Krista H Vandenborne, PhD
Chair
Department:
HP-PHYSICAL THERAPY
Business Phone:
(352) 273-6085
Business Email:
kvandenb@phhp.ufl.edu
About Krista H Vandenborne
Dr. Krista Vandenborne’s research has focused on the implementation of magnetic resonance imaging (MRI) and spectroscopy (MRS) to characterize skeletal muscle in patients. Her laboratory has applied magnetic resonance to the study of skeletal muscle in numerous animal models and a variety of patient populations. Over the last ten years, she has been leading the efforts at the University of Florida to develop a strong translational research program dedicated to the development and validation of MR imaging biomarkers for muscular dystrophy. She serves as the current Director of this project, known as ImagingDMD, which is focused on the development and validation of MRI/MRS biomarkers in Duchenne Muscular Dystrophy. ImagingDMD has collected longitudinal MR images, functional data, clinical endpoints, demographics, and biosamples in ~180 patients with DMD, with 1-9 year followup. The comprehensive natural history data set acquired by ImagingDMD is viewed as one of the field’s most valuable resources for clinical trial design and is utilized by academia, industry and governmental organizations modeling disease trajectory.
Teaching Profile
Courses Taught
2006-2008,2010-2024
RSD7979 Advanced Research
2006-2014,2016-2024,2021-2024,2024
RSD7980 Research for Doctoral Dissertation
2006-2017,2021-2024
RSD6910 Supervised Research
2008,2015-2017,2017-2021,2019-2024,2021-2024,2023-2024
RSD6930 Special Topics in Rehabilitation Science
2006-2008,2012-2017,2015-2017
RSD6940 Supervised Teaching
2006-2016,2022-2023
RSD6905 Individual Work
2006-2010,2012-2015,2015
PHT6935C Seminar
2008-2010
HSC4970 Public Health and Health Professions Senior Honors Thesis
Research Profile
Open Researcher and Contributor ID (ORCID)
0009-0007-8183-1381
Publications
2024
Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy.
Annals of clinical and translational neurology.
11(1):67-78
[DOI] 10.1002/acn3.51933.
[PMID] 37932907.
2024
Five multivariate Duchenne muscular dystrophy progression models bridging six-minute walk distance and MRI relaxometry of leg muscles.
Journal of pharmacokinetics and pharmacodynamics.
[DOI] 10.1007/s10928-024-09910-1.
[PMID] 38609673.
2024
Large scale serum proteomics identifies proteins associated with performance decline and clinical milestones in Duchenne muscular dystrophy.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2024.08.05.24311516.
[PMID] 39148831.
2024
Meaningful changes in motor function in Duchenne muscular dystrophy (DMD): A multi-center study.
PloS one.
19(7)
[DOI] 10.1371/journal.pone.0304984.
[PMID] 38985784.
2024
Safety and efficacy of givinostat in boys with Duchenne muscular dystrophy (EPIDYS): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
The Lancet. Neurology.
23(4):393-403
[DOI] 10.1016/S1474-4422(24)00036-X.
[PMID] 38508835.
2024
Serum protein and imaging biomarkers after intermittent steroid treatment in muscular dystrophy.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2024.06.14.24308858.
[PMID] 38947030.
2024
Skeletal muscle symptoms and quantitative MRI in females with dystrophinopathy.
Muscle & nerve.
[DOI] 10.1002/mus.28235.
[PMID] 39221574.
2023
Givinostat for Becker muscular dystrophy: A randomized, placebo-controlled, double-blind study.
Frontiers in neurology.
14
[DOI] 10.3389/fneur.2023.1095121.
[PMID] 36793492.
2023
Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials.
CPT: pharmacometrics & systems pharmacology.
12(10):1437-1449
[DOI] 10.1002/psp4.13021.
[PMID] 37534782.
2022
Characterization of patients with Becker muscular dystrophy by histology, magnetic resonance imaging, function, and strength assessments.
Muscle & nerve.
65(3):326-333
[DOI] 10.1002/mus.27475.
[PMID] 34918368.
2022
Characterizing Expiratory Respiratory Muscle Degeneration in Duchenne Muscular Dystrophy Using MRI.
Chest.
161(3):753-763
[DOI] 10.1016/j.chest.2021.08.078.
[PMID] 34536384.
