Luis R Martinez

Luis R Martinez, Ph.D., M.S., M.B.A.

Associate Professor

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-8135
Business Email: lmartinez@dental.ufl.edu

About Luis R Martinez

I was born and raised in Puerto Rico. I am an associate professor in the Department of Oral Biology at the University of Florida College of Dentistry. My research focuses on elucidating the mechanisms of fungal brain invasion and colonization in immunocompromised individuals.

Related Links:

Accomplishments

UTEP-Edge Fellowship
2019 · The University of Texas at El Paso
UTEP-Outstanding Performance Award
2019 · The University of Texas at El Paso
AAAS Leshner Public Engagement Fellow in Infectious Diseases
2017 · American Association for the Advancement of Science (AAAS)
NYIT-Faculty Scholar (distinguished speaker)
2017 · New York Institute of Technology
ABRCMS Judges' Travel Subsidy Program
2015 · Annual Biomedical Research Conference For Minoritized Scientists
Thomas J. Walsh Junior Investigator Award
2014 · Medical Mycological Society of the Americas (MMSA)
Protein Purification and Characterization
2012 · Cold Spring Harbor Laboratory
Health Care Hero Award
2011 · Long Island Business News
LIU-Research Faculty Committee Award
2011 · Long Island University
NIH-NIAID Career Transition Award (K22)
2011 · National Institute of Allergy and Infectious Diseases
Dennis Shield Travel Award for Outstanding Post-doctoral Research
2010 · Albert Einstein College of Medicine
NIH-Loan Repayment Program
2010 · National Institutes of Health
ASM-Minority Travel Award
2007 · American Society for Microbiology
Molecular Mycology: Current Approaches to Fungal Pathogenesis
2006 · Marine Biological Laboratory
NIH-Molecular Pathogenesis Training Grant (Postdoctoral fellowship)
2006 · National Institutes of Health
NIH-Synergy of Host Defense Mechanisms Training Grant (PhD training)
2002 · National Institutes of Health
FASEB-MARC Travel Award to Experimental Biology Annual Meeting
2001 · Experimental Biology
NIH-Minority Bridge to the doctorate awardee
2000 · National Institutes of Health

Teaching Profile

Courses Taught
2020-2022
GMS6040 Host-Pathogen Interactions
2021
GMS6162 Oral Microbiology and Immunology
2021-2022
DEN5127 Infectious Diseases
2021-2022
DEN6128 Host Defense
2022
DEN6681 Craniofacial Pathobiology
2022
GMS6121 Infectious Diseases

Research Profile

The encapsulated fungus Cryptococcus neoformans is the most common cause of fungal meningitis, with the highest rate of disease in patients with AIDS. This microbe has developed its virulence factors by interacting with other organisms in the environment. It enters into the human body via the respiratory tract and the infection is controlled in the lungs of people with normal immunity. When a person’s immune system is defective, C. neoformans moves into the bloodstream and the fungus disseminates with a particular propensity to infect the brain. We are interested in elucidating the mechanisms of central nervous system (CNS) invasion by C. neoformans and the interactions of the fungus with cells of the CNS including microglia, astrocytes, and neurons.

Open Researcher and Contributor ID (ORCID)

0000-0001-6372-6501

Areas of Interest
  • Central nervous system fungal infections
  • Fungal biofilms
  • Fungal pathogenesis and immunology

