Kevin K Wang

Kevin K Wang, Ph.D.

Research Professor

Department: MD-EMERGENCY MED-AED
Business Phone: (352) 294-4900
Business Email: kwang@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9343-6473

Publications

2020
Acute Effects of Sport-Related Concussion on Serum GFAP, UCH-L1, Total Tau, and Neurofilament Light Measured by a Multiplex Assay
Journal of Neurotrauma. 37(13):1537-1545 [DOI] 10.1089/neu.2019.6831. [PMID] 32024456.
2020
Traumatic brain injury and methamphetamine: A double-hit neurological insult.
Journal of the neurological sciences. 411 [DOI] 10.1016/j.jns.2020.116711. [PMID] 32035311.
2020
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.
PloS one. 15(7) [DOI] 10.1371/journal.pone.0224952. [PMID] 32692785.
2020
Penetrating Traumatic Brain Injury Triggers Subacute Dysregulation of Cathepsin B Protein Levels Independently of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid
Journal of Neurotrauma. 37(13):1574-1586 [DOI] 10.1089/neu.2019.6537. [PMID] 31973644.
2020
Altered monoaminergic levels, spasticity, and balance disability following repetitive blast-induced traumatic brain injury in rats.
Brain research. 1747 [DOI] 10.1016/j.brainres.2020.147060. [PMID] 32828734.
2020
Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study.
EBioMedicine. 56 [DOI] 10.1016/j.ebiom.2020.102785. [PMID] 32464528.
2020
Anti-pituitary and anti-hypothalamus autoantibody associations with inflammation and hypogonadotropic hypogonadism in men with traumatic brain injury
Journal of Neurotrauma. 37(14):1609-1626 [DOI] 10.1089/neu.2019.6780. [PMID] 32111134.
2020
Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy.
Journal of the American Chemical Society. 142(8):3862-3872 [DOI] 10.1021/jacs.9b11490. [PMID] 31991082.
2019
Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges.
International journal of molecular sciences. 20(20) [DOI] 10.3390/ijms20205213. [PMID] 31640160.
2019
Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study.
Journal of neurotrauma. 36(2):348-359 [DOI] 10.1089/neu.2017.5586. [PMID] 29987972.
2019
Single mild traumatic brain injury deteriorates progressive inter-hemispheric functional and structural connectivity
Journal of Neurotrauma. [DOI] 10.1089/neu.2018.6196. [PMID] 30931824.
2018
Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.
Molecular neurobiology. 55(3):2174-2184 [DOI] 10.1007/s12035-017-0424-7. [PMID] 28290147.
2018
Protein Characterization of Extracellular Microvesicles/Exosomes Released from Cytotoxin-Challenged Rat Cerebrocortical Mixed Culture and Mouse N2a Cells.
Molecular neurobiology. 55(3):2112-2124 [DOI] 10.1007/s12035-017-0474-x. [PMID] 28283886.
2018
Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury.
Molecular neurobiology. 55(7):6112-6128 [DOI] 10.1007/s12035-017-0821-y. [PMID] 29188495.
2018
Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.
Behavioural brain research. 340:14-22 [DOI] 10.1016/j.bbr.2017.04.025. [PMID] 28419850.
2018
Identification and Characterization of DNA Aptamers Specific for Phosphorylation Epitopes of Tau Protein.
Journal of the American Chemical Society. 140(43):14314-14323 [DOI] 10.1021/jacs.8b08645. [PMID] 30277395.
2018
Erratum to: Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Molecular neurobiology. 55(1):898-900 [DOI] 10.1007/s12035-017-0764-3. [PMID] 28975597.
2018
Correction to: Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury.
Molecular neurobiology. 55(7) [DOI] 10.1007/s12035-018-0909-z. [PMID] 29344927.
2018
An update on diagnostic and prognostic biomarkers for traumatic brain injury.
Expert review of molecular diagnostics. 18(2):165-180 [DOI] 10.1080/14737159.2018.1428089. [PMID] 29338452.
2017
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Expert opinion on therapeutic targets. 21(6):627-638 [DOI] 10.1080/14728222.2017.1321635. [PMID] 28434268.
2017
The Application of Proteomics to Traumatic Brain and Spinal Cord Injuries.
Current neurology and neuroscience reports. 17(3) [DOI] 10.1007/s11910-017-0736-z. [PMID] 28283963.
2017
Prognostic utility of neuroinjury biomarkers in post out-of-hospital cardiac arrest (OHCA) patient management.
Medical hypotheses. 105:34-47 [DOI] 10.1016/j.mehy.2017.06.016. [PMID] 28735650.
2017
Hypothesis: Exosomal microRNAs as potential biomarkers for schizophrenia.
Medical hypotheses. 103:21-25 [DOI] 10.1016/j.mehy.2017.04.003. [PMID] 28571801.
2017
In Vitro Neurotoxicity Resulting from Exposure of Cultured Neural Cells to Several Types of Nanoparticles.
Journal of cell death. 10 [DOI] 10.1177/1179670717694523. [PMID] 28469474.
2017
Calpain Zymography: General Methodology and Protocol.
Methods in molecular biology (Clifton, N.J.). 1626:279-285 [DOI] 10.1007/978-1-4939-7111-4_26. [PMID] 28608220.
2017
MicroRNAs as potential prognosticators of neurological outcome in out-of-hospital cardiac arrest patients.
Biomarkers in medicine. 11(12):1113-1123 [DOI] 10.2217/bmm-2017-0215. [PMID] 29219009.
2016
A Repetitive Concussive Head Injury Model in Mice.
Journal of visualized experiments : JoVE. (116) [DOI] 10.3791/54530. [PMID] 27768069.
2016
Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury.
Molecular & cellular proteomics : MCP. 15(7):2379-95 [DOI] 10.1074/mcp.M116.058115. [PMID] 27150525.
2016
Examining the Neural and Astroglial Protective Effects of Cellular Prion Protein Expression and Cell Death Protease Inhibition in Mouse Cerebrocortical Mixed Cultures.
Molecular neurobiology. 53(7):4821-32 [DOI] 10.1007/s12035-015-9407-8. [PMID] 26337296.
2016
Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats.
Frontiers in neurology. 7 [PMID] 27920753.
View on: PubMed
2016
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(9):1378-1389 [DOI] 10.1016/j.euroneuro.2016.07.007. [PMID] 27461514.
2016
Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study.