2022
Development of Contractures in DMD in Relation to MRI-Determined Muscle Quality and Ambulatory Function.
Journal of neuromuscular diseases.
9(2):289-302
[DOI] 10.3233/JND-210731.
[PMID] 35124659.
2022
Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI.
Neurology.
99(21):e2406-e2416
[DOI] 10.1212/WNL.0000000000201163.
[PMID] 36240102.
2022
Longitudinal changes in cardiac function in Duchenne muscular dystrophy population as measured by magnetic resonance imaging.
BMC cardiovascular disorders.
22(1)
[DOI] 10.1186/s12872-022-02688-5.
[PMID] 35681116.
2022
Step Activity Monitoring in Boys with Duchenne Muscular Dystrophy and its Correlation with Magnetic Resonance Measures and Functional Performance.
Journal of neuromuscular diseases.
9(3):423-436
[DOI] 10.3233/JND-210746.
[PMID] 35466946.
2021
Assessment of rAAVrh.74.MHCK7.micro-dystrophin Gene Therapy Using Magnetic Resonance Imaging in Children With Duchenne Muscular Dystrophy.
JAMA network open.
4(1)
[DOI] 10.1001/jamanetworkopen.2020.31851.
[PMID] 33394000.
2021
Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy: Results of the MoveDMD phase 2 and open label extension trial.
Neuromuscular disorders : NMD.
31(5):385-396
[DOI] 10.1016/j.nmd.2021.02.001.
[PMID] 33678513.
2021
Postcontractile blood oxygenation level-dependent (BOLD) response in Duchenne muscular dystrophy.
Journal of applied physiology (Bethesda, Md. : 1985).
131(1):83-94
[DOI] 10.1152/japplphysiol.00634.2020.
[PMID] 34013753.
2021
Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy.
Muscle & nerve.
63(3):320-326
[DOI] 10.1002/mus.27137.
[PMID] 33295018.
2021
Walking activity in a large cohort of boys with Duchenne muscular dystrophy.
Muscle & nerve.
63(2):192-198
[DOI] 10.1002/mus.27119.
[PMID] 33188573.
2020
Characterizing Enrollment in Observational Studies of Duchenne Muscular Dystrophy by Race and Ethnicity.
Journal of neuromuscular diseases.
7(2):167-173
[DOI] 10.3233/JND-190447.
[PMID] 31929119.
2020
Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury.
Journal of neuroscience research.
98(5):843-868
[DOI] 10.1002/jnr.24564.
[PMID] 31797423.
2020
Lower Extremity Muscle Involvement in the Intermediate and Bethlem Myopathy Forms of COL6-Related Dystrophy and Duchenne Muscular Dystrophy: A Cross-Sectional Study.
Journal of neuromuscular diseases.
7(4):407-417
[DOI] 10.3233/JND-190457.
[PMID] 32538860.
2020
Magnetic Resonance Imaging Studies in Duchenne Muscular Dystrophy: Linking Findings to the Physical Therapy Clinic.
Physical therapy.
100(11):2035-2048
[DOI] 10.1093/ptj/pzaa140.
[PMID] 32737968.
2020
Modeling disease trajectory in Duchenne muscular dystrophy.
Neurology.
94(15):e1622-e1633
[DOI] 10.1212/WNL.0000000000009244.
[PMID] 32184340.
2020
MR biomarkers predict clinical function in Duchenne muscular dystrophy.
Neurology.
94(9):e897-e909
[DOI] 10.1212/WNL.0000000000009012.
[PMID] 32024675.
2020
Suitability of external controls for drug evaluation in Duchenne muscular dystrophy.
Neurology.
95(10):e1381-e1391
[DOI] 10.1212/WNL.0000000000010170.
[PMID] 32611643.
2020
Upper and Lower Extremities in Duchenne Muscular Dystrophy Evaluated with Quantitative MRI and Proton MR Spectroscopy in a Multicenter Cohort.
Radiology.
295(3):616-625
[DOI] 10.1148/radiol.2020192210.
[PMID] 32286193.
2019
Age-dependent changes in metabolite profile and lipid saturation in dystrophic mice.
NMR in biomedicine.
32(5)
[DOI] 10.1002/nbm.4075.
[PMID] 30848538.
2019
Effects of PDE5 inhibition on dystrophic muscle following an acute bout of downhill running and endurance training.
