive Evaluation via Digital clockfacEdrawing
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Apr 2016 – Mar 2017
Mechanisms of neurodegeneration in ataxia.
Role: Principal Investigator
Funding: UF FOU

Education

PhD
1997-2004 · University of Rochester, Department of Biology, Rochester, NY
BS
1993-1993 · King's College, Wilkes-Barre, PA

Teaching Profile

Courses Taught
2019
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles

Contact Details

Phones:
Business:
(352) 273-9554