Christiaan Leeuwenburgh

Christiaan Leeuwenburgh, Ph.D.

Professor & Chief, Division Of Biology Of Aging

Department: MD-AGING/ GERIATRIC RES-OTHER
Business Phone: (352) 273-5735
Business Email: cleeuwen@ufl.edu

About Christiaan Leeuwenburgh

Christiaan Leeuwenburgh received his PhD from the University of Illinois, Urbana-Champagne in 1995 where his doctoral work focused on the regulation of glutathione homeostasis during chronic glutathione deficiencies and/or supplementation. He completed postdoctoral studies in Internal Medicine, Division of Geriatrics and Gerontology and Division of Atherosclerosis, Nutrition and Lipid Research at Washington University School of Medicine, Saint Louis. He became an Assistant Professor in 1998 at the University of Florida and the Director of the Biochemistry of Aging Laboratory. He was promoted to Associate Professor in 2002, Professor in 2007. In 2005 he joined the newly created Department of Aging and Geriatric Research, College of Medicine and Institute on Aging at the University of Florida. He is the Chief of the Division of Biology of Aging for the Department. Dr. Leeuwenburgh has joint faculty appointments in the Departments of Anatomy and Cell Biology, Biochemistry and Molecular Biology and a member of the department’s doctoral research faculty of the College of Medicine. Dr. Leeuwenburgh’s major research focus is to understand the molecular mechanism of oxidative stress and apoptosis with age in rodent models. The biochemistry of aging laboratory utilizes several animal models of aging. He is conducting research on the role of apoptosis in the loss of human skeletal muscle with age and it’s role in human frailty. He has participated in NIH workshops focused on the biology of aging and geriatric research of the National Institute on Aging. He has published papers in The Journal of Biological Chemistry, American Journal of Physiology and Science. He reviews regularly for numerous journals including American Journal of Physiology, Experimental Gerontology, Biogerontology, and the Journal of Gerontology and is a section editor for the Journal of Experimental Gerontology. In 2004 he received the Nathan Shock Award from the National Institute on Aging. He received the Merck Geriatric Cardiology Research Award from the Society of Geriatric Cardiology in 1999; the National Research Service Award of the NIH from the National Institute on Aging in 1997 and 1998; a Young Investigator Award from the Oxygen Society in 1996; and held an American Heart Association Pre-doctoral Fellowship from the Illinois Affiliate from 1993 through 1995. His work on assessment of oxidative damage in aging and apoptosis has been increasingly recognized and appreciated by gerontologists worldwide.

Accomplishments

Professorship Award
2019 · University of Florida
Dr. G. Lombard Kelly Lecturer
2018 · Medical College of Georgia, Augusta University
Professorship Award
2017 · University of Florida
University of Florida Research Foundation Professor
2011-2013 · University of Florida
Exemplary Teacher Award
2010 · College of Medicine, University of Florida
University of Florida Research Foundation Professor
2004-2006 · University of Florida
Nathan W. Shock Lecture Award
2004 · National Institute on Aging
American Heart Association, Young Investigator Award
2000-2002 · American Heart Association
Merck Geriatric Cardiology Research Award
1999-2000 · Society of Geriatric Cardiology
National Research Service Award, NRSA-NIH
1997-1998 · National Institute of Aging
Young Investigator Award, Oxygen Society, Intern
1996 · Soc. Free Rad. Res., Miami, FL
Honorary Fellow
1994-1995 · University of Wisconsin, Madison, WI
American Heart Association, Pre-doctoral Fellowship
1993-1995 · American Heart Association, Illinois Affiliate
The Avery Brundage Scholarship Award
1993 · University of Illinois, Urbana-Champaign, IL

Research Profile

Christiaan Leeuwenburgh’s major research focus is to understand the molecular mechanism of oxidative stress and apoptosis with age. His laboratory utilizes short and long lived animal models of aging. He is a pioneer in conducting research on the role of apoptosis in the loss of heart and skeletal muscle function with age.