Publications

2022
Autoxidation of a C2-Olefinated Dihydroartemisinic Acid Analogue to Form an Aromatic Ring: Application to Serrulatene Biosynthesis.
Journal of natural products. 85(4):951-962 [DOI] 10.1021/acs.jnatprod.1c01101. [PMID] 35357832.
2022
Methamphetamine Enhances Cryptococcus neoformans Melanization, Antifungal Resistance, and Pathogenesis in a Murine Model of Drug Administration and Systemic Infection
Infection and Immunity. 90(4) [DOI] 10.1128/iai.00091-22. [PMID] 35357221.
2022
Ozonated oil is effective at killing Candida species and Streptococcus mutans biofilm-derived cells under aerobic and microaerobic conditions
Medical Mycology. 60(8) [DOI] 10.1093/mmy/myac055. [PMID] 35869980.
2021
Cryptococcus neoformans–astrocyte interactions: effect on fungal blood brain barrier disruption, brain invasion, and meningitis progression
Critical Reviews in Microbiology. 47(2):206-223 [DOI] 10.1080/1040841x.2020.1869178.
2021
Acinetobacter baumannii Strains Deficient in the Clp Chaperone-Protease Genes Have Reduced Virulence in a Murine Model of Pneumonia.
Pathogens (Basel, Switzerland). 10(2) [DOI] 10.3390/pathogens10020204. [PMID] 33668542.
2021
Editorial: Pathogenesis of Fungal Biofilms in Different Environmental Conditions and Clinical Outcomes.
Frontiers in cellular and infection microbiology. 11 [DOI] 10.3389/fcimb.2021.778458. [PMID] 34746037.
2021
Gut Microbiome Changes with Osteopathic Treatment of Constipation in Parkinson’s Disease: A Pilot Study.
Neurology (E-Cronicon). 13(2):19-33 [PMID] 33899052.
2021
Methamphetamine Compromises the Adaptive B Cell-Mediated Immunity to Antigenic Challenge in C57BL/6 Mice.
Frontiers in toxicology. 3 [DOI] 10.3389/ftox.2021.629451. [PMID] 34109323.
2021
Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity.
The Journal of pharmacology and experimental therapeutics. 379(3):372-385 [DOI] 10.1124/jpet.121.000767. [PMID] 34535563.
2021
Methamphetamine facilitates pulmonary and splenic tissue injury and reduces T cell infiltration in C57BL/6 mice after antigenic challenge.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-87728-4. [PMID] 33859291.
2021
Nitric Oxide-Releasing Nanoparticles Are Similar to Efinaconazole in Their Capacity to Eradicate Trichophyton rubrum Biofilms.
Frontiers in cellular and infection microbiology. 11 [DOI] 10.3389/fcimb.2021.684150. [PMID] 34336712.
2021
Understanding the Basis of METH Mouth Using a Rodent Model of Methamphetamine Injection, Sugar Consumption, and Streptococcus mutans Infection
mBio. 12(2) [DOI] 10.1128/mbio.03534-20.
2020
Biological depletion of neutrophils attenuates pro-inflammatory markers and the development of the psoriatic phenotype in a murine model of psoriasis.
Clinical immunology (Orlando, Fla.). 210 [DOI] 10.1016/j.clim.2019.108294. [PMID] 31678366.
2020
Characterization of a novel yeast phase-specific antigen expressed during in vitro thermal phase transition of Talaromyces marneffei.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-78178-5. [PMID] 33273617.
2020
Depletion of Alveolar Macrophages Increases Pulmonary Neutrophil Infiltration, Tissue Damage, and Sepsis in a Murine Model of Acinetobacter baumannii Pneumonia
Infection and Immunity. 88(7) [DOI] 10.1128/iai.00128-20.
2020
Methamphetamine alters the TLR4 signaling pathway, NF-κB activation, and pro-inflammatory cytokine production in LPS-challenged NR-9460 microglia-like cells.
Molecular immunology. 121:159-166 [DOI] 10.1016/j.molimm.2020.03.013. [PMID] 32222586.
2020
Polymicrobial interactions involving fungi and their importance for the environment and in human disease.
Microbial pathogenesis. 140 [DOI] 10.1016/j.micpath.2019.103942. [PMID] 31881258.
2019
Coccidioidomycosis: Epidemiology, Fungal Pathogenesis, and Therapeutic Development.
Current tropical medicine reports. 6(3):132-144 [DOI] 10.1007/s40475-019-00184-z. [PMID] 34367879.
2019
Combination of acute intravenous methamphetamine injection and LPS challenge facilitate leukocyte infiltration into the central nervous system of C57BL/6 mice.
International immunopharmacology. 75 [DOI] 10.1016/j.intimp.2019.105751. [PMID] 31319359.
2019
