Stefan Prokop

Stefan Prokop, M.D.

AST PROF

Department: MD-PATHOLOGY-GENERAL
Business Phone: (352) 294-5781
Business Email: sprokop@ufl.edu

About Stefan Prokop

Stefan Prokop, M.D. joined the University of Florida in July 2019 from the University of Pennsylvania. Dr. Prokop serves as the director of the UF Neuromedicine Human Brain and Tissue bank (UF HBTB) and core leader for the Neuropathology core of the 1Florida Alzheimer’s disease research center (ADRC). He is also a Fixel scholar with the newly formed Norman Fixel Institute for Neurological Diseases. Dr. Prokop interfaces between clinical neuropathology with a focus on brain autopsies and research activities in the Center for Translational Research in Neurodegenerative Diseases (CTRND), the 1Florida ADRC and the Fixel Institute for Neurological diseases.

Prior to joining UF Dr. Prokop completed Neuropathology training in Switzerland and Germany and practiced for several years at the Charite Medical University in Berlin, one of the largest academic Neuropathology centers in Europe. He subsequently completed training in Anatomic Pathology and Neuropathology at the University of Pennsylvania, where he also served as a research fellow in the Center for Neurodegenerative Disease Research (CNDR).

Board Certifications

  • Anatomic Pathology
    American Board of Pathology
  • Neuropathology
    American Board of Pathology
  • Neuropathology
    Swiss Medical Society (FMH)

Clinical Profile

Specialties
  • Pathology, Immunology and Laboratory Medicine
Subspecialties
  • Anatomic Pathology
  • Neuropathology
Areas of Interest
  • Alzheimer disease
  • Dementia
  • Frontotemporal dementia
  • Parkinson disease

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-5633-2149

Areas of Interest
  • Alzheimer’s disease
  • Microglia
  • Neuroimmune interactions in Neurodegenerative diseases
  • Neuropathology of Neurodegenerative diseases
  • Parkinson’s disease

