Selective Knockout of Acid Alpha-Glucosidase Gaa Gene Expression in the Medulla Alters Breathing
The FASEB's Journal. 28(1, S)
Raav2/5-Mediated Gene Transfer Is Less Efficient in the Aged Rat Brain: Examination of Alpha-Synuclein-Mediated Neurodegeneration in the Nigrostriatal System
Cell Transplantation. 22
Viral Vector Mediated Overexpression of Pleiotrophin for Disease Modification in Parkinson’s Disease
Molecular Therapy. 21:S146-S147
Alpha-Synuclein Overexpression in the Aged Brain: Is the Aging Nigrostriatal System More Susceptible To Alpha-Synuclein-Mediated Neurodegeneration?
Cell Transplantation. 21(4):779-780
Alpha-Synuclein Overexpression in the Aged Rat Brain: Is the Aging Nigrostriatal System More Suseptible To Alpha-Synuclein Mediated Neurodegeneration?
Molecular Therapy. 20
Effects of Minozak And/Or Genistein On the Central Nervous System of Sanfilippo Syndrome Type B Mice
Molecular Genetics and Metabolism. 105(2) [DOI] 10.1016/j.ymgme.2011.11.060.
View on: Publisher’s Site
Raav-Mediated Shrna Knockdown of Alpha-Synuclein in the Rat Substantia Nigra Results in Aberrant Dopamine Handling
Cell Transplantation. 20
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Human molecular genetics. 20(14):2770-82 [DOI] 10.1093/hmg/ddr176. [PMID] 21515588.
Effects of Oxyten in An Invertebrate Model of Amphetamine Neurotoxicity
Biological Psychiatry. 69
Optimal Nigrostriatal Transduction Targets for Pleiotrophin Gene Therapy in the Parkinsonian Rodent Model
Cell Transplantation. 19
Enhanced Cns Transgene Expression By Raav Capsid Tyrosine Mutants
Cell Transplantation. 19
CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer’s disease.
Current opinion in molecular therapeutics. 12(2):240-7 [PMID] 20373268.
Cere-110, An Adeno-Associated Virus-Based Gene Delivery Vector Expressing Human Nerve Growth Factor for the Treatment of Alzheimer’s Disease
Current Opinion in Molecular Therapeutics. 12:240-247
A Behavioral, Histopatholgical, and Anatomical Characterization of the Cag140 Huntington’s Disease Mouse Model
Cell Transplantation. 19
Development of gene therapy for neurological disorders.
Discovery medicine. 9(46):204-11 [PMID] 20350486.
Weight Loss in Obese Leptin-Resistant Rats Induced By Activation of Crh Neurons in the Paraventricular Nucleus of the Hypothalamus By Overexpression of Substantial Nigral-Injected Raav5-Gdnf
Cell Transplantation. 18
Tight Durable Long-Term Doxycycline-Mediated Gdnf Regulation From a Single Raav Vector in the Nigrostiatal Tract
Cell Transplantation. 18:224-225
Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(5):1544-53 [DOI] 10.1523/JNEUROSCI.4491-08.2009. [PMID] 19193901.
Gene therapy for neurological disorders: challenges and future prospects for the use of growth factors for the treatment of Parkinson’s disease.
Current gene therapy. 9(5):375-88 [PMID] 19860652.
Differential Infectivity Following Basal Ganglia Administration of Differing Aav Serotypes in Nonhuman Primates
Cell Transplantation. 18:212-213
Determination of Peak Developmental Levels of Pleiotrophin for Optimized Gene Transfer Therapy in Parkinsonian Animal Models
Cell Transplantation. 18
Bilateral Nigral Raav5-Mediated Gdnf Over-Expression Activates Crh Neurons in the Paraventricular Nucleus of the Hypothalamus and Induces Robust Weight Loss in Obese Leptin-Resistant Rats
Molecular Therapy. 17
Absolute Control of Raav Mediated Gdnf Expression in the Nigrostriatal Tract Using a Single Vector Tetracycline Responsive Expression System
Molecular Therapy. 17
Viral vectors for in vivo gene transfer in Parkinson’s disease: properties and clinical grade production.
Experimental neurology. 209(1):58-71 [PMID] 17916354.
The Potential for the Trophic Factor Pleiotrophin (Ptn) To Protect the Parkinsonian Brain
Cell Transplantation. 17
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America. 105(2):763-8 [DOI] 10.1073/pnas.0711053105. [PMID] 18178617.
Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat.
Human gene therapy. 19(1):71-82 [PMID] 18072858.
Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons.
Human gene therapy. 19(1):61-70 [PMID] 18052722.