Open Researcher and Contributor ID (ORCID)

0000-0003-0826-4257

Publications

2021
The Effect of Aging Physiology on Critical Care.
Critical care clinics. 37(1):135-150 [DOI] 10.1016/j.ccc.2020.08.006. [PMID] 33190766.
2020
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. [DOI] 10.1096/fj.202002150R. [PMID] 33140449.
2020
Skeletal Muscle Pathology in Peripheral Artery Disease: A Brief Review.
Arteriosclerosis, thrombosis, and vascular biology. 40(11):2577-2585 [DOI] 10.1161/ATVBAHA.120.313831. [PMID] 32938218.
2020
Septic Stability? Gut Microbiota in Young Adult MICE Maintains Overall Stability After Sepsis Compared to Old Adult MICE.
Shock (Augusta, Ga.). [DOI] 10.1097/SHK.0000000000001648. [PMID] 32826817.
2020
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
Experimental gerontology. [DOI] 10.1016/j.exger.2020.111111. [PMID] 33068691.
2020
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
Journal of the American Geriatrics Society. [DOI] 10.1111/jgs.16435. [PMID] 32294254.
2020
Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults?
Experimental gerontology. 137 [DOI] 10.1016/j.exger.2020.110972. [PMID] 32450270.
2020
Mitochondrial DNA damage in calf skeletal muscle and walking performance in people with peripheral artery disease.
Free radical biology & medicine. 160:680-689 [DOI] 10.1016/j.freeradbiomed.2020.09.004. [PMID] 32911084.
2020
Meaningful change in 6-minute walk in people with peripheral artery disease.
Journal of vascular surgery. [DOI] 10.1016/j.jvs.2020.03.052. [PMID] 32335305.
2020
Innovations in Geroscience to enhance mobility in older adults.
Experimental gerontology. 142 [DOI] 10.1016/j.exger.2020.111123. [PMID] 33191210.
2020
American Heart Association Vascular Disease Strategically Focused Research Network
Arteriosclerosis Thrombosis and Vascular Biology.
2020
Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease.
Journal of the American Heart Association. 9(10) [DOI] 10.1161/JAHA.118.015929. [PMID] 32390569.
2020
Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease.
Journal of vascular surgery. 71(3):988-1001 [DOI] 10.1016/j.jvs.2019.05.058. [PMID] 31870756.
2020
Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial.
Circulation research. 126(5):589-599 [DOI] 10.1161/CIRCRESAHA.119.315600. [PMID] 32078436.
2020
Clinical Characteristics and Response to Supervised Exercise Therapy in People with Lower Extremity Peripheral Artery Disease.
Journal of vascular surgery. [DOI] 10.1016/j.jvs.2020.04.498. [PMID] 32416309.
2020
Associations of Poly (ADP-Ribose) Polymerase1 abundance in calf skeletal muscle with walking performance in peripheral artery disease.
Experimental gerontology. 140 [DOI] 10.1016/j.exger.2020.111048. [PMID] 32755612.
2020
Associations of Peripheral Artery Disease With Calf Skeletal Muscle Mitochondrial DNA Heteroplasmy.
Journal of the American Heart Association. 9(7) [DOI] 10.1161/JAHA.119.015197. [PMID] 32200714.
2020
American Heart Association Vascular Disease Strategically Focused Research Network.
Arteriosclerosis, thrombosis, and vascular biology. 40(3):e47-e54 [DOI] 10.1161/ATVBAHA.120.313967. [PMID] 31969016.
2020
Differential response to targeted acupuncture by gender in patients with gastrointestinal cancer cachexia: secondary analysis of a randomized controlled trial.
Acupuncture in medicine : journal of the British Medical Acupuncture Society. 38(1):53-60 [DOI] 10.1177/0964528419873670. [PMID] 31544469.
2019
The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study.
Nutrients. 11(7) [DOI] 10.3390/nu11071500. [PMID] 31262054.
2019
Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise.
Expert opinion on therapeutic targets. 23(2):153-160 [DOI] 10.1080/14728222.2019.1559827. [PMID] 30580640.
2019
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.
Critical care (London, England). 23(1) [DOI] 10.1186/s13054-019-2505-7. [PMID] 31234943.
2019
Persistent inflammation and anemia among critically ill septic patients.
The journal of trauma and acute care surgery. 86(2):260-267 [DOI] 10.1097/TA.0000000000002147. [PMID] 30489504.
2019
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Critical care medicine. 47(11):e919-e929 [DOI] 10.1097/CCM.0000000000003926. [PMID] 31389840.
2019
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England). 23(1) [DOI] 10.1186/s13054-019-2628-x. [PMID] 31722736.
