Nitya Subrahmanian

Nitya Subrahmanian,

Research Assistant Professor

Department: MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone: (352) 273-5550

About Nitya Subrahmanian

Dr. Subrahmanian obtained her Bachelors in Biotechnology, from VIT University, Vellore, Tamil Nadu, India. She earned her doctoral degree from the Department of Molecular Genetics at The Ohio State University (2015). For her doctoral research, Nitya investigated mitochondrial biogenesis, chloroplastic thiol-disulfide chemistry, and algal biofuel production, using a unicellular plant model system. She has extensive expertise in the study of mitochondrial complex I biology. Her research led to the discovery of a novel factor required for complex I biogenesis that functions through regulating mitochondrial gene expression.

Nitya has long been interested in elucidating the molecular bases of mitochondrial disorders to open new avenues for potential therapeutics. This motivation led her to transition from plant systems to mammalian models by joining Dr. LaVoie’s laboratory as a postdoctoral researcher (2020), where her research focused on the role of mitochondrial pathways in the development of neurodegenerative diseases. As a research assistant professor, she will investigate the role of mild complex I deficiency in the abnormal aggregation of alpha-synuclein using cellular (mammalian cell culture, including stem cells and iPSC-derived neurons) and animal models of Parkinson’s disease. As part of her academic career, Dr. Subrahmanian is also deeply committed to mentoring students in research and has mentored >25 students to date.

Publications

2024
The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons.
Stem cell reports. 19(2):163-173 [DOI] 10.1016/j.stemcr.2024.01.001. [PMID] 38307024.
2023
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
Acta neuropathologica communications. 11(1) [DOI] 10.1186/s40478-023-01704-9. [PMID] 38110990.
2023
The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary but distinct disease-relevant phenotypes in human neurons.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.04.30.538317. [PMID] 37163109.
2021
Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson’s disease? A critical reappraisal.
Brain research. 1767 [DOI] 10.1016/j.brainres.2021.147434. [PMID] 33745923.
2020
Assembly of Mitochondrial Complex I Requires the Low-Complexity Protein AMC1 in Chlamydomonas reinhardtii.
Genetics. 214(4):895-911 [DOI] 10.1534/genetics.120.303029. [PMID] 32075865.
2020
Chlamydomonas reinhardtii as a plant model system to study mitochondrial complex I dysfunction.
Plant direct. 4(2) [DOI] 10.1002/pld3.200. [PMID] 32025618.
2016
Plant mitochondrial Complex I composition and assembly: A review.
Biochimica et biophysica acta. 1857(7):1001-14 [DOI] 10.1016/j.bbabio.2016.01.009. [PMID] 26801215.
2011
A forward genetic screen identifies mutants deficient for mitochondrial complex I assembly in Chlamydomonas reinhardtii.
Genetics. 188(2):349-58 [DOI] 10.1534/genetics.111.128827. [PMID] 21467570.

Grants

Jun 2022 ACTIVE
Protection of dopaminergic neuronal function
Role: Principal Investigator
Funding: PARKINSONS FOU

Contact Details

Phones:
Business:
(352) 273-5550
Addresses:
Business Mailing:
PO Box 100159
GAINESVILLE FL 32610
Business Street:
1275 CENTER DR
GAINESVILLE FL 32610