Matthew R Sarkisian

Matthew R Sarkisian

Associate Professor, Program Director MS In Neuroscience Graduate Program

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-5534
Business Email: msarkisian@ufl.edu

Publications

2020
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Proceedings of the National Academy of Sciences of the United States of America. 117(2):1129-1138 [DOI] 10.1073/pnas.1910856117. [PMID] 31879345.
2019
In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons.
Neuroscience research. 143:44-52 [DOI] 10.1016/j.neures.2018.05.006. [PMID] 29857015.
2019
Emerging Roles of Primary Cilia in Glioma.
Frontiers in cellular neuroscience. 13 [DOI] 10.3389/fncel.2019.00055. [PMID] 30842728.
2018
Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma.
The EMBO journal. 37(23) [DOI] 10.15252/embj.201798772. [PMID] 30322894.
2018
Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy.
Nano letters. 18(10):6195-6206 [DOI] 10.1021/acs.nanolett.8b02179. [PMID] 30259750.
2018
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles.
Cilia. 7 [DOI] 10.1186/s13630-018-0060-5. [PMID] 30410731.
2016
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Oncotarget. 7(6):7029-43 [DOI] 10.18632/oncotarget.6854. [PMID] 26760767.
2016
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Experimental neurology. 282:119-27 [DOI] 10.1016/j.expneurol.2016.05.015. [PMID] 27181411.
2016
Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex.
Neuroscience. 337:48-65 [DOI] 10.1016/j.neuroscience.2016.08.049. [PMID] 27595889.
2016
PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide.
Translational oncology. 9(5):392-402 [DOI] 10.1016/j.tranon.2016.08.006. [PMID] 27661404.
2016
Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia.
Frontiers in aging neuroscience. 8 [DOI] 10.3389/fnagi.2016.00127. [PMID] 27303293.
2015
Influences of primary cilia on cortical morphogenesis and neuronal subtype maturation.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 21(2):136-51 [DOI] 10.1177/1073858414531074. [PMID] 24740576.
2014
Detection of primary cilia in human glioblastoma.
Journal of neuro-oncology. 117(1):15-24 [DOI] 10.1007/s11060-013-1340-y. [PMID] 24510433.
2013
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance.
EMBO molecular medicine. 5(8):1196-212 [DOI] 10.1002/emmm.201302827. [PMID] 23818228.
2013
Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(6):2626-38 [DOI] 10.1523/JNEUROSCI.2906-12.2013. [PMID] 23392690.
2012
Development and distribution of neuronal cilia in mouse neocortex.
The Journal of comparative neurology. 520(4):848-73 [DOI] 10.1002/cne.22793. [PMID] 22020803.
2012
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Acta neuropathologica. 123(6):807-23 [DOI] 10.1007/s00401-012-0979-3. [PMID] 22539017.
2012
Abnormal levels of Gadd45alpha in developing neocortex impair neurite outgrowth.
PloS one. 7(9) [DOI] 10.1371/journal.pone.0044207. [PMID] 22970179.
2011
Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.
Neuroscience. 190:398-408 [DOI] 10.1016/j.neuroscience.2011.06.010. [PMID] 21689730.
2011
Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multiciliated neurons.
Cerebral cortex (New York, N.Y. : 1991). 21(2):338-44 [DOI] 10.1093/cercor/bhq099. [PMID] 20525772.
2010
Discs large 5: A new regulator of Citron kinase localization in developing neocortex.
Cell Cycle. 9(10) [PMID] 20505324.
View on: PubMed
2010
Discs large 5: a new regulator of Citron kinase localization in developing neocortex: comment on: Chang Y, et al. Cell Cycle 2010; 9:1990-7.
Cell cycle (Georgetown, Tex.). 9(10) [PMID] 20505324.
View on: PubMed
2008
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.
Neuron. 60(2):273-84 [DOI] 10.1016/j.neuron.2008.09.026. [PMID] 18957219.
2008
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America. 105(35):13127-32 [DOI] 10.1073/pnas.0804558105. [PMID] 18728187.
2008
The stumpy gene is required for mammalian ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America. 105(8):2853-8 [DOI] 10.1073/pnas.0712385105. [PMID] 18287022.
2008
Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortex.
Trends in neurosciences. 31(2):54-61 [DOI] 10.1016/j.tins.2007.11.009. [PMID] 18201775.
2007
Citron kinase is required for postnatal neurogenesis in the hippocampus.
Developmental neuroscience. 29(1-2):113-23 [PMID] 17148954.
View on: PubMed
2007
Genetic determinants of neuronal migration in the cerebral cortex.
Novartis Foundation symposium. 288:45-53; discussion 53 [PMID] 18494251.
View on: PubMed
2006
MEKK4 signaling regulates filamin expression and neuronal migration.
Neuron. 52(5):789-801 [PMID] 17145501.
View on: PubMed
2005
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.
Proceedings of the National Academy of Sciences of the United States of America. 102(10):3846-51 [PMID] 15731347.
View on: PubMed
2003
Phosphatidylserine receptor is required for clearance of apoptotic cells.
Science (New York, N.Y.). 302(5650):1560-3 [PMID] 14645847.
View on: PubMed
2002
Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(8) [PMID] 11932363.
View on: PubMed
2002
Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus.
Epilepsy research. 48(1-2):3-13 [PMID] 11823105.
View on: PubMed
2001
Altered interneuron development in the cerebral cortex of the flathead mutant.
Cerebral cortex (New York, N.Y. : 1991). 11(8):734-43 [PMID] 11459763.
View on: PubMed
2001
Animal Models for Human Seizure and Epileptic Activity. Reply.
Epilepsy & behavior : E&B. 2(5):506-507 [PMID] 12609298.
View on: PubMed
2001
Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons.
Brain research. Molecular brain research. 93(2):127-36 [PMID] 11589990.
View on: PubMed
2001
Overview of the Current Animal Models for Human Seizure and Epileptic Disorders.
Epilepsy & behavior : E&B. 2(3):201-216 [PMID] 12609365.
View on: PubMed
2000
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(22) [PMID] 11069978.
View on: PubMed
1999
Mossy fiber sprouting after recurrent seizures during early development in rats.
The Journal of comparative neurology. 404(4):537-53 [PMID] 9987996.
View on: PubMed
1999
Effects of hyperthermia and continuous hippocampal stimulation on the immature and adult brain.
Brain & development. 21(5):318-25 [PMID] 10413019.
View on: PubMed
1999
Consequences of recurrent seizures during early brain development.
Neuroscience. 92(4):1443-54 [PMID] 10426498.
View on: PubMed
1999
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Epilepsia. 40(4):394-400 [PMID] 10219263.
View on: PubMed
1999
Consequences of cortical dysplasia during development in rats.
Epilepsia. 40(5):537-44 [PMID] 10386521.
View on: PubMed
1998
A gene essential to brain growth and development maps to the distal arm of rat chromosome 12.
Neuroscience letters. 251(1):5-8 [PMID] 9714451.
View on: PubMed
1998
Comparison of valproate and phenobarbital treatment after status epilepticus in rats.
Neurology. 51(1):41-8 [PMID] 9674776.
View on: PubMed
1998
Synaptic reorganization following kainic acid-induced seizures during development.
Brain research. Developmental brain research. 107(2):169-77 [PMID] 9593878.
View on: PubMed
1997
[Consequences of recurrent seizures during development].
Revista de neurologia. 25(141):749-53 [PMID] 9206603.
View on: PubMed
1997
Multiple kainic acid seizures in the immature and adult brain: ictal manifestations and long-term effects on learning and memory.
Epilepsia. 38(11):1157-66 [PMID] 9579915.
View on: PubMed
1997
Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study.
Neuroreport. 8(8):2019-23 [PMID] 9223095.
View on: PubMed
1996
Age-dependent effects of glutamate toxicity in the hippocampus.
Brain research. Developmental brain research. 97(2):178-84 [PMID] 8997502.
View on: PubMed
1996
Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain.
Brain research. Developmental brain research. 95(2):256-62 [PMID] 8874901.
View on: PubMed
1996
Recurrent seizures in immature rats: effect on auditory and visual discrimination.
Brain research. Developmental brain research. 95(2):283-92 [PMID] 8874904.
View on: PubMed

