Krista H Vandenborne

Krista H Vandenborne

Chair

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-6085
Business Email: kvandenb@phhp.ufl.edu

About Krista H Vandenborne

Dr. Krista Vandenborne’s research has focused on the implementation of magnetic resonance imaging (MRI) and spectroscopy (MRS) to characterize skeletal muscle in patients. Her laboratory has applied magnetic resonance to the study of skeletal muscle in numerous animal models and a variety of patient populations. Over the last ten years, she has been leading the efforts at the University of Florida to develop a strong translational research program dedicated to the development and validation of MR imaging biomarkers for muscular dystrophy. She serves as the current Director of this project, known as ImagingDMD, which is focused on the development and validation of MRI/MRS biomarkers in Duchenne Muscular Dystrophy. ImagingDMD has collected longitudinal MR images, functional data, clinical endpoints, demographics, and biosamples in ~180 patients with DMD, with 1-9 year followup. The comprehensive natural history data set acquired by ImagingDMD is viewed as one of the field’s most valuable resources for clinical trial design and is utilized by academia, industry and governmental organizations modeling disease trajectory.

Publications

2020
Characterizing Enrollment in Observational Studies of Duchenne Muscular Dystrophy by Race and Ethnicity.
Journal of neuromuscular diseases. 7(2):167-173 [DOI] 10.3233/JND-190447. [PMID] 31929119.
2020
Walking activity in a large cohort of boys with Duchenne muscular dystrophy.
Muscle & nerve. [DOI] 10.1002/mus.27119. [PMID] 33188573.
2020
Upper and Lower Extremities in Duchenne Muscular Dystrophy Evaluated with Quantitative MRI and Proton MR Spectroscopy in a Multicenter Cohort.
Radiology. 295(3):616-625 [DOI] 10.1148/radiol.2020192210. [PMID] 32286193.
2020
Suitability of external controls for drug evaluation in Duchenne muscular dystrophy.
Neurology. 95(10):e1381-e1391 [DOI] 10.1212/WNL.0000000000010170. [PMID] 32611643.
2020
MR biomarkers predict clinical function in Duchenne muscular dystrophy.
Neurology. 94(9):e897-e909 [DOI] 10.1212/WNL.0000000000009012. [PMID] 32024675.
2020
Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury.
Journal of neuroscience research. 98(5):843-868 [DOI] 10.1002/jnr.24564. [PMID] 31797423.
2020
Magnetic Resonance Imaging Studies in Duchenne Muscular Dystrophy: Linking Findings to the Physical Therapy Clinic.
Physical therapy. 100(11):2035-2048 [DOI] 10.1093/ptj/pzaa140. [PMID] 32737968.
2020
Lower Extremity Muscle Involvement in the Intermediate and Bethlem Myopathy Forms of COL6-Related Dystrophy and Duchenne Muscular Dystrophy: A Cross-Sectional Study.
Journal of neuromuscular diseases. 7(4):407-417 [DOI] 10.3233/JND-190457. [PMID] 32538860.
2020
Modeling disease trajectory in Duchenne muscular dystrophy.
Neurology. 94(15):e1622-e1633 [DOI] 10.1212/WNL.0000000000009244. [PMID] 32184340.
2019
Age-dependent changes in metabolite profile and lipid saturation in dystrophic mice.
NMR in biomedicine. 32(5) [DOI] 10.1002/nbm.4075. [PMID] 30848538.
2019
Effects of PDE5 inhibition on dystrophic muscle following an acute bout of downhill running and endurance training.
Journal of applied physiology (Bethesda, Md. : 1985). 126(6):1737-1745 [DOI] 10.1152/japplphysiol.00664.2018. [PMID] 30946638.
2019
Imaging respiratory muscle quality and function in Duchenne muscular dystrophy.
Journal of neurology. 266(11):2752-2763 [DOI] 10.1007/s00415-019-09481-z. [PMID] 31350642.
2019
Magnetic resonance imaging characteristics of injection site reactions after long-term subcutaneous delivery of drisapersen.
European journal of pediatrics. 178(5):777-778 [DOI] 10.1007/s00431-019-03349-0. [PMID] 30790036.
2019
Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF-κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dystrophy.
Journal of neuromuscular diseases. 6(1):43-54 [DOI] 10.3233/JND-180341. [PMID] 30452422.
2019
Texture Analysis for Muscular Dystrophy Classification in MRI with Improved Class Activation Mapping.
Pattern recognition. 86:368-375 [DOI] 10.1016/j.patcog.2018.08.012. [PMID] 31105339.