2019
Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults – A pilot study
Experimental Gerontology. 131 [DOI] 10.1016/j.exger.2019.110821. [PMID] 31891746.
2019
LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.
BMJ open. 9(9) [DOI] 10.1136/bmjopen-2019-029348. [PMID] 31537565.
2019
Glycine supplementation extends lifespan of male and female mice.
Aging cell. 18(3) [DOI] 10.1111/acel.12953. [PMID] 30916479.
2019
Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.
The journals of gerontology. Series A, Biological sciences and medical sciences. 74(10):1612-1619 [DOI] 10.1093/gerona/gly277. [PMID] 30541065.
2019
Differential response to targeted acupuncture by gender in patients with gastrointestinal cancer cachexia: secondary analysis of a randomized controlled trial.
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2019
Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats.
International journal of molecular sciences. 20(10) [DOI] 10.3390/ijms20102601. [PMID] 31137890.
2019
Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease
Journal of Vascular Surgery.
2019
Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease.
Journal of the American Heart Association. 8(13) [DOI] 10.1161/JAHA.118.010890. [PMID] 31257970.
2019
Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.
Cells. 8(12) [DOI] 10.3390/cells8121525. [PMID] 31783583.
2018
The “BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons” (BIOSPHERE) study: Rationale, design and methods.
European journal of internal medicine. 56:19-25 [DOI] 10.1016/j.ejim.2018.05.001. [PMID] 29753582.
2018
Persistent injury-associated anemia in aged rats.
Experimental gerontology. 103:63-68 [DOI] 10.1016/j.exger.2018.01.001. [PMID] 29307734.
2018
Persistent injury-associated anemia and aging: Novel insights.
The journal of trauma and acute care surgery. 84(3):490-496 [DOI] 10.1097/TA.0000000000001766. [PMID] 29466280.
2018
Persistent injury-associated anemia and aging: Novel insights
Journal of Trauma and Acute Care Surgery. 84(3):490-496
2018
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
Surgery. 164(2):178-184 [DOI] 10.1016/j.surg.2018.04.011. [PMID] 29807651.
2018
Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.
Nature reviews. Cardiology. 15(9):543-554 [DOI] 10.1038/s41569-018-0059-z. [PMID] 30042431.
2018
Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers.
Aging cell. 17(4) [DOI] 10.1111/acel.12761. [PMID] 29774638.
2018
Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart.
Free radical biology & medicine. 124:447-453 [DOI] 10.1016/j.freeradbiomed.2018.06.041. [PMID] 29969715.
2018
Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance.
Vascular medicine (London, England). 23(4):340-348 [DOI] 10.1177/1358863X18765667. [PMID] 29734865.
2018
HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study.
Shock (Augusta, Ga.). 50(1):66-70 [DOI] 10.1097/SHK.0000000000001030. [PMID] 29049133.
2018
Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart.
Biomolecules. 8(4) [DOI] 10.3390/biom8040177. [PMID] 30563025.
2018
Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.
Obesity (Silver Spring, Md.). 26(2):254-268 [DOI] 10.1002/oby.22065. [PMID] 29086496.
2018
Exciting Perspectives for Translational Myology in the Abstracts of the 2018Spring Paduamuscledays: Giovanni Salviati Memorial – Chapter II – Abstracts of March 15, 2018
European Journal of Translational Myology. 28(1):10-29 [DOI] 10.4081/ejtm.2018.7364. [PMID] 30057726.
2018
Effects of Fermented Papaya Preparation (Fpp) on Safety Outcomes in Older Adults – a Short Report of a Placebo- Controlled Clinical Trial
Journal of Frailty & Aging. 7(2):142-146 [DOI] 10.14283/jfa.2018.6.
2018
Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders.
Rejuvenation research. 21(4):350-359 [DOI] 10.1089/rej.2017.1989. [PMID] 29125070.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery. 84(2):342-349 [DOI] 10.1097/TA.0000000000001758. [PMID] 29251709.
2018
HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock.
PloS one. 13(9) [DOI] 10.1371/journal.pone.0203813. [PMID] 30216360.
2017
Systemic inflammation, body composition, and physical performance in old community-dwellers.
Journal of cachexia, sarcopenia and muscle. 8(1):69-77 [DOI] 10.1002/jcsm.12134. [PMID] 27897412.