Journal of neurotrauma. 33(13):1270-7 [DOI] 10.1089/neu.2015.3881. [PMID] 26560343.
2015
Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model.
Scientific reports. 5 [DOI] 10.1038/srep11178. [PMID] 26058556.
2015
Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker.
Trends in neurosciences. 38(6):364-74 [DOI] 10.1016/j.tins.2015.04.003. [PMID] 25975510.
2015
Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Molecular neurobiology. 52(1):696-709 [DOI] 10.1007/s12035-014-8898-z. [PMID] 25270371.
2015
Biomarker identification in psychiatric disorders: from neuroscience to clinical practice.
Journal of psychiatric practice. 21(1):37-48 [DOI] 10.1097/01.pra.0000460620.87557.02. [PMID] 25603450.
2014
Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34(9):1444-52 [DOI] 10.1038/jcbfm.2014.105. [PMID] 24917042.
2014
Overpressure Blast Injury Induced Structural and Functional Changes in the Brain and Basilar Artery
Journal of Neurotrauma. 31(12)
2014
Wave Heave Energy Conversion Using Modular Multistability
Applied Energy. 130(1, SI):148-156 [DOI] 10.1016/j.apenergy.2014.05.038.
2013
Transplantation of Mesenchymal Stem Cells To the Brain By Topical Application in An Experimental Traumatic Brain Injury Model
Journal of Clinical Neuroscience. 20(2):300-303 [DOI] 10.1016/j.jocn.2012.03.028. [PMID] 23219830.
2013
Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms.
Frontiers in neuroscience. 7 [DOI] 10.3389/fnins.2013.00108. [PMID] 23781171.
2013
Operation Brain Trauma Therapy Consortium: Dose-Response Evaluation of Erythropoietin in the Pittsburgh Controlled Cortical Impact Model of Traumatic Brain Injury
Journal of Neurotrauma. 30:A159-A160
2013
Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla.
Neuroscience letters. 544:62-7 [DOI] 10.1016/j.neulet.2013.03.042. [PMID] 23570732.
2013
Hypothesizing that designer drugs containing cathinones (“bath salts”) have profound neuro-inflammatory effects and dangerous neurotoxic response following human consumption.
Medical hypotheses. 81(3):450-5 [DOI] 10.1016/j.mehy.2013.06.007. [PMID] 23845561.
2013
Biomarkers Track Damage After Graded Injury Severity in a Rat Model of Penetrating Brain Injury
Journal of Neurotrauma. 30(13):1161-1169 [DOI] 10.1089/neu.2012.2762. [PMID] 23409698.
2013
Assessing neuro-systemic & behavioral components in the pathophysiology of blast-related brain injury.
Frontiers in neurology. 4 [DOI] 10.3389/fneur.2013.00186. [PMID] 24312074.
2013
Operation Brain Trauma Therapy Consortium: Dose-Response Evaluation of Erythropoietin in the Pittsburgh Controlled Cortical Impact Model of Traumatic Brain Injury
Journal of Neurotrauma. 30:A159-A160
2012
Predicting Poor 6-Month Outcome in Severe Tbi Using the Impact Score and Early Csf Biomarkers
Journal of Neurotrauma. 29
2012
Mass Spectrometry-Based Identification and Quantitation of Proteins Released in Traumatic Brain Injury Cell Culture Model
Journal of Neurotrauma. 29:A98-A99
2012
Methods in drug abuse models: comparison of different models of methamphetamine paradigms.
Methods in molecular biology (Clifton, N.J.). 829:269-78 [DOI] 10.1007/978-1-61779-458-2_17. [PMID] 22231820.
2012
Persistent Vegetative State Following Severe Traumatic Brain Injury Is Associated With Brain-Reactive Antibodies in Serum
Journal of Neurotrauma. 29
2012
Predicting Mortality in Severe Tbi Using the Impact Score and Early Csf Map-2 Levels
Journal of Neurotrauma. 29
2012
Qualitative versus quantitative methods in psychiatric research.
Methods in molecular biology (Clifton, N.J.). 829:49-62 [DOI] 10.1007/978-1-61779-458-2_3. [PMID] 22231806.
2012
Similarities and Dissimilarities of Two Experimental Models of Tbi (Closed Head and Blast Tbi) in Long-Term Disabilities: Spasticity, Cognitive and Synaptic Function, Balance, Anxiety, and Pain Related Behaviors
Journal of Neurotrauma. 29:A56-A57
2012
Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Alpha Ii-Spectrin Breakdown Product 145 Kda Correlate With Outcome After Pediatric Tbi
Journal of Neurotrauma. 29(1):162-167 [DOI] 10.1089/neu.2011.1989. [PMID] 22022780.
2012
Serum Levels of Spectrin Breakdown Product 150 (Sbdp150) Distinguish Mild Traumatic Brain Injury From Trauma and Uninjured Controls and Predict Intracranial Injuries On Ct and Neurosurgical Intervention
Journal of Neurotrauma. 29:A39-A40
2012
Serum Levels of Ubiquitin C-Terminal Hydrolase Distinguish Mild Traumatic Brain Injury From Trauma Controls and Are Elevated in Mild and Moderate Traumatic Brain Injury Patients With Intracranial Lesions and Neurosurgical Intervention
Journal of Trauma and Acute Care Surgery. 72(5):1335-1344 [DOI] 10.1097/TA.0b013e3182491e3d. [PMID] 22673263.
2012
Marshall Classification Versus the Rotterdam Score in Predicting 6-Month Mortality in Severe Tbi
Journal of Neurotrauma. 29:A191-A192
2012
Uch-L1 and Map-2 Biomarkers Improve 6-Month Functional Outcome Prediction in Severe Traumatic Brain Injury
Journal of Neurotrauma. 29:A42-A43
2012
Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenges.
Frontiers in neurology. 3 [DOI] 10.3389/fneur.2012.00147. [PMID] 23093947.
2012
Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury.
Brain injury. 26(13-14):1629-35 [DOI] 10.3109/02699052.2012.700083. [PMID] 22794497.
2012
Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes.
Cell death and differentiation. 19(12):1917-27 [DOI] 10.1038/cdd.2012.75. [PMID] 22722334.
2012
Glial neuronal ratio: a novel index for differentiating injury type in patients with severe traumatic brain injury.
Journal of neurotrauma. 29(6):1096-104 [DOI] 10.1089/neu.2011.2092. [PMID] 22165978.