2018
Leg muscle MRI in identical twin boys with duchenne muscular dystrophy.
Muscle & nerve. [DOI] 10.1002/mus.26081. [PMID] 29365354.
2018
Longitudinal timed function tests in Duchenne muscular dystrophy: ImagingDMD cohort natural history.
Muscle & nerve. 58(5):631-638 [DOI] 10.1002/mus.26161. [PMID] 29742798.
2018
Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy.
PloS one. 13(3) [DOI] 10.1371/journal.pone.0194283. [PMID] 29554116.
2018
Two-Year Longitudinal Changes in Lower Limb Strength and Its Relation to Loss in Function in a Large Cohort of Patients With Duchenne Muscular Dystrophy.
American journal of physical medicine & rehabilitation. 97(10):734-740 [DOI] 10.1097/PHM.0000000000000957. [PMID] 29734234.
2017
Multi-slice MRI reveals heterogeneity in disease distribution along the length of muscle in Duchenne muscular dystrophy.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology. 36(3):151-162 [PMID] 29774305.
View on: PubMed
2017
Molecular signatures of differential responses to exercise trainings during rehabilitation.
Biomedical genetics and genomics. 2(1) [DOI] 10.15761/BGG.1000127. [PMID] 28845464.
2017
Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy.
Journal of neurology. 264(1):64-71 [DOI] 10.1007/s00415-016-8311-0. [PMID] 27778157.
2017
Magnetic Resonance Monitoring of Disease Progression in mdx Mice on Different Genetic Backgrounds.
The American journal of pathology. 187(9):2060-2070 [DOI] 10.1016/j.ajpath.2017.05.010. [PMID] 28826559.
2017
Duchenne Regulatory Science Consortium Meeting on Disease Progression Modeling for Duchenne Muscular Dystrophy.
PLoS currents. 9 [DOI] 10.1371/currents.md.83071bbd728982f2f1073f4950e03586. [PMID] 28228973.
2017
Contrast-Enhanced Near-Infrared Optical Imaging Detects Exacerbation and Amelioration of Murine Muscular Dystrophy.
Molecular imaging. 16 [DOI] 10.1177/1536012117732439. [PMID] 29271299.
2017
A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy.
Neurology. 89(17):1811-1820 [DOI] 10.1212/WNL.0000000000004570. [PMID] 28972192.
2016
Age-related T2 changes in hindlimb muscles of mdx mice.
Muscle & nerve. 53(1):84-90 [DOI] 10.1002/mus.24675. [PMID] 25846867.
2016
MRI quantifies neuromuscular disease progression.
The Lancet. Neurology. 15(1):26-8 [DOI] 10.1016/S1474-4422(15)00320-8. [PMID] 26549781.
2016
Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort.
Annals of neurology. 79(4):535-47 [DOI] 10.1002/ana.24599. [PMID] 26891991.
2016
Near-Infrared Optical Imaging Noninvasively Detects Acutely Damaged Muscle.
The American journal of pathology. 186(10):2692-700 [DOI] 10.1016/j.ajpath.2016.06.019. [PMID] 27565039.
2015
Transcriptional Pathways Associated with Skeletal Muscle Changes after Spinal Cord Injury and Treadmill Locomotor Training.
BioMed research international. 2015 [DOI] 10.1155/2015/387090. [PMID] 26380273.
2015
Speed, not magnitude, of knee extensor torque production is associated with self-reported knee function early after anterior cruciate ligament reconstruction.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 23(11):3214-20 [DOI] 10.1007/s00167-014-3168-1. [PMID] 25026933.
2015
Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements.
PloS one. 10(6) [DOI] 10.1371/journal.pone.0128915. [PMID] 26103164.
2015
Longitudinal Evaluation of Muscle Composition Using Magnetic Resonance in 4 Boys With Duchenne Muscular Dystrophy: Case Series.
Physical therapy. 95(7):978-88 [DOI] 10.2522/ptj.20140234. [PMID] 25592189.
2014
¹³C NMR metabolomics: applications at natural abundance.
Analytical chemistry. 86(18):9242-50 [DOI] 10.1021/ac502346h. [PMID] 25140385.
2014
Participation in daily life activities and its relationship to strength and functional measures in boys with Duchenne muscular dystrophy.
Disability and rehabilitation. 36(22):1918-23 [DOI] 10.3109/09638288.2014.883444. [PMID] 24499260.
2014
Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study.
PloS one. 9(9) [DOI] 10.1371/journal.pone.0106435. [PMID] 25203313.
2014
Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression.