2017
Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial.
Contemporary clinical trials communications. 6:58-63 [DOI] 10.1016/j.conctc.2017.03.002. [PMID] 28944303.
2017
Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers.
Journal of geriatric oncology. 8(1):69-75 [DOI] 10.1016/j.jgo.2016.09.004. [PMID] 27743848.
2017
Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets.
International journal of molecular sciences. 18(5) [DOI] 10.3390/ijms18050933. [PMID] 28452964.
2017
Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation.
Shock (Augusta, Ga.). 48(5):539-544 [DOI] 10.1097/SHK.0000000000000887. [PMID] 28452909.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open. 7(7) [DOI] 10.1136/bmjopen-2016-015136. [PMID] 28765125.
2017
Erratum to: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study.
Journal of translational medicine. 15(1) [DOI] 10.1186/s12967-017-1127-6. [PMID] 28241774.
2017
ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design.
Journal of the American Geriatrics Society. 65(9):1961-1968 [DOI] 10.1111/jgs.14965. [PMID] 28734043.
2017
Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials.
Nutrients. 9(8) [DOI] 10.3390/nu9080822. [PMID] 28758964.
2017
Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial.
JAMA cardiology. 2(8):902-907 [DOI] 10.1001/jamacardio.2017.0538. [PMID] 28403379.
2017
Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults.
Journal of the American Geriatrics Society. 65(10):2251-2256 [DOI] 10.1111/jgs.15037. [PMID] 28799216.
2017
Exercise-Induced Autophagy in Fatty Liver Disease.
Exercise and sport sciences reviews. 45(3):181-186 [DOI] 10.1249/JES.0000000000000116. [PMID] 28419000.
2016
Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study.
Journal of translational medicine. 14(1) [DOI] 10.1186/s12967-016-1030-6. [PMID] 27687713.
2016
Low- Versus High-Intensity Plyometric Exercise During Rehabilitation After Anterior Cruciate Ligament Reconstruction.
The American journal of sports medicine. 44(3):609-17 [DOI] 10.1177/0363546515620583. [PMID] 26797700.
2016
Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study.
Journal of translational medicine. 14(1) [PMID] 27784315.
View on: PubMed
2016
Integrated control of brown adipose tissue.
Heart and metabolism : management of the coronary patient. 69:9-14 [PMID] 27524955.
View on: PubMed
2016
Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle.
Oncotarget. 7(33):52695-52709 [DOI] 10.18632/oncotarget.10685. [PMID] 27447862.
2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 12(1):1-222 [DOI] 10.1080/15548627.2015.1100356. [PMID] 26799652.
2016
Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle.
The Journal of physiology. 594(18):5105-23 [DOI] 10.1113/JP270659. [PMID] 26503074.
2016
Autophagy in the liver: cell’s cannibalism and beyond.
Archives of pharmacal research. 39(8):1050-61 [DOI] 10.1007/s12272-016-0807-8. [PMID] 27515049.
2016
Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion.
Experimental gerontology. 85:88-94 [DOI] 10.1016/j.exger.2016.09.013. [PMID] 27647172.
2016
“What makes some rats live so long?” The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content.
Experimental gerontology. 85:33-40 [DOI] 10.1016/j.exger.2016.09.010. [PMID] 27620821.
2016
Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice
The Journal of Neuroscience. 36(44):11308-11319 [DOI] 10.1523/JNEUROSCI.2493-16.2016.
2015
The Role of Genome Instability in Frailty: Mitochondria versus Nucleus.
Nestle Nutrition Institute workshop series. 83:19-27 [DOI] 10.1159/000382055. [PMID] 26524430.
2015
Successful aging: Advancing the science of physical independence in older adults.
Ageing research reviews. 24(Pt B):304-27 [DOI] 10.1016/j.arr.2015.09.005. [PMID] 26462882.
2015
Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism.
Rejuvenation research. 18(2):162-72 [DOI] 10.1089/rej.2014.1624. [PMID] 25546413.
2015
Human Myeloid Derived Suppressor Cells Induce Immune Suppression After Severe Sepsis
Shock. 43(6, 1)
2015
Effect of Resistance Training During the Month of Ramadan on Antioxidants and Oxidative Stress Biomarkers in Recreational Bodybuilders
Biological Rhythm Research. 46(4):459-470 [DOI] 10.1080/09291016.2015.1015232.
2015
Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects.
