Ron J Mandel,
Professor
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About Ron J Mandel
My research has focused on gene transfer to the nervous system both to treat animal models of neurological disorders and to model neurological disorders. The bulk of my research has focused on Parkinson’s disease. During my second stint at Wallenberg Neuroscience Center, we developed and validated the nigral rAAV-α-synuclein model of Parkinson’s disease. In collaboration with Nicholas Muzyczka, we have continued to use rAAV vectors to study the basic biology of α-synuclein in substantia nigra both by studying various forms of α-synuclein and by knocking down α-synuclein via shRNAs. I have done the most work on rAAV mediated GDNF delivery for the treatment of PD. More recently, I have branched out to gene therapy for many neurological disorders. Currently, I am using rAAV delivered DREADDs to study the basal ganglia circuits involved in repetitive behaviors which may be related to autism.
Teaching Profile
Courses Taught
Research Profile
0000-0002-4070-725X
Publications
Academic Articles
Grants
-
OR-DRPD-ROF2020:Role of the Hyperdirect Basal Ganglia Pathway in Mediating Repetitive, Inflexible Behavior
- Role:
- Co-Investigator
- Funding:
- UF RESEARCH
-
Optimizing AAV Vectors for Central Nervous System transduction
- Role:
- Co-Investigator
- Funding:
- NATL INST OF HLTH NINDS
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Functional mapping of peripheral and central circuits for airway protection and breathing
- Role:
- Co-Investigator
- Funding:
- NATL INST OF HLTH OD
-
Development of appropriate control transgenes for long term viral vector mediated gene transfer and optical imaging in the Nigra
- Role:
- Principal Investigator
- Funding:
- FOX FOU, MICHAEL J
Contact Details
- Business:
- (352) 294-5547
- Business:
- rmandel@ufl.edu
- Business Street:
-
PO BOX 100244
Department of Neuroscience
Gainesville FL 32610