Neuromuscular disorders : NMD. 24(5):393-401 [DOI] 10.1016/j.nmd.2013.12.012. [PMID] 24491484.
2014
Intrinsic transient tracheal occlusion training and myogenic remodeling of rodent parasternal intercostal fibers.
Journal of rehabilitation research and development. 51(5):841-54 [PMID] 25509059.
View on: PubMed
2014
In vivo (31)P NMR spectroscopy assessment of skeletal muscle bioenergetics after spinal cord contusion in rats.
European journal of applied physiology. 114(4):847-58 [DOI] 10.1007/s00421-013-2810-9. [PMID] 24399112.
2014
Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: a pilot study.
The journals of gerontology. Series A, Biological sciences and medical sciences. 69(1):101-8 [DOI] 10.1093/gerona/gls337. [PMID] 23682155.
2014
Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS.
Neurology. 83(11):974-80 [DOI] 10.1212/WNL.0000000000000775. [PMID] 25098537.
2014
Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus.
Gene therapy. 21(4):387-92 [DOI] 10.1038/gt.2014.9. [PMID] 24572791.
2014
Bone loss in a new rodent model combining spinal cord injury and cast immobilization.
Journal of musculoskeletal & neuronal interactions. 14(3):255-66 [PMID] 25198220.
View on: PubMed
2014
Assessment of intramuscular lipid and metabolites of the lower leg using magnetic resonance spectroscopy in boys with Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 24(7):574-82 [DOI] 10.1016/j.nmd.2014.03.013. [PMID] 24798221.
2014
Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle.
Magnetic resonance in medicine. 72(1):8-19 [DOI] 10.1002/mrm.24917. [PMID] 24006208.
2013
A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy.
International journal of computer assisted radiology and surgery. 8(5):763-74 [DOI] 10.1007/s11548-012-0810-6. [PMID] 23299128.
2013
Hindlimb muscle morphology and function in a new atrophy model combining spinal cord injury and cast immobilization.
Journal of neurotrauma. 30(3):227-35 [DOI] 10.1089/neu.2012.2504. [PMID] 22985272.
2013
Magnetic Resonance Imaging and Spectroscopy Detect Changes With Age, Corticosteroid Treatment, and Functional Progression in Dmd
Neuromuscular Disorders. 23(9-10) [DOI] 10.1016/j.nmd.2013.06.599.
2013
Overexpression of IGF-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse
.
2013
Overexpression of insulin-like growth factor-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse.
Experimental physiology. 98(5):1038-52 [DOI] 10.1113/expphysiol.2012.070722. [PMID] 23291913.
2013
Regenerative responses in slow- and fast-twitch muscles following moderate contusion spinal cord injury and locomotor training.
European journal of applied physiology. 113(1):191-200 [DOI] 10.1007/s00421-012-2429-2. [PMID] 22644570.
2013
Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy.
Radiology. 269(1):198-207 [DOI] 10.1148/radiol.13121948. [PMID] 23696684.
2013
T₂ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.
NMR in biomedicine. 26(3):320-8 [DOI] 10.1002/nbm.2851. [PMID] 23044995.
2013
White Matter Integrity After Severe Contusion Spinal Cord Injury Under Different Levels of Activity
Journal of Neurotrauma. 30:A116-A117
2012
Use of skeletal muscle MRI in diagnosis and monitoring disease progression in Duchenne muscular dystrophy.
Physical medicine and rehabilitation clinics of North America. 23(1):1-10, ix [DOI] 10.1016/j.pmr.2011.11.004. [PMID] 22239869.
2012
Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.
PloS one. 7(2) [DOI] 10.1371/journal.pone.0032829. [PMID] 22389725.
2012
Relationships of thigh muscle contractile and non-contractile tissue with function, strength, and age in boys with Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 22(1):16-25 [DOI] 10.1016/j.nmd.2011.06.750. [PMID] 21807516.
2012
Participation and quality of life in children with Duchenne muscular dystrophy using the International Classification of Functioning, Disability, and Health.
Health and quality of life outcomes. 10 [DOI] 10.1186/1477-7525-10-43. [PMID] 22545870.
2012
MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 22 Suppl 2:S111-21 [DOI] 10.1016/j.nmd.2012.05.013. [PMID] 22980762.
2012
Forelimb Neuroplasticity Following Incomplete Cervical Spinal Cord Injury in Adult Rat
Cell Transplantation. 21(4)
2012
Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping.
Molecular therapy : the journal of the American Society of Gene Therapy. 20(3):580-9 [DOI] 10.1038/mt.2011.264. [PMID] 22146342.