BMC immunology. 16 [DOI] 10.1186/s12865-015-0106-z. [PMID] 26204934.
2015
Calorie Restriction Combined With Resveratrol Induces Autophagy and Protects 26-Month-Old Rat Hearts From Doxorubicin-Induced Toxicity (Vol 74, Pg 252, 2014)
Free Radical Biology and Medicine. 81 [DOI] 10.1016/j.freeradbiomed.2014.09.019.
2015
Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.
Medicine and science in sports and exercise. 47(9):1857-68 [DOI] 10.1249/MSS.0000000000000620. [PMID] 25606815.
2015
A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.
Journal of immunology (Baltimore, Md. : 1950). 195(5):2396-407 [DOI] 10.4049/jimmunol.1500984. [PMID] 26246141.
2015
Age-related cellular changes in the long-lived bivalve A. islandica.
Age (Dordrecht, Netherlands). 37(5) [DOI] 10.1007/s11357-015-9831-8. [PMID] 26318854.
2015
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Critical care (London, England). 19 [DOI] 10.1186/s13054-015-0788-x. [PMID] 25880307.
2014
A better understanding of why murine models of trauma do not recapitulate the human syndrome.
Critical care medicine. 42(6):1406-13 [DOI] 10.1097/CCM.0000000000000222. [PMID] 24413577.
2014
The authors reply.
Critical care medicine. 42(9) [DOI] 10.1097/CCM.0000000000000482. [PMID] 25126819.
2014
Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study.
Experimental gerontology. 57:181-7 [DOI] 10.1016/j.exger.2014.05.015. [PMID] 24866496.
2014
Quantitation of Oxidative Stress and Base Excision Repair in Skeletal Muscle of High- and Low-Functioning Elderly Individuals
The FASEB's Journal. 28(1, S)
2014
Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Journal of immunology (Baltimore, Md. : 1950). 192(7):3156-65 [DOI] 10.4049/jimmunol.1301726. [PMID] 24591376.
2014
Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery.
American journal of respiratory and critical care medicine. 190(7):837-9 [DOI] 10.1164/rccm.201405-0993LE. [PMID] 25271750.
2014
Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach.
Frontiers in medicine. 1 [DOI] 10.3389/fmed.2014.00027. [PMID] 25593902.
2014
Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach
Frontiers of Medicine. 1(27)
2014
Inadequate Pmn Chemokine Receptor Expression After Polymicrobial Abdominal Sepsis Contributes To Defective Pmn Chemotaxis in the Aged
Shock. 41(2)
2014
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
The journal of trauma and acute care surgery. 76(1):21-9; discussion 29 [DOI] 10.1097/TA.0b013e3182ab1ab5. [PMID] 24368353.
2014
Genomic Analysis of Individual Leukocyte Populations After Severe Trauma
Shock. 41(2)
2014
Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm.
Critical care medicine. 42(2):e152-6 [DOI] 10.1097/CCM.0b013e3182a63fdf. [PMID] 24126442.
2014
Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity.
Free radical biology & medicine. 74:252-62 [DOI] 10.1016/j.freeradbiomed.2014.06.011. [PMID] 24975655.
2014
Brown adipose tissue and the cold war against obesity.
Diabetes. 63(12):3998-4000 [DOI] 10.2337/db14-1373. [PMID] 25414014.
2014
Aged mice are unable to mount an effective myeloid response to sepsis.
Journal of immunology (Baltimore, Md. : 1950). 192(2):612-22 [DOI] 10.4049/jimmunol.1302109. [PMID] 24337739.
2014
Advanced Age Is An Independent Predictor of Complicated Outcomes and Mortality Among Severely Injured Pateints in Hemorrhagic Shock
Shock. 41(2)
2014
Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults.
Journal of applied physiology (Bethesda, Md. : 1985). 116(11):1481-90 [DOI] 10.1152/japplphysiol.01350.2012. [PMID] 23493365.
2014
Host responses to sepsis vary in different low-lethality murine models.
PloS one. 9(5) [DOI] 10.1371/journal.pone.0094404. [PMID] 24788351.
2014
A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat.
Biochimica et biophysica acta. 1840(7):2184-91 [DOI] 10.1016/j.bbagen.2014.03.004. [PMID] 24631828.
2013
Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation.
Evolution; international journal of organic evolution. 67(5):1527-36 [DOI] 10.1111/evo.12014. [PMID] 23617928.
2013
Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals.
Experimental gerontology. 48(9):858-68 [DOI] 10.1016/j.exger.2013.05.061. [PMID] 23747682.
2013
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences. 68(4):447-55 [DOI] 10.1093/gerona/gls196. [PMID] 23051977.
2013
