Sruti Rayaprolu, PhD

In 2018, Sruti Rayaprolu received her PhD in Biomedical Sciences, focused in Neuroscience, at the University of Florida COM. Her graduate work aimed at developing and characterizing animal models of Atypical Parkinson’s disease and ALS. Following this, she pursued a postdoctoral fellowship at Emory University where she investigated the cellular mechanisms of Alzheimer’s disease by isolating specific cell-types (glia, endothelial cells, oligodendrocytes) from human and mouse brain and performing mass spectrometry-based proteomics. She also developed a novel mouse model (Rosa-TurboID) that can be used to capture a snapshot of the cellular proteome of a specific brain cell type while retaining their native state. Using this model, she has successfully defined the proteome of excitatory neurons and astrocytes within the mouse brain. Subsequently, Sruti transitioned to the biotechnology sector where she led the design and execution of pivotal experiments to assess the feasibility, efficacy, and safety of AAV gene therapies in preclinical models of inherited retinal diseases. Sruti’s hobbies include raising chickens, spending time with her two kids and husband, learning how to garden, and watching The Sopranos.