2012
Chronic intrinsic transient tracheal occlusion elicits diaphragmatic muscle fiber remodeling in conscious rodents.
PloS one. 7(11) [DOI] 10.1371/journal.pone.0049264. [PMID] 23133678.
2012
Mri and Dti Characterization of Spinal Cord Severe Contusion Injury in the Rat
The FASEB's Journal. 26
2012
Age-related differences in lower extremity tissue compartments and associations with physical function in older adults.
Experimental gerontology. 47(1):38-44 [DOI] 10.1016/j.exger.2011.10.001. [PMID] 22015325.
2011
Design of a Multi-Center Study To Examine Skeletal Muscles of Children With Duchenne Muscular Dystrophy Using Mri/Mrs
Neuromuscular Disorders. 21(9-10):653-654 [DOI] 10.1016/j.nmd.2011.06.801.
2011
A New Rat Model of Spinal Cord Injury Without Muscle Reloading: Morphological and Functional Assessment By Mr Imaging and (31)P Spectroscopy
Journal of Neurotrauma. 28
2011
Changes in muscle T2 and tissue damage after downhill running in mdx mice.
Muscle & nerve. 43(6):878-86 [DOI] 10.1002/mus.21986. [PMID] 21488051.
2011
Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy.
Human gene therapy. 22(12):1499-509 [DOI] 10.1089/hum.2011.102. [PMID] 21787232.
2010
Daily Step Count, Gait Parameters, Strength, and Function in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Distribution of T2 in the Soleus Muscle of Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Impact of treadmill locomotor training on skeletal muscle IGF1 and myogenic regulatory factors in spinal cord injured rats.
European journal of applied physiology. 109(4):709-20 [DOI] 10.1007/s00421-010-1392-z. [PMID] 20213470.
2010
Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization.
American journal of physiology. Endocrinology and metabolism. 299(5):E730-40 [DOI] 10.1152/ajpendo.00230.2010. [PMID] 20739512.
2010
Muscle Pathology and Functional Ability in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Nnls Analyses of Skeletal Muscle T2 in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Skeletal Muscle Contractile and Non-Contractile Components in Boys With Duchenne Muscular Dystrophy By Mri
Medicine and Science in Sports and Exercise. 42
2010
The Effect of Igf-I Overexpression in Skeletal Muscle Following Spinal Cord Injury and Locomotor Training
Medicine and Science in Sports and Exercise. 42
2010
Age-related differences in lower-limb muscle cross-sectional area and torque production in boys with Duchenne muscular dystrophy.
Archives of physical medicine and rehabilitation. 91(7):1051-8 [DOI] 10.1016/j.apmr.2010.03.024. [PMID] 20599043.
2009
Health-related quality of life after hip arthroplasty with and without an extended-duration continuous posterior lumbar plexus nerve block: a prospective, 1-year follow-up of a randomized, triple-masked, placebo-controlled study.
Anesthesia and analgesia. 109(2):586-91 [DOI] 10.1213/ane.0b013e3181a9db5d. [PMID] 19608835.
2009
Health-related quality of life after tricompartment knee arthroplasty with and without an extended-duration continuous femoral nerve block: a prospective, 1-year follow-up of a randomized, triple-masked, placebo-controlled study.
Anesthesia and analgesia. 108(4):1320-5 [DOI] 10.1213/ane.0b013e3181964937. [PMID] 19299806.
2009
Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle.
Human molecular genetics. 18(17):3194-205 [DOI] 10.1093/hmg/ddp257. [PMID] 19483197.
2008
Non-invasive assessment of lower extremity muscle composition after incomplete spinal cord injury.
Spinal cord. 46(8):565-70 [DOI] 10.1038/sc.2008.10. [PMID] 18347608.
2008
Non-Invasive Assessment of Lower Extremity Muscle Composition After Incomplete Spinal Cord Injury
Spinal Cord. 46:565-570 [DOI] 10.1038/sc.2008.10. [PMID] 18347608.
2008
Muscle Strength and Functional Status in Boys With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 40(Supplement) [DOI] 10.1249/01.mss.0000323019.33764.4c.
2008
Locomotor training and muscle function after incomplete spinal cord injury: case series.
The journal of spinal cord medicine. 31(2):185-93 [PMID] 18581666.
View on: PubMed
2008
Ambulatory continuous posterior lumbar plexus nerve blocks after hip arthroplasty: a dual-center, randomized, triple-masked, placebo-controlled trial.
Anesthesiology. 109(3):491-501 [DOI] 10.1097/ALN.0b013e318182a4a3. [PMID] 18719448.