Urinary Concentrations of Type II Collagen Cleavage Following Anterior Cruciate Ligament Reconstruction
. 21 [DOI] https://doi.org/10.1016/j.joca.2013.02.173.
2013
Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity.
Autophagy. 9(3):328-44 [DOI] 10.4161/auto.22971. [PMID] 23298947.
2013
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.
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Mitochondrial Function and Fatigability in Older Adults Who Report Severe Fatigue
Gerontologist. 53(1)
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The FASEB's Journal. 26
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2005
Age-related differences in apoptosis with disuse atrophy in soleus muscle.
American journal of physiology. Regulatory, integrative and comparative physiology. 288(5):R1288-96 [PMID] 15650125.
View on: PubMed
2005
Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 19(3):419-21 [PMID] 15642720.
View on: PubMed
2004
Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content.
American journal of physiology. Regulatory, integrative and comparative physiology. 286(2):R254-9 [PMID] 14592935.
View on: PubMed
2004
Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria.
Annals of the New York Academy of Sciences. 1019:333-42 [PMID] 15247039.
View on: PubMed
2004
Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet
Annals of the New York Academy of Sciences. 1019:269-273
2004
Linkage between insulin and the free radical theory of aging.
American journal of physiology. Regulatory, integrative and comparative physiology. 286(1):R20-1 [PMID] 14660473.
View on: PubMed
2004
Lifelong aspirin supplementation as a means to extending life span.
Rejuvenation research. 7(4):243-51 [PMID] 15671726.
View on: PubMed
2004
Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats.
FEBS letters. 577(3):483-90 [PMID] 15556633.
View on: PubMed
2004
Effects of age and caloric restriction on brain neuronal cell death/survival.
Annals of the New York Academy of Sciences. 1019:96-105 [PMID] 15247000.
View on: PubMed
2004
Ageing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production
Acta Physiologica. 182(4):333-341
2004
C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels.
Arteriosclerosis, thrombosis, and vascular biology. 24(10):1874-9 [PMID] 15271790.
View on: PubMed
2004
Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12.
Free radical biology & medicine. 36(1):27-39 [PMID] 14732288.
View on: PubMed
2004
Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm.
American journal of physiology. Regulatory, integrative and comparative physiology. 287(1):R33-8 [PMID] 14764436.
View on: PubMed
2003
The role of Id2 and apoptosis during skeletal muscle remodeling.
American journal of physiology. Regulatory, integrative and comparative physiology. 284(2):R538-9 [PMID] 12529289.
View on: PubMed
2003
Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats.
Biogerontology. 4(3):141-7 [PMID] 12815313.
View on: PubMed
2003
Role of apoptosis in sarcopenia.
The journals of gerontology. Series A, Biological sciences and medical sciences. 58(11):999-1001 [PMID] 14630880.
View on: PubMed
2003
Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction.
American journal of physiology. Regulatory, integrative and comparative physiology. 285(5):R1259-67 [PMID] 12855419.
View on: PubMed
2003
Lifelong caloric restriction increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(3):494-6 [PMID] 12514107.
View on: PubMed
2003
Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels.
Experimental gerontology. 38(8):897-903 [PMID] 12915211.
View on: PubMed
2003
Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart
American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 284(2):R474-R480
2003
A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males.
Medicine and science in sports and exercise. 35(12):2032-7 [PMID] 14652498.
View on: PubMed
2003
Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space.
Journal of applied physiology (Bethesda, Md. : 1985). 95(6):2554-62 [PMID] 12972444.
View on: PubMed
2002
Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis.
Biochimica et biophysica acta. 1588(1):94-101 [PMID] 12379319.
View on: PubMed
2002
The role of apoptosis in the normal aging brain, skeletal muscle, and heart.
Annals of the New York Academy of Sciences. 959:93-107 [PMID] 11976189.