Journal of applied physiology (Bethesda, Md. : 1985).
126(6):1737-1745
[DOI] 10.1152/japplphysiol.00664.2018.
[PMID] 30946638.
2019
Imaging respiratory muscle quality and function in Duchenne muscular dystrophy.
Journal of neurology.
266(11):2752-2763
[DOI] 10.1007/s00415-019-09481-z.
[PMID] 31350642.
2019
Magnetic resonance imaging characteristics of injection site reactions after long-term subcutaneous delivery of drisapersen.
European journal of pediatrics.
178(5):777-778
[DOI] 10.1007/s00431-019-03349-0.
[PMID] 30790036.
2019
Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF-κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dystrophy.
Journal of neuromuscular diseases.
6(1):43-54
[DOI] 10.3233/JND-180341.
[PMID] 30452422.
2019
Texture Analysis for Muscular Dystrophy Classification in MRI with Improved Class Activation Mapping.
Pattern recognition.
86:368-375
[DOI] 10.1016/j.patcog.2018.08.012.
[PMID] 31105339.
2018
Leg muscle MRI in identical twin boys with duchenne muscular dystrophy.
Muscle & nerve.
[DOI] 10.1002/mus.26081.
[PMID] 29365354.
2018
Longitudinal timed function tests in Duchenne muscular dystrophy: ImagingDMD cohort natural history.
Muscle & nerve.
58(5):631-638
[DOI] 10.1002/mus.26161.
[PMID] 29742798.
2018
Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy.
PloS one.
13(3)
[DOI] 10.1371/journal.pone.0194283.
[PMID] 29554116.
2018
Two-Year Longitudinal Changes in Lower Limb Strength and Its Relation to Loss in Function in a Large Cohort of Patients With Duchenne Muscular Dystrophy.
American journal of physical medicine & rehabilitation.
97(10):734-740
[DOI] 10.1097/PHM.0000000000000957.
[PMID] 29734234.
2017
A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy.
Neurology.
89(17):1811-1820
[DOI] 10.1212/WNL.0000000000004570.
[PMID] 28972192.
2017
Contrast-Enhanced Near-Infrared Optical Imaging Detects Exacerbation and Amelioration of Murine Muscular Dystrophy.
Molecular imaging.
16
[DOI] 10.1177/1536012117732439.
[PMID] 29271299.
2017
Duchenne Regulatory Science Consortium Meeting on Disease Progression Modeling for Duchenne Muscular Dystrophy.
PLoS currents.
9
[DOI] 10.1371/currents.md.83071bbd728982f2f1073f4950e03586.
[PMID] 28228973.
2017
Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy.
Journal of neurology.
264(1):64-71
[DOI] 10.1007/s00415-016-8311-0.
[PMID] 27778157.
2017
Magnetic Resonance Monitoring of Disease Progression in mdx Mice on Different Genetic Backgrounds.
The American journal of pathology.
187(9):2060-2070
[DOI] 10.1016/j.ajpath.2017.05.010.
[PMID] 28826559.
2017
Molecular signatures of differential responses to exercise trainings during rehabilitation.
Biomedical genetics and genomics.
2(1)
[DOI] 10.15761/BGG.1000127.
[PMID] 28845464.
2017
Multi-slice MRI reveals heterogeneity in disease distribution along the length of muscle in Duchenne muscular dystrophy.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology.
36(3):151-162
[PMID] 29774305.
2016
Age-related T2 changes in hindlimb muscles of mdx mice.
Muscle & nerve.
53(1):84-90
[DOI] 10.1002/mus.24675.
[PMID] 25846867.
2016
MRI quantifies neuromuscular disease progression.
The Lancet. Neurology.
15(1):26-8
[DOI] 10.1016/S1474-4422(15)00320-8.
[PMID] 26549781.
2016
Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort.
Annals of neurology.
79(4):535-47
[DOI] 10.1002/ana.24599.
[PMID] 26891991.
2016
Near-Infrared Optical Imaging Noninvasively Detects Acutely Damaged Muscle
.
186:2692-2700
2016
Near-Infrared Optical Imaging Noninvasively Detects Acutely Damaged Muscle.
The American journal of pathology.
186(10):2692-700
[DOI] 10.1016/j.ajpath.2016.06.019.