2008
Ambulatory continuous femoral nerve blocks decrease time to discharge readiness after tricompartment total knee arthroplasty: a randomized, triple-masked, placebo-controlled study.
Anesthesiology. 108(4):703-13 [DOI] 10.1097/ALN.0b013e318167af46. [PMID] 18362603.
2008
Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse.
NMR in biomedicine. 21(2):101-10 [PMID] 17516466.
View on: PubMed
2008
A longitudinal study of skeletal muscle following spinal cord injury and locomotor training.
Spinal cord. 46(7):488-93 [DOI] 10.1038/sj.sc.3102169. [PMID] 18283294.
2008
Changes in Soleus Muscle Function and Fiber Morphology with One Week of Locomotor Training in Spinal Cord Contusion Injured Rats
Journal of Neurotrauma. 25(5)
2007
A quantitative study of bioenergetics in skeletal muscle lacking carbonic anhydrase III using 31P magnetic resonance spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America. 104(1):371-6 [PMID] 17182736.
View on: PubMed
2007
Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase.
American journal of physiology. Endocrinology and metabolism. 293(2):E507-14 [PMID] 17488806.
View on: PubMed
2007
Resistance training and locomotor recovery after incomplete spinal cord injury: a case series.
Spinal cord. 45(7):522-30 [PMID] 17228358.
View on: PubMed
2007
Transcriptional pathways associated with skeletal muscle disuse atrophy in humans.
Physiological genomics. 31(3):510-20 [PMID] 17804603.
View on: PubMed
2006
Relative contributions of muscle activation and muscle size to plantarflexor torque during rehabilitation after immobilization.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 24(8):1729-36 [PMID] 16779833.
View on: PubMed
2006
Total hip arthroplasty as an overnight-stay procedure using an ambulatory continuous psoas compartment nerve block: a prospective feasibility study.
Regional anesthesia and pain medicine. 31(2):113-8 [PMID] 16543096.
View on: PubMed
2006
Total elbow arthroplasty as an outpatient procedure using a continuous infraclavicular nerve block at home: a prospective case report.
Regional anesthesia and pain medicine. 31(2):172-6 [PMID] 16543104.
View on: PubMed
2006
Lower-extremity muscle cross-sectional area after incomplete spinal cord injury.
Archives of physical medicine and rehabilitation. 87(6):772-8 [PMID] 16731211.
View on: PubMed
2006
Total knee arthroplasty as an overnight-stay procedure using continuous femoral nerve blocks at home: a prospective feasibility study.
Anesthesia and analgesia. 102(1):87-90 [PMID] 16368810.
View on: PubMed
2006
Deficit in human muscle strength with cast immobilization: contribution of inorganic phosphate.
European journal of applied physiology. 98(1):71-8 [PMID] 16841201.
View on: PubMed
2006
Changes in soleus muscle function and fiber morphology with one week of locomotor training in spinal cord contusion injured rats.
Journal of neurotrauma. 23(11):1671-81 [PMID] 17115912.
View on: PubMed
2006
Changes in muscle T2 relaxation properties following spinal cord injury and locomotor training.
European journal of applied physiology. 97(3):355-61 [PMID] 16770473.
View on: PubMed
2006
Ambulatory continuous interscalene nerve blocks decrease the time to discharge readiness after total shoulder arthroplasty: a randomized, triple-masked, placebo-controlled study.
Anesthesiology. 105(5):999-1007 [PMID] 17065895.
View on: PubMed
2006
Lower extremity skeletal muscle function in persons with incomplete spinal cord injury.
Spinal cord. 44(11):680-7 [PMID] 16344848.
View on: PubMed
2005
Noninvasive monitoring of muscle damage during reloading following limb disuse.
Muscle & nerve. 32(5):605-12 [PMID] 16003743.
View on: PubMed
2005
Metabolic and phenotypic characteristics of human skeletal muscle fibers as predictors of glycogen utilization during electrical stimulation.
European journal of applied physiology. 95(4):276-82 [PMID] 16096841.
View on: PubMed
2005
Total shoulder arthroplasty as an outpatient procedure using ambulatory perineural local anesthetic infusion: a pilot feasibility study.
Anesthesia and analgesia. 101(5):1319-22 [PMID] 16243987.
View on: PubMed
2005
Changes in inorganic phosphate and force production in human skeletal muscle after cast immobilization.
Journal of applied physiology (Bethesda, Md. : 1985). 98(1):307-14 [PMID] 15333614.