Effects of Raav Delivered Heat Shock Protein 27 and 70 To the Striatum of a Knock-in Mouse Model of Huntington’S Disease
Cell Transplantation. 17
Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(8):1504-11 [PMID] 17565350.
rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson’s disease.
Experimental neurology. 207(2):289-301 [PMID] 17678648.
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.
Brain : a journal of neurology. 130(Pt 3):799-815 [PMID] 17303591.
Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions.
Current gene therapy. 7(5):347-60 [PMID] 17979681.
BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson’s disease in diverse ethnic groups.
Neuroscience letters. 415(1):59-63 [PMID] 17229524.
Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments.
Neurobiology of learning and memory. 87(1):21-41 [PMID] 16829144.
Comprehensive screening of a North American Parkinson’s disease cohort for LRRK2 mutation.
Neuro-degenerative diseases. 4(5):386-91 [PMID] 17622782.
A method for a more complete in vitro Parkinson’s model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit.
Journal of neuroscience methods. 157(1):1-9 [PMID] 16704878.
Genome-wide genotyping in Parkinson’s disease and neurologically normal controls: first stage analysis and public release of data.
The Lancet. Neurology. 5(11):911-6 [PMID] 17052657.
Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity.
Neurobiology of aging. 27(3):459-70 [PMID] 15964099.
LRRK2 mutations in a clinic-based cohort of Parkinson’s disease.
European journal of neurology. 13(12):1298-301 [PMID] 17116211.
Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders.
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RNA knockdown as a potential therapeutic strategy in Parkinson’s disease.
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The human prion gene M129V polymorphism is not associated with idiopathic Parkinson’s disease in three distinct populations.
Neuroscience letters. 395(3):227-9 [PMID] 16298483.
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington’s disease transgenic mice.
Molecular therapy : the journal of the American Society of Gene Therapy. 12(4):618-33 [PMID] 16019264.
Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse.
Biochemical and biophysical research communications. 326(3):638-44 [PMID] 15596147.
Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion.
Molecular therapy : the journal of the American Society of Gene Therapy. 11(2):327-31 [PMID] 15668145.
Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson’s disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(4):769-77 [PMID] 15673656.
Recombinant adeno-associated viral vectors in the nervous system.
Human gene therapy. 16(7):781-91 [PMID] 16000060.
Reversal of dyskinesias in an animal model of Parkinson’s disease by continuous L-DOPA delivery using rAAV vectors.
Brain : a journal of neurology. 128(Pt 3):559-69 [PMID] 15659429.
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.
Archives of neurology. 61(12):1898-904 [PMID] 15596610.
Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain.
Journal of virology. 78(12):6344-59 [PMID] 15163728.
Clinical trials in neurological disorders using AAV vectors: promises and challenges.
Current opinion in molecular therapeutics. 6(5):482-90 [PMID] 15537049.
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system.
Molecular therapy : the journal of the American Society of Gene Therapy. 10(2):302-17 [PMID] 15294177.
Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease.
Molecular therapy : the journal of the American Society of Gene Therapy. 7(5 Pt 1):580-7 [PMID] 12718900.
Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke.
The European journal of neuroscience. 17(12):2667-78 [PMID] 12823474.
Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats.
Neurobiology of disease. 14(3):542-56 [PMID] 14678770.
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson’s disease.
Proceedings of the National Academy of Sciences of the United States of America. 100(5):2884-9 [PMID] 12601150.
Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus).
Experimental neurology. 184(1):536-48 [PMID] 14637123.
Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor.
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Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.
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Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(7):2780-91 [PMID] 11923443.
Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors.
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Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats.
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Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra.
The Journal of comparative neurology. 426(4):534-48 [PMID] 11027397.
Effect of acute L-Dopa pretreatment on apomorphine-induced rotational behavior in a rat model of Parkinson’s disease.
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Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson’s model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.
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The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS.
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Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model.
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Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson’s disease.
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Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced degeneration.
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Progress in direct striatal delivery of L-dopa via gene therapy for treatment of Parkinson’s disease using recombinant adeno-associated viral vectors.
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Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson’s disease.
Experimental neurology. 160(1):205-14 [PMID] 10630205.
Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice.
Neuron. 22(1):167-78 [PMID] 10027299.
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery.
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Regulation of gene expression in vivo following transduction by two separate rAAV vectors.
Nature biotechnology. 16(8):757-61 [PMID] 9702775.
Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson’s disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 18(11):4271-84 [PMID] 9592104.
A third-generation lentivirus vector with a conditional packaging system.
Journal of virology. 72(11):8463-71 [PMID] 9765382.
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase.
Experimental neurology. 151(2):249-64 [PMID] 9628761.
Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson’s disease in rats.
Proceedings of the National Academy of Sciences of the United States of America. 94(25):14083-8 [PMID] 9391156.
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
Nature biotechnology. 15(9):871-5 [PMID] 9306402.
Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson’s disease.
Experimental neurology. 144(1):147-56 [PMID] 9126164.
Amphetamine sensitivity in open-field activity vs. the prepulse inhibition paradigm.
Brain research bulletin. 37(2):219-22 [PMID] 7606498.
Amphetamine induces excess release of striatal acetylcholine in vivo that is independent of nigrostriatal dopamine.
Brain research. 653(1-2):57-65 [PMID] 7982076.
Characterization of GABA release from intrastriatal striatal transplants: dependence on host-derived afferents.
Neuroscience. 53(2):403-15 [PMID] 8098510.
Trophism, transplantation, and animal models of Parkinson’s disease.
Experimental neurology. 124(1):140-9 [PMID] 8282071.
A quantitative estimate of the role of striatal D-2 receptor proliferation in dopaminergic behavioral supersensitivity: the contribution of mesolimbic dopamine to the magnitude of 6-OHDA lesion-induced agonist sensitivity in the rat.
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Behavioral quantification of striatal dopaminergic supersensitivity after bilateral 6-hydroxydopamine lesions in the mouse.
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Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum.
Neuroscience. 46(4):943-57 [PMID] 1347413.
Fos expression in intrastriatal striatal grafts: regulation by host dopaminergic afferents.
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Independent effects of age and nucleus basalis magnocellularis lesion: maze learning, cortical neurochemistry, and morphometry.
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Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat.
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The Importance of Graft Placement and Task Complexity for Transplant-Induced Recovery of Simple and Complex Sensorimotor Deficits in Dopamine Denervated Rats.
The European journal of neuroscience. 2(10):888-894 [PMID] 12106096.
Tetrahydroaminoacridine improves the spatial acquisition deficit produced by nucleus basalis lesions in rats.
Experimental neurology. 108(3):221-8 [PMID] 2351210.
Behavioral demonstration of a reciprocal interaction between dopamine receptor subtypes in the mouse striatum: possible involvement of the striato-nigral pathway.
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Bromocriptine-induced rotation: characterization using a striatal efferent lesion in the mouse.
Brain research bulletin. 24(2):175-80 [PMID] 2108786.
Nucleus basalis lesions fail to induce senile plaques in the rat.
Experimental neurology. 108(1):88-90 [PMID] 2318291.
Continuous physostigmine infusion in rats with excitotoxic lesions of the nucleus basalis magnocellularis: effects on performance in the water maze task and cortical cholinergic markers.
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Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial learning deficit in rats by modification of training regimen.
Behavioural brain research. 31(3):221-9 [PMID] 2914073.
Multisite recording of brain field potentials and unit activity in freely moving rats.
Journal of neuroscience methods. 28(3):209-17 [PMID] 2755179.
Spatial learning in rats: correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage.
Experimental neurology. 104(3):208-17 [PMID] 2721623.
Nucleus basalis and thalamic control of neocortical activity in the freely moving rat.
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Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats.
Psychopharmacology. 96(3):421-5 [PMID] 3146779.
Alteration of calmodulin distribution does not accompany dopaminergic supersensitization of the mouse striatum.
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Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in the mouse.
Brain research. 330(2):358-63 [PMID] 3921193.
Thermal denaturation of DNA and DNA:polypeptide complexes. Simultaneous absorption and circular dichroism measurements.
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Jul 2020 ACTIVE
OR-DRPD-ROF2020:Role of the Hyperdirect Basal Ganglia Pathway in Mediating Repetitive, Inflexible Behavior
Funding: UF RESEARCH
Aug 2017 ACTIVE
Optimizing AAV Vectors for Central Nervous System transduction
Funding: NATL INST OF HLTH NINDS
Sep 2016 ACTIVE
Functional mapping of peripheral and central circuits for airway protection and breathing
Funding: NATL INST OF HLTH OD
May 2013 – Dec 2017
Development of appropriate control transgenes for long t
Role: Principal Investigator
Funding: FOX FOU, MICHAEL J
GMS6705 Functional Human Neuroanatomy
GMS7795 Special Topics in Neuroscience
GMS6750 Molecular Pathobiology of Neural Disease
GMS6029 Brain Journal Club
BMS6020 Clinical Neuroscience
MDT7801 Elect Top/Neuroscienc
GMS7980 Research for Doctoral Dissertation
GMS7979 Advanced Research
VEM5110 Animal Systems 1
IDH4917 Undergrad Research
GMS7794 Neuroscience Seminar