[PMID] 27565039.
2015
Longitudinal Evaluation of Muscle Composition Using Magnetic Resonance in 4 Boys With Duchenne Muscular Dystrophy: Case Series.
Physical therapy.
95(7):978-88
[DOI] 10.2522/ptj.20140234.
[PMID] 25592189.
2015
Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements.
PloS one.
10(6)
[DOI] 10.1371/journal.pone.0128915.
[PMID] 26103164.
2015
Speed, not magnitude, of knee extensor torque production is associated with self-reported knee function early after anterior cruciate ligament reconstruction.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA.
23(11):3214-20
[DOI] 10.1007/s00167-014-3168-1.
[PMID] 25026933.
2015
Transcriptional Pathways Associated with Skeletal Muscle Changes after Spinal Cord Injury and Treadmill Locomotor Training.
BioMed research international.
2015
[DOI] 10.1155/2015/387090.
[PMID] 26380273.
2014
Assessment of intramuscular lipid and metabolites of the lower leg using magnetic resonance spectroscopy in boys with Duchenne muscular dystrophy.
Neuromuscular disorders : NMD.
24(7):574-82
[DOI] 10.1016/j.nmd.2014.03.013.
[PMID] 24798221.
2014
Bone loss in a new rodent model combining spinal cord injury and cast immobilization.
Journal of musculoskeletal & neuronal interactions.
14(3):255-66
[PMID] 25198220.
2014
Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle.
Magnetic resonance in medicine.
72(1):8-19
[DOI] 10.1002/mrm.24917.
[PMID] 24006208.
2014
Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: a pilot study.
The journals of gerontology. Series A, Biological sciences and medical sciences.
69(1):101-8
[DOI] 10.1093/gerona/gls337.
[PMID] 23682155.
2014
Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS.
Neurology.
83(11):974-80
[DOI] 10.1212/WNL.0000000000000775.
[PMID] 25098537.
2014
Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus.
Gene therapy.
21(4):387-92
[DOI] 10.1038/gt.2014.9.
[PMID] 24572791.
2014
In vivo (31)P NMR spectroscopy assessment of skeletal muscle bioenergetics after spinal cord contusion in rats.
European journal of applied physiology.
114(4):847-58
[DOI] 10.1007/s00421-013-2810-9.
[PMID] 24399112.
2014
Intrinsic transient tracheal occlusion training and myogenic remodeling of rodent parasternal intercostal fibers.
Journal of rehabilitation research and development.
51(5):841-54
[PMID] 25509059.
2014
Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression.
Neuromuscular disorders : NMD.
24(5):393-401
[DOI] 10.1016/j.nmd.2013.12.012.
[PMID] 24491484.
2014
Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study.
PloS one.
9(9)
[DOI] 10.1371/journal.pone.0106435.
[PMID] 25203313.
2014
Participation in daily life activities and its relationship to strength and functional measures in boys with Duchenne muscular dystrophy.
Disability and rehabilitation.
36(22):1918-23
[DOI] 10.3109/09638288.2014.883444.
[PMID] 24499260.
2014
¹³C NMR metabolomics: applications at natural abundance.
Analytical chemistry.
86(18):9242-50
[DOI] 10.1021/ac502346h.
[PMID] 25140385.
2013
A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy.
International journal of computer assisted radiology and surgery.
8(5):763-74
[DOI] 10.1007/s11548-012-0810-6.
[PMID] 23299128.
2013
Hindlimb muscle morphology and function in a new atrophy model combining spinal cord injury and cast immobilization.
Journal of neurotrauma.
30(3):227-35
[DOI] 10.1089/neu.2012.2504.
[PMID] 22985272.
2013
Magnetic Resonance Imaging and Spectroscopy Detect Changes With Age, Corticosteroid Treatment, and Functional Progression in Dmd
Neuromuscular Disorders.
23(9-10)
[DOI] 10.1016/j.nmd.2013.06.599.
2013
Overexpression of IGF-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse
.
2013
Overexpression of insulin-like growth factor-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse.
Experimental physiology.
98(5):1038-52
[DOI] 10.1113/expphysiol.2012.070722.
[PMID] 23291913.
2013
Regenerative responses in slow- and fast-twitch muscles following moderate contusion spinal cord injury and locomotor training.
European journal of applied physiology.