View on: PubMed
2005
A model of muscle atrophy using cast immobilization in mice.
Muscle & nerve. 32(5):672-4 [PMID] 16025524.
View on: PubMed
2005
Early quadriceps strength loss after total knee arthroplasty. The contributions of muscle atrophy and failure of voluntary muscle activation.
The Journal of bone and joint surgery. American volume. 87(5):1047-53 [PMID] 15866968.
View on: PubMed
2004
Muscle adaptations with immobilization and rehabilitation after ankle fracture.
Medicine and science in sports and exercise. 36(10):1695-701 [PMID] 15595289.
View on: PubMed
2004
Resistance training improves strength and functional capacity in persons with multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England). 10(6):668-74 [PMID] 15584492.
View on: PubMed
2003
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects.
American journal of physiology. Regulatory, integrative and comparative physiology. 285(1):R183-92 [PMID] 12609816.
View on: PubMed
2003
Effects of testosterone replacement therapy on skeletal muscle after spinal cord injury.
Spinal cord. 41(1):23-8 [PMID] 12494317.
View on: PubMed
2003
Human and rat skeletal muscle adaptations to spinal cord injury.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquee. 28(3):491-500 [PMID] 12955874.
View on: PubMed
2002
Effects of muscle activation on fatigue and metabolism in human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985). 92(5):1978-86 [PMID] 11960948.
View on: PubMed
2002
Factors in fatigue during intermittent electrical stimulation of human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985). 93(2):469-78 [PMID] 12133852.
View on: PubMed
2002
Metabolic costs of isometric force generation and maintenance of human skeletal muscle.
American journal of physiology. Endocrinology and metabolism. 282(2):E448-57 [PMID] 11788378.
View on: PubMed
2001
Metabolic enzymes and phenotypic expression among human locomotor muscles.
Muscle & nerve. 24(3):387-93 [PMID] 11353424.
View on: PubMed
2001
Magnetic resonance spectroscopy of the masseter muscle in different facial morphological patterns.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 120(4):427-34 [PMID] 11606968.
View on: PubMed
2000
Relationship between muscle T2* relaxation properties and metabolic state: a combined localized 31P-spectroscopy and 1H-imaging study.
European journal of applied physiology. 82(1-2):76-82 [PMID] 10879446.
View on: PubMed
2000
Effects of immobilization on plantar-flexion torque, fatigue resistance, and functional ability following an ankle fracture.
Physical therapy. 80(8):769-80 [PMID] 10911415.
View on: PubMed
1999
In vivo ATP synthesis rates in single human muscles during high intensity exercise.
The Journal of physiology. 519 Pt 3:901-10 [PMID] 10457099.
View on: PubMed
1999
Spectral quantitation by principal component analysis using complex singular value decomposition.
Magnetic resonance in medicine. 41(3):450-5 [PMID] 10204865.
View on: PubMed
1998
Autonomic testing in patients with chronic fatigue syndrome
The American journal of medicine. 105(3A):22S-26S
1998
Fast imaging of phosphocreatine using a RARE pulse sequence.
Magnetic resonance in medicine. 39(5):851-4 [PMID] 9581617.
View on: PubMed
1998
Longitudinal study of skeletal muscle adaptations during immobilization and rehabilitation.
Muscle & nerve. 21(8):1006-12 [PMID] 9655118.
View on: PubMed
1997
Noninvasive measurement of phosphocreatine recovery kinetics in single human muscles.
The American journal of physiology. 272(2 Pt 1):C525-34 [PMID] 9124295.
View on: PubMed
1997
Volumetric measurement of human calf muscle from magnetic resonance imaging.
Magma (New York, N.Y.). 5(2):93-8 [PMID] 9268071.
View on: PubMed
1995
Energy-rich phosphates in slow and fast human skeletal muscle.
The American journal of physiology. 268(4 Pt 1):C869-76 [PMID] 7733235.
View on: PubMed
1995
pH heterogeneity during exercise in localized spectra from single human muscles
. 268(4):C869-C876
1993
31P magnetic resonance muscle spectroscopy in fibromyalgia.
The Journal of rheumatology. 20(11):1985-6 [PMID] 8179665.
View on: PubMed
1993
pH heterogeneity during exercise in localized spectra from single human muscles.
The American journal of physiology. 265(5 Pt 1):C1332-9 [PMID] 8238485.
View on: PubMed
1992
Muscle metabolism in track athletes, using 31P magnetic resonance spectroscopy.
Canadian journal of physiology and pharmacology. 70(10):1353-9 [PMID] 1490254.