Methamphetamine Impairs IgG1-Mediated Phagocytosis and Killing of Cryptococcus neoformans by J774.16 Macrophage- and NR-9640 Microglia-Like Cells.
Infection and immunity. 87(2) [DOI] 10.1128/IAI.00113-18. [PMID] 30510106.
2019
Reduced phagocytosis and killing of Cryptococcus neoformans biofilm-derived cells by J774.16 macrophages is associated with fungal capsular production and surface modification.
Fungal genetics and biology : FG & B. 132 [DOI] 10.1016/j.fgb.2019.103258. [PMID] 31356873.
2018
Factors Contributing to the Success of NIH-Designated Underrepresented Minorities in Academic and Nonacademic Research Positions.
CBE life sciences education. 17(2) [DOI] 10.1187/cbe.16-09-0287. [PMID] 29799320.
2018
Host membrane glycosphingolipids and lipid microdomains facilitateHistoplasma capsulatuminternalisation by macrophages
Cellular Microbiology. [DOI] 10.1111/cmi.12976. [PMID] 30427108.
2018
Relationship of environmental disturbances and the infectious potential of fungi.
Microbiology (Reading, England). 164(3):233-241 [DOI] 10.1099/mic.0.000620. [PMID] 29458659.
2018
The apolipoprotein N-acyl transferase Lnt is dispensable for growth in Acinetobacter species.
Microbiology (Reading, England). 164(12):1547-1556 [DOI] 10.1099/mic.0.000726. [PMID] 30307391.
2017
Capsular specific IgM enhances complement-mediated phagocytosis and killing of Cryptococcus neoformans by methamphetamine-treated J774.16 macrophage-like cells.
International immunopharmacology. 49:77-84 [DOI] 10.1016/j.intimp.2017.05.024. [PMID] 28551495.
2017
Diversity of Graduates from Bachelor’s, Master’s and Doctoral Degree Neuroscience Programs in the United States.
Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience. 16(1):A6-A13 [PMID] 29371835.
2017
Pre-Medical Preparation in Microbiology among Applicants and Matriculants in Osteopathic Medical School in the United States.
Journal of microbiology & biology education. 18(3) [DOI] 10.1128/jmbe.v18i3.1372. [PMID] 29854054.
2017
Role of microglia in fungal infections of the central nervous system.
Virulence. 8(6):705-718 [DOI] 10.1080/21505594.2016.1261789. [PMID] 27858519.
2017
Sustained Nitric Oxide-Releasing Nanoparticles Interfere with Methicillin-Resistant Staphylococcus aureus Adhesion and Biofilm Formation in a Rat Central Venous Catheter Model.
Antimicrobial agents and chemotherapy. 61(1) [DOI] 10.1128/AAC.02020-16. [PMID] 27821454.
2017
The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System.
Journal of fungi (Basel, Switzerland). 3(1) [DOI] 10.3390/jof3010010. [PMID] 29371529.
2016
A Gram Stain Hands-On Workshop Enhances First Year Medical Students’ Technique Competency in Comprehension and Memorization.
PloS one. 11(10) [DOI] 10.1371/journal.pone.0163658. [PMID] 27711118.
2016
Current Approaches in Implementing Citizen Science in the Classroom.
Journal of microbiology & biology education. 17(1):17-22 [DOI] 10.1128/jmbe.v17i1.1032. [PMID] 27047583.
2016
Enhanced virulence of Histoplasma capsulatum through transfer and surface incorporation of glycans from Cryptococcus neoformans during co-infection.
Scientific reports. 6 [DOI] 10.1038/srep21765. [PMID] 26908077.
2016
Methamphetamine compromises gap junctional communication in astrocytes and neurons.
Journal of neurochemistry. 137(4):561-75 [DOI] 10.1111/jnc.13603. [PMID] 26953131.
2016
Microbicides Alter the Expression and Function of RND-Type Efflux Pump AdeABC in Biofilm-Associated Cells of Acinetobacter baumannii Clinical Isolates.
Antimicrobial agents and chemotherapy. 60(1):57-63 [DOI] 10.1128/AAC.01045-15. [PMID] 26459900.
2016
Sustained Nitric Oxide-Releasing Nanoparticles Induce Cell Death in Candida albicans Yeast and Hyphal Cells, Preventing Biofilm Formation In Vitro and in a Rodent Central Venous Catheter Model.
Antimicrobial agents and chemotherapy. 60(4):2185-94 [DOI] 10.1128/AAC.02659-15. [PMID] 26810653.
2015
Biofilm Formation by Cryptococcus neoformans.
Microbiology spectrum. 3(3) [DOI] 10.1128/microbiolspec.MB-0006-2014. [PMID] 26185073.
2015
Commentary: Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development.
Frontiers in microbiology. 6 [DOI] 10.3389/fmicb.2015.01112. [PMID] 26500643.
2015
Fungal serotype-specific differences in bacterial-yeast interactions.