Grants

Jul 2019 ACTIVE
Enhancing TTFields Therapy for Glioblastoma By Dual Inhibition of HDAC6 and SIRT2
Role: Principal Investigator
Funding: AMER ASSO FOR CANCER RESEARCH
Sep 2018 ACTIVE
Targeting CCR2-expressing myeloid cells to overcome immune checkpoint inhibitor resistance in glioma
Role:
Funding: NATL INST OF HLTH NINDS
Jun 2018 ACTIVE
Primary Cilia-Derived ARL13B As a Biomarker and Promoter of?Gliomagenesis
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Jul 2017 – Feb 2019
Effects of Early Hypo- and Hyperthyroidism on Long-term Cortical Circuit Plasticity
Role:
Funding: AMERICAN THYROID ASSOCIATION
Jun 2016 – Aug 2018
Investigation of the Human Glioblastoma Ciliome
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
May 2015 – May 2016
Influence of neonatal seizure on neuronal ciliogenesis
Role: Principal Investigator
Funding: EPILEPSY FOU OF AMERICA
Apr 2015 – Mar 2018
Cortical Circuit Formation and Plasticity Following Neonatal Brain Injury
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Jul 2013 ACTIVE
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Project Manager
Funding: FL DEPT OF HLTH
Jan 2013 – Dec 2017
Identifying and Targeting Therapy Resistant Cells in Glioblastoma
Role: Principal Investigator
Funding: AMER CANCER SOC
Apr 2008 ACTIVE
Evelyn F. McKnight Brain Research Program in Age-Related Memory Loss.
Role: Project Manager
Funding: MCKNIGHT FOU

Teaching Profile

Courses Taught
2011-2020
GMS6021 Principles of Neuroscience I: Organization and Development of the Nervous System
2017-2019
GMS6705 Functional Human Neuroanatomy
2019
GMS6013 Developmental Genetics
2018
GMS7980 Research for Doctoral Dissertation
2015
GMS7794 Neuroscience Seminar
2011
GMS6073 Developmental Neurobiology
2010
GMS7795 Special Topics in Neuroscience

Contact Details

Phones:
Business:
(352) 273-5534
Emails:
Business:
msarkisian@ufl.edu