Rebecca L Wallings,
Department:
Department of Neuroscience
Business Phone:
(352) 627-9200
Publications
Academic Articles
2025
ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses.
Molecular neurodegeneration.
20(1)
[DOI] 10.1186/s13024-025-00829-w.
[PMID] 40200337.
2025
MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson’s HLA locus exhibits epigenetic regulation.
Scientific reports.
15(1)
[DOI] 10.1038/s41598-025-95679-3.
[PMID] 40258905.
2025
MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson’s HLA locus exhibits epigenetic regulation.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.08.31.610581.
[PMID] 40093159.
2025
Peripheral immune cell response to stimulation stratifies Parkinson’s disease progression from prodromal to clinical stages
Communications Biology.
8(1)
[DOI] 10.1038/s42003-025-08088-7.
[PMID] 40341772.
2024
Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner.
Journal of neuroinflammation.
21(1)
[DOI] 10.1186/s12974-024-03271-9.
[PMID] 39487477.
2024
ASO-mediated knockdown of GPNMB in mutant- GRN and Grn -deficient peripheral myeloid cells disrupts lysosomal function and immune responses.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.07.22.604676.
[PMID] 39211224.
2024
Investigating the Role and Regulation of GPNMB in Progranulin-deficient Macrophages.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.03.12.584649.
[PMID] 38558966.
2024
Investigating the role and regulation of GPNMB in progranulin-deficient macrophages.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1417836.
[PMID] 39391322.
2024
Peripheral immune cell response to stimulation stratifies Parkinson’s disease progression from prodromal to clinical stages.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.12.05.625499.
[PMID] 39677794.
2024
The R1441C-Lrrk2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner in mice
Science Translational Medicine.
16(772)
[DOI] 10.1126/scitranslmed.adl1535.
2024
The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.10.12.562063.
[PMID] 37905053.
2023
APOE and immunity: Research highlights.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
19(6):2677-2696
[DOI] 10.1002/alz.13020.
[PMID] 36975090.
2023
ASO-mediated knockdown or kinase inhibition of G2019S-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages.
Molecular therapy. Nucleic acids.
34
[DOI] 10.1016/j.omtn.2023.102064.
[PMID] 38028198.
2023
Disease mechanisms as subtypes: Lysosomal dysfunction in the endolysosomal Parkinson’s disease subtype.
Handbook of clinical neurology.
193:33-51
[DOI] 10.1016/B978-0-323-85555-6.00009-6.
[PMID] 36803821.
2023
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease.
Journal of neuroinflammation.
20(1)
[DOI] 10.1186/s12974-023-02965-w.
[PMID] 38037070.
2023
Totally tubular: ASO-mediated knock-down of G2019S -Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.07.14.549028.
[PMID] 37503274.
2022
Inflammation and immune dysfunction in Parkinson disease.
Nature reviews. Immunology.
22(11):657-673
[DOI] 10.1038/s41577-022-00684-6.
[PMID] 35246670.
2022
Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system.
Frontiers in immunology.
13
[DOI] 10.3389/fimmu.2022.1056417.
[PMID] 36618392.
2022
WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson’s Disease Monocytes.
Frontiers in cellular neuroscience.
16
[DOI] 10.3389/fncel.2022.892899.
[PMID] 35755775.
2021
Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism
Science Translational Medicine.
13(594)
[DOI] 10.1126/scitranslmed.aaw1564.
[PMID] 34011628.
2020
Linking mitochondria to the immune response
eLife.
9
[DOI] 10.7554/elife.56214.
2020
LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson’s.
Frontiers in neuroscience.
14
[DOI] 10.3389/fnins.2020.00443.
[PMID] 32508566.
2019
LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function
Human Molecular Genetics.
28(16):2696-2710
[DOI] 10.1093/hmg/ddz088.
[PMID] 31039583.
2019
LRRK2 regulation of immune-pathways and inflammatory disease.
Biochemical Society transactions.
47(6):1581-1595
[DOI] 10.1042/BST20180463.
[PMID] 31769472.
2019
Lysosomal Dysfunction at the Centre of Parkinson’s Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.
Trends in neurosciences.
42(12):899-912
[DOI] 10.1016/j.tins.2019.10.002.
[PMID] 31704179.
2016
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Human molecular genetics.
25(5):951-63
[DOI] 10.1093/hmg/ddv628.
[PMID] 26744332.
2015
Cellular processes associated with LRRK2 function and dysfunction.
The FEBS journal.
282(15):2806-26
[DOI] 10.1111/febs.13305.
[PMID] 25899482.
Grants
Aug 2024
– Dec 2024
Investigating the effects of LRRK2 mutations in immune exhuastion
Role: Principal Investigator
Funding: PARKINSONS FOU
Jul 2021
– Dec 2023
The role of the peripheral immune-system in FTD-GRN; increasing understanding for future therapeutic target development
Role: Principal Investigator
Funding: BRIGHTFOCUS FOU
Contact Details
Phones:
- Business:
- (352) 627-9200
Addresses:
- Business Mailing:
-
PO Box 100244
GAINESVILLE FL 32610 - Business Street:
-
1149 NEWELL DR
MCKNIGHT BRAIN INSTITUTE
GAINESVILLE FL 326103011