View on: PubMed
2002
Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.
Cancer research. 62(16):4592-8 [PMID] 12183413.
View on: PubMed
2002
Aging and the role of reactive nitrogen species.
Annals of the New York Academy of Sciences. 959:66-81 [PMID] 11976187.
View on: PubMed
2002
Apoptosis in skeletal muscle with aging.
American journal of physiology. Regulatory, integrative and comparative physiology. 282(2):R519-27 [PMID] 11792662.
View on: PubMed
2002
Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age.
American journal of physiology. Regulatory, integrative and comparative physiology. 282(2):R423-30 [PMID] 11792651.
View on: PubMed
2001
A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease
The Journal Of Clinical Investigation. 107(7):853-860
2001
Aged rat hearts are not more susceptible to ischemia-reperfusion injury in vivo: role of glutathione
Mechanisms of Ageing and Development. 122(6):503-518
2001
Apoptosis and aging: role of the mitochondria
Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 56(11):B475-B482
2001
Apoptosis and exercise
. 33(3):393-396
2001
Oxidative stress and antioxidants in exercise.
Current medicinal chemistry. 8(7):829-38 [DOI] 10.2174/0929867013372896. [PMID] 11375753.
2001
Reactive carbonyl formation by oxidative and non-oxidative pathways
. 6:A17-A24
2001
Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise
Free Radical Biology and Medicine. 31(6):745-753
2000
Increased oxidative stress in kwashiorkor
Journal of Pediatrics. 137(3):421-424
1999
Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review.
Medicine and Science in Sports and Exercise. 31(7):987-97 [DOI] 10.1097/00005768-199907000-00011. [PMID] 10416560.
1999
Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine
Free Radical Biology and Medicine. 27(1-2):186-192
1999
Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease
Circulation. 99(25):3234-3240
1999
Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo
American Journal of Physiology. 276(1):R128-R135
1999
Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues
Methods In Enzymology. 300:124-144
1998
Oxidative stress and mitochondrial function in skeletal muscle: Effects of aging and exercise training
Age. 21(3):109-117
1998
Oxidative stress and aging. Role of exercise and its influences on antioxidant systems
Annals of the New York Academy of Sciences. 854:102-117
1998
Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats
. 274(2):R453-R461
1998
Glutathone and glutathione ethyl ester supplementation of mice alter glutathione homeostasis during exercise
Journal of Nutrition. 128(12):2420-2426
1998
Endurance training alters antioxidant enzyme gene expression in rat skeletal muscle
Canadian Journal of Physiology and Pharmacology. 76(12):1139-1145
1998
Isotope dilution mass spectrometric quantification of 3-nitrotyrosine in proteins and tissues is facilitated by reduction to 3-aminotyrosine
Annals of Clinical Biochemistry. 259(1):127-135
1997
Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific
American Journal of Physiology. 272(1):R363-R369
1997
Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice
Archives of Biochemistry and Biophysics. 346(1):74-80
1997
Fatty streak formation in fat-fed mice expressing human copper-zinc superoxide dismutase
Arteriosclerosis Thrombosis and Vascular Biology. 17(9):1734-1740
1997
Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques
Journal of Biological Chemistry. 272(6):3520-3526
1997
Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima
Journal of Biological Chemistry. 272(3):1433-1436
1997
Rigorous swim training impairs mitochondrial function in post-ischaemic rat heart
. 160(2):139-148
1996
Alteration of glutathione and antioxidant status with exercise in unfed and refed rats
Journal of Nutrition. 126(7):1833-1843
1996
Effect of acute exercise on glutathione deficient heart
. 156(1):17-24
1996
Ischaemia-reperfusion induced alterations of mitochondrial function in hypertrophied rat heart
. 156(1):51-60
1995
Glutathione depletion in rested and exercised mice: biochemical consequence and adaptation
Archives of Biochemistry and Biophysics. 316(2):941-949
1994
Aging and exercise training in skeletal muscle: responses of glutathione and antioxidant enzyme systems
. 267(2):R439-R445