Virulence. 6(6):652-7 [DOI] 10.1080/21505594.2015.1066962. [PMID] 26132337.
2015
Methamphetamine Alters the Antimicrobial Efficacy of Phagocytic Cells during Methicillin-Resistant Staphylococcus aureus Skin Infection.
mBio. 6(6):e01622-15 [DOI] 10.1128/mBio.01622-15. [PMID] 26507236.
2015
Neutropenia exacerbates infection by Acinetobacter baumannii clinical isolates in a murine wound model.
Frontiers in microbiology. 6 [DOI] 10.3389/fmicb.2015.01134. [PMID] 26528277.
2014
Alcohol enhances Acinetobacter baumannii-associated pneumonia and systemic dissemination by impairing neutrophil antimicrobial activity in a murine model of infection.
PloS one. 9(4) [DOI] 10.1371/journal.pone.0095707. [PMID] 24752133.
2014
Impact of methamphetamine on infection and immunity.
Frontiers in neuroscience. 8 [DOI] 10.3389/fnins.2014.00445. [PMID] 25628526.
2014
Intracellular Haemophilus influenzae invades the brain: is zyxin a critical blood brain barrier component regulated by TNF-α?
Virulence. 5(6):645-7 [DOI] 10.4161/viru.36086. [PMID] 25127527.
2013
Alcohol impairs J774.16 macrophage-like cell antimicrobial functions in Acinetobacter baumannii infection.
Virulence. 4(6):467-72 [DOI] 10.4161/viru.25641. [PMID] 23863607.
2013
Characterization of a cyclophosphamide-induced murine model of immunosuppression to study Acinetobacter baumannii pathogenesis.
Journal of medical microbiology. 62(Pt 11):1747-1754 [DOI] 10.1099/jmm.0.060004-0. [PMID] 24000227.
2013
Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues.
Immunobiology. 218(8):1063-8 [DOI] 10.1016/j.imbio.2013.02.001. [PMID] 23518444.
2013
Methamphetamine alters blood brain barrier protein expression in mice, facilitating central nervous system infection by neurotropic Cryptococcus neoformans.
The Journal of infectious diseases. 208(4):699-704 [DOI] 10.1093/infdis/jit117. [PMID] 23532099.
2013
Methamphetamine enhances Cryptococcus neoformans pulmonary infection and dissemination to the brain.
mBio. 4(4) [DOI] 10.1128/mBio.00400-13. [PMID] 23900172.
2013
Use of a stainless steel washer platform to study Acinetobacter baumannii adhesion and biofilm formation on abiotic surfaces.
Microbiology (Reading, England). 159(Pt 12):2594-2604 [DOI] 10.1099/mic.0.068825-0. [PMID] 24025603.
2012
Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans.
Infection and immunity. 80(9):3065-76 [DOI] 10.1128/IAI.00358-12. [PMID] 22710871.
2012
Nitric oxide nanoparticles: pre-clinical utility as a therapeutic for intramuscular abscesses.
Virulence. 3(1):62-7 [DOI] 10.4161/viru.3.1.18816. [PMID] 22286699.
2012
Nitric oxide releasing nanoparticles for treatment of Candida albicans burn infections.
Frontiers in microbiology. 3 [DOI] 10.3389/fmicb.2012.00193. [PMID] 22701111.
2012
Nitric oxide-releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition.
The American journal of pathology. 180(4):1465-73 [DOI] 10.1016/j.ajpath.2011.12.013. [PMID] 22306734.
2012
Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice.
Nanomedicine : nanotechnology, biology, and medicine. 8(8):1364-71 [DOI] 10.1016/j.nano.2012.02.014. [PMID] 22406184.
2012
Nitric oxide-releasing nanoparticles: challenges and future prospects.
Therapeutic delivery. 3(10):1139-42 [PMID] 23116007.
2011
Candida parapsilosis fat storage-inducing transmembrane (FIT) protein 2 regulates lipid droplet formation and impacts virulence.
Microbes and infection. 13(7):663-72 [DOI] 10.1016/j.micinf.2011.02.009. [PMID] 21396481.
2011
Chronological aging is associated with biophysical and chemical changes in the capsule of Cryptococcus neoformans.
Infection and immunity. 79(12):4990-5000 [DOI] 10.1128/IAI.05789-11. [PMID] 21968999.
2011
Effects of microplusin, a copper-chelating antimicrobial peptide, against Cryptococcus neoformans.
FEMS microbiology letters. 324(1):64-72 [DOI] 10.1111/j.1574-6968.2011.02386.x. [PMID] 22092765.
2011
Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione.
Nitric oxide : biology and chemistry. 25(4):381-6 [DOI] 10.1016/j.niox.2011.09.001. [PMID] 21946032.
2011
Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.
The Journal of clinical investigation. 121(4):1471-83 [DOI] 10.1172/JCI44261. [PMID] 21364279.
2011