2012
In Vitro Ms-Based Proteomic Analysis and Absolute Quantification of Neuronal-Glial Injury Biomarkers in Cell Culture System
Electrophoresis. 33(24):3786-3797 [DOI] 10.1002/elps.201200326. [PMID] 23161537.
2012
Assessing a Necrosis and Apoptosis Index Using Csf Alpha Ii-Spectrin Breakdown Product Levels in Severe Tbi
Journal of Neurotrauma. 29:A93-A94
2012
Blast Brain Injury Elevates Catecholamine Biosynthesis in the Nucleus Tractus Solitaries and Oxidative Stress in the Hypothalamus in Rats
Journal of Neurotrauma. 29
2012
Blast Brain Injury Elevates Catecholamine Biosynthesis in the Rat Adrenal Medulla
The FASEB's Journal. 26
2012
Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator.
Journal of neurotrauma. 29(9):1770-8 [DOI] 10.1089/neu.2011.2127. [PMID] 22435839.
2012
Characterization of Beta Ii-Spectrin Degradation Under Both Excitotoxic Challenge and After Traumatic Brain Injury
Journal of Neurotrauma. 29
2012
Exposure Characteristics of Uch-L1 in Csf Are Associated With 6-Month Outcome in Severe Tbi
Journal of Neurotrauma. 29
2012
Cross Model Comparison of Behavior, Neuropathology, and Serum Biomarkers After Controlled Cortical Impact, Parasagittal Fluid Percussion, and Penetrating Ballistic-Like Brain Injury: Results From Operation Brain Trauma Therapy
Journal of Neurotrauma. 29
2012
Differential Effect of Nicotinamide On Serum Damage Marker Profiles Following Controlled Cortical Impact, Parasagittal Fluid Percussion, and Penetrating Ballistic-Like Brain Injury: Results From Operation Brain Trauma Therapy
Journal of Neurotrauma. 29
2012
Early Induced Hypothermia Attenuates Reperfusional Neuronal and Subsequent Glial Damages in a Rat Subdural Hematoma Model: a Microdialysis Study
Journal of Neurotrauma. 29:A149-A150
2012
Effect of Nicotinamide On Behavioral, Neuropathological, and Biomarker Outcomes After Controlled Cortical Impact in Rats: An Operation Brain Trauma Therapy Consortium Study
Journal of Neurotrauma. 29
2012
Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury.
Neurosurgery. 70(3):666-75 [DOI] 10.1227/NEU.0b013e318236a809. [PMID] 21937927.
2011
Serum Levels of Uch-L1 Distinguishes Mild and Moderate Traumatic Brain Injury From Trauma Controls and Is Associated With Lesions On Computed Tomography
Journal of Neurotrauma. 28
2011
Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study.
Critical care (London, England). 15(3) [DOI] 10.1186/cc10286. [PMID] 21702960.
2011
Map-2 Concentration in Serum of Patients After Traumatic Brain Injury: Insight Into the Pathophysiological Mechanisms of the Chronic Phase
Journal of Neurotrauma. 28:A83-A84
2011
Leveraging biomarker platforms and systems biology for rehabilomics and biologics effectiveness research.
PM & R : the journal of injury, function, and rehabilitation. 3(6 Suppl 1):S139-47 [DOI] 10.1016/j.pmrj.2011.02.012. [PMID] 21703572.
2011
Inhibition of Lps Toxicity By Hepatic Argininosuccinate Synthase (Ass): Novel Roles for Ass in Innate Immune Responses To Bacterial Infection
International Immunopharmacology. 11(9):1180-1188 [DOI] 10.1016/j.intimp.2011.03.016. [PMID] 21481813.
2011
In Vivo Monitoring of Cytokines and Brain Biomarker Damage Following Severe Traumatic Brain Injury: a Microdialysis Study
Journal of Neurotrauma. 28
2011
Identification of Tyrosine Nitration in Uch-L1 and Gapdh
Electrophoresis. 32(13):1692-1705 [DOI] 10.1002/elps.201100133. [PMID] 21706495.
2011
Quantitative Cerebrospinal Fluid Biokinetic Parameters of Alpha Ii-Spectrin Breakdown Products in Severe Traumatic Brain Injury Patients
Journal of Neurotrauma. 28
2011
Early Csf Levels of Uch-L1 Are Associated With Injury Severity in Patients With Severe Tbi
Journal of Neurotrauma. 28
2011
Early Csf Levels of Uch-L1 Are Associated With Injury Severity in Patients With Severe Tbi
Journal of Neurotrauma. 28
2011
Dual Vulnerability of Tau To Calpains and Caspase-3 Proteolysis Under Neurotoxic and Neurodegenerative Conditions
Asn Neuro. 3(1):25-36 [DOI] 10.1042/AN20100012. [PMID] 21359008.
2011
Blood-Based Diagnostics of Traumatic Brain Injuries
Expert Review of Molecular Diagnostics. 11(1):65-78 [DOI] 10.1586/ERM.10.104. [PMID] 21171922.
2011
Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (Uch-L1) in Severe Traumatic Brain Injury Patient Biofluids
Journal of Neurotrauma. 28(6):861-870 [DOI] 10.1089/neu.2010.1564. [PMID] 21309726.
2011
Early Serum Levels of Glial Fibrillary Acidic Protein Breakdown Product (Gfap-Bdp) Are Associted With Global Outcome At One Month Post Injury in Mild and Moderate Traumatic Brain Injury
Journal of Neurotrauma. 28:A63-A64
2011
A Novel Multicenter Preclinical Drug Screening and Biomarker Consortium for Experimental Traumatic Brain Injury: Operation Brain Trauma Therapy
Journal of Trauma. 71(1 Suppl):S15-S24 [DOI] 10.1097/TA.0b013e31822117fe. [PMID] 21795873.
2010
αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients.
Journal of neurotrauma. 27(7):1203-13 [DOI] 10.1089/neu.2010.1278. [PMID] 20408766.
2010
Ubiquitin C-Terminal Hydrolase-L1 as a Biomarker for Ischemic and Traumatic Brain Injury in Rats
European Journal of Neuroscience. 31(4):722-732 [DOI] 10.1111/j.1460-9568.2010.07097.x. [PMID] 20384815.
2010
Neuroproteomics: a Biochemical Means To Discriminate the Extent and Modality of Brain Injury
Journal of Neurotrauma. 27(10):1837-1852 [DOI] 10.1089/neu.2010.1374. [PMID] 20698760.