113(1):191-200
[DOI] 10.1007/s00421-012-2429-2.
[PMID] 22644570.
2013
Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy.
Radiology.
269(1):198-207
[DOI] 10.1148/radiol.13121948.
[PMID] 23696684.
2013
T₂ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.
NMR in biomedicine.
26(3):320-8
[DOI] 10.1002/nbm.2851.
[PMID] 23044995.
2013
White Matter Integrity After Severe Contusion Spinal Cord Injury Under Different Levels of Activity
Journal of Neurotrauma.
30:A116-A117
2012
Age-related differences in lower extremity tissue compartments and associations with physical function in older adults.
Experimental gerontology.
47(1):38-44
[DOI] 10.1016/j.exger.2011.10.001.
[PMID] 22015325.
2012
Chronic intrinsic transient tracheal occlusion elicits diaphragmatic muscle fiber remodeling in conscious rodents.
PloS one.
7(11)
[DOI] 10.1371/journal.pone.0049264.
[PMID] 23133678.
2012
Forelimb Neuroplasticity Following Incomplete Cervical Spinal Cord Injury in Adult Rat
Cell Transplantation.
21(4)
2012
Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping.
Molecular therapy : the journal of the American Society of Gene Therapy.
20(3):580-9
[DOI] 10.1038/mt.2011.264.
[PMID] 22146342.
2012
Mri and Dti Characterization of Spinal Cord Severe Contusion Injury in the Rat
The FASEB's Journal.
26
2012
MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy.
Neuromuscular disorders : NMD.
22 Suppl 2(Suppl 2):S111-21
[DOI] 10.1016/j.nmd.2012.05.013.
[PMID] 22980762.
2012
Participation and quality of life in children with Duchenne muscular dystrophy using the International Classification of Functioning, Disability, and Health.
Health and quality of life outcomes.
10
[DOI] 10.1186/1477-7525-10-43.
[PMID] 22545870.
2012
Relationships of thigh muscle contractile and non-contractile tissue with function, strength, and age in boys with Duchenne muscular dystrophy.
Neuromuscular disorders : NMD.
22(1):16-25
[DOI] 10.1016/j.nmd.2011.06.750.
[PMID] 21807516.
2012
Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.
PloS one.
7(2)
[DOI] 10.1371/journal.pone.0032829.
[PMID] 22389725.
2012
Use of skeletal muscle MRI in diagnosis and monitoring disease progression in Duchenne muscular dystrophy.
Physical medicine and rehabilitation clinics of North America.
23(1):1-10, ix
[DOI] 10.1016/j.pmr.2011.11.004.
[PMID] 22239869.
2011
A New Rat Model of Spinal Cord Injury Without Muscle Reloading: Morphological and Functional Assessment By Mr Imaging and (31)P Spectroscopy
Journal of Neurotrauma.
28
2011
Changes in muscle T2 and tissue damage after downhill running in mdx mice.
Muscle & nerve.
43(6):878-86
[DOI] 10.1002/mus.21986.
[PMID] 21488051.
2011
Design of a Multi-Center Study To Examine Skeletal Muscles of Children With Duchenne Muscular Dystrophy Using Mri/Mrs
Neuromuscular Disorders.
21(9-10):653-654
[DOI] 10.1016/j.nmd.2011.06.801.
2011
Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy.
Human gene therapy.
22(12):1499-509
[DOI] 10.1089/hum.2011.102.
[PMID] 21787232.
2010
Age-related differences in lower-limb muscle cross-sectional area and torque production in boys with Duchenne muscular dystrophy.
Archives of physical medicine and rehabilitation.
91(7):1051-8
[DOI] 10.1016/j.apmr.2010.03.024.
[PMID] 20599043.
2010
Daily Step Count, Gait Parameters, Strength, and Function in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise.
42
2010
Distribution of T2 in the Soleus Muscle of Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise.
42
2010
Impact of treadmill locomotor training on skeletal muscle IGF1 and myogenic regulatory factors in spinal cord injured rats.
European journal of applied physiology.
109(4):709-20
[DOI] 10.1007/s00421-010-1392-z.
[PMID] 20213470.
2010
Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization.
American journal of physiology. Endocrinology and metabolism.
299(5):E730-40
[DOI] 10.1152/ajpendo.00230.2010.
[PMID] 20739512.