Publications

2020
Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.
Journal of neuropathology and experimental neurology. 79(4):407-418 [DOI] 10.1093/jnen/nlaa007. [PMID] 32106300.
2020
The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-63989-3. [PMID] 32346002.
2020
Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies.
Acta neuropathologica communications. 8(1) [DOI] 10.1186/s40478-020-00967-w. [PMID] 32571418.
2020
Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein.
Neuroscience letters. 738 [DOI] 10.1016/j.neulet.2020.135353. [PMID] 32905837.
2020
Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease.
Acta neuropathologica communications. 8(1) [DOI] 10.1186/s40478-020-0891-3. [PMID] 32164763.
2019
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples
Acta Neuropathologica. 138(4):613-630
2019
Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology.
Acta neuropathologica communications. 7(1) [DOI] 10.1186/s40478-019-0818-z. [PMID] 31665069.
2019
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples.
Acta neuropathologica. 138(4):613-630 [DOI] 10.1007/s00401-019-02048-2. [PMID] 31350575.
2019
Neuroimmune interactions in Alzheimer’s disease-New frontier with old challenges?
Progress in molecular biology and translational science. 168:183-201 [DOI] 10.1016/bs.pmbts.2019.10.002. [PMID] 31699314.
2017
Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice.
Acta neuropathologica communications. 5(1) [DOI] 10.1186/s40478-017-0453-5. [PMID] 28646899.
2016
High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia.
Acta neuropathologica. 132(3):361-75 [DOI] 10.1007/s00401-016-1595-4. [PMID] 27393312.
2016
Conserved size and periodicity of pyramidal patches in layer 2 of medial/caudal entorhinal cortex.
The Journal of comparative neurology. 524(4):783-806 [DOI] 10.1002/cne.23865. [PMID] 26223342.
2015
An azide functionalized oligothiophene ligand–a versatile tool for multimodal detection of disease associated protein aggregates.
Biosensors & bioelectronics. 63:204-211 [DOI] 10.1016/j.bios.2014.07.042. [PMID] 25089818.
2015
Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease-like mice.
The Journal of experimental medicine. 212(11):1811-8 [DOI] 10.1084/jem.20150479. [PMID] 26458768.
2015
Lymphocytes modulate innate immune responses and neuronal damage in experimental meningitis.
Infection and immunity. 83(1):259-67 [DOI] 10.1128/IAI.02682-14. [PMID] 25348636.
2015
The most fulminant course of the Marburg variant of multiple sclerosis-autopsy findings
Multiple Sclerosis Journal. 21(4):485-487 [DOI] 10.1177/1352458514537366. [PMID] 25824955.
2014
Novel γ-sarcoglycan-mutation affects cardiac function and N-terminal dystrophin expression.
Muscle & nerve. 49(1):144-5 [DOI] 10.1002/mus.23981. [PMID] 23929688.
2014
Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.
The Journal of biological chemistry. 289(29):20182-91 [DOI] 10.1074/jbc.M114.564690. [PMID] 24878959.
2013
Cellular origin and diagnostic significance of high-fluorescent cells in cerebrospinal fluid detected by the XE-5000 hematology analyzer
International Journal of Laboratory Hematology. 35(6):580-588 [DOI] 10.1111/ijlh.12090. [PMID] 23551597.
2013
Enhanced fluorescent assignment of protein aggregates by an oligothiophene-porphyrin-based amyloid ligand.
Macromolecular rapid communications. 34(9):723-30 [DOI] 10.1002/marc.201200817. [PMID] 23468206.
2013
Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits.
ACS chemical biology. 8(6):1128-33 [DOI] 10.1021/cb4000376. [PMID] 23521783.
2013
Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies.
Chembiochem : a European journal of chemical biology. 14(5):607-16 [DOI] 10.1002/cbic.201200731. [PMID] 23450708.
2013
Microglia actions in Alzheimer’s disease.
Acta neuropathologica. 126(4):461-77 [PMID] 24224195.
View on: PubMed
2013
Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology.
PloS one. 8(4) [DOI] 10.1371/journal.pone.0060921. [PMID] 23577177.
2012
Inhibition of IL-12/IL-23 signaling reduces Alzheimer’s disease-like pathology and cognitive decline.
Nature medicine. 18(12):1812-9 [DOI] 10.1038/nm.2965. [PMID] 23178247.
2011
Atypical prion protein conformation in familial prion disease with PRNP P105T mutation.
Brain pathology (Zurich, Switzerland). 21(2):209-14 [DOI] 10.1111/j.1750-3639.2010.00439.x. [PMID] 20875062.
2011
Comparison of immunosorbent assays for the quantification of biomarkers for Alzheimer’s disease in human cerebrospinal fluid
Dementia and Geriatric Cognitive Disorders. 31(2):139-145 [DOI] 10.1159/000322588. [PMID] 21304219.
2011
Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.
PLoS pathogens. 7(9) [DOI] 10.1371/journal.ppat.1002233. [PMID] 21909276.
2011
Long-term stability of Alzheimer’s disease biomarker proteins in cerebrospinal fluid
Journal of Alzheimers Disease. 26(2):255-262 [DOI] 10.3233/JAD-2011-110329. [PMID] 21606567.
2011
Long-term stability of Alzheimer’s disease biomarker proteins in cerebrospinal fluid.
Journal of Alzheimer's disease : JAD. 26(2):255-62 [DOI] 10.3233/JAD-2011-110329. [PMID] 21606567.
2011
M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis.
The American journal of pathology. 178(3):1279-86 [DOI] 10.1016/j.ajpath.2010.11.065. [PMID] 21356378.
2010
Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation.
Neuromuscular disorders : NMD. 20(8):531-3 [DOI] 10.1016/j.nmd.2010.06.008. [PMID] 20621480.
2009
Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia.
Nature neuroscience. 12(11):1361-3 [DOI] 10.1038/nn.2432. [PMID] 19838177.
2009
Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.
ACS chemical biology. 4(8):673-84 [DOI] 10.1021/cb900112v. [PMID] 19624097.
2009
[Amyloidoses in neuropathology]
Der Pathologe. 30(3):193-196 [DOI] 10.1007/s00292-009-1131-6. [PMID] 19340430.
2005
Gamma-secretase complex assembly within the early secretory pathway.
The Journal of biological chemistry. 280(8):6471-8 [PMID] 15591316.
View on: PubMed
2005
Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Journal of neurochemistry. 94(1):57-62 [PMID] 15953349.
View on: PubMed
2004
Identification of distinct gamma-secretase complexes with different APH-1 variants.
The Journal of biological chemistry. 279(40):41340-5 [PMID] 15286082.
View on: PubMed
2004
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.
The Journal of biological chemistry. 279(22):23255-61 [PMID] 15039426.
View on: PubMed
2002
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
The Journal of biological chemistry. 277(42):39062-5 [PMID] 12198112.
View on: PubMed

Grants

Jan 2020 ACTIVE
Innate immune profiling in Lewy body dementia
Role: Principal Investigator
Funding: UF FOU

Education

Neuropathology Fellowship
2019 · University of Pennsylvania
Anatomic Pathology Residency
2017 · University of Pennsylvania
Neuropathology Residency
2011 · Charite Medical University Berlin
Neuropathology Residency
2008 · University of Zurich
Medical Degree
2005 · Ludwig-Maximilians-University Munich

Teaching Profile

Courses Taught
2019-2020
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
2019
GMS7794 Neuroscience Seminar

Contact Details

Phones:
Business:
(352) 294-5781
Emails:
Business:
sprokop@ufl.edu