Passive administration of monoclonal antibodies against H. capsulatum and other fungal pathogens.
Journal of visualized experiments : JoVE. (48) [DOI] 10.3791/2532. [PMID] 21372781.
2011
Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology.
Virulence. 2(3):217-21 [PMID] 21577055.
2010
Augmented production of Panton-Valentine leukocidin toxin in methicillin-resistant and methicillin-susceptible Staphylococcus aureus is associated with worse outcome in a murine skin infection model.
The Journal of infectious diseases. 201(1):92-6 [DOI] 10.1086/648613. [PMID] 19929693.
2010
Demonstration of antibiofilm and antifungal efficacy of chitosan against candidal biofilms, using an in vivo central venous catheter model.
The Journal of infectious diseases. 201(9):1436-40 [DOI] 10.1086/651558. [PMID] 20331379.
2010
Fungal Biofilms: Relevance in the Setting of Human Disease.
Current fungal infection reports. 4(4):266-275 [PMID] 21660222.
2010
Monoclonal antibodies against peptidorhamnomannans of Scedosporium apiospermum enhance the pathogenicity of the fungus.
PLoS neglected tropical diseases. 4(10) [DOI] 10.1371/journal.pntd.0000853. [PMID] 20976055.
2010
The use of chitosan to damage Cryptococcus neoformans biofilms.
Biomaterials. 31(4):669-79 [DOI] 10.1016/j.biomaterials.2009.09.087. [PMID] 19819009.
2010
The use of nitric oxide releasing nanoparticles as a treatment against Acinetobacter baumannii in wound infections.
Virulence. 1(2):62-7 [DOI] 10.4161/viru.1.2.10038. [PMID] 21178416.
2009
Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection.
The Journal of investigative dermatology. 129(10):2463-9 [DOI] 10.1038/jid.2009.95. [PMID] 19387479.
2009
Methamphetamine enhances histoplasmosis by immunosuppression of the host.
The Journal of infectious diseases. 200(1):131-41 [DOI] 10.1086/599328. [PMID] 19473099.
2009
Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus abscesses in a murine model of infection.
PloS one. 4(11) [DOI] 10.1371/journal.pone.0007804. [PMID] 19915659.
2008
Characterization of phenotypic switching in Cryptococcus neoformans biofilms.
Mycopathologia. 166(4):175-80 [DOI] 10.1007/s11046-008-9133-0. [PMID] 18568421.
2007
Caspofungin reduces the incidence of fungal contamination in cell culture.
Mycopathologia. 164(6):279-86 [PMID] 17899440.
2007
Cryptococcus neoformans biofilm formation depends on surface support and carbon source and reduces fungal cell susceptibility to heat, cold, and UV light.
Applied and environmental microbiology. 73(14):4592-601 [PMID] 17513597.
2007
Voriconazole inhibits melanization in Cryptococcus neoformans.
Antimicrobial agents and chemotherapy. 51(12):4396-400 [PMID] 17923488.
2006
Cryptococcus neoformans cells in biofilms are less susceptible than planktonic cells to antimicrobial molecules produced by the innate immune system.
Infection and immunity. 74(11):6118-23 [PMID] 17057089.
2006
Specific antibody to Cryptococcus neoformans glucurunoxylomannan antagonizes antifungal drug action against cryptococcal biofilms in vitro.
The Journal of infectious diseases. 194(2):261-6 [PMID] 16779734.
2006
Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro.
Antimicrobial agents and chemotherapy. 50(3):1021-33 [PMID] 16495265.
2005
Specific antibody can prevent fungal biofilm formation and this effect correlates with protective efficacy.
Infection and immunity. 73(10):6350-62 [PMID] 16177306.
2004
Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen.
Infection and immunity. 72(6):3674-9 [PMID] 15155683.
Clinical and pathological characterization of Central Nervous System cryptococcosis in an experimental mouse model of stereotaxic intracerebral infection
. [DOI] 10.1101/2022.10.31.514648.
Glucuronoxylomannan intranasal challenge prior toCryptococcus neoformanspulmonary infection enhances cerebral cryptococcosis in rodents
. [DOI] 10.1101/2022.10.24.513461.

Grants

Jul 2020 ACTIVE
Unraveling Cryptococcus neoformans mechanisms of brain invasion and colonization
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID

Education

PhD in Microbiology and Immunology
2006 · Albert Einstein College of Medicine

Contact Details

Phones:
Business:
(352) 273-8135
Emails:
Addresses:
Business Mailing:
PO Box 100424
GAINESVILLE FL 32611