2010
Muscle Pathology and Functional Ability in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise.
42
2010
Nnls Analyses of Skeletal Muscle T2 in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise.
42
2010
Skeletal Muscle Contractile and Non-Contractile Components in Boys With Duchenne Muscular Dystrophy By Mri
Medicine and Science in Sports and Exercise.
42
2010
The Effect of Igf-I Overexpression in Skeletal Muscle Following Spinal Cord Injury and Locomotor Training
Medicine and Science in Sports and Exercise.
42
2009
Health-related quality of life after hip arthroplasty with and without an extended-duration continuous posterior lumbar plexus nerve block: a prospective, 1-year follow-up of a randomized, triple-masked, placebo-controlled study.
Anesthesia and analgesia.
109(2):586-91
[DOI] 10.1213/ane.0b013e3181a9db5d.
[PMID] 19608835.
2009
Health-related quality of life after tricompartment knee arthroplasty with and without an extended-duration continuous femoral nerve block: a prospective, 1-year follow-up of a randomized, triple-masked, placebo-controlled study.
Anesthesia and analgesia.
108(4):1320-5
[DOI] 10.1213/ane.0b013e3181964937.
[PMID] 19299806.
2009
Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle.
Human molecular genetics.
18(17):3194-205
[DOI] 10.1093/hmg/ddp257.
[PMID] 19483197.
2008
A longitudinal study of skeletal muscle following spinal cord injury and locomotor training.
Spinal cord.
46(7):488-93
[DOI] 10.1038/sj.sc.3102169.
[PMID] 18283294.
2008
Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse.
NMR in biomedicine.
21(2):101-10
[PMID] 17516466.
2008
Ambulatory continuous femoral nerve blocks decrease time to discharge readiness after tricompartment total knee arthroplasty: a randomized, triple-masked, placebo-controlled study.
Anesthesiology.
108(4):703-13
[DOI] 10.1097/ALN.0b013e318167af46.
[PMID] 18362603.
2008
Ambulatory continuous posterior lumbar plexus nerve blocks after hip arthroplasty: a dual-center, randomized, triple-masked, placebo-controlled trial.
Anesthesiology.
109(3):491-501
[DOI] 10.1097/ALN.0b013e318182a4a3.
[PMID] 18719448.
2008
Locomotor training and muscle function after incomplete spinal cord injury: case series.
The journal of spinal cord medicine.
31(2):185-93
[PMID] 18581666.
2008
Muscle Strength and Functional Status in Boys With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise.
40(5)
[DOI] 10.1249/01.mss.0000323019.33764.4c.
2008
Non-invasive assessment of lower extremity muscle composition after incomplete spinal cord injury.
Spinal cord.
46(8):565-70
[DOI] 10.1038/sc.2008.10.
[PMID] 18347608.
2007
A quantitative study of bioenergetics in skeletal muscle lacking carbonic anhydrase III using 31P magnetic resonance spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America.
104(1):371-6
[PMID] 17182736.
2007
Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase.
American journal of physiology. Endocrinology and metabolism.
293(2):E507-14
[PMID] 17488806.
2007
Resistance training and locomotor recovery after incomplete spinal cord injury: a case series.
Spinal cord.
45(7):522-30
[PMID] 17228358.
2007
Transcriptional pathways associated with skeletal muscle disuse atrophy in humans.
Physiological genomics.
31(3):510-20
[PMID] 17804603.
2006
Ambulatory continuous interscalene nerve blocks decrease the time to discharge readiness after total shoulder arthroplasty: a randomized, triple-masked, placebo-controlled study.
Anesthesiology.
105(5):999-1007
[PMID] 17065895.
2006
Changes in muscle T2 relaxation properties following spinal cord injury and locomotor training.
European journal of applied physiology.
97(3):355-61
[PMID] 16770473.
2006
Changes in soleus muscle function and fiber morphology with one week of locomotor training in spinal cord contusion injured rats.
Journal of neurotrauma.
23(11):1671-81
[PMID] 17115912.
2006
Deficit in human muscle strength with cast immobilization: contribution of inorganic phosphate.
European journal of applied physiology.
98(1):71-8
[PMID] 16841201.
2006
Lower extremity skeletal muscle function in persons with incomplete spinal cord injury.
Spinal cord.
44(11):680-7
[PMID] 16344848.
2006
Lower-extremity muscle cross-sectional area after incomplete spinal cord injury.
Archives of physical medicine and rehabilitation.
87(6):772-8
[PMID] 16731211.
2006
Relative contributions of muscle activation and muscle size to plantarflexor torque during rehabilitation after immobilization
.
24(8):1729-1736
2006
Relative contributions of muscle activation and muscle size to plantarflexor torque during rehabilitation after immobilization.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
24(8):1729-36
[PMID] 16779833.
2006
Total elbow arthroplasty as an outpatient procedure using a continuous infraclavicular nerve block at home: a prospective case report.
Regional anesthesia and pain medicine.
31(2):172-6
[PMID] 16543104.
2006
Total hip arthroplasty as an overnight-stay procedure using an ambulatory continuous psoas compartment nerve block: a prospective feasibility study.
Regional anesthesia and pain medicine.
31(2):113-8
[PMID] 16543096.
2006
Total knee arthroplasty as an overnight-stay procedure using continuous femoral nerve blocks at home: a prospective feasibility study.
Anesthesia and analgesia.
102(1):87-90
[PMID] 16368810.
2005
A model of muscle atrophy using cast immobilization in mice
.
32(5):605-612
2005
A model of muscle atrophy using cast immobilization in mice.
Muscle & nerve.
32(5):672-4
[PMID] 16025524.
2005
Changes in inorganic phosphate and force production in human skeletal muscle after cast immobilization.
Journal of applied physiology (Bethesda, Md. : 1985).
98(1):307-14
[PMID] 15333614.
2005
Early quadriceps strength loss after total knee arthroplasty. The contributions of muscle atrophy and failure of voluntary muscle activation
.
87(5):1047-1053
2005
Early quadriceps strength loss after total knee arthroplasty. The contributions of muscle atrophy and failure of voluntary muscle activation.
The Journal of bone and joint surgery. American volume.
87(5):1047-53
[PMID] 15866968.
2005
Metabolic and phenotypic characteristics of human skeletal muscle fibers as predictors of glycogen utilization during electrical stimulation.
European journal of applied physiology.
95(4):276-82
[PMID] 16096841.
2005
Noninvasive monitoring of muscle damage during reloading following limb disuse
.
32(5):605-612
2005
Noninvasive monitoring of muscle damage during reloading following limb disuse.
Muscle & nerve.
32(5):605-12
[PMID] 16003743.
2005
Total shoulder arthroplasty as an outpatient procedure using ambulatory perineural local anesthetic infusion: a pilot feasibility study.
Anesthesia and analgesia.
101(5):1319-1322
[DOI] 10.1213/01.ANE.0000180199.52383.CE.
[PMID] 16243987.
2004
Muscle adaptations with immobilization and rehabilitation after ankle fracture.
Medicine and science in sports and exercise.
36(10):1695-701
[PMID] 15595289.
2004
Resistance training improves strength and functional capacity in persons with multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England).
10(6):668-74
[PMID] 15584492.
2003
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects.
American journal of physiology. Regulatory, integrative and comparative physiology.
285(1):R183-92
[PMID] 12609816.
2003
Effects of testosterone replacement therapy on skeletal muscle after spinal cord injury.
Spinal cord.
41(1):23-8
[PMID] 12494317.
2003
Human and rat skeletal adaptations to spinal cord injury
.
28(3):491-500
2003
Human and rat skeletal muscle adaptations to spinal cord injury.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.
28(3):491-500
[PMID] 12955874.
2002
Effects of muscle activation on fatigue and metabolism in human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985).
92(5):1978-86
[PMID] 11960948.
2002
Factors in fatigue during intermittent electrical stimulation of human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985).
93(2):469-78
[PMID] 12133852.
2002
Metabolic costs of isometric force generation and maintenance of human skeletal muscle.
American journal of physiology. Endocrinology and metabolism.
282(2):E448-57
[PMID] 11788378.
2001
Magnetic resonance spectroscopy of the masseter muscle in different facial morphological patterns.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.
120(4):427-34
[PMID] 11606968.
2001
Metabolic enzymes and phenotypic expression among human locomotor muscles
.
24(3):387-393
2001
Metabolic enzymes and phenotypic expression among human locomotor muscles.
Muscle & nerve.
24(3):387-93
[PMID] 11353424.
2000
Effects of immobilization on plantar-flexion torque, fatigue resistance, and functional ability following an ankle fracture.
Physical therapy.
80(8):769-80
[PMID] 10911415.
2000
Relationship between muscle T2* relaxation properties and metabolic state: a combined localized 31P-spectroscopy and 1H-imaging study.
European journal of applied physiology.
82(1-2):76-82
[PMID] 10879446.
2000
The effects of immobilization on plantar flexion strength, endurance, and functional ability following an ankle fracture
.
80(8):769-780
1999
In vivo ATP synthesis rates in single human muscles during high intensity exercise.
The Journal of physiology.
519 Pt 3(Pt 3):901-10
[PMID] 10457099.
1999
In vivo ATP synthesis rates in single human muscles during high-intensity exercise
.
519(3):901-910
1999
Spectral quantitation by principal component analysis using complex singular value decomposition.
Magnetic resonance in medicine.
41(3):450-5
[PMID] 10204865.
1998
Autonomic testing in patients with chronic fatigue syndrome
The American journal of medicine.
105(3A):22S-26S
1998
Fast imaging of phosphocreatine using a RARE pulse sequence.
Magnetic resonance in medicine.
39(5):851-4
[PMID] 9581617.
1998
Longitudinal study of skeletal muscle adaptations during immobilization and rehabilitation
.
21(8):1006-1012
1998
Longitudinal study of skeletal muscle adaptations during immobilization and rehabilitation.
Muscle & nerve.
21(8):1006-12
[PMID] 9655118.
1997
Noninvasive measurement of phosphocreatine recovery kinetics in single human muscles
.
272(2):C525-C534
1997
Noninvasive measurement of phosphocreatine recovery kinetics in single human muscles.
The American journal of physiology.
272(2 Pt 1):C525-34
[PMID] 9124295.
1997
Volumetric measurement of human calf muscle from magnetic resonance imaging.
Magma (New York, N.Y.).
5(2):93-8
[PMID] 9268071.
1997
Volumetric measurement of human calf muscle from MRI
Magnetic Resonance Materials in Physics Biology and Medicine.
5(2):93-98
1995
Energy-rich phosphates in slow and fast human skeletal muscle
.
268(4):C869-C876
1995
Energy-rich phosphates in slow and fast human skeletal muscle.
The American journal of physiology.
268(4 Pt 1):C869-76
[PMID] 7733235.
1995
pH heterogeneity during exercise in localized spectra from single human muscles
.
268(4):C869-C876
1993
31P magnetic resonance muscle spectroscopy in fibromyalgia
.
20(11):1985-1986
1993
31P magnetic resonance muscle spectroscopy in fibromyalgia.
The Journal of rheumatology.
20(11):1985-6
[PMID] 8179665.
1993
pH heterogeneity during exercise in localized spectra from single human muscles.
The American journal of physiology.
265(5 Pt 1):C1332-9
[PMID] 8238485.
1992
Muscle metabolism in track athletes, using 31P magnetic resonance spectroscopy
.
7(10):1353-1359
1992
Muscle metabolism in track athletes, using 31P magnetic resonance spectroscopy.
Canadian journal of physiology and pharmacology.
70(10):1353-9
[PMID] 1490254.
1991
Metabolic heterogeneity in human calf muscle during maximal exercise.
Proceedings of the National Academy of Sciences of the United States of America.
88(13):5714-8
[PMID] 2062850.
1991
Noninvasive measurements of activity-induced changes in muscle metabolism.
Journal of biomechanics.
24 Suppl 1:153-61
[PMID] 1791175.
Education
Ph.D Physical Therapy
1988-1993
·
Free University of Brussels
Licentiate Physical Therapy and Motoric Revalidation
1984-1988
·
Free University of Brussels
Contact Details
Phones:
- Business:
- (352) 273-6085
Emails:
- Business:
- kvandenb@phhp.ufl.edu
Addresses:
- Business Mailing:
-
DEPT OF PHYSICAL THERAPY, HPNP, RM 1142
GAINESVILLE FL 32610 - Business Street:
-
DEPT OF PHYSICAL THERAPY
HPNP BUILDING, ROOM 1142
DR. KRISTA VANDENBORNE
GAINESVILLE FL 32610