2010
Morphologic and Biochemical Characterization of Brain Injury in a Model of Controlled Blast Overpressure Exposure
Journal of Trauma. 69(4):795-804 [DOI] 10.1097/TA.0b013e3181bbd885. [PMID] 20215974.
2010
Microtubule-Associated Protein-2: a New Sensitive and Specific Marker for Traumatic Brain Injury
Critical Care Medicine. 38
2010
Ubiquitin C-Terminal Hydrolase Is a Novel Biomarker in Humans for Severe Traumatic Brain Injury
Critical Care Medicine. 38(1):138-144 [DOI] 10.1097/CCM.0b013e3181b788ab. [PMID] 19726976.
2010
Effects of Environmental Tobacco Smoke On Adult Rat Brain Biochemistry
Journal of molecular neuroscience : MN. 41(1):165-171 [DOI] 10.1007/s12031-009-9316-2. [PMID] 19960371.
2010
Methods in systems biology of experimental methamphetamine drug abuse.
Methods in molecular biology (Clifton, N.J.). 662:303-16 [DOI] 10.1007/978-1-60761-800-3_15. [PMID] 20824478.
2010
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.
BMC neuroscience. 11 [DOI] 10.1186/1471-2202-11-21. [PMID] 20167092.
2010
Comparing Levels of Biochemical Markers in Csf From Cannulated and Non-Cannulated Rats
Journal of Neuroscience Methods. 192(2):249-253 [DOI] 10.1016/j.jneumeth.2010.07.042. [PMID] 20692294.
2010
Brain Tissue Oxygenation and Putative Biomarkers in Severe Traumatic Brain Injury
Intensive Care Medicine. 36
2009
Alpha Ii-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms After Severe Traumatic Brain Injury
Journal of Neurotrauma. 26(4):471-479 [DOI] 10.1089/neu.2008.0657. [PMID] 19206997.
2009
Biochemical, Structural, and Biomarker Evidence for Calpain-Mediated Cytoskeletal Change After Diffuse Brain Injury Uncomplicated By Contusion
Journal of Neuropathology and Experimental Neurology. 68:241-249
2009
Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase (Uch-L1) in Severe Traumatic Brain Injury Patient Biofluids
Journal of Neurotrauma. 26
2009
Biomarkers of Blast-Induced Neurotrauma: Profiling Molecular and Cellular Mechanisms of Blast Brain Injury
Journal of Neurotrauma. 26(6):913-921 [DOI] 10.1089/neu.2008.0609. [PMID] 19422293.
2009
Collapsin response mediator protein-2 is a calmodulin-binding protein.
Cellular and molecular life sciences : CMLS. 66(3):526-36 [DOI] 10.1007/s00018-008-8362-1. [PMID] 19151921.
2009
Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates.
Biological psychiatry. 66(2):118-27 [DOI] 10.1016/j.biopsych.2009.02.021. [PMID] 19345341.
2009
Methods in drug abuse neuroproteomics: methamphetamine psychoproteome.
Methods in molecular biology (Clifton, N.J.). 566:217-28 [DOI] 10.1007/978-1-59745-562-6_15. [PMID] 20058175.
2009
Necrotic and Apoptotic Cell Death Processes in Severe Traumatic Brain Injury Assessed By Sandwich Elisa-Based Analysis of Alpha Ii-Spectrin Breakdown Products in Cerebrospinal Fluid – Clinical Significance and Temporal Profile
Journal of Neurotrauma. 26
2009
P43/Pro-Emapii: a Potential Biomarker for Discriminating Traumatic Versus Ischemic Brain Injury
Journal of Neurotrauma. 26(8):1295-1305 [DOI] 10.1089/neu.2008.0811. [PMID] 19317603.
2009
Spillway-Induced Salmon Head Injury Triggers the Generation of Brain Alpha Ii-Spectrin Breakdown Product Biomarkers Similar To Mammalian Traumatic Brain Injury
PLoS One. 4 [DOI] 10.1371/journal.pone.0004491. [PMID] 19214235.
2009
Spillway-Induced Salmon Head Injury Triggers the Generation of Brain Alpha Ii-Spectrin Breakdown Product Biomarkers Similar To Mammalian Traumatic Brain Injury
PLoS One. 4(2) [DOI] 10.1371/journal.pone.0004491. [PMID] 19214235.
2009
Calmodulin-binding proteome in the brain.
Methods in molecular biology (Clifton, N.J.). 566:181-90 [DOI] 10.1007/978-1-59745-562-6_12. [PMID] 20058172.
2009
Traumatic brain injury biomarkers: from pipeline to diagnostic assay development.
Methods in molecular biology (Clifton, N.J.). 566:293-302 [DOI] 10.1007/978-1-59745-562-6_19. [PMID] 20058179.
2009
Uch-L1 Levels in Csf and Serum: Diagnosis and Outcome in Severe Traumatic Brain Injury Patients
Critical Care Medicine. 37
2008
Alpha-Ii Spectrin Breakdown Product Kinetics in Acute Brain Injury
Journal of Neurotrauma. 25
2008
Using Psychoproteomics To Identify Protein Pathways Relevant To Methamphetamine Neurotoxicity
Biological Psychiatry. 63
2008
Traumatic Brain Injury Biomarkers: a Neuroproteomic-Based Discovery, Systems Biology-Based Selection and Validation in Animal Studies
Journal of Neurotrauma. 25
2008
Psychoproteomic analysis of rat cortex following acute methamphetamine exposure.
Journal of proteome research. 7(5):1971-83 [DOI] 10.1021/pr800029h. [PMID] 18452277.
2008
Psychiatric research: psychoproteomics, degradomics and systems biology.
Expert review of proteomics. 5(2):293-314 [DOI] 10.1586/14789450.5.2.293. [PMID] 18466058.
2008
Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry.
Journal of neurochemistry. 104(5):1404-14 [PMID] 18036155.
View on: PubMed
2008
Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry.
Journal of Neurochemistry. 104(5) [DOI] 10.1111/j.1471-4159.2007.05086.x. [PMID] 18036155.
2008
Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry
Journal of Neurochemistry. (104):1404-1414
2008
Physiological and pathological actions of calpains in glutamatergic neurons.
Science signaling. 1(23) [DOI] 10.1126/scisignal.123tr3. [PMID] 18544749.
2008
Quantitative Assays of Proteolytic Degradation of Alpha-Spectrin in Human Csf Following Severe Traumatic Brain Injury (Tbi)
Journal of Neurotrauma. 25
2008
Levels of Uch-L1 in Human Csf and Outcome Following Severe Traumatic Brain Injury
Journal of Neurotrauma. 25
2008
Increased Csf Levels of Microtubule Associated Protein-2 (Map-2) Human Subjects With Severe Traumatic Brain Injury (Tbi)
Journal of Neurotrauma. 25
2008
In Vitro Neurotoxicity Resulting From Selected Nanomaterials
Journal of Neurotrauma. 25
2008
Dicyclomine, An M1 Muscarinic Antagonist, Reduces Biomarker Levels, But Not Neuronal Degeneration, in Fluid Percussion Brain Injury
Journal of Neurotrauma. 25(11):1355-1365 [DOI] 10.1089/neu.2008.0671. [PMID] 19061379.
2008
Calpain in the CNS: from synaptic function to neurotoxicity.
Science signaling. 1(14) [DOI] 10.1126/stke.114re1. [PMID] 18398107.
2008
Detection of Protein Biomarkers Using High-Throughput Immunoblotting Following Focal Ischemic Or Penetrating Ballistic-Like Brain Injuries in Rats
Brain injury. 22(10):723-732 [DOI] 10.1080/02699050802304706. [PMID] 18720098.
2008
Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury.
Biochemical and biophysical research communications. 373(4):478-81 [DOI] 10.1016/j.bbrc.2008.05.031. [PMID] 18486600.
2008
Neuroproteomics and systems biology-based discovery of protein biomarkers for traumatic brain injury and clinical validation.
Proteomics. Clinical applications. 2(10-11):1467-83 [DOI] 10.1002/prca.200800011. [PMID] 21136795.
2007
Novel neuroproteomic approaches to studying traumatic brain injury.
Progress in brain research. 161:401-18 [PMID] 17618994.
View on: PubMed
2007
Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury.
Journal of neurotrauma. 24(2):354-66 [PMID] 17375999.
View on: PubMed
2007
Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury.
Journal of neurotrauma. 24(3):460-72 [PMID] 17402852.
View on: PubMed
2007
Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.
Acta neuropathologica. 114(3):277-86 [PMID] 17647000.
View on: PubMed
2007
Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury.
Journal of neurosurgery. 107(4):792-6 [PMID] 17937225.
View on: PubMed
2007
Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure.
The international journal of neuropsychopharmacology. 10(4):479-89 [PMID] 16882358.
View on: PubMed
2006
Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 11(4):355-69 [PMID] 16908442.
View on: PubMed
2006
Unfolded protein response after neurotrauma.
Journal of neurotrauma. 23(6):807-29 [PMID] 16774469.
View on: PubMed
2006
Novel differential neuroproteomics analysis of traumatic brain injury in rats.
Molecular & cellular proteomics : MCP. 5(10):1887-98 [PMID] 16801361.
View on: PubMed
2006
Novel differential neuroproteomics analysis of traumatic brain injury in rats
Molecular & Cellular Proteomics. (5):1887-1898
2006
Neuroproteomics in neurotrauma.
Mass spectrometry reviews. 25(3):380-408 [PMID] 16498609.
View on: PubMed
2006
Neuroprotection targets after traumatic brain injury.
Current opinion in neurology. 19(6):514-9 [PMID] 17102687.
View on: PubMed
2006
Generation of aberrant forms of DFF40 concurrent with caspase-3 activation during acute and chronic liver injury in rats.
Biochemical and biophysical research communications. 350(2):457-62 [PMID] 17011520.
View on: PubMed
2006
Amino acid starvation induced autophagic cell death in PC-12 cells: evidence for activation of caspase-3 but not calpain-1.
Apoptosis : an international journal on programmed cell death. 11(9):1573-82 [PMID] 16703260.
View on: PubMed
2006
Elevation of cytoskeletal protein breakdown in aged Wistar rat brain.
Neurobiology of aging. 27(4):624-32 [PMID] 15913844.
View on: PubMed
2006
Ecstasy toxicity: a comparison to methamphetamine and traumatic brain injury.
Journal of addictive diseases. 25(4):115-23 [PMID] 17088231.
View on: PubMed
2006
Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells.
Cellular & molecular biology letters. 11(1):12-29 [PMID] 16847745.
View on: PubMed
2006
Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis.
The Biochemical journal. 394(Pt 3):715-25 [PMID] 16351572.
View on: PubMed
2006
Alpha-II-spectrin after controlled cortical impact in the immature rat brain.
Developmental neuroscience. 28(4-5):457-65 [PMID] 16943668.
View on: PubMed
2006
Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury.
Journal of neurochemistry. 98(3):700-12 [PMID] 16893416.
View on: PubMed
2005
Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry.
Journal of neurotrauma. 22(6):629-44 [PMID] 15941373.
View on: PubMed
2005
Proteomic identification of biomarkers of traumatic brain injury.
Expert review of proteomics. 2(4):603-14 [PMID] 16097892.
View on: PubMed
2005
Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury.
Life sciences. 78(3):301-9 [PMID] 16125733.
View on: PubMed
2005
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat.
Experimental neurology. 193(1):19-28 [PMID] 15817261.
View on: PubMed
2005
A quantitative degradomics approach to biomarker validation by nano-LC MSMS
Analytical chemistry. (77):4836-4845
2005
A multidimensional differential proteomic platform using dual-phase ion-exchange chromatography-polyacrylamide gel electrophoresis/reversed-phase liquid chromatography tandem mass spectrometry.
Analytical chemistry. 77(15):4836-45 [PMID] 16053296.
View on: PubMed
2005
Cell-specific DNA fragmentation may be attenuated by a survivin-dependent mechanism after traumatic brain injury in rats.
Experimental brain research. 167(1):17-26 [PMID] 16193270.
View on: PubMed
2004
Increased expression and processing of caspase-12 after traumatic brain injury in rats.
Journal of neurochemistry. 88(1):78-90 [PMID] 14675152.
View on: PubMed
2004
Molecular cloning and characterization of rat and human calpain-5.
Biochemical and biophysical research communications. 324(1):46-51 [PMID] 15464980.
View on: PubMed
2004
Lysophosphatidic acid induces clonal generation of mouse neurospheres via proliferation of Sca-1- and AC133-positive neural progenitors.
Stem cells and development. 13(6):685-93 [PMID] 15684836.
View on: PubMed
2004
Increased expression of tissue-type transglutaminase following middle cerebral artery occlusion in rats.
Journal of neurochemistry. 89(5):1301-7 [PMID] 15147523.
View on: PubMed
2004
Effects of injury severity on regional and temporal mRNA expression levels of calpains and caspases after traumatic brain injury in rats.
Journal of neurotrauma. 21(7):829-41 [PMID] 15307896.
View on: PubMed
2004
Proteomics studies of traumatic brain injury.
International review of neurobiology. 61:215-40 [PMID] 15482817.
View on: PubMed
2004
Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats.
Journal of neurochemistry. 88(3):689-97 [PMID] 14720218.
View on: PubMed
2004
Biomarkers of proteolytic damage following traumatic brain injury.
Brain pathology (Zurich, Switzerland). 14(2):202-9 [PMID] 15193033.
View on: PubMed
2004
Accumulation of calpain and caspase-3 proteolytic fragments of brain-derived alphaII-spectrin in cerebral spinal fluid after middle cerebral artery occlusion in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 24(1):98-106 [PMID] 14688621.
View on: PubMed
2004
A novel marker for traumatic brain injury: CSF alphaII-spectrin breakdown product levels.
Journal of neurotrauma. 21(10):1443-56 [PMID] 15672634.
View on: PubMed
2004
Cell-specific upregulation of survivin after experimental traumatic brain injury in rats.
Journal of neurotrauma. 21(9):1183-95 [PMID] 15453988.
View on: PubMed
2002
Up-regulation of tissue-type transglutaminase after traumatic brain injury.
Journal of neurochemistry. 80(4):579-88 [PMID] 11841565.
View on: PubMed
2001
TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures.
Journal of neuroscience research. 64(2):121-31 [PMID] 11288141.
View on: PubMed
2001
The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury.
Journal of neurotrauma. 18(11):1229-40 [PMID] 11721741.
View on: PubMed
2001
Temporal and spatial profile of caspase 8 expression and proteolysis after experimental traumatic brain injury.
Journal of neurochemistry. 78(4):862-73 [PMID] 11520907.
View on: PubMed
2001
Molecular cloning and characterization of a novel caspase-3 variant that attenuates apoptosis induced by proteasome inhibition.
Biochemical and biophysical research communications. 283(4):762-9 [PMID] 11350049.
View on: PubMed
2001
Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons.
Cellular & molecular biology letters. 6(2):173-84 [PMID] 11544639.
View on: PubMed
2001
Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture.
Journal of neurovirology. 7(1):1-10 [PMID] 11519477.
View on: PubMed
2001
Concurrent assessment of calpain and caspase-3 activation after oxygen-glucose deprivation in primary septo-hippocampal cultures.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 21(11):1281-94 [PMID] 11702043.
View on: PubMed
2001
Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation.
Biochemical and biophysical research communications. 285(5):1192-9 [PMID] 11478781.
View on: PubMed
2001
Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells.
Neuroscience letters. 301(2):99-102 [PMID] 11248432.
View on: PubMed
2001
Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats.
Journal of neurochemistry. 78(6):1297-306 [PMID] 11579138.
View on: PubMed
2000
Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells.
Biochemical and biophysical research communications. 274(1):16-21 [PMID] 10903889.
View on: PubMed
2000
Novel characteristics of glutamate-induced cell death in primary septohippocampal cultures: relationship to calpain and caspase-3 protease activation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 20(3):550-62 [PMID] 10724120.
View on: PubMed
2000
Cytochrome c release and caspase activation in traumatic axonal injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(8):2825-34 [PMID] 10751434.
View on: PubMed
2000
Activation of apoptosis-linked caspase(s) in NMDA-injured brains in neonatal rats.
Neurochemistry international. 36(2):119-26 [PMID] 10676875.
View on: PubMed
2000
Calpain and caspase: can you tell the difference?
Trends in neurosciences. 23(1):20-6 [PMID] 10631785.
View on: PubMed
2000
Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells.
Archives of biochemistry and biophysics. 379(2):337-43 [PMID] 10898953.
View on: PubMed
1999
Alterations of extracellular calcium elicit selective modes of cell death and protease activation in SH-SY5Y human neuroblastoma cells.
Journal of neurochemistry. 72(5):1853-63 [PMID] 10217261.
View on: PubMed
1999
Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis.
Journal of neurochemistry. 72(5):1899-906 [PMID] 10217266.
View on: PubMed
1999
Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septo-hippocampal cultures.
Neurochemical research. 24(3):371-82 [PMID] 10215511.
View on: PubMed
1999
Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates.
Biochemical and biophysical research communications. 263(1):94-9 [PMID] 10486259.
View on: PubMed
1998
Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures.
Journal of neuroscience research. 52(5):505-20 [PMID] 9632307.
View on: PubMed
1998
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 18(2):161-7 [PMID] 9469158.
View on: PubMed
1998
Simultaneous degradation of alphaII- and betaII-spectrin by caspase 3 (CPP32) in apoptotic cells.
The Journal of biological chemistry. 273(35):22490-7 [PMID] 9712874.
View on: PubMed
1998
Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury.
Neuroreport. 9(11):2437-42 [PMID] 9721910.
View on: PubMed
1998
Potential contribution of proteases to neuronal damage.
Drug news & perspectives. 11(4):215-22 [PMID] 15616663.
View on: PubMed
1998
pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat.
Neuroscience letters. 247(1):53-7 [PMID] 9637408.
View on: PubMed
1998
Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis.
Archives of biochemistry and biophysics. 356(2):187-96 [PMID] 9705209.
View on: PubMed
1998
Caspase-3-like activity is necessary for IL-2 release in activated Jurkat T-cells.
Experimental cell research. 244(1):302-9 [PMID] 9770373.
View on: PubMed
1998
Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis.
The Journal of biological chemistry. 273(32):19993-20000 [PMID] 9685336.
View on: PubMed
1998
Evidence for activation of caspase-3-like protease in excitotoxin- and hypoxia/hypoglycemia-injured neurons.
Journal of neurochemistry. 71(1):186-95 [PMID] 9648865.
View on: PubMed
1997
A purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3-like protease activity in MOLT-4 T cells.
Immunopharmacology. 37(2-3):231-44 [PMID] 9403342.
View on: PubMed
1997
Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells.
Journal of neurochemistry. 68(6):2328-37 [PMID] 9166725.
View on: PubMed
1997
Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.
Journal of neurochemistry. 69(3):1006-13 [PMID] 9282922.
View on: PubMed
1997
Thapsigargin induces apoptosis in SH-SY5Y neuroblastoma cells and cerebrocortical cultures.
Biochemistry and molecular biology international. 43(1):197-205 [PMID] 9315298.
View on: PubMed
1996
Total protein extraction from cultured cells for use in electrophoresis and western blotting.
BioTechniques. 20(4):662-8 [PMID] 8800687.
View on: PubMed
1996
Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis.
The Biochemical journal. 319 ( Pt 3):683-90 [PMID] 8920967.
View on: PubMed
1996
N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America. 93(8):3362-7 [PMID] 8622942.
View on: PubMed
1996
Phenytoin pretreatment prevents hypoxic-ischemic brain damage in neonatal rats.
Brain research. Developmental brain research. 95(2):169-75 [PMID] 8874891.
View on: PubMed
1996
Maitotoxin induces calpain activation in SH-SY5Y neuroblastoma cells and cerebrocortical cultures.
Archives of biochemistry and biophysics. 331(2):208-14 [PMID] 8660700.
View on: PubMed
1996
Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis.
Neuroreport. 8(1):249-55 [PMID] 9051790.
View on: PubMed
1996
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.
Proceedings of the National Academy of Sciences of the United States of America. 93(13):6687-92 [PMID] 8692879.
View on: PubMed
1996
Modulation of hypoxia-induced calpain activity in rat renal proximal tubules.
Kidney international. 50(4):1150-7 [PMID] 8887272.
View on: PubMed
1995
A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 15(5 Pt 2):4093-101 [PMID] 7538570.
View on: PubMed
1995
Aurintricarboxylic acid is an inhibitor of mu- and m-calpain.
Biochemistry and molecular biology international. 36(2):291-9 [PMID] 7663433.
View on: PubMed
1995
Calcium-activated proteases in the bovine parathyroid gland: potential role in degradation of parathyroid hormone to peptide fragments.
Journal of molecular endocrinology. 15(1):61-71 [PMID] 8546814.
View on: PubMed
1995
Casein zymography: a method to study mu-calpain, m-calpain, and their inhibitory agents.
Archives of biochemistry and biophysics. 319(1):211-6 [PMID] 7771786.
View on: PubMed
1994
Characterization of a novel high molecular mass protein with peptidase activity purified from the human erythrocyte membrane by calmodulin affinity chromatography.
The Journal of biological chemistry. 269(13):10016-21 [PMID] 8144498.
View on: PubMed
1994
Differential proteolysis of the full-length form of the L-type calcium channel alpha 1 subunit by calpain.
Journal of neurochemistry. 63(4):1558-64 [PMID] 7931310.
View on: PubMed
1994
Phosphorylated and non-phosphorylated connexin-32 molecules in gap junction plaques are protected against calpain proteolysis after phosphorylation by protein kinase C.
Biochemical Society transactions. 22(3):793-6 [PMID] 7821687.
View on: PubMed
1993
Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain.
The Journal of biological chemistry. 268(19):14294-300 [PMID] 8390988.
View on: PubMed
1991
Structure–function relationship of the human erythrocyte plasma membrane Ca(2+)-ATPase revealed by V8 protease treatment.
The Biochemical journal. 279 ( Pt 2):537-44 [PMID] 1835379.
View on: PubMed
1990
Persistent Ca2(+)-induced activation of erythrocyte membrane Ca2(+)-ATPase unrelated to calpain proteolysis.
Archives of biochemistry and biophysics. 279(1):78-86 [PMID] 2140035.
View on: PubMed
1989
Calmodulin-binding proteins as calpain substrates.
The Biochemical journal. 262(3):693-706 [PMID] 2556106.
View on: PubMed
1988
Further characterization of calpain-mediated proteolysis of the human erythrocyte plasma membrane Ca2+-ATPase.
Archives of biochemistry and biophysics. 267(1):317-27 [PMID] 2848452.
View on: PubMed

Grants

Sep 2020 ACTIVE
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2020 ACTIVE
IPA for Jiepei Zhu
Role: Mentor
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Aug 2020 ACTIVE
Analytical Validation of Tau and P-Tau as acute and subacute prognostic biomarkers for complicated mild TBI
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2020 ACTIVE
Combinatorial biosignatures of network dysfunction to predict post-traumatic epilepsy: clinical translation from a robust mouse model
Role: Principal Investigator
Funding: MARIO NEGRI INSTITUTE via US ARMY MED RES ACQUISITION
Jun 2020 ACTIVE
Transforming Research And Clinical Knowledge in Geriatric Traumatic Brain Injury (TRACK-GERI)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via NATL INST OF HLTH NINDS
Feb 2020 ACTIVE
Project 1: Tau, Synapsin Biomarker Testing on Gryphon-provided biofluid biosamples, with Additional Testing on four other biomarkers
Role: Principal Investigator
Funding: GRYPHON BIO
Sep 2019 ACTIVE
PROOF-OF-PRINCIPLE TESTING OF TAU-SPECIFIC APTAMERS IN TBI-LINKED TAUOPATHY MODEL
Role: Principal Investigator
Funding: GRYPHON BIO via US ARMY MED RES ACQUISITION
May 2019 ACTIVE
Biomarker-based Precision Medicine Approach to Traumatic Brain Injury Subphenotypes
Role: Principal Investigator
Funding: SUNY DOWNSTATE MEDICAL CENTER via US ARMY MED RES ACQUISITION
Dec 2018 – May 2019
Evaluating the Use of Biofluid-based Biomarkers in pig samples as part of TBI Drug Development
Role: Principal Investigator
Funding: NEUROVIVE PHARMACEUTICAL AB
Sep 2018 ACTIVE
TRACK-TBI Precision Medicine – Pathomechanistic Classification of Traumatic Brain Injury: The Bridge to Targeted Therapies
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via US ARMY MED RES ACQUISITION
Sep 2018 ACTIVE
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Network (TRACK-TBI NET)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via US ARMY MED RES AND MATERIAL COM
May 2018 – Apr 2020
Animal TBI and neuroinflammation and autoimmunity responses
Role: Principal Investigator
Funding: MARIO NEGRI INSTITUTE
Apr 2018 ACTIVE
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2018 ACTIVE
Identifying proteomic, metabolomic and microRNA biomarkers signifying spontaneous post-traumatic epilepsy in a rat model of penetrating ballistic brain injury
Role: Principal Investigator
Funding: CURE-CITIZENS UNITED FOR RES IN EPILEPSY via US ARMY MED RES AND MATERIAL COM
Sep 2017 ACTIVE
Biomedical Research: Housing of mice to conduct brain research
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2017 – Sep 2018
Task Order #1 – Evaluating the use of biofluid-based biomarkers in TBI drug development study
Role: Principal Investigator
Funding: NEUROVIVE PHARMACEUTICAL AB
Apr 2017 – Mar 2020
International Collaboration On Neuroinflammation in Traumatic Brain Injury (ICON-TBI)
Role: Principal Investigator
Funding: UNIVERSITY OF CAMBRIDGE via NETWORK OF EUROPEAN FUNDING NEUROSCIENCE
Mar 2017 – Mar 2019
Evaluation of Tau and Phospho-Tau as TBI Biomarkers on the hs-HISCL Platform: Phase I
Role: Principal Investigator
Funding: SYSMEX CORPORATION
Apr 2016 – Mar 2020
TGF-BETA SIGNALING AS A NOVEL THERAPEUTIC TARGET FOR MILDTRAUMATIC BRAIN INJURY
Role: Principal Investigator
Funding: PALO ALTO VETERANS INST FOR RES via NATL INST OF HLTH NINDS
Mar 2016 – Jun 2019
BIOMARKERS OF SUBACUTE AND CHRONIC TBI
Role: Project Manager
Funding: SALEM VA MEDICAL CENTER
Jan 2016 – Jul 2016
Blade in vivo mouse fibrosis model with calpain inhibitors – calpain biomarker study
Role: Principal Investigator
Funding: BLADE THERAPEUTICS INC
Jan 2016 – Jan 2016
Enhancing the "regulatory readiness" of top 5 TBI biomarkers towards FDA drug development "Biomarker Qualification Program"
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via US DEPT OF DEFENSE
Sep 2014 – Sep 2020
TBI Endpoints Development (TED)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via US ARMY MED RES AND MATERIAL COM
Sep 2014 – Sep 2017
Biomarker Signatures in Blood for Acute and Chronic mTBI Using the SOFIA Technology
Role: Principal Investigator
Funding: STATE UNIV OF NEW YORK RES FOU via US ARMY MED RES ACQUISITION
Sep 2014 – Sep 2017
Biomarkers for Spinal Cord Injury-Related Medical Complications
Role: Principal Investigator
Funding: UNIV OF MIAMI via US ARMY MED RES ACQUISITION
Jul 2014 – Dec 2018
The Role of the Intestinal Microbiota in the Development
Role: Project Manager
Funding: FL BREAST CANCER FOU
May 2014 – Apr 2017
Elucidate Consequences of Autoimmune Response
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
May 2014 – Apr 2016
OBTT Extended Studies
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via US ARMY
Oct 2013 ACTIVE
COLLABORATIVE EUROPEAN NEUROTRAUMA EFFECTIVENESS RESEARCH(CENTER) TBICENTER-TBI
Role: Principal Investigator
Funding: UNIVERSITAIR ZIEKENHUIS ANTWERPEN via EUROPEAN UNION
Sep 2013 – Aug 2020
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via NATL INST OF HLTH NINDS
Jul 2013 – Jun 2018
Dr. Wang's Multtiple Sponsors
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Sep 2012 – Sep 2016
Biomarkers for Spinal Cord Injury-Related Medical Compli
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2011 – Sep 2016
Operation Brain Trauma Therapy (OBTT)
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via US ARMY
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH

Patents

Issued May 2006
Novel Application of Nanotechnology and Sensor Technologies for In Vitro Diagnostics
#7,052,854
Published April 2007
Real-Time Assessment of Biomarkers in Biological Fluids for Human Disease and Wellness and for Pathogen Contamination Monitoring in Water/fluid Supplies
#US-2008-0204043 A1
Issued November 2007
Detection of Spectrin and Spectrin Proteolytic Cleavage Products in Assessing Nerve Cell Damage
#7,291,710
Published November 2007
Imaging of Neural and Organ Injury or Damage
#US-2008-0311036-A1
Published June 2008
Neural Proteins as BioMarkers for Nervous System Injury and Other Neural Disorders (DIV of 11330)
#UF-2009-0087868-A1
Issued July 2008
Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders
#7,396,654
Issued November 2008
Proteolytic Biomarkers for Traumatic Injury to the Nervous System
#7,456,027
Issued November 2009
Detection of Cannabinoid Receptor Biomarkers and Uses Thereof (CIP of 11619)
#7,611,858
Issued January 2010
Biomarkers of Liver Ischemic Injury
#7,645,584
Issued September 2010
Endothelial-Monocyte Activating Polypeptide II (EMAP-II) As Brain Injury or Organ Injury Biomarker
#7799536
Issued November 2011
Biomarkers of Liver Ischemic Injury (CIP)
#8,048,638
Published December 2011
Biomarkers of Traumatic Brain Injury
#US-2012-0196307-A1
Published May 2012
In Vitro Diagnostic Devices for Nervous System Injury and Other Neural Disorders (CIP of 13629)
#US-2014-0303041-A1
Issued October 2012
Proteolytic Markers as Diagnostic Biomarkers for Cancer, Organ Injury and Muscle Rehabilitation/Exercise Overtraining
#8,298,835
Issued July 2013
Neural Proteins as BioMarkers for Nervous System Injury and Other Neural Disorders (CIP)
#8,492,107
Issued October 2013
Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury (CIP of PCT)
#8,557,526
Published September 2014
Endothelial-Monocyte Activating Polypeptide II (EMAP-II) As Brain Injury or Organ Injury Biomarker
#2015-0057193 A1
Published November 2016
Protein Biomarkers for Acute, Subacute and Chronic Traumatic Injuries of the Central Nervous System
#2017-0146555 A1
Issued May 2017
Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders [CON of 11330]
#9,664,694
Published November 2017
Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders [CON of 14378]
#US-2018-0059123-A1
Issued November 2017
Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders [CON of 13629]
#9,810,695

Teaching Profile

Courses Taught
2018-2019
IDH3931 Interdisciplinary Junior Honors
2018
MDT7090 Elective Topics
2018
CHM7980 Research for Doctoral Dissertation
2014
GMS6029 Brain Journal Club

Contact Details

Phones:
Business:
(352) 294-4900
Emails:
Business:
kwang@ufl.edu