Brenda Moore

Brenda Moore

Research Assistant Professor

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-9691
Business Email: brendar@ufl.edu

Publications

2020
Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila.
Alzheimer's research & therapy. 12(1) [DOI] 10.1186/s13195-020-00698-z. [PMID] 33069251.
2019
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
The Journal of experimental medicine. 216(11):2479-2491 [DOI] 10.1084/jem.20190430. [PMID] 31467037.
2018
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.
PloS one. 13(4) [DOI] 10.1371/journal.pone.0195211. [PMID] 29608591.
2018
Short Aβ peptides attenuate Aβ42 toxicity in vivo.
The Journal of experimental medicine. 215(1):283-301 [DOI] 10.1084/jem.20170600. [PMID] 29208777.
2018
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease.
The Journal of experimental medicine. 215(9):2247-2264 [DOI] 10.1084/jem.20180484. [PMID] 30158114.
2017
A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.
PloS one. 12(9) [DOI] 10.1371/journal.pone.0184731. [PMID] 28910367.
2017
Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.
Acta neuropathologica communications. 5(1) [DOI] 10.1186/s40478-017-0458-0. [PMID] 28760159.
2014
Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.
Journal of neurochemistry. 131(6):859-67 [DOI] 10.1111/jnc.12806. [PMID] 24984882.
2013
Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis.
Human molecular genetics. 22(14):2765-74 [DOI] 10.1093/hmg/ddt121. [PMID] 23512986.
2013
Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3765-79 [DOI] 10.1523/JNEUROSCI.4251-12.2013. [PMID] 23447589.
2013
Steroids as γ-secretase modulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(9):3775-85 [DOI] 10.1096/fj.12-225649. [PMID] 23716494.
2012
Overlapping profiles of Aβ peptides in the Alzheimer’s disease and pathological aging brains.
Alzheimer's research & therapy. 4(3) [DOI] 10.1186/alzrt121. [PMID] 22621179.
2012
Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).
The Journal of biological chemistry. 287(48):40629-40 [DOI] 10.1074/jbc.M112.418442. [PMID] 23043097.
2011
Lysine 624 of the Amyloid Precursor Protein (App) Is a Critical Determinant of Amyloid Beta Peptide Length Support for a Sequential Model of Gamma-Secretase Intramembrane Proteolysis and Regulation By the Amyloid Beta Precursor Protein (App) Juxtamembrane Region
Journal of Biological Chemistry. 286(46):39804-39812 [DOI] 10.1074/jbc.M111.274696. [PMID] 21868378.
2009
Biophysical analyses of synthetic amyloid-beta(1-42) aggregates before and after covalent cross-linking. Implications for deducing the structure of endogenous amyloid-beta oligomers.
Biochemistry. 48(49):11796-806 [DOI] 10.1021/bi901571t. [PMID] 19916493.
2009
Rationally designed dehydroalanine (DeltaAla)-containing peptides inhibit amyloid-beta (Abeta) peptide aggregation.
Biopolymers. 91(6):456-65 [DOI] 10.1002/bip.21151. [PMID] 19189374.
2008
BRI2 (ITM2b) inhibits Abeta deposition in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(23):6030-6 [DOI] 10.1523/JNEUROSCI.0891-08.2008. [PMID] 18524908.
2007
Amyloid-beta(1-42) rapidly forms protofibrils and oligomers by distinct pathways in low concentrations of sodium dodecylsulfate.
Biochemistry. 46(43):12451-62 [PMID] 17910477.
View on: PubMed
2006
Secondary structure and interfacial aggregation of amyloid-beta(1-40) on sodium dodecyl sulfate micelles.
Biochemistry. 45(28):8639-48 [PMID] 16834338.
View on: PubMed

Grants

Dec 2016 – Nov 2019
Is there a form of benign brain amyloidosis in aging?
Role:
Funding: NATL INST OF HLTH NIA
Aug 2015 ACTIVE
University of Florida – Mt. Sinai Medical Center AD Research Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA

Contact Details

Phones:
Business:
(352) 273-9691
Emails:
Business:
brendar@ufl.edu