View on: PubMed
1991
Metabolic heterogeneity in human calf muscle during maximal exercise.
Proceedings of the National Academy of Sciences of the United States of America. 88(13):5714-8 [PMID] 2062850.
View on: PubMed
1991
Noninvasive measurements of activity-induced changes in muscle metabolism.
Journal of biomechanics. 24 Suppl 1:153-61 [PMID] 1791175.
View on: PubMed

Grants

Sep 2020 ACTIVE
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2020 ACTIVE
Rehabilitation Research Career Development Program
Role: Principal Investigator
Funding: UNIVERSITY OF TEXAS MEDICAL BRANCH via NATL INST OF HLTH NICHD
Aug 2020 ACTIVE
Development of MRI, Alternative Splicing, and Functional Abilities as Biomarkers in Myotonic Dystrophy Type 1
Role:
Funding: NATL INST OF HLTH NIAMS
Aug 2020 ACTIVE
Sarepta Therapeutics, Inc. Services Agreement
Role: Principal Investigator
Funding: SAREPTA THERAPEUTICS
Sep 2019 – Aug 2020
Rehabilitation Research Career Development Program
Role: Principal Investigator
Funding: UNIVERSITY OF TEXAS MEDICAL BRANCH via NATL INST OF HLTH NICHD
Jun 2019 – Jun 2022
Data Transfer Agreement between iDMD and Sarepta Therapeutics, Inc. to share iDMD Natural History data.
Role: Principal Investigator
Funding: SAREPTA THERAPEUTICS
Jun 2019 – Sep 2019
FibroGen DUA
Role: Principal Investigator
Funding: FIBROGEN INC
May 2019 ACTIVE
Interdisciplinary Training in Neuromuscular Plasticity and Rehabilitation
Role:
Funding: NATL INST OF HLTH NICHD
Apr 2019 – Apr 2023
Wave Life Sciences Data Transfer Agreement
Role: Principal Investigator
Funding: WAVE LIFE SCIENCES
Sep 2018 – Aug 2019
Rehabilitation Research Career Development Program
Role: Principal Investigator
Funding: UNIVERSITY OF TEXAS MEDICAL BRANCH via NATL INST OF HLTH NICHD
Apr 2018 – Apr 2021
Collaborative study between iDMD and Trajectory Analysis Project Collaboration ("cTAP").
Role: Principal Investigator
Funding: ANALYSIS GROUP
Nov 2017 – Jul 2018
Summit-iDMD Natural History Data Transfer Agreement
Role: Principal Investigator
Funding: SUMMIT (OXFORD) LTD
Nov 2017 – Jul 2018
Summit C11006 Expansion Site Feasibility
Role: Principal Investigator
Funding: SUMMIT (OXFORD) LTD
Oct 2017 – Feb 2020
A randomised, double blind, placebo controlled study to evaluate the micro-macroscopic effects on muscles, the safety and tolerability, and the efficacy of givinostat in patients with Becker Muscular Dystrophy
Role: Principal Investigator
Funding: ITALFARMACO S P A
Sep 2017 – Aug 2018
Rehabilitation Research Career Development Program
Role: Principal Investigator
Funding: UNIVERSITY OF TEXAS MEDICAL BRANCH via NATL INST OF HLTH NICHD
Nov 2016 – Nov 2019
Imaging DMD DUA for C-Path
Role: Principal Investigator
Funding: CRITICAL PATH INSTITUTE
Sep 2016 ACTIVE
MR Assessment of Bioenergetics and Microvascular Function in Dystrophic Muscle
Role:
Funding: NATL INST OF HLTH NIAMS
Jul 2016 – Dec 2020
ImagingDMD for Givinostat Phase 3 Clinical Trial
Role: Principal Investigator
Funding: ITALFARMACO S P A
Jun 2016 – Aug 2018
Development of Magnetic Resonance Imaging as an Endpoint in Myotonic Dystrophy Type 1
Role:
Funding: WYCK FOUNDATION via MYOTONIC DYSTROPHY FOU
Mar 2016 – Mar 2020
protocol CAT-1004-201-moveDMD part B
Role: Principal Investigator
Funding: CATABASIS PHARMACEUTICALS
Feb 2016 – Aug 2018
A phase 2 clinical study to assess the activity and
Role: Principal Investigator
Funding: SUMMIT (OXFORD) LTD
Dec 2015 – Dec 2016
Data Transfer Agreement
Role: Principal Investigator
Funding: ITALFARMACO S P A
Oct 2015 – Oct 2020
Data Transfer Agreement
Role: Principal Investigator
Funding: CATABASIS PHARMACEUTICALS
Oct 2015 – Mar 2019
OneFlorida Clinical Research Consortium Phase II
Role: Project Manager
