Brad E. Hoffman, PhD
Associate Professor
About Brad E. Hoffman
Associate Professor,
Department of Pediatrics
Department of Neuroscience
Accomplishments
Teaching Profile
Research Profile
The major focus of my research program is aimed at understanding and exploiting the unique molecular and cellular mechanisms required for the induction of immunological tolerance. As such, my research group is developing novel immunotherapies using the Adeno-associated virus (AAV) gene-therapy platform that are capable of inducing tolerogenic antigen-specific regulatory T cells (Tregs) as a therapeutic intervention for autoimmune and genetic disease such as Multiple Sclerosis. Recently, we were the first to demonstrate that an AAV vector could be used therapeutically to not only prevent development of disease, but to also abrogate preexisting (reverse) disease in multiple mouse models of Multiple Sclerosis.
0000-0002-5560-9580
- Adeno-Associated Viral Gene Therapy
- Autoimmune Disease
- Gene therapy
- Immune Tolerance
- Immunotherapy
- Multiple Sclerosis
Publications
Grants
Education
Contact Details
- Business:
- (352) 273-8152
- Business:
- bhoffman@ufl.edu
- Business Mailing:
-
CGRC 207
2033 MOWRY RD
PO BOX 103610
GAINESVILLE FL 326103010 - Business Street:
-
CGRC 403
2203 MOWRY RD
GAINESVILLE FL 32611