Grants

May 2020 ACTIVE
Translational Research Training on Aging and Mobility (TRAM)
Role:
Funding: NATL INST OF HLTH NIA
Apr 2020 ACTIVE
The Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
Role:
Funding: NATL INST OF HLTH NIGMS
Sep 2019 ACTIVE
Nicotinamide riboside as an Enhancer of Exercise Therapy in hypertensive older adults: The NEET Trial
Role:
Funding: NATL INST OF HLTH NIA
Jul 2019 ACTIVE
Molecular Biology in Burns and Trauma
Role:
Funding: NATL INST OF HLTH NIGMS
Aug 2018 ACTIVE
Senescence and Growth Differentiation Factors as Modifiers of Aging
Role:
Funding: MAYO CLINIC via NATL INST OF HLTH NIA
Aug 2018 ACTIVE
INTERmittent pneumatic ComprEssion for Disablility rEversal in PAD: the INTERCEDE Trial
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via NATL INST OF HLTH NIA
Jul 2018 ACTIVE
Cardiac Dysfunction in Older Sepsis Survivors
Role:
Funding: AMER HEART ASSOCIATION
Jul 2018 ACTIVE
Role of PFKFB3 in peripheral artery disease
Role:
Funding: AMER HEART ASSOCIATION
Jun 2018 ACTIVE
OR-DRPD-ROF2018: The LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P) Trial
Role:
Funding: UF RESEARCH
Jun 2018 – May 2020
PICS: A New Horizon for Surgical Critical Care
Role:
Funding: NATL INST OF HLTH NIGMS
Apr 2018 ACTIVE
Biobehavioral mechanisms underlying symptoms and healing outcomes in older individuals with CVLU
Role:
Funding: NATL INST OF HLTH NINR
Apr 2018 ACTIVE
Calf Muscle Mitochondrial Dysfunction and Impaired Autophagy in Peripheral Artery Disease
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via AMER HEART ASSOCIATION
Apr 2018 ACTIVE
NICotinomidE riboside with and without resveratrol to improve functioning in peripheral artery disease: The NICE Trial
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via AMER HEART ASSOCIATION
Sep 2017 ACTIVE
The University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)
Role:
Funding: NATL INST OF HLTH NIA
Aug 2017 – Apr 2018
Resveratrol and exercise to treat functional limitations in late life
Role:
Funding: UNIV OF ALABAMA BIRMINGHAM via NATL INST OF HLTH NIA
Jul 2017 ACTIVE
The effect of intermittent hemidiaphragm stimulation during surgery on mitochondrial function, single fiber contractile force and catabolic pathways in humans
Role:
Funding: NATL INST OF HLTH NIAMS
Jun 2017 – May 2018
PICS: A New Horizon for Surgical Critical Care
Role:
Funding: NATL INST OF HLTH NIGMS
Apr 2017 ACTIVE
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role:
Funding: NATL INST OF HLTH NIA
Dec 2016 ACTIVE
UF PASS: Regulation of exercise transducers
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Dec 2016 ACTIVE
Improve PAD PERformance with METformin: The PERMET Trial
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via NATL INST OF HLTH NHLBI
Dec 2016 ACTIVE
MoTrPAC Consortium Coordinating Center
Role:
Funding: NATL INST OF HLTH NIAMS
Sep 2016 – Aug 2020
The Role of Dysfunctional HDL in Sepsis
Role:
Funding: NATL INST OF HLTH NIGMS
Jun 2016 – Feb 2019
COCOA to improve walking performance in Peripheral Artery Disease: the COCOA-PAD Study
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via NATL INST OF HLTH NIA
Jun 2016 – May 2017
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Apr 2016 – Mar 2017
Claude D Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Aug 2015 – Apr 2020
Telmisartan Plus Exercise to Improve Functioning in PAD: The TELEX Trial
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via NATL INST OF HLTH NHLBI
Jun 2015 – May 2016
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Apr 2015 – Mar 2016
Claude D. Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Apr 2015 – Jan 2019
Low intensity exercise intervention in peripheral artery disease
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via NATL INST OF HLTH NHLBI
Apr 2015 ACTIVE
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe Injury
Role:
Funding: NATL INST OF HLTH NIGMS
Jun 2014 ACTIVE
Obesity and Type-2 Diabetes: Bariatric Surgery Effects on Brain Function
Role:
Funding: NATL INST OF HLTH NIDDK
May 2014 – Apr 2017
RESTORE TRIAL
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via NATL INST OF HLTH
Jan 2014 – Dec 2018
MtDNA variant modifiers of cardiopulmonary responsiveness to physical activity
Role:
Funding: NATL INST OF HLTH NHLBI
Sep 2013 – Dec 2019
REVIVE – Resveratrol to enhance vitality and vigor in elders
Role:
Funding: NATL CTR FOR COMPLEM AND INTEGRATIVE HLT
Apr 2012 – Mar 2017
Mitophagy: A novel target to improve liver function afte
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Sep 2011 – Nov 2018
The LIFE Study
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jul 2007 – Aug 2016
CTSI
Role: Project Manager
Funding: UF RESEARCH FOU via UF RESEARCH FOUNDATION

Patents

Issued April 2003
Human Model to Rapidly Test the Efficacy of a variety of Anti-inflammatory and Antioxidant Compounds (Pharmaceutical or Non-pharmaceutical)
#6,541,265

Education

Post-Doc, Internal Medicine
1995-1998 · Washington University School of Medicine Instructor Geriatrics & Gerontology
Fellow, Biochemistry and Aging
1993-1995 · University of Wisconsin
PhD in Biochemistry and Aging
1990-1995 · University of Illinois
Masters of Science in Applied Physiology
1988-1990 · University of Florida
Bachelors of Science in Applied Physiology
1986-1988 · University of Florida

Teaching Profile

Courses Taught
2010,2013-2016,2016-2020,2018-2020,2020
GMS6622 Mitochondrial Biology in Aging and Disease
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
VME7980 Research for Doctoral Dissertation
2014,2016-2018
GMS6421 Cell Biology
2013-2015
GMS6417 Integrative Aging Physiology
2015
GMS6063 Mechanisms of Aging

Contact Details

Phones:
Business:
(352) 273-5735
Emails:
Business:
cleeuwen@ufl.edu