Funding: PATIENT-CENTERED OUTCOMES RES INST
Sep 2015 – Aug 2020
DSR Match support-Magnetic Resonance imaging and biomarkers for muscular distrophy
Role: Principal Investigator
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Sep 2015 – Aug 2016
VBP15, an Innovative Steroid-like Intervention on DMD: V
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via NATL INST OF HLTH
Sep 2015 – Sep 2020
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2015 – Aug 2016
Idera Pharmaceuticals Data Use Agreement
Role: Principal Investigator
Funding: IDERA PHARMACEUTICALS
Aug 2015 ACTIVE
Failed Regeneration in the Muscular Dystrophies: Inflammation, Fibrosis and Fat
Role:
Funding: NATL INST OF HLTH NIAMS
Aug 2015 – Jul 2018
MRI, MRS, and functional characterization of the arm in DMD
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Jul 2015 – Jul 2016
summit therapeutics DUA
Role: Principal Investigator
Funding: SUMMIT THERAPEUTICS
Jun 2015 – Mar 2016
Data Use agreement Pfizer-ImagingDMD
Role: Principal Investigator
Funding: PFIZER INC
Jun 2015 – Jun 2016
Sarepta data transfer agreement
Role: Principal Investigator
Funding: SAREPTA THERAPEUTICS
May 2015 – May 2023
A Phase 1/2 STUDY OF CAT-1004 IN PEDIATRIC PATIENTS with Duchenne Muscular Dystrophy
Role: Principal Investigator
Funding: CATABASIS PHARMACEUTICALS
May 2015 – May 2018
A PHASE 2 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, EFFICACY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF-06252616 IN AMBULATORY BOYS WITH DUCHENNE MUSCULAR DYSTROPHY
Role: Project Manager
Funding: PFIZER INC
Apr 2015 – Jun 2017
catabasis study
Role: Principal Investigator
Funding: CATABASIS PHARMACEUTICALS
Mar 2015 – Jun 2019
MR Imaging in Eteplirsen Study 4658-203
Role: Principal Investigator
Funding: SAREPTA THERAPEUTICS
Sep 2014 – Jun 2018
Development of a Strength Training Protocol in Duchenne
Role: Project Manager
Funding: NATL INST OF HLTH NIAMS
May 2014 – Apr 2019
DSR Matching – T32 Interdisciplinary Training
Role:
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
May 2014 – Apr 2019
Interdisciplinary Training in Rehabilitation and Neuromuscular Plasticity
Role:
Funding: NATL INST OF HLTH NICHD
Dec 2013 – Jul 2016
Eli Lilly Contract
Role: Principal Investigator
Funding: ELI LILLY AND CO
Sep 2013 – Aug 2018
The relationship between genomic variants and MRI/MRS markers in DMD
Role: Project Manager
Funding: NATL INST OF HLTH NIAMS
Sep 2013 – Aug 2017
Rehabilitation Research Career Development Program
Role: Principal Investigator
Funding: UNIVERSITY OF TEXAS MEDICAL BRANCH via NATL INST OF HLTH NICHD
Sep 2012 – Sep 2017
MD110050 Optical Imaging of Dystrophic and Damaged Muscle
Role: Project Manager
Funding: US DEPT OF DEFENSE
Sep 2011 – Mar 2016
FL Trauma Rehab Center for Returning Military Personnel
Role: Project Manager
Funding: US DEPT OF DEFENSE
Jul 2010 – Apr 2016
Matching Funds – MRI and Biomarkers for Muscular Dystrop
Role: Principal Investigator
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jan 2008 – Aug 2017
K12 Rehabilitation Research Career Development Program
Role: Principal Investigator
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS

Teaching Profile

Courses Taught
2006-2008,2010-2020
RSD7979 Advanced Research
2008,2015-2017,2017-2019,2019
RSD6930 Special Topics in Rehabilitation Science
2006-2014,2016-2018
RSD7980 Research for Doctoral Dissertation
2006-2008,2012-2017,2015-2017
RSD6940 Supervised Teaching
2006-2017
RSD6910 Supervised Research
2006-2016
RSD6905 Individual Work
2006-2010,2012-2015,2015
PHT6935C Seminar
2008-2010
HSC4970 Public Health and Health Professions Senior Honors Thesis

Contact Details

Phones:
Business:
(352) 273-6085
Emails: