ALS Background

ALS Background

What is ALS: ALS is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons.  This neuron loss leads to the loss of muscle control, eventually progressing to paralysis and death.

The majority of patients suffering with ALS have Sporadic ALS which have an unknown origin and are not inheritable.

Approximately 20% of all ALS cases are Familial ALS (fALS) which is an inheritable condition linked to mutations of several different genes.  Among the genes linked to fALS are those encoding AR (Androgen Receptor), TDP-43 (TAR DNA binding property), SOD1 (Superoxide dismutase 1), OPTN (otpineurin), and AND (angiogenin).

ALS Related Links

ALS Association