Yong Ran

Yong Ran

Research Assistant Professor

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-9690
Business Email: yran@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9748-4392

Publications

2020
CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.00735. [PMID] 32457739.
2020
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Alzheimer's research & therapy. 12(1) [DOI] 10.1186/s13195-020-00622-5. [PMID] 32430033.
2019
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
The Journal of experimental medicine. 216(11):2479-2491 [DOI] 10.1084/jem.20190430. [PMID] 31467037.
2019
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
The Journal of biological chemistry. 294(29):11276-11285 [DOI] 10.1074/jbc.RA119.008041. [PMID] 31167792.
2018
High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
EMBO molecular medicine. 10(11) [DOI] 10.15252/emmm.201809027. [PMID] 30341064.
2018
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.
PloS one. 13(4) [DOI] 10.1371/journal.pone.0195211. [PMID] 29608591.
2018
Short Aβ peptides attenuate Aβ42 toxicity in vivo.
The Journal of experimental medicine. 215(1):283-301 [DOI] 10.1084/jem.20170600. [PMID] 29208777.
2017
A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.
PloS one. 12(9) [DOI] 10.1371/journal.pone.0184731. [PMID] 28910367.
2017
γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.
EMBO molecular medicine. 9(7):950-966 [DOI] 10.15252/emmm.201607265. [PMID] 28539479.
2015
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.
Molecular neurodegeneration. 10 [DOI] 10.1186/s13024-015-0021-z. [PMID] 26169917.
2015
Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.
PloS one. 10(6) [DOI] 10.1371/journal.pone.0128619. [PMID] 26046535.
2015
Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.
Acta neuropathologica communications. 3 [DOI] 10.1186/s40478-015-0252-9. [PMID] 26566997.
2015
The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity.
The EMBO journal. 34(12):1674-86 [DOI] 10.15252/embj.201488795. [PMID] 25964433.
2014
Characterizing solution surface loop conformational flexibility of the GM2 activator protein.
The journal of physical chemistry. B. 118(36):10607-17 [DOI] 10.1021/jp505938t. [PMID] 25127419.
2014
Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.
PloS one. 9(10) [DOI] 10.1371/journal.pone.0111553. [PMID] 25350374.
2014
γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.
The Journal of biological chemistry. 289(6):3276-87 [DOI] 10.1074/jbc.M113.512921. [PMID] 24352661.
2014
Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.
Biochemistry. 53(12):1947-57 [DOI] 10.1021/bi401521t. [PMID] 24620716.
2013
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.
Acta neuropathologica communications. 1 [DOI] 10.1186/2051-5960-1-38. [PMID] 24252149.
2012
Shifting a complex debate on γ-secretase cleavage and Alzheimer’s disease.
The EMBO journal. 31(10):2237-9 [DOI] 10.1038/emboj.2012.111. [PMID] 22505028.
2009
Interactions of the GM2 activator protein with phosphatidylcholine bilayers: a site-directed spin-labeling power saturation study.
Biophysical journal. 97(5):1436-44 [DOI] 10.1016/j.bpj.2009.05.058. [PMID] 19720032.
2009
Ligand extraction properties of the GM2 activator protein and its interactions with lipid vesicles.
Biophysical journal. 97(1):257-66 [DOI] 10.1016/j.bpj.2009.03.065. [PMID] 19580763.
2008
A dansyl fluorescence-based assay for monitoring kinetics of lipid extraction and transfer.
Analytical biochemistry. 382(2):132-4 [DOI] 10.1016/j.ab.2008.07.022. [PMID] 18694718.
2008
Anyl 105-Fluorescence Resonance Energy Transfer (Fret) Studies of the Effects of Popc Vesicle Size On Gm2-Activator Protein Binding
. 235
2008
Biol 21-Characterization of the Interactions of the Gm2 Activator Protein With Bilayer Membrane Surfaces
. 235
2008
Biol 230-Membrane Binding and Dissociation Kinetics of Gm2 Activator Protein
. 235
2008
StAR-like activity and molten globule behavior of StARD6, a male germ-line protein.
Biochemistry. 47(8):2277-88 [DOI] 10.1021/bi701966a. [PMID] 18211099.

Contact Details

Phones:
Business:
(352) 273-9690
Emails:
Business:
yran@ufl.edu